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1. 发明专利

JP5826311B2 哺乳類遺伝子発現のためのヒトハイブリッド宿主細胞有权
标题翻译：用于哺乳动物基因表达的人杂交宿主细胞
公开(公告)号：JP5826311B2
公开(公告)日：2015-12-02
申请号：JP2014032748
申请日：2014-02-24
申请人：バイエル・コーポレーシヨン , BAYER CORPORATION
发明人：ミユング−サム・チヨー
IPC分类号： C12N5/10
CPC分类号： C12N5/163 , C12N2510/02

2. 发明申请

WO2005116613A2 VIAL PRESENCE INDICATOR FOR VIAL-BEARING RACK 审中-公开
标题翻译： VIAL轴承架的VIAL存在指示器
公开(公告)号：WO2005116613A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/018217
申请日：2005-05-24
申请人： BAYER CORPORATION , SCHUTT, Alexander , TRUMP, Martin
发明人： SCHUTT, Alexander , TRUMP, Martin
IPC分类号： G01N21/03
CPC分类号： G01N35/026 , B01L9/06 , B01L2200/025 , B01L2200/143 , G01N2035/0429 , G01N2035/0493 , Y10T436/11
摘要： An indicator for enabling an analytical instrument to positively detect the presence of a vial in respective vial-receiving rack position regardless of whether the vial is oriented in a manner necessary for a code reader to read a code printed on the vial. Translation of a leaf spring upon insertion of a vial into a rack position causes a flag to obscure a code provided adjacent the rack position. An instrument into which the rack is installed interprets the failure of the code reader to detect this code as positive indication that a vial is disposed within the respective rack position.
摘要翻译：用于使分析仪器能够在相应的小瓶容纳架位置中积极地检测小瓶的存在的指示器，而不管小瓶是否以代码读取器读取在小瓶上打印的代码所必需的方式定向。当将小瓶插入机架位置时，板簧的翻译将导致标志遮盖在机架位置附近提供的代码。安装机架的仪器解释了代码阅读器的故障，将该代码检测为一个小瓶被置于相应机架位置的正面指示。

3. 发明申请

WO2003099190A2 SERUM TRANSFER CUP 审中-公开
标题翻译：血清转移杯
公开(公告)号：WO2003099190A2
公开(公告)日：2003-12-04
申请号：PCT/US2003/014936
申请日：2003-05-13
申请人： BAYER CORPORATION , DeYOUNG, Thomas , VOULGARIS, John, A. , VINCENT, Loretta
发明人： DeYOUNG, Thomas , VOULGARIS, John, A. , VINCENT, Loretta
IPC分类号： A61J
CPC分类号： G01N29/222 , B01L3/5082 , B01L3/5453 , B01L9/06 , B01L2200/023 , G01N2291/02466 , G01N2291/02836 , G01N2291/02854
摘要： The serum transfer cup is nestable in two different size blood collection tubes such as a 13mm diameter sample tube and a 16mm diameter sample tube of the same axial length. The serum transfer cup includes a flange stepped down from a top edge of the cup by a distinctive axial distance that permits ultrasonic identification of the presence of the serum transfer cup regardless of which sample tube nests the serum transfer cup. The serum transfer cup has a higher elevation in the 13mm sample tube than in the 16mm sample tube and the different flange heights can be detected using ultrasonic signals. Thus ultrasonic measurement of the flange position of the nested serum transfer cup identifies the presence of different serum transfer cups in the 13mm sample tube and in the 16mm sample tube, and also identifies the 13mm and 16mm sample tubes with the nested serum transfer cups.
摘要翻译：血清转移杯可嵌套在两个不同尺寸的采血管中，例如13mm直径的样品管和相同轴向长度的16mm直径的样品管。血清转移杯包括从杯的顶部边缘向下逐渐下降的凸缘，其具有独特的轴向距离，允许超声波识别血清转移杯的存在，而不管哪个样品管嵌套血清转移杯。血清转移杯在13mm样品管中的高度高于16mm样品管，并且可以使用超声波信号检测不同的法兰高度。因此，嵌套血清转移杯的法兰位置的超声波测量识别13mm样品管和16mm样品管中存在不同的血清转移杯，并且还用嵌套的血清转移杯识别13mm和16mm的样品管。

