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1. 发明专利

JP2001068053A IONIZATION CHAMBER USING ELECTRON SOURCE 失效
公开(公告)号：JP2001068053A
公开(公告)日：2001-03-16
申请号：JP2000216270
申请日：2000-07-17
申请人： BRUKER SAXONIA ANALYTIK GMBH
发明人： DOERING HANS-RUEDIGER
IPC分类号： G01N27/62 , G01N23/00 , G01N23/22 , G01N27/64 , H01J49/16
摘要： PROBLEM TO BE SOLVED: To enhance the ionization rate of an ion molecular reaction necessary in a reaction section chamber by providing a vacuum section chamber, a reaction section chamber, a feeding part of an analyzed object to the reaction section chamber, and a discharging part for discharging the analyzed object, separating the reaction section chamber from the vacuum section chamber by a gas-impermeable partition, and composing a negative electrode of an acceleration passage by disposing a non-emissive electron source in the vacuum section chamber. SOLUTION: In this ionization chamber, by using a positive electrode of an acceleration part as an X-ray anode in the vacuum section chamber or as a surface of the partition in some cases, X-ray light generated by colliding electrons reaches the partition in the direction of the reaction section chamber, the partition is substantially impermeable for an electron having kinetic energy provided by an acceleration voltage, but is permeable for the X-ray light generated from the X-ray anode, and one or more electrodes each used as a surface of the partition in some cases in the reaction section chamber generate photoelectrons from the X-ray light passing the partition. Preferably, the partition is formed of beryllium, having a thickness of 10-200 μm. The ionization chamber has a high ionization rate and a long service life.

2. 发明申请

WO1992018859A1 METHOD AND DEVICE FOR DETECTING SUBSTANCES IN AN AMBIENT SUBSTANCE, IN PARTICULAR FOR DETECTING CHEMICAL WARFARE AGENTS 审中-公开
标题翻译：用于检测环境物质中的物质的方法和装置，特别是用于检测化学战剂
公开(公告)号：WO1992018859A1
公开(公告)日：1992-10-29
申请号：PCT/DE1991000295
申请日：1991-04-09
申请人： BRUKER-SAXONIA ANALYTIK GMBH , DÖRING, Hans-Rüdiger , HARTMANN, Eberhard
发明人： BRUKER-SAXONIA ANALYTIK GMBH
IPC分类号： G01N27/66
CPC分类号： G01N27/66
摘要： The invention concerns a method and a device for detecting substances (A, B) in an ambient substance, in particular for detecting chemical warfare agents in the ambient air. First, light reaction ions (02 , H with H2O clusters) are generated in a reaction substance (ambient air, H2O) and added to the mixture of substance (A, B) and ambient substance. Reaction ions (O2 , H with H2O clusters) are deposited in a measurement chamber (10) in a spatially non-uniform distribution of heavy molecules (MA, MB) of the substance (A, B) to form quasi-molecule ions (MA , MB ). A time-variant electric field of predetermined basic frequency and predetermined amplitude which alternates about a zero line is generated in the measurement chamber (10). The quasi-molecule ion stream established due to the electric field is measured and the measurement signal evaluated. To distinguish a first substance (A) from a second substance (B) present at the same time in the ambient substance, a preliminary test is first carried out for a particular measurement chamber (10) to determine the dependence of the quasi-molecule ion stream on the basic frequency, and both the amplitude and asymmetry of the variation with time of the electric field strength about the zero line are separately derived for the first (A) and for the second (B) substance. A first measurement is then carried out on the mixture (32) at a first asymmetry, followed by a second measurement on the mixture (32) at a second asymmetry. The measurement signals of the two measurements are logically combined.
摘要翻译：本发明涉及用于检测环境物质中物质（A，B）的方法和装置，特别是用于检测环境空气中的化学战剂。首先，在反应物质（环境空气，H 2 O）中产生轻反应离子（O 2 - ，H +与H 2 O簇），并加入到物质（A，B）和环境物质的混合物中。在物质（A，B）的重分子（MA，MB）的空间不均匀分布中，在测量室（10）中沉积反应离子（O 2，H +与H 2 O 3簇）准分子离子（MA +，MB +）。在测量室（10）中产生预定基本频率和预定幅度的在零线上交替的时变电场。测量由于电场而建立的准分子离子流并评估测量信号。为了区分第一物质（A）和环境物质中同时存在的第二物质（B），首先对特定的测量室（10）进行初步测试，以确定准分子离子的依赖性基本频率上的流，并且对于第一（A）和第二（B）物质分别导出关于零线的电场强度随时间的变化的幅度和不对称性两者。然后以第一不对称性对混合物（32）进行第一测量，然后在第二不对称性下对混合物（32）进行第二次测量。两个测量的测量信号被逻辑组合。

