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1. 发明申请

WO2010002010A1 NOVEL SPIROCHROMANONE CARBOXYLIC ACIDS 审中-公开
标题翻译：新型螺环酮羧酸
公开(公告)号：WO2010002010A1
公开(公告)日：2010-01-07
申请号：PCT/JP2009/062237
申请日：2009-06-29
申请人： BANYU PHARMACEUTICAL CO.,LTD. , JONA, Hideki , SHIBATA, Yoshihiro , YAMAKAWA, Takeru
发明人： JONA, Hideki , SHIBATA, Yoshihiro , YAMAKAWA, Takeru
IPC分类号： C07D491/107 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61P1/16 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P31/00 , A61P35/00
CPC分类号： C07D491/107 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/4709
摘要： The invention relates to a compound of a general formula (I): wherein A represents a linking group; Ar 1 represents a group formed from an aromatic ring; R 1 and R 2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a cyclo-C3-C6 alkyloxy group, a C2-C7 alkanoyl group, a halo-C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, a halo-C2-C7 alkoxycarbonyl group, a cyclo-C3-C6 alkyloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q 1 -N(R a )-Q 2 -R b ; a C1-C6 alkyl group optionally having substituent(s); an aryl or heterocyclic group optionally having substituent(s); or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom, a sulfur atom or an imino group. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.
摘要翻译：本发明涉及通式（I）的化合物：其中A表示连接基团; Ar 1表示由芳香环形成的基团; R 1和R 2各自独立地表示氢原子，卤素原子，氰基，C 2 -C 6烯基，C 1 -C 6烷氧基，卤代-C 1 -C 6烷氧基，环-C 3 -C 6烷氧基， C2-C7烷酰基，卤代-C2-C7烷酰基，C2-C7烷氧基羰基，卤代-C2-C7烷氧基羰基，环-C3-C6烷氧基羰基，芳烷氧基羰基，氨基甲酰基C1- C6烷氧基，羧基-C2-C6烯基或-Q1-N（Ra）-Q2-Rb的基团; 任选具有取代基的C1-C6烷基; 任选具有取代基的芳基或杂环基; 或具有芳基或杂环基的C 1 -C 6烷基或C 2 -C 6烯基; T和U各自独立地表示氮原子或次甲基; V表示氧原子，硫原子或亚氨基。本发明的化合物可用作各种ACC相关疾病的治疗剂。

2. 发明申请

WO2005095364A8 PHENOXYACETIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME 审中-公开
标题翻译：苯氧基酸衍生物及含有其的药物
公开(公告)号：WO2005095364A8
公开(公告)日：2006-01-05
申请号：PCT/JP2005005740
申请日：2005-03-28
申请人： DAIICHI SEIYAKU CO , KAGECHIKA KATSUJI , SHIBATA YOSHIHIRO , USUI HIROYUKI
发明人： KAGECHIKA KATSUJI , SHIBATA YOSHIHIRO , USUI HIROYUKI
IPC分类号： A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61P3/10 , C07D263/32 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D413/12 , C07D263/32 , C07D413/14 , C07D417/12 , C07D417/14
摘要： A novel compound having excellent PPARa/? agonistic activity and having desirable properties required of medicines. It is a peroxisome proliferation-activated receptor a/? agonist represented by the following general formula (I) (wherein Q represents an optionally substituted benzene ring or pyridine ring; R 1 and R 2 each represents an optionally substituted, phenyl or 5- or 6-membered aromatic heterocyclic group; X, Y, and Z each independently represents carbon, oxygen, sulfur, or nitrogen; R 3 to R 9 each represents hydrogen, lower alkyl, etc.; and n is an integer of 0 to 3).
摘要翻译：一种具有优异PPARa / 具有激动作用并且具有药物所需的所需性质。它是一种过氧化物酶体增殖激活受体a /？由以下通式（I）表示的激动剂（其中Q表示任选取代的苯环或吡啶环; R 1和R 2各自表示任选取代的苯基或 5-或6-元芳族杂环基; X，Y和Z各自独立地表示碳，氧，硫或氮; R 3至R 9各自表示氢，低级烷基等; n为0〜3的整数）。

3. 发明专利

JP2000257035A RAIL FOR CARRIAGE WAY 失效
公开(公告)号：JP2000257035A
公开(公告)日：2000-09-19
申请号：JP10703599
申请日：1999-03-10
申请人： SHIBATA YOSHIHIRO
发明人： SHIBATA YOSHIHIRO
IPC分类号： E01F15/00
摘要： PROBLEM TO BE SOLVED: To prevent the deviation of a vehicle by forming a slope or a curved surface on the inside face of a curbstone for a carriage way, to reduce frictional resistance, and guiding a steered wheel in the carriage way without breaking a rim or a tire when it is brought into contact with the curbstone. SOLUTION: A guide face (flat face or a curved face) at the inclination of 80 deg. or below against a road surface 2 is provided on the inside face of a rail (curbstone) for a carriage way provided at a garage, a superhighway tollgate, a drive through or the like. A stainless sheet or the like is provided on the guide face to make the surface smooth and to reduce frictional resistance. When the tire 3 of a steered wheel is brought into contact with the lower section of a rail (curbstone) and tends to ride on it, the tire 3 is slid, the balance of moment around the axes of the right and left kingpins is broken, the steered wheel is oscillated, and a vehicle is guided in the vehicle passage, thereby the deviation of the vehicle to the outside of the vehicle passage is prevented, and safety can be secured.

4. 发明专利

JP2002104890A ELECTROMAGNETIC WAVE PREVENTIVE CERAMIC AND METHOD OF MANUFACTURING IT 失效
公开(公告)号：JP2002104890A
公开(公告)日：2002-04-10
申请号：JP2001041113
申请日：2001-02-19
申请人： SHIBATA YOSHIHIRO , INO HIKARI
发明人： INO HIKARI
IPC分类号： C04B41/87 , C04B41/88
摘要： PROBLEM TO BE SOLVED: To provide a electromagnetic wave preventive ceramic able to well display having electrical property of tolmarine that can absorb electromagnetic wave, and its manufacturing method. SOLUTION: The electric magnetic wave preventive ceramic 10 is manufactured as follows. First, mixture containing granular tolmarine is formed by press, next the porous ceramic body 11 is sintered by baking the formed mixture at the temperature preserving the electrical property of the tolmarine. After that, a conductive layer 12 is formed on the outside surface of the ceramic body 11 in condition that all is not perfectly covered. This electromagnetic wave preventive ceramic 10 is used with installed on outside surface of the pocket telephone 14.

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