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    • 5. 发明申请
    • ANTIMYCOTIC SYNERGISTIC PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF
    • 抗菌协同药物组合物及其制备方法
    • WO1982001821A1
    • 1982-06-10
    • PCT/HU1980000005
    • 1980-11-27
    • CHINOIN GYOGYSZER ES VEGYESZETKOVACS ANDRASSZEBENI RUDOLFNEMES JOZSEFNGYKALDI ATTILA
    • CHINOIN GYOGYSZER ES VEGYESZET
    • A61K31/71
    • A61K31/70A61K31/12A61K2300/00
    • Antimycotic synergistic pharmaceutical compositions comprising nystatine and a 2-lower alkyl-l, 4-naphthoquinone or an addition product thereof in admixture with suitable inert pharmaceutical carriers. The invention also relates to a process for the above compositions by admixing the active ingredients with suitable inert carriers. It is preferred to use 2-methyl-1, -naphthoquinone or the sodium bisulfite adduct thereof. The ratio of the active ingredients is preferably 20.000 to 100.000 IU of nystatine for 1 mg of 2-methyl-1,4-naphthoquinone-sodium bisulfite adduct. The compositions show strong synergism in the treatment of infections caused by Candida albicans and Trichomonas vaginalis and are active against resistant strains too. The compositions may be finished in forms suitable for topical use, such as suppository, aerosol, jelly or vaginal tablets.
    • 抗微生物协同药物组合物,其包含与合适的惰性药物载体混合的营养素和2-低级烷基-1,4-萘醌或其加成产物。 本发明还涉及通过将活性成分与合适的惰性载体混合而获得的上述组合物的方法。 优选使用2-甲基-1'-萘醌或其亚硫酸氢钠加成物。 对于1mg 2-甲基-1,4-萘醌 - 亚硫酸氢钠加合物,活性成分的比例优选为20.000〜100.000IU的营养元素。 该组合物在治疗由白色念珠菌和阴道毛滴虫引起的感染中表现出强烈的协同作用,并且对抗性菌株也具有活性。 组合物可以以适于局部使用的形式,例如栓剂,气雾剂,果冻或阴道片剂来完成。