4. 发明申请

WO2003076506A1 STABILIZED PIGMENTED POLYMER COMPOSITIONS 审中-公开
标题翻译：稳定的引发聚合物组合物
公开(公告)号：WO2003076506A1
公开(公告)日：2003-09-18
申请号：PCT/US2003/006648
申请日：2003-03-05
申请人： BAYER CORPORATION
发明人： REDISKE, James, E. , POTTER; Terry, A
IPC分类号： C08K13/08
CPC分类号： C08K5/0041 , C08K3/013 , C08K3/22
摘要： The present invention relates to a composition containing A) a polymer, B) a pigment or a dye and C) ZnO as a stabilizer, wherein the initial CIELab value DE of the stabilized pigmented polymer is less than 10 compared to the pigmented polymer and the reduction of AE of the stabilized pigmented polymer after 1500 kj UV radiation is at least 10 compared to the pigmented polymer.
摘要翻译：本发明涉及包含A）聚合物，B）颜料或染料和C）ZnO作为稳定剂的组合物，其中稳定的着色聚合物的初始CIELab值DE与着色聚合物相比小于10，与着色聚合物相比，1500kj UV辐射后稳定的着色聚合物的AE的减少至少为10。

5. 发明申请

WO2003073909A3 ASSAYS TO MONITOR LEVELS OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) EXTRACELLULAR DOMAIN (ECD) IN CANCER PATIENTS 审中-公开
公开(公告)号：WO2003073909A3
公开(公告)日：2003-09-12
申请号：PCT/US2003/005831
申请日：2003-02-27
申请人： BAYER CORPORATION
发明人： CARNEY, Walter, P. , HAMER, Peter, J. , LIPTON, Allan , LEITZEL, Kim , ALI, Suhail, M.
IPC分类号： G01N33/48
摘要： The present invention describes clinically and medically important methods of monitoring outcome of a cancer patient who is suffering from disease or who is undergoing treatment or therapy for his or her disease. More specifically, the invention provides a method of monitoring the progression of disease or cancer treatment effectiveness in a cancer patient by measuring the level of the extracellular domain (ECD) of the epidermal growth factor receptor (EGFR) in a sample taken from the cancer patient, preferably, before treatment, at the start of treatment, and at various time intervals during treatment, wherein a decrease in the level of the ECD of the EGFR in the cancer patient compared with the level of the ECD of the EGFR in normal control individuals serves as an indicator of cancer advancement or progression and/or a lack of treatment effectiveness for the patient. As another aspect of determining disease outcome and survival, the invention further provides assessing both EGFR and HER-2/neu levels, in combination, in a patient sample. A finding of decreased levels of EGFR concomitantly with elevated or increased levels of HER-2/neu relative to control levels indicates poor outcome and short time to progression.

6. 发明申请

WO2003062227A1 RHO-KINASE INHIBITORS 审中-公开
标题翻译： RHO-激酶抑制剂
公开(公告)号：WO2003062227A1
公开(公告)日：2003-07-31
申请号：PCT/US2003/001840
申请日：2003-01-23
申请人： BAYER CORPORATION , NAGARATHNAM, Dhanapalan , DUMAS, Jacques , HATOUM-MOKDAD, Holia , BOYER, Stephen , PLUEMPE, Hans
发明人： NAGARATHNAM, Dhanapalan , DUMAS, Jacques , HATOUM-MOKDAD, Holia , BOYER, Stephen , PLUEMPE, Hans
IPC分类号： C07D401/14
CPC分类号： C07D401/12 , C07D401/14
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译：公开了其化合物及其衍生物，其合成及其作为Rho-激酶抑制剂的用途。这些化合物可用于抑制肿瘤生长，治疗勃起功能障碍和治疗由Rho-激酶介导的其它适应症，例如冠心病。

