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1. 发明专利

DE69840365D1 未知
公开(公告)号：DE69840365D1
公开(公告)日：2009-01-29
申请号：DE69840365
申请日：1998-10-06
申请人： CARDIOMETRIX INC
发明人： CIMOCHOWSKI GEORGE E , KEILMAN GEORGE W
IPC分类号： A61B5/02 , A61B5/00 , A61B5/0215 , A61B5/026 , A61B8/04 , A61B8/06 , A61F2/02 , A61M1/36
摘要： A parameter indicative of the status of fluid flow is remotely monitored in a vessel, a natural graft, or a synthetic graft. One or more transducers are provided either in a wall of a synthetic graft or adjacent to a vessel or natural graft to monitor the parameter. A conformal array transducer or a tilted element is used to monitor fluid flow or velocity through the graft or vessel based on the effect of the fluid on ultrasonic waves produced by the transducers. The conformal array transducer comprises a plurality of elements that curve around the graft or vessel and are excited with an input signal provided by an implantable electronics circuit, producing ultrasonic waves that propagate into the fluid flowing within the graft or vessel. Transit time or Doppler measurements are made using an appropriate number of these transducer to determine either fluid flow or velocity. Various implantable electronic circuits are provided that enable a selected transducer to be driven and to receive an ultrasonic signal or a pressure signal indicative of the status of fluid flow monitored by the transducer. The implanted electronic circuit is connected to an implanted radio frequency (RF) coil. An external coil that is connected to a power supply and monitoring console is coupled to the implanted RF coil to convey power and receive data signals from the transducer that are indicative of the parameter being monitored.

2. 发明专利

DE69841003D1 未知
公开(公告)号：DE69841003D1
公开(公告)日：2009-09-03
申请号：DE69841003
申请日：1998-10-23
申请人： CARDIOMETRIX INC
发明人： CIMOCHOWSKI GEORGE E , KEILMAN GEORGE W
IPC分类号： A61B5/02 , A61B5/00 , A61B9/00 , A61F2/02 , A61F2/82
摘要： A stent or graft stent energized from an external power source is provided with one or more sensors to sense a parameter, producing a signal that is transmitted outside a vessel in which the stent is implanted. At least a portion of a body of the stent or an insulated electrical conductor comprises a plurality of turns that serve as an RF antenna. An expandable mesh or helical coils that form the stent body may serve as the antenna or it may comprise a separate insulated conductor. The RF antenna receives energy electromagnetically coupled to the antenna from an external (or implanted) coil and conveys a data signal corresponding to the parameter sensed by the sensor(s) on the stent or stent graft to a monitor disposed outside the patient's body. In one form of the invention, a plurality of conformal array transducers are used to produce and sense ultrasonic waves that are affected by a fluid flowing through a lumen of the stent. This transducer determines fluid flow or fluid velocity. In other embodiments, one or more integrated circuit (IC) sensors are used to sense other physical or biological parameters in the proximity of the stent, producing signals that are multiplexed by an electronics circuit and transmitted to the external monitor/power supply.

3. 发明授权

EP1026984B1 ULTRASONIC SENSORS FOR MONITORING THE CONDITION OF A VASCULAR GRAFT 有权
标题翻译：超声波换能器状态监测血管移植
公开(公告)号：EP1026984B1
公开(公告)日：2008-12-17
申请号：EP98952113.3
申请日：1998-10-06
申请人： CardioMetrix, Inc.
发明人： Cimochowski, George E. , Keilman, George W.
IPC分类号： A61B5/02 , A61B8/04 , A61B5/0215 , A61B8/06 , A61B5/00 , A61F2/02 , A61B5/026
CPC分类号： A61B5/6876 , A61B5/0031 , A61B5/6862 , A61B8/04 , A61B8/06 , A61B8/12 , A61B8/56 , A61B2560/0219 , A61F2250/0001 , A61M1/3656 , Y10S128/903
摘要： A parameter indicative of the status of fluid flow is remotely monitored in a vessel, a natural graft, or a synthetic graft (106). One or more conformal array transducers (44-46) comprising a plurality of elements that curve around the graft (106) or vessel, are excited with an input signal provided by one of various implantable electronic circuits. The implantable electronic circuits enable a selected transducer to be driven, and to receive an ultrasonic signal or pressure signal indicative of the status of fluid flow monitored by the transducer. The implanted electronic circuit is connected to an implanted radio frequency (RF) coil. An external coil that is connected to a power supply (32), receive data signals from the transducer that are indicative of the parameter being monitored.

