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1. 发明申请

WO1989001778A1 AGENTS FOR PROPHYLAXIS AND TREATMENT OF THROMBOPENIA 审中-公开
标题翻译：丙肝治疗药物和治疗血栓形成
公开(公告)号：WO1989001778A1
公开(公告)日：1989-03-09
申请号：PCT/JP1988000883
申请日：1988-09-02
申请人： DAIICHI SEIYAKU CO., LTD. , NAKAYASU, Toshiro , MASUO, Ken , TAKAYANAGI, Teruo , INOUE, Atsuo , TSUBURA, Eiro , MASAOKA, Toru
发明人： DAIICHI SEIYAKU CO., LTD.
IPC分类号： A61K37/02
CPC分类号： C07K9/005
摘要： Agents for prophylaxis and treatment of thrombopenia, which contain as an effective ingredient a muramyldipeptide derivative represented by general formula (I) (wherein X represents a residue of an amino acid selected from among L-alanine, L-serine and L-valine, Y represents (II), R1 represents a carboxyl group, n represents an integer of 1 to 6, A represents a saturated, optionally branched aliphatic hydrocarbyl residue containing 7 to 29 carbon atoms, and Acyl represents an acyl group containing 2 to 6 carbon atoms). The agents show an excellent effect for prophylaxis and treatment of thrombopenia.

2. 发明申请

WO0073270A8 REMEDIES FOR PERIODONTAL DISEASES 审中-公开
标题翻译：周围疾病的补救措施
公开(公告)号：WO0073270A8
公开(公告)日：2001-03-01
申请号：PCT/JP0003483
申请日：2000-05-31
申请人： DAIICHI SEIYAKU CO , MATSUSHITA KENJI , IMAMURA TAKAHISA , MARUYAMA IKURO , TOMIKAWA MUNEHIRO
发明人： MATSUSHITA KENJI , IMAMURA TAKAHISA , MARUYAMA IKURO , TOMIKAWA MUNEHIRO
IPC分类号： A61K31/40 , A61K31/445 , C07D207/12 , A61K31/4025 , A61K31/4535 , A61K31/454 , C07D211/46 , C07D401/12 , C07D403/12 , C07D409/12
CPC分类号： C07D207/12 , A61K31/40 , A61K31/445
摘要： Preventive and/or therapeutic drugs for periodontal diseases containing as the active ingredient compounds of general formula (1) or salts thereof and being capable of preventing and/or treating effectively various periodontal diseases such as periodontitis, wherein R is hydrogen or the like; R is hydrogen, lower alkyl, or the like; R is hydrogen, carboxyl, or the like; R is hydrogen, halogeno, or the like; n is a number of 0 to 4; A is C1-C4 alkylene which may be substituted with one or two members selected from among hydroxyalkyl, carboxyl, and alkoxycarbonyl, or the like, X is a single bond, oxygen, or the like; and Y is an optionally substituted, saturated or unsaturated, five- or six-membered heterocyclic group or the like.
摘要翻译：含有作为活性成分的通式（1）化合物或其盐的牙周病的预防和/或治疗药物能够有效预防和/或治疗牙周炎等牙周病，其中R 1是氢或喜欢; R 2是氢，低级烷基等; R 3是氢，羧基等; R 4是氢，卤素等; n是0到4的数; A是可以被一个或两个选自羟烷基，羧基和烷氧基羰基的成员取代的C 1 -C 4亚烷基，X是单键，氧等; 并且Y是任选取代的饱和或不饱和的五元或六元杂环基等。

3. 发明申请

WO9711683A3 STABILISED PHOSPHOLIPID COMPOSITIONS 审中-公开
标题翻译：稳定的磷脂组合物
公开(公告)号：WO9711683A3
公开(公告)日：1997-06-26
申请号：PCT/GB9602364
申请日：1996-09-25
申请人： NYCOMED IMAGING AS , DAIICHI SEIYAKU CO , COCKBAIN JULIAN , DYVIK KARI , DUGSTAD HARALD , SKURTVEIT ROALD , KLAVENESS JO , OESTENSEN JONNY , YACHI KIYOTO
发明人： DYVIK KARI , DUGSTAD HARALD , SKURTVEIT ROALD , KLAVENESS JO , OESTENSEN JONNY , YACHI KIYOTO
IPC分类号： A61K8/00 , A61K8/14 , A61K8/41 , A61K8/46 , A61K9/127 , A61K49/04 , A61K49/00 , A61K51/12
CPC分类号： A61K49/0433 , A61K9/127
摘要： The stability of phospholipid compositions is enhanced by the inclusion of a buffer system comprising ammonia or a water soluble amine having a pH at 15 °C of less than or equal to 9.5.

