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1. 发明授权

US09090737B2 Viscous terpolymers as drug delivery platform 有权
标题翻译：粘性三元共聚物作为药物递送平台
公开(公告)号：US09090737B2
公开(公告)日：2015-07-28
申请号：US12269135
申请日：2008-11-12
申请人： Peter Markland , Howard Bowman
发明人： Peter Markland , Howard Bowman
IPC分类号： C08G63/08 , A61K9/00 , C08G63/664 , A61K31/7088 , A61K47/02 , A61K47/10 , A61K47/34 , A61K47/36
CPC分类号： C08G63/08 , A61K9/0019 , A61K31/7088 , A61K47/02 , A61K47/10 , A61K47/34 , A61K47/36 , C08G63/664 , C08G2261/126
摘要： Disclosed are terpolymer compositions of lactide, glycolide, and caprolactone and methods of making such polymers with an initiator. Methods of using the terpolymers as a drug delivery platform are also disclosed.
摘要翻译：公开了丙交酯，乙交酯和己内酯的三元共聚物组合物以及用引发剂制备这种聚合物的方法。还公开了使用三元共聚物作为药物递送平台的方法。

2. 发明授权

US08920921B2 Terpolymer blends and their use as pressure-sensitive adhesives 有权
标题翻译：三元共聚物共混物及其作为压敏粘合剂的用途
公开(公告)号：US08920921B2
公开(公告)日：2014-12-30
申请号：US13221415
申请日：2011-08-30
申请人： Howard Bowman , Bruce W. Hudson
发明人： Howard Bowman , Bruce W. Hudson
IPC分类号： C08G63/08 , C09J7/02 , A61L15/26 , C09J167/04 , C09J7/00 , A61L15/58 , A61L24/04 , C08L67/04
CPC分类号： C08G63/08 , A61L15/26 , A61L15/58 , A61L24/046 , C08L67/04 , C09J7/00 , C09J7/255 , C09J7/38 , C09J167/04 , C09J2467/00 , C09J2467/006 , Y10T428/1334 , Y10T428/1352 , Y10T428/1476 , Y10T428/21 , Y10T428/24777 , Y10T428/24942 , Y10T428/249921 , Y10T428/2839 , Y10T428/2865 , Y10T428/31681 , Y10T428/31786 , Y10T428/31855 , Y10T442/172
摘要： Disclosed herein are blends prepared from polyester terpolymers that function as pressure-sensitive adhesives. The disclosed articles comprise the terpolymer blends adhered to a release liner. The disclosed implant devices comprise the pressure-sensitive adhesive blend adhered to a surface thereof. The pressure-sensitive adhesive blend can promote adhesion of the implant device to a location in a subject.
摘要翻译：本文公开了由作为压敏粘合剂起作用的聚酯三元共聚物制备的共混物。所公开的制品包括粘附到剥离衬垫上的三元共聚物混合物。所公开的植入装置包括粘附到其表面的压敏粘合剂共混物。压敏粘合剂共混物可以促进植入装置对受试者中的位置的粘附。

3. 发明申请

US20120078155A1 BIODEGRADABLE TERPOLYMERS AND TERPOLYMER BLENDS AS PRESSURE-SENSITIVE ADHESIVES 有权
标题翻译：作为压敏粘合剂的生物可降解的二烯丙基共聚物和三聚物共混物
公开(公告)号：US20120078155A1
公开(公告)日：2012-03-29
申请号：US13221464
申请日：2011-08-30
申请人： Howard Bowman , Don Lucast , Philip Morris
发明人： Howard Bowman , Don Lucast , Philip Morris
IPC分类号： C09J7/02 , A61L15/58 , C09J7/04 , A61F13/02 , B32B7/12 , B32B1/02
CPC分类号： C08G63/08 , A61L15/26 , A61L15/58 , A61L24/046 , C08L67/04 , C09J7/00 , C09J7/255 , C09J7/38 , C09J167/04 , C09J2467/00 , C09J2467/006 , Y10T428/1334 , Y10T428/1352 , Y10T428/1476 , Y10T428/21 , Y10T428/24777 , Y10T428/24942 , Y10T428/249921 , Y10T428/2839 , Y10T428/2865 , Y10T428/31681 , Y10T428/31786 , Y10T428/31855 , Y10T442/172
摘要： Disclosed herein are terpolymers and blends prepared from polyester terpolymers that can function as pressure-sensitive adhesives. The disclosed articles can comprise the terpolymer and terpolymer blends coated to a conformable backing member. The terpolymer and terpolymer blends can further comprise a bioactive agent.
摘要翻译：本文公开了由可用作压敏粘合剂的聚酯三元共聚物制备的三元共聚物和共混物。所公开的制品可以包括涂覆到适形背衬构件的三元共聚物和三元共聚物共混物。三元共聚物和三元共聚物共混物可进一步包含生物活性剂。