4. 发明公开

EP1065978A4 IMPLANTABLE THERAPEUTIC DEVICE AND METHOD 审中-公开
标题翻译：植入式治疗设备和方法
公开(公告)号：EP1065978A4
公开(公告)日：2007-12-12
申请号：EP99905662
申请日：1999-02-03
申请人： CARDIOMETRIX INC
发明人： KEILMAN GEORGE W , CIMOCHOWSKI GEORGE E
IPC分类号： A61B17/20 , A61B5/00 , A61B5/026 , A61B5/04 , A61B5/06 , A61B8/04 , A61B8/06 , A61F2/02 , A61F2/07 , A61H1/00 , A61K9/00 , A61K9/22 , A61M1/36 , A61M37/00
CPC分类号： A61M37/0092 , A61B5/0031 , A61B5/026 , A61B5/04 , A61B5/4839 , A61B5/6862 , A61B5/6876 , A61B8/04 , A61B8/06 , A61B8/12 , A61B8/445 , A61B8/4483 , A61B8/56 , A61B2560/0219 , A61F2/07 , A61F2250/0001 , A61M1/3656

5. 发明公开

EP1210012A4 ULTRASONIC MONITORING OF CARDIAC VALVULAR FLOW CONDITION 审中-公开
标题翻译：超声监测心脏瓣膜的流动条件
公开(公告)号：EP1210012A4
公开(公告)日：2008-11-26
申请号：EP00950699
申请日：2000-07-26
申请人： CARDIOMETRIX INC
发明人： CIMOCHOWSKI GEORGE E , KEILMAN GEORGE W
IPC分类号： A61B5/00 , A61B8/04 , A61B8/06 , A61B8/12 , A61M1/36
CPC分类号： A61B8/06 , A61B5/0031 , A61B5/6876 , A61B5/6884 , A61B8/04 , A61B8/12 , A61B8/4227 , A61B8/4472 , A61B8/56 , A61B2560/0219 , A61M1/3656
摘要： A parameter indicative of the condition of a cardiac valve is determined by monitoring blood flow, and/or velocity in a vessel that is coupled to the cardiac valve or in a chamber adjacent to an artificial cardiac valve. One or more ultrasonic transducers (174A, 174B) are provided either in a wall or a cuff (302) disposed about a cardiac vessel (304) to monitor the parameter in regard to a natural or artificial cardiac valve, or in a support sewing ring of an artificial cardiac valve. A conformal array transducer or a tilted element is used to monitor fluid flow or velocity based on the effect of the blood on ultrasonic waves produced by the transducers. The conformal array transducer comprises a plurality of elements that are excited with an input signal provided by an implanted electronics circuit producing ultrasonic waves.

