专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007006095A3 CHAPERONIN 10-INDUCED IMMUNOMODULATION 审中-公开
标题翻译： CHAPERONIN 10诱导免疫调节
公开(公告)号：WO2007006095A3
公开(公告)日：2007-04-12
申请号：PCT/AU2006000980
申请日：2006-07-11
申请人： CBIO LTD , JOHNSON BARBARA JANE , DOBBIN CAROLINE AMANDA , NAYLOR DEAN JASON , WARD LINDA ALLISON , FLESH INGE E A , HOWARD CHRISTOPHER BRUCE
发明人： JOHNSON BARBARA JANE , DOBBIN CAROLINE AMANDA , NAYLOR DEAN JASON , WARD LINDA ALLISON , FLESH INGE E A , HOWARD CHRISTOPHER BRUCE
IPC分类号： A61K38/16
CPC分类号： A61K38/1709 , A61K38/212 , A61K38/215 , C07K16/18 , A61K2300/00
摘要： The present invention relates to methods for modulating Toll-like receptor signalling in a subject, or in at least one cell, tissue or organ thereof, methods for treating or preventing a disease or condition in a subject, methods for modulating the production and/or secretion of one or more immunomodulators in a subject, or at least one cell, tissue or organ thereof, wherein said methods involve the administration of chaperonin 10, and wherein the chaperonin 10 associates with a Toll-like receptor in an activation cluster. Also contemplated are associated compositions and uses thereof.
摘要翻译：本发明涉及用于调节受试者或其至少一种细胞，组织或器官中Toll样受体信号传导的方法，用于治疗或预防受试者的疾病或病症的方法，调节生产和/或在受试者或其至少一个细胞，组织或器官中分泌一种或多种免疫调节剂，其中所述方法涉及伴侣伴侣10的施用，并且其中伴侣蛋白10与活化簇中的Toll样受体结合。还考虑了相关的组合物及其用途。

2. 发明申请

WO2011041847A1 CHAPERONIN 10 VARIANTS 审中-公开
公开(公告)号：WO2011041847A1
公开(公告)日：2011-04-14
申请号：PCT/AU2010001327
申请日：2010-10-08
申请人： CBIO LTD , NAYLOR DEAN JASON , BROWN RICHARD JAMES , HOWARD CHRISTOPHER BURCE , DE BAKKER CHRISTOPHER JOHN , STOK JEANETTE ELIZABETH , JAMES ANDREW LEIGH , LAMBERT DANIEL SCOTT , RALSTON KYLIE JANE , VAN HEUMEN WALTER RENE ANTONIUS , WARD LINDA ALISSON
发明人： NAYLOR DEAN JASON , BROWN RICHARD JAMES , HOWARD CHRISTOPHER BURCE , DE BAKKER CHRISTOPHER JOHN , STOK JEANETTE ELIZABETH , JAMES ANDREW LEIGH , LAMBERT DANIEL SCOTT , RALSTON KYLIE JANE , VAN HEUMEN WALTER RENE ANTONIUS , WARD LINDA ALISSON
IPC分类号： A61K38/16 , A61P37/02 , C07K14/47 , C12N15/12
CPC分类号： C07K14/4715 , A61K38/00 , A61K38/1709 , A61K48/005 , G01N33/5023 , G01N33/5047
摘要： The invention relates generally to chaperonin 10 N-terminal variants. More specifically, the invention relates to chaperonin 10 N-terminal variants with enhanced immunomodulatory capacity and/or enhanced binding affinity for pathogen-associated molecular patterns (PAMPs) and/or damage-associated molecular patterns (DAMPs).
摘要翻译：本发明一般涉及伴侣蛋白10个N-末端变体。更具体地，本发明涉及具有增强的免疫调节能力和/或对病原体相关分子模式（PAMP）和/或损伤相关分子模式（DAMP）的增强的结合亲和力的伴侣蛋白10N末端变体。