4. 发明申请

WO2005095364A8 PHENOXYACETIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME 审中-公开
标题翻译：苯氧基酸衍生物及含有其的药物
公开(公告)号：WO2005095364A8
公开(公告)日：2006-01-05
申请号：PCT/JP2005005740
申请日：2005-03-28
申请人： DAIICHI SEIYAKU CO , KAGECHIKA KATSUJI , SHIBATA YOSHIHIRO , USUI HIROYUKI
发明人： KAGECHIKA KATSUJI , SHIBATA YOSHIHIRO , USUI HIROYUKI
IPC分类号： A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61P3/10 , C07D263/32 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D413/12 , C07D263/32 , C07D413/14 , C07D417/12 , C07D417/14
摘要： A novel compound having excellent PPARa/? agonistic activity and having desirable properties required of medicines. It is a peroxisome proliferation-activated receptor a/? agonist represented by the following general formula (I) (wherein Q represents an optionally substituted benzene ring or pyridine ring; R 1 and R 2 each represents an optionally substituted, phenyl or 5- or 6-membered aromatic heterocyclic group; X, Y, and Z each independently represents carbon, oxygen, sulfur, or nitrogen; R 3 to R 9 each represents hydrogen, lower alkyl, etc.; and n is an integer of 0 to 3).
摘要翻译：一种具有优异PPARa / 具有激动作用并且具有药物所需的所需性质。它是一种过氧化物酶体增殖激活受体a /？由以下通式（I）表示的激动剂（其中Q表示任选取代的苯环或吡啶环; R 1和R 2各自表示任选取代的苯基或 5-或6-元芳族杂环基; X，Y和Z各自独立地表示碳，氧，硫或氮; R 3至R 9各自表示氢，低级烷基等; n为0〜3的整数）。

5. 发明申请

WO0118005A8 PROCESS FOR THE PREPARATION OF BENZOXAZINE DERIVATIVES AND INTERMEDIATES THEREFOR 审中-公开
标题翻译：由此制备苯并恶嗪衍生物及其中间体的方法
公开(公告)号：WO0118005A8
公开(公告)日：2001-05-25
申请号：PCT/JP0006094
申请日：2000-09-07
申请人： DAIICHI SEIYAKU CO , SATO KOUJI , TAKAYANAGI YOSHIHIRO , OKANO KATSUHIKO , NAKAYAMA KEIJI , IMURA AKIHIRO , ITOH MIKIHIRO , YAGI TSUTOMU , KOBAYASHI YUKINARI , NAGAI TOMOYUKI
发明人： SATO KOUJI , TAKAYANAGI YOSHIHIRO , OKANO KATSUHIKO , NAKAYAMA KEIJI , IMURA AKIHIRO , ITOH MIKIHIRO , YAGI TSUTOMU , KOBAYASHI YUKINARI , NAGAI TOMOYUKI
IPC分类号： A61P31/04 , C07C213/00 , C07C215/16 , C07C227/08 , C07C227/34 , C07C227/36 , C07C229/18 , C07C229/30 , C07D265/36 , C07D498/06 , C12P13/00 , C07C227/06
CPC分类号： C07D498/06 , C07B57/00 , C07B2200/07 , C07C213/00 , C07C227/08 , C07C227/34 , C07C227/36 , C07C229/18 , C07C229/30 , C07D265/36 , C12P13/001 , C12P13/02 , C12P13/04 , C12P41/005 , Y02P20/55 , C07C215/16
摘要： The invention provides an industrially advantageous process for the preparation of antimicrobial drugs and industrially advantageous processes for the preparation of intermediates of antimicrobial drugs. Specifically, a process for preparing compounds (VI-a) according to the following reaction scheme; and intermediates therefor: (A)
摘要翻译：本发明提供了用于制备抗微生物药物的工业上有利的方法和用于制备抗微生物药物中间体的工业上有利的方法。具体而言，按照以下反应方案制备化合物（VI-a）的方法; 及其中间体：（A）

