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1. 发明专利

JP2010031036A Injectable naltrexone microsphere composition, and use thereof for reducing consumption of heroin and alcohol 审中-公开
标题翻译：可注射的纳曲酮微球组合物及其用于降低HEROIN和醇的消耗
公开(公告)号：JP2010031036A
公开(公告)日：2010-02-12
申请号：JP2009252183
申请日：2009-11-02
申请人： Brookwood Pharmaceuticals Inc , ブルックウッドファーマシューティカルズ,インコーポレイティド
发明人： TICE THOMAS R , STAAS JAY K , FERRELL TERESA M
IPC分类号： A61K9/58 , A61K31/485 , A61K9/16 , A61K9/50 , A61K9/62 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/34 , A61K47/38 , A61P25/32 , A61P25/36
CPC分类号： A61K9/1647 , A61K31/485 , A61K47/34 , Y10S514/811 , Y10S514/812 , Y10S514/872 , Y10S514/964
摘要： PROBLEM TO BE SOLVED: To provide an injectable slow-release naltrexone formulation. SOLUTION: The injectable slow-release naltrexone formulation comprises a poly(D,L-lactide), and naltrexone in a small amount of residual ethyl acetate. The naltrexone is released in a controlled manner over an extended period of time by intramuscular injection of the composition. The formulation can be used in the treatment of heroin addiction and alcoholism to reduce consumption of abused substances. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供可注射的缓释纳曲酮制剂。解决方案：注射缓释纳曲酮制剂包含少量残留乙酸乙酯的聚（D，L-丙交酯）和纳曲酮。纳曲酮通过肌内注射组合物在延长的时间内以受控的方式释放。该制剂可用于治疗海洛因成瘾和酒精中毒，以减少滥用物质的消耗。版权所有（C）2010，JPO＆INPIT

2. 发明申请

WO2009085952A1 PROCESS FOR PREPARING MICROPARTICLES HAVING A LOW RESIDUAL SOLVENT VOLUME 审中-公开
标题翻译：制备具有低残留溶剂量的微生物的方法
公开(公告)号：WO2009085952A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/087428
申请日：2008-12-18
申请人： BROOKWOOD PHARMACEUTICALS, INC. , BIGGS, Danielle , NETTLES, Heather
发明人： BIGGS, Danielle , NETTLES, Heather
IPC分类号： A61K9/14 , B29C39/10
CPC分类号： A61K9/1694 , A01N25/12 , A01N25/28 , A61K8/0241 , A61K8/06 , A61K8/90 , A61K9/1641 , A61K9/1647 , A61K2800/412 , A61K2800/654 , B01J13/02 , C11D3/505 , C11D17/0039
摘要： The disclosed processes for forming microparticles utilize low volumes of processing water while still providing microparticles having low residual solvent levels. The processes are adaptable to both continuous and batch processes using oil/water or water/oil or water/oil/water or oil/water/oil emulsions.
摘要翻译：所公开的形成微粒的方法利用低体积的处理水，同时仍然提供具有低残留溶剂水平的微粒。该方法适用于使用油/水或水/油或水/油/水或油/水/油乳液的连续和间歇方法。

3. 发明申请

WO2006078320A3 METHODS FOR MANUFACTURING DELIVERY DEVICES AND DEVICES THEREOF 审中-公开
标题翻译：用于制造交付设备的方法及其设备
公开(公告)号：WO2006078320A3
公开(公告)日：2006-10-19
申请号：PCT/US2005027477
申请日：2005-08-03
申请人： BROOKWOOD PHARMACEUTICALS INC , STAAS JAY K , TICE THOMAS R , HUDSON BRUCE W , TIPTON ARTHUR J
发明人： STAAS JAY K , TICE THOMAS R , HUDSON BRUCE W , TIPTON ARTHUR J
IPC分类号： A61K9/00
CPC分类号： A61L31/06 , A61K9/0024 , A61K9/2027 , A61K9/204 , A61L27/34 , A61L27/54 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/606
摘要： Described herein are methodes for reducing and achieving the desired release of an agent from a delivery system. The desired release kinetics are achieved by exposing the surface of the delivery system with a fluid for a desired period of time.
摘要翻译：这里描述的是用于减少和实现药剂从递送系统的期望释放的方法。所需的释放动力学通过用流体暴露输送系统的表面达所需的时间段来实现。