3. 发明申请

US20020187493A1 Mutation analysis by mass spectrometry using photolytically cleavable primers 有权
标题翻译：使用光解性切割引物的质谱进行突变分析
公开(公告)号：US20020187493A1
公开(公告)日：2002-12-12
申请号：US10079043
申请日：2002-02-20
申请人： Bruker Saxonia Analytik GmbH
发明人： Markus Kostrzewa , Thomas Frohlich , Thomas Wenzel , Andres Jaschke , Felix Hausch
IPC分类号： C12Q001/68 , C12P019/34
CPC分类号： C12Q1/6858 , C12Q2565/627 , C12Q2523/319
摘要： The invention relates to a method of a mass-spectrometric analysis of known mutation sites in the genome, such as single nucleotide polymorphisms (SNPs), using the method of restricted primer extension. The invention consists of the use of primers with a photocleavable linker. The linker creates a gap in a DNA strand which is almost the same size as a natural DNA building block (nucleoside). The linker forms a bridge over a base pair without inhibiting hybridization or enzymatic extension. However, the linker allows the primers to be cleaved after extension in order to obtain short DNA fragments which can be more easily detected on the mass spectrometer.
摘要翻译：本发明涉及使用限制性引物延伸的方法对基因组中已知突变位点进行质谱分析的方法，例如单核苷酸多态性（SNP）。本发明包括使用具有光可透洗接头的引物。接头在DNA链中产生与天然DNA构建块（核苷）几乎相同大小的间隙。连接体在碱基对上形成桥，而不抑制杂交或酶促延伸。然而，接头允许引物在延伸后被切割，以获得在质谱仪上更容易检测到的短DNA片段。

4. 发明申请

US20020185593A1 Ion mobility spectrometer with non-radioactive ion source 有权
标题翻译：具有非放射性离子源的离子迁移谱仪
公开(公告)号：US20020185593A1
公开(公告)日：2002-12-12
申请号：US10132065
申请日：2002-04-25
申请人： Bruker Saxonia Analytik GmbH
发明人： Hans-Rudiger Doring
IPC分类号： H01J049/40
CPC分类号： G01N27/622
摘要： An ion mobility spectrometer (IMS) is provided that has a non-radioactive electron source in an evacuated chamber that is separated from the reaction chamber of the IMS by an x-ray window. Electrons from the source impinge upon an x-ray anode, causing the emission of x-ray radiation toward the window. A current controller is provided by which currents in the electron-source chamber are monitored and controlled using a microprocessor circuit. If a maximum permissible residual gas pressure is exceeded, the electron source is automatically shut down and a gettering process is activated.
摘要翻译：提供了离子迁移谱仪（IMS），其在通过X射线窗从IMS的反应室分离的真空室中具有非放射性电子源。来自源的电子撞击x射线阳极，导致向窗口发射x射线辐射。提供电流控制器，通过该电流控制器利用微处理器电路监测和控制电子源室中的电流。如果超过允许的最大允许残余气体压力，则自动关闭电子源并激活吸气过程。