6. 发明申请

WO2007043295A9 METHOD OF IDENTIFYING COMPOUNDS INHIBITING DDX39 审中-公开
标题翻译：鉴定化合物抑制DDX39的方法
公开(公告)号：WO2007043295A9
公开(公告)日：2007-06-14
申请号：PCT/JP2006318696
申请日：2006-09-21
申请人： DAIICHI SEIYAKU CO , SUGIURA TAKEYUKI , NAGANO YUKI
发明人： SUGIURA TAKEYUKI , NAGANO YUKI
IPC分类号： C12N15/09 , C12Q1/25 , C12Q1/42 , C12Q1/68 , G01N33/15
CPC分类号： C12Q1/34 , G01N2500/02
摘要： [PROBLEMS] To clarify the relationship between DDX39 and a disease and the functions of DDX39 to thereby provide a method of identifying a compound which inhibits the functions of DDX39 and a method of examining a disease with the use of a means of detecting DDX39. [MEANS FOR SOLVING PROBLEMS] A method of identifying any one of the following compounds capable of controlling the functions of DDX39: a compound inhibiting the nucleoside triphosphatase (NTPase) activity of DDX39; a compound inhibiting the RNA helicase activity of DDX39; a compound inhibiting the RNA-binding activity of DDX39; a compound inhibiting an activity of enhancing the above binding which is exerted by a nucleotide or a nucleotide analog; and a compound inhibiting the biding of DDX39 to a nonhydrolyzable nucleotide analog; an NTPase activity inhibitor and an RNA helicase inhibitor containing any one of the above compounds; and a method of identifying a cancer tissue with the use of a means of detecting the expression of DDX39 gene.
摘要翻译： [问题]为了阐明DDX39与疾病和DDX39功能之间的关系，从而提供鉴定抑制DDX39功能的化合物的方法和使用检测DDX39的方法检测疾病的方法。用于鉴定能够控制DDX39的功能的以下化合物中的任一种的方法：抑制DDX39的核苷三磷酸酶（NTPase）活性的化合物; 抑制DDX39的RNA解旋酶活性的化合物; 抑制DDX39的RNA结合活性的化合物; 抑制由核苷酸或核苷酸类似物发挥的上述结合增强作用的化合物; 和抑制DDX39与不可水解的核苷酸类似物结合的化合物; 含有任何一种上述化合物的NTPase活性抑制剂和RNA解旋酶抑制剂; 以及使用检测DDX39基因表达的手段鉴定癌组织的方法。

7. 发明申请

WO02053534A8 VLA-4 INHIBITORS 审中-公开
标题翻译： VLA-4抑制剂
公开(公告)号：WO02053534A8
公开(公告)日：2002-09-19
申请号：PCT/JP0111641
申请日：2001-12-28
申请人： DAIICHI SEIYAKU CO , NAKAYAMA ATSUSHI , MACHINAGA NOBUO , YONEDA YOSHIYUKI , SUGIMOTO YUICHI , CHIBA JUN , WATANABE TOSHIYUKI , IIMURA SHIN
发明人： NAKAYAMA ATSUSHI , MACHINAGA NOBUO , YONEDA YOSHIYUKI , SUGIMOTO YUICHI , CHIBA JUN , WATANABE TOSHIYUKI , IIMURA SHIN
IPC分类号： A61P1/04 , A61P3/10 , A61P11/06 , A61P17/06 , A61P19/02 , A61P27/16 , A61P29/00 , A61P35/04 , A61P37/06 , C07C275/42 , C07D209/42 , C07D263/58 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D471/04 , C07D491/04 , C07D491/056 , A61K31/404 , A61K31/416 , A61K31/421 , A61K31/423 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/5415 , C07D403/06
CPC分类号： C07D263/58 , C07C275/42 , C07D209/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D471/04 , C07D491/04
摘要： Compounds represented by the general formula (I) or salts thereof, and medicines containing the same: (I) [wherein W is W -A -W - (wherein W is optionally substituted aryl or the like; A is -NR -, a single bond, -C(O)-, or the like; and W is optionally substituted arylene or the like); R is a single bond, -NH-, -OCH2-, alkenylene, or the like; X is -C(O)-, -CH2-, or the like; and M is, e.g., a group represented by the general formula (iii): (iii) (wherein R , R , and R are each independently hydrogen, hydroxyl, amino, halogeno, or the like; R is hydrogen or lower alkyl; Y is -CH2-O- or the like; Z is optionally substituted arylene or the like; A is a single bond or the like; and R is hydroxyl or lower alkoxy)]. The compounds or the salts selectively inhibit the binding of cell adhesion molecules to VLA-4 and exhibit high oral absorbability, thus being useful as preventive and/or therapeutic drugs for inflammatory diseases, autoimmune diseases, cancerous metastasis, bronchial asthma, nasal occlusion, diabetes, and so on.
摘要翻译：由通式（I）表示的化合物或其盐和含有它们的药物：（I）[其中W是WA-A 1 -WB-（其中WA是任选取代的芳基等; A 1是-NR 1 - ，单键，-C（O） - 等;并且W B是任选取代的亚芳基等）。 R为单键，-NH - ， - OCH 2 - ，亚烯基等; X是-C（O） - ， - CH 2 - 等; M是例如由通式（iii）表示的基团：（iii）（其中R 11，R 12和R 13各自独立地为氢，羟基，氨基，卤素或 R 14为氢或低级烷基; Y为-CH 2 -O-等; Z为任选取代的亚芳基等; A 2为单键等;且R 10为羟基或低级烷氧基）]。该化合物或其盐选择性地抑制细胞粘附分子与VLA-4的结合并表现出高的口服吸收性，因此可用作炎症性疾病，自身免疫性疾病，癌性转移，支气管哮喘，鼻塞，糖尿病的预防和/或治疗药物，等等。

