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1. 发明申请

WO2022269497A1 A METHOD AND SYSTEM FOR DETERMINING A PERFUSION METRIC USING DEOXYHEMOGLOBIN AS A CONTRAST AGENT 审中-公开
公开(公告)号：WO2022269497A1
公开(公告)日：2022-12-29
申请号：PCT/IB2022/055769
申请日：2022-06-21
申请人： MIKULIS, David , POUBLANC, Julien , SOBCZYK, Olivia , DUFFIN, James , SAYIN, Ece Su , FISHER, Joseph Arnold , WOOD, John , VU, Chau
发明人： MIKULIS, David , POUBLANC, Julien , SOBCZYK, Olivia , DUFFIN, James , SAYIN, Ece Su , FISHER, Joseph Arnold , WOOD, John , VU, Chau
IPC分类号： A61B5/0205 , A61B5/00 , A61B5/083 , A61B5/1455 , A61M1/14
摘要： Hypoxia-induced deoxyhemoglobin concentration ([dOHb]) may be used as a susceptibility contrast agent in subjects. While the maximal rate of generating blood [dOHb] are limited by constraints in pulmonary gas mixing, decreasing dOHb with re-oxygenation of the lungs can be accomplished in one breath, resulting in a step reduction in arterial [dOHb] and thereby a step increase in cerebral BOLD signal recorded with MRI. The BOLD signal changes accompanying a step decrease in [dOHb] can be analyzed to calculate cerebral perfusion measures and compare their maps to those obtained using a bolus of a conventional contrast agent, gadolinium, and a conventional analysis requiring the identification of an arterial input function. The two methods provided comparable anatomically-distributed hemodynamic information.

2. 发明申请

WO2023286040A1 IMPLEMENTING A PERIODIC DEOXYHEMOGLOBIN SIGNAL 审中-公开
公开(公告)号：WO2023286040A1
公开(公告)日：2023-01-19
申请号：PCT/IB2022/056604
申请日：2022-07-18
申请人： FISHER, Joseph Arnold , DUFFIN, James , POUBLANC, Julien , SOBCZYK, Olivia , MIKULIS, David , SAYIN, Ece Su
发明人： FISHER, Joseph Arnold , DUFFIN, James , POUBLANC, Julien , SOBCZYK, Olivia , MIKULIS, David , SAYIN, Ece Su
IPC分类号： A61B5/145 , A61B5/055 , A61B5/0205
摘要： A method of implementing changes in deoxyhemoglobin concentration, the method comprising: targeting a sequence of partial pressures of oxygen in arterial blood (PaCh) values in a subject using a sequential gas delivery device in a periodic input pattern; measuring a blood- oxygen level dependent (BOLD) signal in a voxel of the subject's brain using a magnetic resonance imaging device while targeting the sequence of values; comparing the pattern to the signal; and determining a vascular tissue characteristic (vessel type, vessel orientation, or pathological condition) for the voxel based on the comparison.

3. 发明申请

WO2023286039A1 INDUCING DEOXYHEMOGLOBIN AS A CONTRAST AGENT IN A SUBJECT FOR MRI 审中-公开
公开(公告)号：WO2023286039A1
公开(公告)日：2023-01-19
申请号：PCT/IB2022/056603
申请日：2022-07-18
申请人： FISHER, Joseph Arnold , DUFFIN, James , SOBCZYK, Olivia , SAYIN, Ece Su , MIKULIS, David , POUBLANC, Julien , SCHULMAN, Jacob B.
发明人： FISHER, Joseph Arnold , DUFFIN, James , SOBCZYK, Olivia , SAYIN, Ece Su , MIKULIS, David , POUBLANC, Julien , SCHULMAN, Jacob B.
IPC分类号： A61M16/10
摘要： The speed and range of the transition to low lung PO2 can be optimized such that it approaches the PO2 and timing profile of reoxygenation from a hypoxic profile. However, such hypoxic "spikes" are much more difficult to implement than re-oxygenation. A solution is to control the independent variables which contribute to hypoxia in the lung. These variables may be controlled in alone or in aggregate to minimize the time required to generate a target profile of transient lung hypoxia. In particular, a rapid decrease in [dOHb] can be implemented by breathing deeply, exhaling at least a portion of the functional residual capacity, lowering the PO2 at baseline, increasing the breathing rate, and increasing the PCO2 to shift the oxygen-hemoglobin dissociation curve to the right.

