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1. 发明授权

US09487830B2 Determining the replicative history of lymphocytes 有权
标题翻译：确定淋巴细胞的复制史
公开(公告)号：US09487830B2
公开(公告)日：2016-11-08
申请号：US11409718
申请日：2006-04-24
申请人： Jacobus J. M. van Dongen , Thomasz Szczepanski
发明人： Jacobus J. M. van Dongen , Thomasz Szczepanski
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6881 , C12Q1/6876 , C12Q1/6883 , C12Q2600/156
摘要： The invention relates to the field of immunology and immunodiagnostics. Provided is a method for determining the replicative history of a lymphocyte, preferably a B cell, the method comprising detecting a signal joint nucleotide sequence on an extrachromosomal circular excision product in the lymphocyte, wherein the excision product is deleted from a chromosome to give a chromosomal-coding joint nucleotide sequence, wherein the coding joint is retained in the chromosome, and detecting the coding joint nucleotide sequence in the lymphocyte. Also provided are primers, probes and a control cell for use in a method of the invention. A method provided herein is among others advantageously used to assess recovery of the precursor B-cell compartment, for example, in a patient following bone marrow transplantation
摘要翻译：本发明涉及免疫学和免疫诊断领域。提供了一种确定淋巴细胞，优选B细胞的复制史的方法，所述方法包括检测淋巴细胞中染色体外循环切除产物上的信号联合核苷酸序列，其中切除产物从染色体中缺失以产生染色体编码关节核苷酸序列，其中编码关节保留在染色体中，并检测淋巴细胞中的编码关节核苷酸序列。还提供了用于本发明方法的引物，探针和对照细胞。本文提供的方法有利地用于评估前体B细胞隔室的恢复，例如在骨髓移植后的患者中

2. 发明申请

US20070003951A1 Determining the replicative history of lymphocytes 有权
标题翻译：确定淋巴细胞的复制史
公开(公告)号：US20070003951A1
公开(公告)日：2007-01-04
申请号：US11409718
申请日：2006-04-24
申请人： Jacobus van Dongen , Thomasz Szczepanski
发明人： Jacobus van Dongen , Thomasz Szczepanski
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34 , C12N5/08
CPC分类号： C12Q1/6881 , C12Q1/6876 , C12Q1/6883 , C12Q2600/156
摘要： The invention relates to the field of immunology and immunodiagnostics. Provided is a method for determining the replicative history of a lymphocyte, preferably a B cell, the method comprising detecting a signal joint nucleotide sequence on an extrachromosomal circular excision product in the lymphocyte, wherein the excision product is deleted from a chromosome to give a chromosomal-coding joint nucleotide sequence, wherein the coding joint is retained in the chromosome, and detecting the coding joint nucleotide sequence in the lymphocyte. Also provided are primers, probes and a control cell for use in a method of the invention. A method provided herein is among others advantageously used to assess recovery of the precursor B-cell compartment, for example, in a patient following bone marrow transplantation
摘要翻译：本发明涉及免疫学和免疫诊断领域。提供了一种确定淋巴细胞，优选B细胞的复制史的方法，所述方法包括检测淋巴细胞中染色体外循环切除产物上的信号联合核苷酸序列，其中切除产物从染色体中缺失以产生染色体编码关节核苷酸序列，其中编码关节保留在染色体中，并检测淋巴细胞中的编码关节核苷酸序列。还提供了用于本发明方法的引物，探针和对照细胞。本文提供的方法有利地用于评估前体B细胞隔室的恢复，例如在骨髓移植后的患者中

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