8. 发明申请

WO0007593A8 REMEDIES OR PREVENTIVES FOR INTRACTABLE EPILEPSY 审中-公开
标题翻译：对不能发作的癫痫的补救或预防措施
公开(公告)号：WO0007593A8
公开(公告)日：2000-05-04
申请号：PCT/JP9904264
申请日：1999-08-06
申请人： DAIICHI SEIYAKU CO , TANAKA TATSUYA , TAKAZAWA AKIRA , YOSHII MITSUNOBU , MURASHIMA YOSHIYA
发明人： TANAKA TATSUYA , TAKAZAWA AKIRA , YOSHII MITSUNOBU , MURASHIMA YOSHIYA
IPC分类号： A61K31/40 , A61K31/4015 , A61K31/44 , A61K31/4439 , C07D207/26 , C07D207/27 , C07D401/12
CPC分类号： C07D207/27 , A61K31/40 , A61K31/4015 , A61K31/44 , A61K31/4439 , C07D401/12
摘要： Remedies and preventives for intractable epilepsy which contain as the active ingredient compounds represented by the general formula (I): R -CH2-CONH-R wherein R represents optionally substituted pyridyl or phenyl; and R represents optionally substituted 2-oxo-1-pyrrolidinyl.
摘要翻译：含有作为活性成分的通式（I）所示化合物的难治性癫痫的治疗和预防：R 2 -CH 2 -CONH-R 1其中R 1代表任选取代的吡啶基或苯基; 并且R 2表示任选取代的2-氧代-1-吡咯烷基。

9. 发明申请

WO0005230A8 PYRAZOLE DERIVATIVES AND SALTS THEREOF 审中-公开
标题翻译：吡咯衍生物及其盐
公开(公告)号：WO0005230A8
公开(公告)日：2000-03-09
申请号：PCT/JP9903962
申请日：1999-07-23
申请人： DAIICHI SEIYAKU CO , EJIMA AKIO , OHSUKI SATORU , OHKI HITOSHI , NAITO HIROYUKI , MAKINO CHIE
发明人： EJIMA AKIO , OHSUKI SATORU , OHKI HITOSHI , NAITO HIROYUKI , MAKINO CHIE
IPC分类号： C07D403/04 , C07D403/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07D401/14 , A61K31/505 , A61K31/53 , A61K31/535
CPC分类号： C07D403/04 , C07D403/14 , C07D471/04 , C07D487/04
摘要： Compounds represented by general formula (I) or (Ia) wherein G and G are each a heterotricyclic fused ring, and salts thereof, which exhibit an antitumor effect; and compounds represented by general formula (Ib) and salts thereof.
摘要翻译：由通式（I）或（Ia）表示的化合物，其中G和G 1各自是异三环稠合环及其盐，其具有抗肿瘤效果; 和由通式（Ib）表示的化合物及其盐。

10. 发明授权

KR820001613B1 PROCESS FOR THE PREPARATION OF 4'-(2-CARBOXYETHYL)PHENYL TRANS-4-AMINOMETHYL CYCLOHEXANECARBOXYLATE 失效
公开(公告)号：KR820001613B1
公开(公告)日：1982-09-11
申请号：KR780001224
申请日：1978-04-25
申请人： DAIICHI SEIYAKU CO
发明人： KAMADA MASAHIRO , MIMURA MASATAKA
IPC分类号： C07C101/04
摘要： Title compd.(I), useful for treatment of ulcer, was prepd. by hydrolsis of compd.(IV) which was obtained from the reaction of trans-4-aminomethylcyclohexane carbonylhalide(II; X = halogen) and compd.(III; R1 = lower alkyl, substituted lower alkyl, aryl, alkoxy, amino; R2 = H, lower alkyl,aryl, acyl, alkoxycarbonyl, cyano), Thus, 4'-(2-acetoxyloxy,carbonylethyl)phenyl-trans-4-aminomethylcyclohexane carboxylate HCI salts 4.97 g and sodium bicarbonate 2.10 g were recdted at 40≦̸C for 40 hr. The obtained ppt.was filtered and dried to give 4'-(2-carboxyethyl)phenyl-trans-4-aminomethylcyclohexane carboxylate (CEP-ester) 3.56 g.

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