4. 发明公开

EP0633793A1 ENDOTRACHEAL TUBE INTRODUCER 失效
标题翻译： EINFUEHRRORRICHTUNG EINEN LUFTROERENKANUELE。
公开(公告)号：EP0633793A1
公开(公告)日：1995-01-18
申请号：EP93907703.0
申请日：1993-03-26
申请人： FISHER, Joseph Arnold , BERDOWSKI, Alan
发明人： FISHER, Joseph Arnold , BERDOWSKI, Alan
IPC分类号： A61M25 , A61M16
CPC分类号： A61M16/0488
摘要： An endotracheal tube introducer (100) comprising a proximal end (12) and a distal end (14), the proximal end (12) comprising a mouth (30) of greater diameter than an endotracheal tube being inserted into it and an elongated portion connected to, and extending longitudinally away from, the mouth for insertion thereof past the epiglottis, between the vocal cords, into the trachea, the elongated portion comprising at least one guide (16) and reinforcing portion extending longitudinally along the length of the elongated portion away from the proximal end (12) and mouth (30), and relatively thin pliable side portions or wings (18A, 18B) extending laterally from the sides of the guide portion (16), one from each side and overlap one another at least proximate the distal end (14).
摘要翻译：包括近端和远端的气管插管导管器，所述近端包括比插入其中的气管插管更大的直径的嘴，以及连接到所述口并纵向远离所述口的细长部分，用于将其插入其中会话，在声带之间，进入气管，细长部分包括至少一个引导件和加强部分，该导向件和加强部分沿着细长部分的长度纵向延伸远离近端和口部，以及相对薄的柔软的侧部或翼部，引导部分的侧面，每侧各一个，至少靠近远端彼此重叠。

5. 发明公开

EP0973572A1 ELIMINATION OF VAPOUR ANAESTHETICS FROM PATIENTS AFTER SURGICAL PROCEDURES 失效
标题翻译： NAKROSEMITTELDAMPF从患者手术去除后
公开(公告)号：EP0973572A1
公开(公告)日：2000-01-26
申请号：EP97906959.8
申请日：1997-03-19
申请人： FISHER, Joseph Arnold
发明人： FISHER, Joseph Arnold
IPC分类号： A61M16/00 , A61M16/12
CPC分类号： A61M16/12 , A61M16/024 , A61M16/208 , A61M16/209 , A61M16/22 , A61M2202/0225 , A61M2202/0007
摘要： A method of treatment of an animal to recover from vapour anaesthetics administration is provided, the method comprising delivering to a patient gases which do not contain CO2 at a specified rate, and gases containing CO2 to maintain the same PCO2 in the animal independent of the rate of ventilation, at the rate of ventilation of the animal which exceeds the rate of administration of the gases which do not contain CO2.
摘要翻译：呼吸回路系统，用于在麻醉患者通气。该系统包括一个标准的主要圆麻醉电路，其本身包括用于递送再呼吸的气体的单向吸气分支和用于接受呼出气体的单向呼气分支。因此，该呼吸回路系统包括一个辅助呼吸回路，而纯粹供给非再呼吸气体，并包括非再呼吸的，基本上不含二氧化碳的气体源，非再呼吸新鲜气体贮存器，用于存储新鲜气体，的非源再呼吸储备气体包含二氧化碳和气体输送管道。设置成与吸气分支通信是一种非再吸阀门，同时与两个吸气分支和输送导管连通设置为选择性地允许气体通过从吸气分支或从输送三通呼吸阀管道。

6. 发明授权

EP0633793B1 ENDOTRACHEAL TUBE INTRODUCER 失效
标题翻译： ENDOTRACHEAL导管介绍
公开(公告)号：EP0633793B1
公开(公告)日：1998-01-21
申请号：EP93907703.8
申请日：1993-03-26
申请人： FISHER, Joseph Arnold , BERDOWSKI, Alan
发明人： FISHER, Joseph Arnold , BERDOWSKI, Alan
IPC分类号： A61M16/00
CPC分类号： A61M16/0488
摘要： An endotracheal tube introducer (100) comprising a proximal end (12) and a distal end (14), the proximal end (12) comprising a mouth (30) of greater diameter than an endotracheal tube being inserted into it and an elongated portion connected to, and extending longitudinally away from, the mouth for insertion thereof past the epiglottis, between the vocal cords, into the trachea, the elongated portion comprising at least one guide (16) and reinforcing portion extending longitudinally along the length of the elongated portion away from the proximal end (12) and mouth (30), and relatively thin pliable side portions or wings (18A, 18B) extending laterally from the sides of the guide portion (16), one from each side and overlap one another at least proximate the distal end (14).
摘要翻译：一种包括近端（12）和远端（14）的气管内导管引入器（100），所述近端（12）包括直径大于插入其中的气管内插管的开口（30）并沿纵向远离嘴部延伸，以便将其插入通过会厌，在声带之间进入气管，所述细长部分包括至少一个导向件（16）和沿着细长部分的长度纵向延伸的加强部分（12）和嘴部（30）之间以及从引导部分（16）的侧面横向延伸的相对较薄的柔韧侧部或翼（18A，18B），每个侧面一个且彼此重叠至少接近远端（14）。

7. 发明授权

EP0973572B1 DEVICE FOR ELIMINATION OF VAPOUR ANAESTHETICS FROM PATIENTS AFTER SURGICAL PROCEDURES 失效
标题翻译： DEVICE FOR REMOVING麻醉蒸气从患者手术后
公开(公告)号：EP0973572B1
公开(公告)日：2003-10-22
申请号：EP97906959.8
申请日：1997-03-19
申请人： FISHER, Joseph Arnold
发明人： FISHER, Joseph Arnold
IPC分类号： A61M16/00 , A61M16/12
CPC分类号： A61M16/12 , A61M16/024 , A61M16/208 , A61M16/209 , A61M16/22 , A61M2202/0225 , A61M2202/0007

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