3. 发明专利

JP2012196210A Modified chaperonin 10 有权
标题翻译： MODIFIED CHAPERONIN 10
公开(公告)号：JP2012196210A
公开(公告)日：2012-10-18
申请号：JP2012088841
申请日：2012-04-09
申请人： Cbio Ltd , シーバイオリミテッド
发明人： NAYLOR DEAN JASON , JOHNSON BARBARA JANE , DOBBIN CAROLINE AMANDA , HOWARD CHRISTOPHER BRUCE , WARD LINDA ALLISON
IPC分类号： C12N15/09 , A61K38/00 , A61P11/06 , A61P25/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P37/08 , C07K14/47 , C07K16/18 , G01N33/15 , G01N33/50 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4715
摘要： PROBLEM TO BE SOLVED: To provide isolated chaperonin 10 polypeptides possessing immunomodulatory activity but lacking or substantially lacking protein folding activity.SOLUTION: When compared with a corresponding wild-type chaperonin 10 polypeptides, the isolated chaperonin 10 polypeptides possessing immunomodulatory activity include at least one amino acid substitution, deletion and/or addition in the roof β-hairpin region.
摘要翻译：要解决的问题：提供具有免疫调节活性但缺乏或基本上缺乏蛋白质折叠活性的分离的伴侣蛋白10多肽。解决方案：当与相应的野生型伴侣蛋白10多肽相比时，具有免疫调节活性的分离的伴侣蛋白10多肽包括在屋顶β-发夹区中的至少一个氨基酸取代，缺失和/或添加。版权所有（C）2013，JPO＆INPIT

4. 发明专利

JP2011088920A Chaperonin 10 immunosuppression 审中-公开
标题翻译： CHAPERONIN 10免疫抑制
公开(公告)号：JP2011088920A
公开(公告)日：2011-05-06
申请号：JP2010286005
申请日：2010-12-22
申请人： Cbio Ltd , シーバイオリミテッド
发明人： HILL GEOFFREY R , BANOVIC TATJANA , MORTON HALLE , CAVANAGH ALICE CHRISTINA
IPC分类号： A61K38/00 , A61K31/343 , A61K31/4375 , A61K31/56 , A61K31/706 , A61K38/17 , A61K45/00 , A61P37/06 , A61P43/00
CPC分类号： A61K38/1709 , Y10S514/885 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide treatment and/or prevention of graft versus host disease, to provide a method of treatment of the both of a donor and recipient animal especially donor and/or recipient animal or cells, tissues or organs derived from the donor, and to provide preventive/therapeutic method of graft versus host disease, using chaperonin 10, including the administration of at least one other immunosuppressive agent to the donor and/or recipient animal to prevent or alleviate the graft versus host disease.
SOLUTION: There are provided a method of the administration of chaperonin 10 (Cpn-10) in treatment and/or prevention of graft versus host disease, including the administration of at least one other immunosuppressive agent selected from the group consisting of cyclosporine, tacrolimus, sirolimus, mycophenolate mofetil and methotrexate. (BMT is allogeneic bone marrow transplantation).
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供移植物抗宿主病的治疗和/或预防，以提供治疗供体和受体动物特别是供体和/或受体动物或细胞，组织或器官的方法并且使用伴侣蛋白10提供移植物抗宿主病的预防/治疗方法，包括向供体和/或受体动物施用至少一种其它免疫抑制剂以预防或减轻移植物抗宿主病。解决方案：提供了在治疗和/或预防移植物抗宿主病方面给予伴侣蛋白10（Cpn-10）的方法，包括施用至少一种其它免疫抑制剂，其选自环孢菌素，他克莫司，西罗莫司，霉酚酸酯和甲氨蝶呤。（BMT是同种异体骨髓移植）。版权所有（C）2011，JPO＆INPIT

5. 发明申请

WO2009124353A8 MODIFIED CPN10 AND PRR SIGNALLING 审中-公开
标题翻译：修改CPN10和PRR信号
公开(公告)号：WO2009124353A8
公开(公告)日：2009-12-30
申请号：PCT/AU2009000444
申请日：2009-04-09
申请人： CBIO LTD , NAYLOR DEAN JASON , BROWN RICHARD JAMES , HOWARD CHRISTOPHER BRUCE , DE BAKKER CHRISTOPHER JOHN , WARD LINDA ALISSON , STOK JEANETTE ELIZABETH , JAMES ANDREW LEIGH , LAMBERT DANIEL SCOTT , RALSTON KYLIE JANE , VAN HEUMEN WALTER RENE ANTONIU
发明人： NAYLOR DEAN JASON , BROWN RICHARD JAMES , HOWARD CHRISTOPHER BRUCE , DE BAKKER CHRISTOPHER JOHN , WARD LINDA ALISSON , STOK JEANETTE ELIZABETH , JAMES ANDREW LEIGH , LAMBERT DANIEL SCOTT , RALSTON KYLIE JANE , VAN HEUMEN WALTER RENE ANTONIUS
IPC分类号： C07K14/47 , A61K38/17 , A61P37/02
CPC分类号： C07K14/4715 , A61K38/00
摘要： The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof.
摘要翻译：本发明涉及与Ala Cpn10多肽相比对PRR配体具有增加的亲和力的分离的Cpn10多肽。在另一个实施方案中，本发明还涉及修饰的伴侣蛋白10多肽，编码其的核酸以及包含此类多肽的组合物及其用途。