6. 发明授权

EP1039831B1 ENDOLUMINAL IMPLANT WITH PARAMETER SENSING CAPABILITY 有权
标题翻译：具有测量显示装置腔内移植物
公开(公告)号：EP1039831B1
公开(公告)日：2009-07-22
申请号：EP98957361.3
申请日：1998-10-23
申请人： CardioMetrix, Inc.
发明人： Cimochowski, George E. , Keilman, George W.
IPC分类号： A61B5/02 , A61B9/00 , A61B5/00
CPC分类号： A61B5/6876 , A61B5/0031 , A61B5/6862 , A61F2/82 , A61F2250/0002
摘要： A stent or graft stent (106) energized from an external power source (32) is provided with one or more sensors to sense a parameter, producing a signal that is transmitted outside a vessel in which the stent is implanted. At least a portion of a body of the stent or an insulated electrical conductor comprises a plurality of turns that serves as an RF antenna. An expandable mesh or helical coils (90) that form the stent body may serve as the antenna or it may comprise a separate insulated conductor. The RF antenna receives energy electro-magnetically coupled to the antenna from an external (or implanted) coil, and conveys a data signal corresponding to the parameter sensed by the sensor(s) on the stent or stent graft to a monitor disposed outside the patient's body. In one form of the invention, a plurality of conformal array transducers are used to produce, and sense ultrasonic waves that are affected by a fluid flowing through a lumen of the stent. This transducer determines fluid flow or fluid velocity. In other embodiments, one or more integrated circuit (IC) sensors are used to sense other physical or biological parameters in the proximity of the stent producing signals that are multiplexed by an electronics circuit, and transmitted to the external monitor/power supply.

7. 发明公开

EP1056514A4 ENDOLUMINAL IMPLANT WITH THERAPEUTIC AND DIAGNOSTIC CAPABILITY 审中-公开
标题翻译：具有诊断和治疗特性腔内移植物
公开(公告)号：EP1056514A4
公开(公告)日：2008-01-16
申请号：EP99906709
申请日：1999-02-03
申请人： CARDIOMETRIX INC
发明人： KEILMAN GEORGE W , CIMOCHOWSKI GEORGE E
IPC分类号： A61B5/00 , A61B8/04 , A61B8/06 , A61F2/02 , A61F2/07 , A61F2/82 , A61M1/36 , A61M37/00 , A61N1/30 , A61N1/32 , A61N5/06 , A61N5/00
CPC分类号： A61B8/06 , A61B5/0031 , A61B5/14532 , A61B5/6862 , A61B5/6876 , A61B8/04 , A61B8/12 , A61B8/4483 , A61B8/56 , A61B2560/0219 , A61F2/07 , A61F2/82 , A61F2002/072 , A61F2002/075 , A61F2250/0001 , A61F2250/0002 , A61M1/3656 , A61M37/0092 , A61N1/306 , A61N1/325 , A61N5/0601 , A61N5/062

8. 发明申请

US20090264766A1 ENHANCED INTRALUMINAL FLOW MEASUREMENT METHOD USING REFERENCE AND SHIFTED SIGNALS 审中-公开
标题翻译：使用参考和移位信号的增强的内部流量测量方法
公开(公告)号：US20090264766A1
公开(公告)日：2009-10-22
申请号：US12105068
申请日：2008-04-17
申请人： George W. Keilman , Leigh Bartlett , Timothy Johnson
发明人： George W. Keilman , Leigh Bartlett , Timothy Johnson
IPC分类号： A61B8/06
CPC分类号： A61B8/12 , A61B8/06 , A61B8/565
摘要： An enhanced intraluminal flow measurement system and method is conducive for a low-power ultrasonic system that can use continuous-wave (CW) Doppler sensing and wireless RF telemetry. Applications include measurement of blood flow in situ in living organisms. Implementations include an extraluminal component located outside of a body, such as a human or animal body, containing a lumen. The extraluminal component can be wirelessly coupled via an RF magnetic field or other RF field to an implantable intraluminal component. The intraluminal component (i.e. implant) is implanted inside of the lumen of the body such as a heart or elsewhere in a vasculature (such as in a dialysis shunt). The intraluminal component can telemeter, via RF electromagnetic signals, flow data directly out of the body housing the intraluminal component to be received by the extraluminal component.
摘要翻译：增强的管腔内流量测量系统和方法有利于可以使用连续波（CW）多普勒感测和无线RF遥测的低功率超声波系统。应用包括在生物体内原位测量血流。实施方案包括位于身体外部的外阴部件，例如包含内腔的人体或动物体。管腔内部件可以经由RF磁场或其他RF场无线耦合到可植入的管腔内部件。管腔内成分（即植入物）植入体内的腔内，例如心脏或其它脉管系统（如透析分流）中。管腔内成分可以通过射频电磁信号将流量数据直接传送出外壳体内的腔内部件，以便由腔内部件接收。