4. 发明申请

WO2009064442A1 VISCOUS TERPOLYMERS AS DRUG DELIVERY PLATFORM 审中-公开
标题翻译： VISCOUS TERPOLYMERS作为药物递送平台
公开(公告)号：WO2009064442A1
公开(公告)日：2009-05-22
申请号：PCT/US2008/012755
申请日：2008-11-12
申请人： BROOKWOOD PHARMACEUTICALS, INC. , MARKLAND, Peter , BOWMAN, Howard
发明人： MARKLAND, Peter , BOWMAN, Howard
IPC分类号： A61K9/42
CPC分类号： C08G63/08 , A61K9/0019 , A61K31/7088 , A61K47/02 , A61K47/10 , A61K47/34 , A61K47/36 , C08G63/664 , C08G2261/126
摘要： Disclosed are terpolymer compositions of lactide, glycolide, and caprolactone and methods of making such polymers with an initiator. Methods of using the terpolymers as a drug delivery platform are also disclosed.
摘要翻译：公开了丙交酯，乙交酯和己内酯的三元共聚物组合物以及用引发剂制备这种聚合物的方法。还公开了使用三元共聚物作为药物递送平台的方法。

5. 发明申请

WO2008153997A1 REDUCED-MASS, LONG-ACTING DOSAGE FORMS 审中-公开
标题翻译：减少质量，长效剂型
公开(公告)号：WO2008153997A1
公开(公告)日：2008-12-18
申请号：PCT/US2008/007216
申请日：2008-06-09
申请人： BROOKWOOD PHARMACEUTICALS, INC. , TICE, Thomas, R. , MARKLAND, Peter , STAAS, Jay, K.
发明人： TICE, Thomas, R. , MARKLAND, Peter , STAAS, Jay, K.
IPC分类号： A01N43/04 , A61K31/70 , A61K39/395
CPC分类号： C07K16/00 , A61K9/0048 , A61K9/0051 , A61K9/1647 , A61K31/7088 , A61K2039/505
摘要： Methods and compositions are disclosed whereby free antibody or nucleic acid coadministered with a long-acting formulation, such as microparticle or implant, containing the antibody or nucleic acid to achieve a long duration of antibody or nucleic acid release In one aspect, the free antibody or nucleic acid alone has efficacy for an extended period, during which time, very little or no long-acting formulation antibody or nucleic acid is released In one aspect, after the free antibody or nucleic acid has diminished activity, Is gone, or no longer has activity, the longacting formulation antibody or nucleic acid begins to release for a desired preprogrammed duration to provide long-acting durations Less formulation mass is needed because the entire antibody or nucleic acid Is not encapsulated or implanted with encapsulation or implant excipient or polymer In addition, more antibody or nucleic acid can be administered to afford longer-acting formulations.
摘要翻译：公开了方法和组合物，其中与长效制剂（例如微粒或植入物）共同施用含有抗体或核酸以实现长时间抗体或核酸释放的游离抗体或核酸。一方面，游离抗体或单独的核酸具有长时间的功效，在此期间，非常少的或没有长效的制剂抗体或核酸被释放。一方面，在游离抗体或核酸活性降低之后，已经去除或不再具有活性，长效制剂抗体或核酸开始释放所需的预编程持续时间以提供长效持续时间需要较少的制剂质量，因为整个抗体或核酸不被包封或植入用包封或植入物赋形剂或聚合物。此外，可以施用更多的抗体或核酸以提供长效制剂。

6. 发明申请

WO2008054725A3 SPHERONIZED POLYMER PARTICLES 审中-公开
标题翻译：球形聚合物颗粒
公开(公告)号：WO2008054725A3
公开(公告)日：2008-09-12
申请号：PCT/US2007022885
申请日：2007-10-30
申请人： BROOKWOOD PHARMACEUTICALS INC , CAMPBELL JASON N , HUDSON BRUCE W
发明人： CAMPBELL JASON N , HUDSON BRUCE W
IPC分类号： C08J3/00 , C08J3/12
CPC分类号： C08J3/12 , C08G63/90 , C08J2367/04
摘要： Disclosed are methods for producing spheroid polymer particles from non-spheroid particles by heating the non-spheroid particles in a liquid medium.
摘要翻译：公开了通过加热液体介质中的非球状颗粒来从非球状颗粒生产球状聚合物颗粒的方法。

7. 发明申请

WO2008054725A2 SPHERONIZED POLYMER PARTICLES 审中-公开
标题翻译：球形聚合物颗粒
公开(公告)号：WO2008054725A2
公开(公告)日：2008-05-08
申请号：PCT/US2007/022885
申请日：2007-10-30
申请人： BROOKWOOD PHARMACEUTICALS, INC. , CAMPBELL, Jason, N. , HUDSON, Bruce, W.
发明人： CAMPBELL, Jason, N. , HUDSON, Bruce, W.
IPC分类号： C08J3/00 , C08J3/12
CPC分类号： C08J3/12 , C08G63/90 , C08J2367/04
摘要： Disclosed are methods for producing spheroid polymer particles from non-spheroid particles by heating the non-spheroid particles in a liquid medium.
摘要翻译：公开了通过在液体介质中加热非球形颗粒而由非球形颗粒生产球形聚合物颗粒的方法。