6. 发明申请

WO2007098557A8 REGULATION OF IMMUNE RESPONSES BY MODULATION OF THE FUNCTION OF ANTIGEN PRESENTING CELLS 审中-公开
标题翻译：通过调节抗原呈递细胞的功能来调节免疫应答
公开(公告)号：WO2007098557A8
公开(公告)日：2008-01-17
申请号：PCT/AU2007000254
申请日：2007-03-01
申请人： CBIO LTD , JOHNSON BARBARA JANE , DOBBIN CAROLINE AMANDA , FLESCH INGE E A
发明人： JOHNSON BARBARA JANE , DOBBIN CAROLINE AMANDA , FLESCH INGE E A
IPC分类号： A61K38/16 , A61P37/02
CPC分类号： A61K38/1709
摘要： The present invention relates to the use of chaperonin 10 to modulate the function of antigen presenting cells. More particularly the invention resides in the modulation of cell surface expression of MHC molecules such as HLA.
摘要翻译：本发明涉及伴侣蛋白10调节抗原呈递细胞功能的用途。更具体地，本发明在于MHC分子例如HLA的细胞表面表达的调节。

7. 发明专利

AU2013205017B2 Regulation of immune responses by modulation of the function of antigen presenting cells 未知
公开(公告)号：AU2013205017B2
公开(公告)日：2014-05-01
申请号：AU2013205017
申请日：2013-04-13
申请人： CBIO LTD
发明人： JOHNSON BARBARA JANE , FLESCH INGE E A , DOBBIN CAROLINE AMANDA
IPC分类号： A61K38/16 , A61P37/02
摘要： Abstract Regulation of immune responses by modulation of the function of antigen presenting cells The present invention relates to the use of chaperonin 10 to modulate the function of antigen presenting cells. More particularly the invention resides in the modulation of cell surface expression of MHC molecules such as HLA.

8. 发明专利

NZ566817A Modified chaperonin 10, wherein the N-terminus comprises a single additional glycine residue compared to a corresponding mammalian wild-type 未知
公开(公告)号：NZ566817A
公开(公告)日：2012-02-24
申请号：NZ56681706
申请日：2006-08-31
申请人： CBIO LTD
发明人： NAYLOR DEAN JASON , JOHNSON BARBARA JANE , DOBBIN CAROLINE AMANDA , HOWARD CHRISTOPHER BRUCE , WARD LINDA ALLISON
IPC分类号： C07K16/44 , A61K38/17 , A61P37/02 , C07K14/47
摘要： Disclosed is an isolated Chaperonin 10 (Cpn10) polypeptide, wherein the N-terminus of said polypeptide comprises a single additional glycine residue compared to a corresponding mammalian wild-type Cpn10 polypeptide. Also disclosed is the use of the Cpn10 polypeptide for the manufacture of a medicament for treating a disease, disorder or condition selected from acute or chronic inflammatory diseases, asthma, allergy, multiple sclerosis, GVHD, an autoimmune disease or an infectious disease.

9. 发明专利

CA2720617A1 MODIFIED CPN10 AND PRR SIGNALLING 未知
公开(公告)号：CA2720617A1
公开(公告)日：2009-10-15
申请号：CA2720617
申请日：2009-04-09
申请人： CBIO LTD
发明人： NAYLOR DEAN JASON , BROWN RICHARD JAMES , HOWARD CHRISTOPHER BRUCE , DE BAKKER CHRISTOPHER JOHN , WARD LINDA ALISSON , STOK JEANETTE ELIZABETH , JAMES ANDREW LEIGH , LAMBERT DANIEL SCOTT , VAN HEUMEN WALTER RENE ANTONIUS , RALSTON KYLIE JANE
IPC分类号： C07K14/47 , A61K38/17 , A61P37/02
摘要： The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof.

10. 发明专利

MX2008011167A REGULACIÒN DE RESPUESTAS INMUNES MEDIANTE LA MODULACIÒN DE LA FUNCIÒN DE CÈLULAS PRESENTADORAS DE ANTÌGENOS. 未知
公开(公告)号：MX2008011167A
公开(公告)日：2008-11-12
申请号：MX2008011167
申请日：2007-03-01
申请人： CBIO LTD
发明人： JOHNSON BARBARA JANE , DOBBIN CAROLINE AMANDA , FLESCH INGE E A
IPC分类号： A61P37/02 , A61K38/16
摘要： La presente invención se relaciona con el uso de chaperonin 10 para modular la función del antígeno presentado en células. Más particularmente, la invención reside en la modulación de expresión de la superficie celular de moléculas MHC tales como, HLA.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式