4. 发明授权

US5083400A Adjustable threshold and door sill 失效
标题翻译：可调阈值和门槛
公开(公告)号：US5083400A
公开(公告)日：1992-01-28
申请号：US605779
申请日：1990-10-29
申请人： Howard Bowman
发明人： Howard Bowman
IPC分类号： E06B7/20 , E06B7/215
CPC分类号： E06B7/20 , E06B7/215
摘要： A new door threshold/weatherstripping device is disclosed that uses rollers, installed either in a door to contact a threshold surface, or in the threshold to contact the door. The rollers are supported by bearings that permit the rollers to turn freely as the door is opened or closed. The bearings are mounted in housings that have adjustable, spring loaded pistons. These pistons permit the spacing of rollers with respect to the threshold (or door) to be adjusted to ensure a tight seal. In the embodiment that utilizes a threshold mounted roller, a gripper pad is used to prevent the roller from turning when a person steps on it. This prevent possible slipping injuries. Both embodiments have brushes mounded adjacent to the rollers to clean them of dirt, snow and water.
摘要翻译：公开了一种新的门阈/防风雨条纹装置，其使用安装在门中的辊来接触阈值表面，或者门限接触门。滚子由轴承支撑，允许滚轮在门打开或关闭时自由转动。轴承安装在具有可调节弹簧加载活塞的外壳中。这些活塞允许辊子相对于门槛（或门）的间距进行调节，以确保密封。在利用阈值安装辊的实施例中，当人们踏上辊时，使用夹持垫来防止辊转动。这可以防止可能的滑倒伤。两个实施例都具有与滚子相邻的刷子，以清洁它们的污垢，雪和水。

5. 发明申请

US20090124535A1 VISCOUS TERPOLYMERS AS DRUG DELIVERY PLATFORM 有权
标题翻译： VISCOUS TERPOLYMERS作为药物递送平台
公开(公告)号：US20090124535A1
公开(公告)日：2009-05-14
申请号：US12269135
申请日：2008-11-12
申请人： Peter Markland , Howard Bowman
发明人： Peter Markland , Howard Bowman
IPC分类号： A61K47/34 , C08G63/08 , A61K38/02 , A61K31/7088
CPC分类号： C08G63/08 , A61K9/0019 , A61K31/7088 , A61K47/02 , A61K47/10 , A61K47/34 , A61K47/36 , C08G63/664 , C08G2261/126
摘要： Disclosed are terpolymer compositions of lactide, glycolide, and caprolactone and methods of making such polymers with an initiator. Methods of using the terpolymers as a drug delivery platform are also disclosed.
摘要翻译：公开了丙交酯，乙交酯和己内酯的三元共聚物组合物以及用引发剂制备这种聚合物的方法。还公开了使用三元共聚物作为药物递送平台的方法。

6. 发明授权

US09416221B2 Biodegradable terpolymers and terpolymer blends as pressure-sensitive adhesives 有权
标题翻译：可生物降解的三元共聚物和三元共聚物作为压敏粘合剂
公开(公告)号：US09416221B2
公开(公告)日：2016-08-16
申请号：US13221464
申请日：2011-08-30
申请人： Howard Bowman , Don Lucast , Philip Morris
发明人： Howard Bowman , Don Lucast , Philip Morris
IPC分类号： C09J7/02 , A61L15/58 , C09J7/04 , A61F13/02 , B32B7/12 , B32B1/02 , C08G63/08 , A61L15/26 , A61L24/04 , C09J7/00 , C09J167/04 , C08L67/04
CPC分类号： C08G63/08 , A61L15/26 , A61L15/58 , A61L24/046 , C08L67/04 , C09J7/00 , C09J7/255 , C09J7/38 , C09J167/04 , C09J2467/00 , C09J2467/006 , Y10T428/1334 , Y10T428/1352 , Y10T428/1476 , Y10T428/21 , Y10T428/24777 , Y10T428/24942 , Y10T428/249921 , Y10T428/2839 , Y10T428/2865 , Y10T428/31681 , Y10T428/31786 , Y10T428/31855 , Y10T442/172
摘要： Disclosed herein are terpolymers and blends prepared from polyester terpolymers that can function as pressure-sensitive adhesives. The disclosed articles can comprise the terpolymer and terpolymer blends coated to a conformable backing member. The terpolymer and terpolymer blends can further comprise a bioactive agent.
摘要翻译：本文公开了由可用作压敏粘合剂的聚酯三元共聚物制备的三元共聚物和共混物。所公开的制品可以包括涂覆到适形背衬构件的三元共聚物和三元共聚物共混物。三元共聚物和三元共聚物共混物可进一步包含生物活性剂。