8. 发明申请

WO2006078320A2 METHODS FOR MANUFACTURING DELIVERY DEVICES AND DEVICES THEREOF 审中-公开
标题翻译：制造传送装置及其装置的方法
公开(公告)号：WO2006078320A2
公开(公告)日：2006-07-27
申请号：PCT/US2005/027477
申请日：2005-08-03
申请人： BROOKWOOD PHARMACEUTICALS, INC. , STAAS, Jay, K. , TICE, Thomas, R. , HUDSON, Bruce, W. , TIPTON, Arthur, J.
发明人： STAAS, Jay, K. , TICE, Thomas, R. , HUDSON, Bruce, W. , TIPTON, Arthur, J.
IPC分类号： A61K9/50 , A61K31/00 , A61K38/00
CPC分类号： A61L31/06 , A61K9/0024 , A61K9/2027 , A61K9/204 , A61L27/34 , A61L27/54 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/606
摘要： Described herein are methodes for reducing and achieving the desired release of an agent from a delivery system. The desired release kinetics are achieved by exposing the surface of the delivery system with a fluid for a desired period of time.
摘要翻译：本文描述了用于减少和实现从递送系统期望释放药剂的方法。所希望的释放动力学是通过将流体系统的表面暴露于流体达所需的时间来实现的。

9. 发明申请

US20110129422A1 Viscous Terpolymers as Drug Delivery Platform 审中-公开
标题翻译：粘性三聚物作为药物递送平台
公开(公告)号：US20110129422A1
公开(公告)日：2011-06-02
申请号：US13022720
申请日：2011-02-08
申请人： Peter Markland , Howard Bowman
发明人： Peter Markland , Howard Bowman
IPC分类号： A61K38/02 , A61K39/395 , A61K31/7088 , A61K49/00 , A61P29/00 , A61P23/00 , A61P19/00 , A61P35/00 , A61P25/00 , C08G63/08
CPC分类号： C08G63/08 , A61K9/0019 , A61K31/7088 , A61K47/02 , A61K47/10 , A61K47/34 , A61K47/36 , C08G63/664 , C08G2261/126
摘要： Disclosed are terpolymer compositions of lactide, glycolide, and caprolactone and methods of making such polymers with an initiator. Methods of using the terpolymers as a drug delivery platform are also disclosed.
摘要翻译：公开了丙交酯，乙交酯和己内酯的三元共聚物组合物以及用引发剂制备这种聚合物的方法。还公开了使用三元共聚物作为药物递送平台的方法。

10. 发明申请

US20100003300A1 INJECTABLE DELIVERY OF MICROPARTICLES AND COMPOSITIONS THEREFORE 有权
标题翻译：微生物和组合物的注射输送
公开(公告)号：US20100003300A1
公开(公告)日：2010-01-07
申请号：US12494174
申请日：2009-06-29
申请人： Peter Markland , Gary Anthony Winchester , Thomas Robert Tice , David P. Martin
发明人： Peter Markland , Gary Anthony Winchester , Thomas Robert Tice , David P. Martin
IPC分类号： A61K9/16 , A61F2/00
CPC分类号： A61K9/1647 , A61K9/0019 , A61K9/5031 , A61K31/485 , A61K38/09 , A61L27/34 , A61L31/10 , A61L2400/06 , C08L67/04
摘要： Compositions and methods of making and using of microparticle compositions that provide faster flow or improved injectability through smaller or small-diameter needles have been developed. Notably, the microparticle compositions can be successfully delivered or administered through smaller-diameter needles than other microparticle compositions prepared from biocompatible or biodegradable polymers including, for example, poly(lactide), poly(lactide-co-glycolide), polycaprolactone, or poly-3-hydroxybutyrate. The microparticle compositions can exhibit a higher solids loading for a given needle size and/or faster flow through needles than other microparticle compositions. Further, blending or mixing the polymer of the microparticle composition with other polymer formulations can enhance the injectability of the resulting formulation.
摘要翻译：已经开发了制备和使用通过较小或小直径针提供更快流动或改善的注射性的微粒组合物的组合物和方法。值得注意的是，微粒组合物可以通过比由生物相容或可生物降解的聚合物制备的其它微粒组合物更小直径的针头递送或施用，包括例如聚（丙交酯），聚（丙交酯 - 共 - 乙交酯），聚己内酯或聚 3-羟基丁酸酯。与其它微粒组合物相比，微粒组合物对于给定的针头尺寸和/或针头的流速可以表现出较高的固体负载。此外，将微粒组合物的聚合物与其它聚合物配方混合或混合可增强所得制剂的注射性。

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