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1. 发明专利

DK141638C 未知
公开(公告)号：DK141638C
公开(公告)日：1980-10-13
申请号：DK685073
申请日：1973-12-17
申请人： ERASMUS UNIVERSITEIT ROTTERDAM
发明人： LANCEE C T , ZWIETEN G V
IPC分类号： A61B8/00 , G01N29/40 , G01S7/52
摘要： An echoscope for examination of objects with the aid of ultrasonic pulses, comprising at least one electroacoustic element for transmitting and receiving ultrasonic pulses during a transmission-reception period divided into n consecutive time intervals. The ultrasonic pulses are sent to the objects to be examined and are reflected therefrom. The echo signals supplied by the receiving element are amplified by an amplifier with time-dependent gain control. The gain control is brought about by a control voltage generator which supplies a control voltage to said amplifier for determining its signal gain as a function of time. Adjusting means for the control voltage generator are provided to make it possible to change the magnitude of the control voltage in the time intervals as a function of time. The apparatus also comprises a device for visually displaying the echo signals received during each transmission-reception period.

2. 发明专利

DE2215001C3 未知
公开(公告)号：DE2215001C3
公开(公告)日：1986-11-13
申请号：DE2215001
申请日：1972-03-28
申请人： ERASMUS UNIVERSITEIT ROTTERDAM, ROTTERDAM, NL
发明人： BOM, NICOLAAS, BERKENWOUDE, NL
IPC分类号： A61B8/08 , A61B5/10
摘要： An examination of the human heart is carried out by means of ultrasound waves emitted by piezo-electric crystals. The crystals are inserted in a holder adapted to be placed on the body of a patient; they are arranged in a row and have parallel axes of radiation. The crystals are cyclically excited at a high scanning frequency, and the echo signals reflected by the heart walls and received by the crystals are displayed on the screen of a cathode ray tube to obtain a cross-sectional picture of the heart. In a modification of the invention, the holder comprises two or more rows of crystals radiating at different angles; in this case the echo signals related to a common point of the heart wall are superposed on the screen of the cathode ray tube by means of a coordinate transformation.

3. 发明专利

DE2824165C2 未知
公开(公告)号：DE2824165C2
公开(公告)日：1987-04-30
申请号：DE2824165
申请日：1978-06-02
申请人： ERASMUS UNIVERSITEIT ROTTERDAM, ROTTERDAM, NL
发明人： BRUINVELS, JACQUES, DR., DE BILT, NL , PEPPLINKHUIZEN, LOLKE, DR., ROTTERDAM, NL
IPC分类号： A61K31/195
摘要： Patients suffering from anxiety neurosis and anxietylike neurosis often accompanied by alcoholism are treated by administration of medicine containing a beta -(p-halogen phenyl)- GAMMA -aminobutyric acid as active compound. As a result these patients were totally freed from the above mentioned complaints.

4. 发明专利

DE2363857C3 未知
公开(公告)号：DE2363857C3
公开(公告)日：1982-09-16
申请号：DE2363857
申请日：1973-12-21
申请人： ERASMUS UNIVERSITEIT ROTTERDAM, ROTTERDAM, NL
发明人： LANCEE, CHARLES THEODOOR, WAARDER, NL , ZWIETEN, GERARD VAN, SMITSHOEK, NL
IPC分类号： A61B8/00 , G01N29/40 , G01S7/52 , G01S15/02 , A61B10/00 , G01N29/04
摘要： An echoscope for examination of objects with the aid of ultrasonic pulses, comprising at least one electroacoustic element for transmitting and receiving ultrasonic pulses during a transmission-reception period divided into n consecutive time intervals. The ultrasonic pulses are sent to the objects to be examined and are reflected therefrom. The echo signals supplied by the receiving element are amplified by an amplifier with time-dependent gain control. The gain control is brought about by a control voltage generator which supplies a control voltage to said amplifier for determining its signal gain as a function of time. Adjusting means for the control voltage generator are provided to make it possible to change the magnitude of the control voltage in the time intervals as a function of time. The apparatus also comprises a device for visually displaying the echo signals received during each transmission-reception period.