7. 发明授权

US08900699B2 Terpolymer blends and their use as pressure-sensitive adhesives 有权
公开(公告)号：US08900699B2
公开(公告)日：2014-12-02
申请号：US13221415
申请日：2011-08-30
申请人： Howard Bowman , Bruce W. Hudson
发明人： Howard Bowman , Bruce W. Hudson
IPC分类号： C08G63/08 , C09J7/02 , A61L15/26 , C09J167/04 , C09J7/00 , A61L15/58 , A61L24/04 , C08L67/04
摘要： Disclosed herein are blends prepared from polyester terpolymers that function as pressure-sensitive adhesives. The disclosed articles comprise the terpolymer blends adhered to a release liner. The disclosed implant devices comprise the pressure-sensitive adhesive blend adhered to a surface thereof. The pressure-sensitive adhesive blend can promote adhesion of the implant device to a location in a subject.

8. 发明申请

US20120100613A1 Compositions and Methods for the Modulation of Gene Expression in Plants 审中-公开
标题翻译：植物基因表达调控的组成和方法
公开(公告)号：US20120100613A1
公开(公告)日：2012-04-26
申请号：US13282680
申请日：2011-10-27
申请人： Viki Bowman Vance , Lewis Howard Bowman , Allison Mallory
发明人： Viki Bowman Vance , Lewis Howard Bowman , Allison Mallory
IPC分类号： C12N5/10
CPC分类号： C12N15/821 , C12N15/8216 , C12N15/8218
摘要： Compositions and methods for modulating nucleotide sequence expression, particularly for modulating gene expression in plants, are provided. The compositions comprise precursor RNA constructs for the expression of an RNA precursor. The precursor RNA construct comprises a promoter that is expressed in a plant cell driving the expression of a precursor RNA having a microRNA. The miRNA is complementary or partially complementary to a portion of a target gene or nucleotide sequence and function to modulate expression of the target sequence or gene. In this manner, the RNA precursor construct can be designed to modulate expression of any nucleotide sequence of interest, either an endogenous plant gene or alternatively a transgene. Transformed plants, tissues, cells and seeds are also provided.
摘要翻译：提供了调节核苷酸序列表达，特别是用于调节植物中的基因表达的组合物和方法。组合物包含用于表达RNA前体的前体RNA构建体。前体RNA构建体包含在驱动表达具有微小RNA的前体RNA的植物细胞中表达的启动子。 miRNA与靶基因或核苷酸序列的一部分互补或部分互补，并调节靶序列或基因表达的功能。以这种方式，RNA前体构建体可被设计成调节目的核苷酸序列的表达，即内源植物基因或替代转基因。还提供了转化的植物，组织，细胞和种子。

9. 发明申请

US20100168807A1 BIOACTIVE TERPOLYMER COMPOSITIONS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：生物三聚体组合物及其制备方法和使用方法
公开(公告)号：US20100168807A1
公开(公告)日：2010-07-01
申请号：US12644097
申请日：2009-12-22
申请人： Kevin W. Burton , Howard Bowman , Danielle Biggs , Peter Markland
发明人： Kevin W. Burton , Howard Bowman , Danielle Biggs , Peter Markland
IPC分类号： A61N1/36 , A61K31/56 , A61K9/14 , A61F2/00 , A61K38/18 , A61N1/39
CPC分类号： A61K47/34 , A61K9/0019 , A61K31/56 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/622 , A61M5/19 , A61N1/375 , A61N1/3968 , C08L67/04
摘要： Described herein are terpolymer compositions, kits comprising the compositions, implant devices comprising the compositions, and methods of making and using same, including point of use methods.
摘要翻译：本文描述的是三元共聚物组合物，包含该组合物的试剂盒，包含该组合物的植入装置及其制备和使用方法，包括使用方法。

10. 发明申请

US20110129422A1 Viscous Terpolymers as Drug Delivery Platform 审中-公开
标题翻译：粘性三聚物作为药物递送平台
公开(公告)号：US20110129422A1
公开(公告)日：2011-06-02
申请号：US13022720
申请日：2011-02-08
申请人： Peter Markland , Howard Bowman
发明人： Peter Markland , Howard Bowman
IPC分类号： A61K38/02 , A61K39/395 , A61K31/7088 , A61K49/00 , A61P29/00 , A61P23/00 , A61P19/00 , A61P35/00 , A61P25/00 , C08G63/08
CPC分类号： C08G63/08 , A61K9/0019 , A61K31/7088 , A61K47/02 , A61K47/10 , A61K47/34 , A61K47/36 , C08G63/664 , C08G2261/126
摘要： Disclosed are terpolymer compositions of lactide, glycolide, and caprolactone and methods of making such polymers with an initiator. Methods of using the terpolymers as a drug delivery platform are also disclosed.
摘要翻译：公开了丙交酯，乙交酯和己内酯的三元共聚物组合物以及用引发剂制备这种聚合物的方法。还公开了使用三元共聚物作为药物递送平台的方法。

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