5. 发明授权

US6100521A Ion mobility spectrometer in a centripetal arrangement 失效
标题翻译：离子迁移谱仪在向心排列
公开(公告)号：US6100521A
公开(公告)日：2000-08-08
申请号：US115370
申请日：1998-07-14
申请人： Hans-Rudiger Doring , Stefan Klepel , Jorg Peuker , Roland Schnurpfeil , Gerhard Weiss
发明人： Hans-Rudiger Doring , Stefan Klepel , Jorg Peuker , Roland Schnurpfeil , Gerhard Weiss
IPC分类号： G01N27/64 , H01J49/00
CPC分类号： G01N27/622
摘要： An ion mobility spectrometer (IMS) with electric drift fields directed at a central detector electrode. The IMS is rotationally symmetrical and has a disk shape.
摘要翻译：具有指向中央检测器电极的电漂移场的离子迁移谱仪（IMS）。 IMS是旋转对称的并且具有盘形状。

6. 发明授权

US6064070A Radioactivity ion sources for miniaturized ion mobility spectrometers 失效
标题翻译：用于小型离子迁移谱仪的放射性离子源
公开(公告)号：US6064070A
公开(公告)日：2000-05-16
申请号：US115776
申请日：1998-07-14
申请人： Roland Schnurpfeil , Stefan Klepel
发明人： Roland Schnurpfeil , Stefan Klepel
IPC分类号： G01N27/64 , G21G4/04 , H01J27/02 , C23C8/36
CPC分类号： G21G4/04 , H01J27/02 , G01N27/622
摘要： The invention relates to a radioactive ion source for generation of low-energy .alpha. or .beta. radiation. Both the activity of the source as well as the range of radiation can be adjusted to the respective application. Due to a carrier layer of semiconductive material, release of radioactive substances is prevented.
摘要翻译：本发明涉及用于产生低能α或β辐射的放射性离子源。源的活动以及辐射范围都可以调整到各自的应用。由于半导体材料的载体层，防止了放射性物质的释放。

7. 发明授权

US07160680B2 Mutation analysis by mass spectrometry using photolytically cleavable primers 有权
标题翻译：使用光解性切割引物的质谱进行突变分析
公开(公告)号：US07160680B2
公开(公告)日：2007-01-09
申请号：US10079043
申请日：2002-02-20
申请人： Markus Kostrzewa , Thomas Fröhlich , Thomas Wenzel , Andres Jäschke , Felix Hausch
发明人： Markus Kostrzewa , Thomas Fröhlich , Thomas Wenzel , Andres Jäschke , Felix Hausch
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6858 , C12Q2565/627 , C12Q2523/319
摘要： The invention relates to a method of a mass-spectrometric analysis of known mutation sites in the genome, such as single nucleotide polymorphisms (SNPs), using the method of restricted primer extension. The invention consists of the use of primers with a photocleavable linker. The linker creates a gap in a DNA strand which is almost the same size as a natural DNA building block (nucleoside). The linker forms a bridge over a base pair without inhibiting hybridization or enzymatic extension. However, the linker allows the primers to be cleaved after extension in order to obtain short DNA fragments which can be more easily detected on the mass spectrometer.
摘要翻译：本发明涉及使用限制性引物延伸的方法对基因组中已知突变位点进行质谱分析的方法，例如单核苷酸多态性（SNP）。本发明包括使用具有光可透洗接头的引物。接头在DNA链中产生与天然DNA构建块（核苷）几乎相同大小的间隙。连接体在碱基对上形成桥，而不抑制杂交或酶促延伸。然而，接头允许引物在延伸后被切割，以获得在质谱仪上更容易检测到的短DNA片段。