5. 发明专利

DE2363857B2 未知
公开(公告)号：DE2363857B2
公开(公告)日：1978-09-28
申请号：DE2363857
申请日：1973-12-21
申请人： ERASMUS UNIVERSITEIT ROTTERDAM, ROTTERDAM (NIEDERLANDE)
发明人： LANCEE, CHARLES THEODOOR, WAARDER , ZWIETEN, GERARD VAN, SMITSHOEK
IPC分类号： A61B8/00 , G01N29/40 , G01S7/52 , G01S9/66 , A61B10/00 , G01N29/04
摘要： An echoscope for examination of objects with the aid of ultrasonic pulses, comprising at least one electroacoustic element for transmitting and receiving ultrasonic pulses during a transmission-reception period divided into n consecutive time intervals. The ultrasonic pulses are sent to the objects to be examined and are reflected therefrom. The echo signals supplied by the receiving element are amplified by an amplifier with time-dependent gain control. The gain control is brought about by a control voltage generator which supplies a control voltage to said amplifier for determining its signal gain as a function of time. Adjusting means for the control voltage generator are provided to make it possible to change the magnitude of the control voltage in the time intervals as a function of time. The apparatus also comprises a device for visually displaying the echo signals received during each transmission-reception period.

6. 发明授权

US09487830B2 Determining the replicative history of lymphocytes 有权
标题翻译：确定淋巴细胞的复制史
公开(公告)号：US09487830B2
公开(公告)日：2016-11-08
申请号：US11409718
申请日：2006-04-24
申请人： Jacobus J. M. van Dongen , Thomasz Szczepanski
发明人： Jacobus J. M. van Dongen , Thomasz Szczepanski
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6881 , C12Q1/6876 , C12Q1/6883 , C12Q2600/156
摘要： The invention relates to the field of immunology and immunodiagnostics. Provided is a method for determining the replicative history of a lymphocyte, preferably a B cell, the method comprising detecting a signal joint nucleotide sequence on an extrachromosomal circular excision product in the lymphocyte, wherein the excision product is deleted from a chromosome to give a chromosomal-coding joint nucleotide sequence, wherein the coding joint is retained in the chromosome, and detecting the coding joint nucleotide sequence in the lymphocyte. Also provided are primers, probes and a control cell for use in a method of the invention. A method provided herein is among others advantageously used to assess recovery of the precursor B-cell compartment, for example, in a patient following bone marrow transplantation
摘要翻译：本发明涉及免疫学和免疫诊断领域。提供了一种确定淋巴细胞，优选B细胞的复制史的方法，所述方法包括检测淋巴细胞中染色体外循环切除产物上的信号联合核苷酸序列，其中切除产物从染色体中缺失以产生染色体编码关节核苷酸序列，其中编码关节保留在染色体中，并检测淋巴细胞中的编码关节核苷酸序列。还提供了用于本发明方法的引物，探针和对照细胞。本文提供的方法有利地用于评估前体B细胞隔室的恢复，例如在骨髓移植后的患者中

7. 发明授权

US07993850B2 Method and probes for the detection of a tumor-specific fusion protein 有权
标题翻译：用于检测肿瘤特异性融合蛋白的方法和探针
公开(公告)号：US07993850B2
公开(公告)日：2011-08-09
申请号：US12462637
申请日：2009-08-06
申请人： Jacobus Johannes Maria van Dongen
发明人： Jacobus Johannes Maria van Dongen
IPC分类号： G01N33/533
CPC分类号： B82Y20/00 , B82Y5/00 , B82Y10/00 , G01N33/542 , G01N33/574 , G01N33/57426 , G01N33/57496 , Y10T436/108331
摘要： The invention relates to the detection of fusion proteins. Described are a set of at least a first and a second molecular probe, each probe provided with a dye wherein the dyes together allow energy transfer, at least one probe provided with a reactive group allowing juxtaposing at least the first and second probes wherein the reactive group allows modulation of juxtaposing the probes such that there is an increased likelihood of energy transfer between the dyes. A method is provided which permits detecting the presence of a fusion protein in a cell at the single cell level.
摘要翻译：本发明涉及融合蛋白的检测。描述的是至少第一和第二分子探针的集合，每个探针提供有染料，其中染料一起允许能量转移，提供有反应性基团的至少一个探针允许并置至少第一和第二探针，其中反应性组允许调制并置探针，使得染料之间能量转移的可能性增加。提供了一种允许在单细胞水平检测细胞中融合蛋白的存在的方法。