9. 发明申请

US20090234436A1 VASCULAR ANCHOR TETHERING SYSTEM AND METHOD 审中-公开
标题翻译：血管锚固系统和方法
公开(公告)号：US20090234436A1
公开(公告)日：2009-09-17
申请号：US12048055
申请日：2008-03-13
申请人： Timothy Johnson , George W. Keilman , Brian Doll
发明人： Timothy Johnson , George W. Keilman , Brian Doll
IPC分类号： A61F2/06
CPC分类号： A61F2/86 , A61F2/848 , A61F2/954 , A61F2/966 , A61F2002/821 , A61F2002/9665 , A61F2220/0008 , A61F2230/0008
摘要： As described herein vascular anchoring systems are used to position an implant in a vascular area such as a bifurcated vasculature with relatively high fluid flow, for instance, in an area of a pulmonary artery with associated left and right pulmonary arteries. Implementations include an anchoring trunk member having a first anchoring trunk section and a second anchoring trunk section. Further implementations include a first anchoring branch member extending from the anchoring trunk member. Still further implementations include a second anchoring branch member extending from the anchoring trunk member.
摘要翻译：如本文所描述的，血管锚定系统用于将植入物定位在诸如具有相对高的流体流动的分叉血管的血管区域中，例如在具有相关联的左肺动脉和右肺动脉的肺动脉的区域中。实施方案包括具有第一锚固干线部分和第二锚固干线部分的锚固干线部件。另外的实施方案包括从锚固树干构件延伸的第一锚定分支构件。另外的实施方式包括从锚固树干构件延伸的第二锚定分支构件。

10. 发明申请

US20090005859A1 ENDOLUMINAL IMPLANT WITH THERAPEUTIC AND DIAGNOSTIC CAPABILITY 审中-公开
标题翻译：具有治疗和诊断能力的内膜植入物
公开(公告)号：US20090005859A1
公开(公告)日：2009-01-01
申请号：US12204470
申请日：2008-09-04
申请人： George W. Keilman
发明人： George W. Keilman
IPC分类号： A61F5/00 , A61B19/00
CPC分类号： A61B8/06 , A61B5/0031 , A61B5/14532 , A61B5/6862 , A61B5/6876 , A61B8/04 , A61B8/12 , A61B8/4483 , A61B8/56 , A61B2560/0219 , A61F2/07 , A61F2/82 , A61F2002/072 , A61F2002/075 , A61F2250/0001 , A61F2250/0002 , A61M1/3656 , A61M37/0092 , A61N1/306 , A61N1/325 , A61N5/0601 , A61N5/062
摘要： An apparatus includes an endoluminal implant, a RF coupling coil coupled to the endoluminal implant and a therapeutic transducer electrically coupled to the RF coupling coil and physically coupled to the endoluminal implant. The RF coupling coil supplies electrical power to the therapeutic transducer. The therapeutic transducer has a capability for delivering therapeutic energy to a lumen disposed within the endoluminal implant in response to signals coupled via the RF coupling coil.
摘要翻译：一种装置包括腔内植入物，耦合到腔内植入物的RF耦合线圈和电耦合到RF耦合线圈并物理耦合到腔内植入物的治疗换能器。 RF耦合线圈向治疗换能器提供电力。所述治疗换能器响应于经由所述RF耦合线圈耦合的信号，具有将治疗能量递送至设置在所述腔内植入物内的内腔的能力。

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