8. 发明授权

US5968837A Photo-ionization ion mobility spectrometry 失效
标题翻译：光电离离子迁移谱
公开(公告)号：US5968837A
公开(公告)日：1999-10-19
申请号：US815421
申请日：1997-03-11
申请人： Hans-Rudiger Doring , Gerd Arnold , Joachim Adler , Thomas Robel , Jurgen Riemenschneider
发明人： Hans-Rudiger Doring , Gerd Arnold , Joachim Adler , Thomas Robel , Jurgen Riemenschneider
IPC分类号： G01N27/64 , G01N33/00 , B01D59/44 , H01J49/00
CPC分类号： H01J49/162 , G01N27/622 , Y10T436/163333 , Y10T436/173845 , Y10T436/182 , Y10T436/21 , Y10T436/24
摘要： In a method for photo-ionization ion mobility spectrometry, a reagent gas is added, in particular an aromatic compound, which has a large ionization cross section in the range of ionizing VUV radiation, but a low probability for the formation of protonated quasi-molecular ions. In this way, the detection of only weakly proton affine substances is also amplified or even made possible at all, and also the detection of electronegative substances in a negative operating mode is improved. Preferred reagent gases are benzene, toluene and xylene. FIG. 1
摘要翻译：在光电离离子迁移谱方法中，添加反应气，特别是在电离VUV辐射范围内具有大离子化截面的芳香族化合物，但形成质子化准分子的可能性低离子。这样，只有弱质子仿射物质的检测也被放大甚至成为可能，并且还提高了在负操作模式下检测电负性物质。优选的试剂气体是苯，甲苯和二甲苯。图。

9. 发明申请

US20020185594A1 Ion mobility spectrometer with mechanically stabilized vacuum-tight x-ray window 有权
标题翻译：具有机械稳定的真空密封X射线窗口的离子迁移谱仪
公开(公告)号：US20020185594A1
公开(公告)日：2002-12-12
申请号：US10132066
申请日：2002-04-25
申请人： Bruker Saxonia Analytik GmbH
发明人： Hans-Rudiger Doring
IPC分类号： H01J049/40
CPC分类号： G01N27/622 , H01J49/40 , Y10T436/24 , Y10T436/25875
摘要： An ion mobility spectrometer (IMS) has a non-radioactive electron source and an x-ray anode in an evacuated chamber. The impinging of electrons from the source on the anode results in the generation of x-ray radiation. The x-ray radiation passes through a window that provides a vacuum barrier between the electron source chamber and a reaction chamber of the IMS by an x-ray window. A support grid is attached to the reaction-chamber side of the x-ray window, and mechanically stabilizes the window.
摘要翻译：离子迁移谱仪（IMS）在真空室中具有非放射性电子源和x射线阳极。来自阳极的电子的入射导致X射线辐射的产生。 X射线辐射通过窗口，其通过X射线窗口在电子源室和IMS的反应室之间提供真空阻挡层。支撑栅格连接到x射线窗口的反应室侧，并机械地使窗户稳定。

10. 发明授权

US6144029A Method for trace detection by solvent-assisted introduction of substances into an ion mobility spectrometer 有权
标题翻译：通过溶剂辅助将物质引入离子迁移谱仪进行痕量检测的方法
公开(公告)号：US6144029A
公开(公告)日：2000-11-07
申请号：US248785
申请日：1999-02-12
申请人： Joachim Adler
发明人： Joachim Adler
IPC分类号： G01N1/00 , G01N1/02 , G01N27/64 , H01J49/04
CPC分类号： G01N27/622 , G01N1/22 , G01N2001/022
摘要： The invention relates to a method and an ion mobility spectrometer (IMS) for the detection of contaminations by explosives, drugs, wood preservatives or the like. The substance traces collected on a carrier material, e.g. cellulose, are dissolved in a solvent for detection using an IMS and are vaporized together with this solvent from a sample dispenser in the reaction compartment of the IMS. In this way, the sample dispenser can be operated at a considerably lower temperature.
摘要翻译：本发明涉及用于检测爆炸物，药物，木材防腐剂等污染物的方法和离子迁移谱仪（IMS）。收集在载体材料上的物质痕迹，例如纤维素，使用IMS溶解在用于检测的溶剂中，并与来自IMS的反应室中的样品分配器的该溶剂一起蒸发。以这种方式，样品分配器可以在相当低的温度下操作。

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