8. 发明申请

US20050074786A1 Method for determining susceptibility to heart disease by screening polymorphisms in the vitamin D receptor gene 审中-公开
标题翻译：通过筛选维生素D受体基因多态性来确定心脏病易感性的方法
公开(公告)号：US20050074786A1
公开(公告)日：2005-04-07
申请号：US10703715
申请日：2003-11-07
申请人： Andreas Uitterlinden , Johannes Petrus Van Leeuwen , Huibert Pieter Pols
发明人： Andreas Uitterlinden , Johannes Petrus Van Leeuwen , Huibert Pieter Pols
IPC分类号： G01N33/50 , C12N15/09 , C12Q1/68 , C12Q1/6883
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： The present invention relates to prognostic method and means for determining susceptibility to heart disease in a subject by screening for polymorphisms in the Vitamin D receptor gene. In particular, the present invention provides a method for determining susceptibility to heart disease, the method comprising analysing the genetic material of a subject to determine which of the B/b, A/a or T/t alleles of the restriction enzyme sites BsmI, ApaI and TaqI respectively are present. Specific combinations of alleles represent a haplotype which is associated with susceptibility to heart disease.
摘要翻译：本发明涉及通过筛选维生素D受体基因的多态性来确定受试者对心脏病易感性的预后方法和手段。特别地，本发明提供了一种确定心脏病易感性的方法，所述方法包括分析受试者的遗传物质以确定限制酶位点BsmI的B / b，A / a或T / t等位基因中的哪一个， ApaI和TaqI分别存在。等位基因的特定组合表示与心脏病易感性相关的单倍型。

9. 发明申请

US20040138096A1 Immunoregulator 有权
标题翻译：免疫调节剂
公开(公告)号：US20040138096A1
公开(公告)日：2004-07-15
申请号：US10678995
申请日：2003-10-03
申请人： Erasmus Universiteit Rotterdam
发明人： Nisar Ahmed Khan , Hubertus Franciscus Josef Savelkoul , Robbert Benner
IPC分类号： A61K038/00
CPC分类号： C07K5/1008 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/1709 , A61K38/24 , C07K5/101 , C07K14/59
摘要： The invention relates to the field of immunology. Specifically, the invention relates to the field of immune-mediated disorders such as allergies, auto-immune disease, transplantation-related disease or inflammatory disease. The invention provides for an immunoregulator (IR), use of an IR in preparing a pharmaceutical composition for treating an immune-mediated disorder and a method for treating an immune-mediated disorder.
摘要翻译：本发明涉及免疫学领域。具体地，本发明涉及免疫介导的疾病如过敏，自身免疫疾病，移植相关疾病或炎性疾病的领域。本发明提供免疫调节剂（IR），IR在制备用于治疗免疫介导的病症的药物组合物中的用途以及治疗免疫介导的病症的方法。

10. 发明授权

US4595015A Method and apparatus for estimating the cardiac output of the heart of a patient 失效
标题翻译：用于估计患者心脏的心输出量的方法和装置
公开(公告)号：US4595015A
公开(公告)日：1986-06-17
申请号：US527419
申请日：1983-08-29
申请人： Jozef R. Jansen , Adriaan Versprille
发明人： Jozef R. Jansen , Adriaan Versprille
IPC分类号： A61B5/0275 , A61B5/02
CPC分类号： A61B5/0275
摘要： A method and apparatus are described for estimating the cardiac output of the heart of a patient. An indicator is injected as an impulse in the blood stream of the patient, whereafter a first signal corresponding with the concentration variation of the indicator is measured at a position at a distance downstream of the injection position. Said first signal is supplied to a processor unit for determining the cardiac output from said first signal and the injected amount of indicator. Further, a second signal at least substantially proportional to the cardiac output is measured in the same blood stream adjacent the measurement position for the first signal. Both said signals are stored in a memory. Thereafter, said second signal is normalized by a predetermined value of said second signal and the first signal is corrected by means of the normalized second signal. The processor unit now determines the cardiac output from the corrected first signal.
摘要翻译：描述了一种用于估计患者心脏的心输出量的方法和装置。指示剂作为脉冲注入患者的血液中，之后在与注射位置下游距离处的位置测量与指示剂的浓度变化相对应的第一信号。所述第一信号被提供给处理器单元，用于根据所述第一信号和指示器的注入量确定心输出量。此外，在与第一信号的测量位置相邻的相同血流中测量与心输出量至少基本成比例的第二信号。两个信号都存储在存储器中。此后，所述第二信号由所述第二信号的预定值归一化，并且通过标准化的第二信号校正第一信号。处理器单元现在从校正的第一信号确定心输出量。

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