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1. 发明专利

JP2009161521A New intermediate for producing antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives 有权
标题翻译：用于生产抗坏血酸的方法的新中间体4-二苯基甲基/二苯基甲基哌啶衍生物
公开(公告)号：JP2009161521A
公开(公告)日：2009-07-23
申请号：JP2008313946
申请日：2008-12-10
申请人： Aventis Inc , アベンティス・インコーポレイテッド
发明人： KRAUSS RICHARD C , STROM ROBERT M , SCORTICHINI CAREY L , KRUPER WILLIAM J , WOLF RICHARD A , CARR ALBERT A , RUDISILL DUANE E , PANZONE GIANBATTISTA , HAY DAVID A , WU WEISHI W
IPC分类号： C07C49/80 , C07D295/18 , A61K20060101 , A61K31/445 , A61K31/454 , A61P11/08 , A61P37/00 , A61P37/08 , A61P43/00 , C07B61/00 , C07C33/46 , C07C39/24 , C07C45/46 , C07C45/63 , C07C45/65 , C07C45/67 , C07C47/273 , C07C49/792 , C07C49/798 , C07C49/813 , C07C49/82 , C07C49/825 , C07C49/83 , C07C49/835 , C07C49/86 , C07C59/84 , C07C59/86 , C07C59/88 , C07C59/90 , C07C69/007 , C07C69/16 , C07C69/612 , C07C69/63 , C07C69/65 , C07C69/738 , C07C69/78 , C07C235/34 , C07C235/78 , C07C235/84 , C07C255/16 , C07C255/36 , C07C255/40 , C07C257/06 , C07C259/06 , C07D20060101 , C07D211/08 , C07D211/14 , C07D211/16 , C07D211/22 , C07D211/32 , C07D211/34 , C07D211/44 , C07D211/46 , C07D295/16 , C07D295/185 , C07D401/06 , C07D401/10 , C07D491/107
CPC分类号： C07D295/185 , C07C33/46 , C07C45/46 , C07C45/63 , C07C45/65 , C07C45/673 , C07C49/792 , C07C49/798 , C07C49/80 , C07C49/813 , C07C49/82 , C07C49/825 , C07C49/83 , C07C49/835 , C07C49/86 , C07C59/86 , C07C59/88 , C07C69/007 , C07C69/738 , C07C235/78 , C07C255/16 , C07C259/06 , C07C2601/02 , C07D211/22 , C07D401/06 , C07D401/10
摘要： PROBLEM TO BE SOLVED: To provide an intermediate useful in producing fexofenadine of an antiallergic agent and its analogous compounds. SOLUTION: The compound is represented by the formula [wherein Hal is Cl, Br or I; n is an integer of 1-5; and (i) A is hydroxy and R 5 is H, -H 2 OD (wherein D is H, an acetate or a benzoate), CHO, Br, Cl, I, CN, -COOH, -COOR(R:alkyl), -C(=NH)OR(R:alkyl), (wherein the alkyl is a 1-6C straight chain or branched chain) or -ONR 6 R 7 (wherein R 6 and R 7 are each H, a 1-6C alkyl, a 1-6C alkoxy or form pyrrolidine, piperidine or morpholine together with nitrogen) or (ii) A is hydrogen and R 5 is CHO, Br, Cl or I]. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供可用于制备抗过敏剂的非索非那定的中间体及其类似的化合物。解决方案：该化合物由式[其中Hal为Cl，Br或I表示; n为1-5的整数; 和（i）A是羟基，R 3是H，-H 2 SBO 2（其中D是H，乙酸酯或苯甲酸酯），CHO，Br，Cl， I，CN，-COOH，-COOR（R：烷基），-C（= NH）OR（R：烷基），（其中烷基是1-6C直链或支链）或-ONR SB （其中R SB 6和R SB 7各自为H，1-6C烷基，1-6C烷氧基或与氮一起形成吡咯烷，哌啶或吗啉）或（ii）A是氢，R 5是苯基，Br，Cl或I]。版权所有（C）2009，JPO＆INPIT