7. 发明申请

WO2003059913A1 ROH-KINASE INHIBITORS 审中-公开
标题翻译： ROH-激酶抑制剂
公开(公告)号：WO2003059913A1
公开(公告)日：2003-07-24
申请号：PCT/US2003/000606
申请日：2003-01-10
申请人： BAYER CORPORATION , NAGARATHNAM, Dhanapalan , KHIRE, Uday , ASGARI, Davoud , SHAO, Jianxing , LIU, Xiao-Gao , WANG, Chunguang , HART, Barry , WEBER, Olaf , LYNCH, Mark , ZHANG, Lei , WANG, Lei
发明人： NAGARATHNAM, Dhanapalan , KHIRE, Uday , ASGARI, Davoud , SHAO, Jianxing , LIU, Xiao-Gao , WANG, Chunguang , HART, Barry , WEBER, Olaf , LYNCH, Mark , ZHANG, Lei , WANG, Lei
IPC分类号： C07D495/04
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译：公开了其化合物及其衍生物，其合成及其作为Rho-激酶抑制剂的用途。本发明的这些化合物可用于抑制肿瘤生长，治疗勃起功能障碍，以及治疗由Rho-激酶（例如冠心病）介导的其它适应症。

8. 发明申请

WO2003056310A1 POTASSIUM FLUOROIONOPHORE 审中-公开
公开(公告)号：WO2003056310A1
公开(公告)日：2003-07-10
申请号：PCT/US2002/041245
申请日：2002-12-20
申请人： BAYER CORPORATION , WORCESTER POLYTECHNIC INSTITUTE , BENCO, John, S. , MCGIMPSEY, W., Grant , NIENABER, Hubert
发明人： BENCO, John, S. , MCGIMPSEY, W., Grant , NIENABER, Hubert
IPC分类号： G01N21/64
CPC分类号： C07D273/00 , G01N33/5005
摘要： A fluorionophore for the fluorescent detection of potassium ions.
摘要翻译：用于荧光检测钾离子的荧光团。

9. 发明申请

WO2003051311A3 ANTIBODY INHIBITING STEM CELL FACTOR ACTIVITY AND USE FOR TREATMENT OF ASTHMA 审中-公开
公开(公告)号：WO2003051311A3
公开(公告)日：2003-06-26
申请号：PCT/US2002/040227
申请日：2002-12-16
申请人： BAYER CORPORATION , TAKEUCHI, Toshihiko , TOMKINSON, Adrian , NEBEN, Steven
发明人： TAKEUCHI, Toshihiko , TOMKINSON, Adrian , NEBEN, Steven
IPC分类号： G01N33/53
摘要： The present invention provides human antibodies specific for stem cell factor that contain at least one CDR derived from a combinatorial antibody library. The invention also provides pharmaceutical compositions comprising the antibodies and methods of treating asthma. The invention further provides methods of detecting stem cell factor using the antibodies.

10. 发明申请

WO2003040461A1 PROCESS FOR DYEING MOLDED ARTICLES; DIP-DYED ARTICLES 审中-公开
标题翻译：染色文章的过程; DIP-DYED ARTICLES
公开(公告)号：WO2003040461A1
公开(公告)日：2003-05-15
申请号：PCT/US2002/035260
申请日：2002-11-01
申请人： BAYER CORPORATION
发明人： PYLES, Robert, A. , ARCHEY, Rick, L.
IPC分类号： D06P3/54
CPC分类号： D06P3/54 , D06P1/613 , D06P1/65131
摘要： A process for tinting of articles molded from a polymeric resin is disclosed. Preferably, the article is molded from polycarbonate and the process entails immersing the molded article in a dye bath that contains water, dye, a carrier and an optional surfactant. The carrier is a compound conforming to formula (i): R 1 [-O-(CH 2 ) n ] m OR 2, wherein R?1¿ and R?2¿ independently denote H or C¿1-18? alkyl, benzyl, benzoyl or phenyl radical which may be substituted in the aromatic ring by alkyl and or halogen, preferably R?1¿=butyl, R?2¿=H, n is 2 or 3 and m is 2 to 35. The method is especially useful in the manufacture of tinted lenses.
摘要翻译：公开了一种用于着色由聚合物树脂模制的制品的方法。优选地，制品由聚碳酸酯成型，并且该方法需要将模制品浸入含有水，染料，载体和任选的表面活性剂的染浴中。载体是符合式（i）的化合物：R 1 [-O-（CH 2）n] m OR 2，其中R 1和R 2独立地表示H或C 1-18〜烷基，苄基，苯甲酰基或苯基，其可以在芳环中被烷基和/或卤素取代，优选R 1 =丁基，R 2 = H，n为2或3，m为2至35。方法在着色镜片的制造中特别有用。

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