2. 发明申请

WO2009026128A3 GENE EXPRESSION MARKERS OF RECURRENCE RISK IN CANCER PATIENTS AFTER CHEMOTHERAPY 审中-公开
公开(公告)号：WO2009026128A3
公开(公告)日：2009-02-26
申请号：PCT/US2008/073261
申请日：2008-08-15
申请人： GENOMIC HEALTH, INC. , AVENTIS INC. , SHAK, Steven , BAKER, Joffre , YOSHIZAWA, Carl , SPARANO, Joseph , GRAY, Robert
发明人： SHAK, Steven , BAKER, Joffre , YOSHIZAWA, Carl , SPARANO, Joseph , GRAY, Robert
IPC分类号： C12Q1/68
摘要： The present invention relates to genes, the expression levels of which are correlated with likelihood of breast cancer recurrence in patients after tumor resection and chemotherapy.

3. 发明申请

WO2009140304A1 TESTS TO PREDICT RESPONSIVENESS OF CANCER PATIENTS TO CHEMOTHERAPY TREATMENT OPTIONS 审中-公开
标题翻译：预防癌症患者对化疗治疗选择的反应测试
公开(公告)号：WO2009140304A1
公开(公告)日：2009-11-19
申请号：PCT/US2009/043667
申请日：2009-05-12
申请人： GENOMIC HEALTH INC. , AVENTIS, INC. , SHAK, Steve , BAKER, Joffre, B. , YOSHIZAWA, Carl , SPARANO, Joseph , GRAY, Robert
发明人： SHAK, Steve , BAKER, Joffre, B. , YOSHIZAWA, Carl , SPARANO, Joseph , GRAY, Robert
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N33/57415 , G01N2333/705 , G01N2333/72 , G01N2800/52 , G01N2800/60
摘要： The present disclosure provides methods and compositions to facilitate prediction of the likelihood of responsiveness of cancer patients to treatment including a taxane and/or a cyclophosphamide.
摘要翻译：本公开提供了促进预测癌症患者对包括紫杉烷和/或环磷酰胺的治疗的反应性的可能性的方法和组合物。

4. 发明授权

US3929985A Anhydrous candicidin foam compositions 失效
标题翻译：无水水idin啶泡沫组合物
公开(公告)号：US3929985A
公开(公告)日：1975-12-30
申请号：US43439174
申请日：1974-01-18
申请人： RICHARDSON MERRELL INC
发明人： WEBB JR NORVAL ELLSWORTH
IPC分类号： A61K9/12 , A61K9/14
CPC分类号： A61K31/70 , A61K9/122
摘要： Stable, anhydrous, foam compositions containing candicidin useful in the treatment of vaginitis.
摘要翻译：稳定的，无水的，包含可用于治疗阴道炎的可可啶的泡沫组合物。

5. 发明授权

US3903116A Bis-basic amides of dibenzofuran 失效
标题翻译：二苯并呋喃的双碱性酰胺
公开(公告)号：US3903116A
公开(公告)日：1975-09-02
申请号：US51214774
申请日：1974-10-04
申请人： RICHARDSON MERRELL INC
发明人： ALBRECHT WILLIAM L , FLEMING ROBERT W
IPC分类号： C07D307/91
CPC分类号： C07D307/91
摘要： Novel bis-basic esters and amides of dibenzofuran of the formula

WHEREIN: A. each of R1 and R2 is hydrogen, (lower)alkyl, cycloalkyl of 3 to 6 ring carbon atoms, alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position of the alkenyl group, or each set of R1 and R2 taken together with the nitrogen atom to which they are attached is pyrrolidino, piperidino, N-(lower)alkyl-piperazino, or morpholino; B. each A is alkylene of 3 to 8 carbon atoms and separates its adjacent Y and amino nitrogen by an alkylene chain of at least 3 carbon atoms; C. each Y is oxygen, or N-R wherein R is hydrogen, methyl or ethyl; or a pharmaceutically acceptable acid addition salt thereof. These compounds can be used for preventing or inhibiting viral infections.
摘要翻译：二苯并呋喃的新型双碱性酯和酰胺，式为WHEREIN：

6. 发明授权

US3890445A Lactamimide derivatives useful as hypoglycemic agents 失效
标题翻译：用作降血糖药的内酰胺衍生物
公开(公告)号：US3890445A
公开(公告)日：1975-06-17
申请号：US45356674
申请日：1974-03-22
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J MARTIN , CLAXTON GEORGE P , BLOHM THOMAS R
IPC分类号： A61K31/395 , A61K27/00
CPC分类号： A61K31/395
摘要： WHEREIN X represents oxygen or sulfur; A represents a bond, or a straight or branched alkylene chain of from 1 to 3 carbon atoms; R represents hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, a straight or branched lower alkenyl group of from 3 to 6 carbon atoms, a cycloalkyl group of from 3 to 6 carbon atoms or phenyl; R1 represents hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms; n is an integer of from 3 to 11; and pharmaceutically acceptable acid addition salts and individual optical isomers of the compounds where applicable.
The lactamimide derivatives of this invention useful as hypoglycemic agents are represented by the formula
摘要翻译：用作降血糖剂的本发明的内酰胺衍生物由下式表示：WHEREIN X表示氧或硫; A表示键或具有1至3个碳原子的直链或支链亚烷基链; R代表氢，1至4个碳原子的直链或支链低级烷基，3至6个碳原子的直链或支链低级链烯基，3至6个碳原子的环烷基或苯基; R1表示氢或1〜4个碳原子的直链或支链低级烷基; n为3〜11的整数，和化合物的药学上可接受的酸加成盐和各种旋光异构体。

7. 发明授权

US3890356A 7-Alkyl-{66 {hu 3,5{b -steroids 失效
标题翻译： 7-烷基 - {66 {hu 3,5 {b-类
公开(公告)号：US3890356A
公开(公告)日：1975-06-17
申请号：US34483873
申请日：1973-03-26
申请人： RICHARDSON MERRELL INC
发明人： GRUNWELL JOYCE F , JOHNSTON JOHN O , PETROW VLADIMIR , WEINTRAUB PHILIP M
IPC分类号： C07J1/00 , C07J11/00 , C07J17/00 , C07C167/00 , C07C169/00
CPC分类号： C07J11/00 , C07J1/0011 , C07J1/0022 , C07J1/0029 , C07J1/0037 , C07J1/007 , C07J1/0074 , C07J17/00 , Y10S514/843
摘要： Novel steroids of the class of 7-alkyl-3,5-androstadienes, estradienes and gonadienes are prepared which are useful as antiprogestational and antifertility agents.
摘要翻译：制备7-烷基-3,5-雄甾二烯类，雌二醇和性腺那类的新型类固醇，其可用作抗孕剂和抗生育剂。

8. 发明授权

US3881006A Hypoglycemic compositions containing benzhydryllactamimide derivatives 失效
标题翻译：含有二苯甲酰基内酰胺酰亚胺衍生物的低血糖组合物
公开(公告)号：US3881006A
公开(公告)日：1975-04-29
申请号：US36610673
申请日：1973-06-01
申请人： RICHARDSON MERRELL INC
发明人： GRISAR JOHANN MARTIN , BLOHM THOMAS R
IPC分类号： A61K31/395 , A61K31/55 , A61K27/00
CPC分类号： A61K31/395 , A61K31/55 , Y10S514/884
摘要： WHEREIN R is hydrogen or lower alkoxy of from 1 to 6 carbon atoms, and when R represents lower alkoxy the substituent alkoxy radical may be attached at the ortho-, meta- or para-position of the phenyl radical; R1 is hydrogen or lower alkyl of from 1 to 4 carbon atoms; n is a whole integer of from 3 to 11; or pharmaceutically acceptable acid addition salts of said compounds and individual optical isomers where applicable.

Pharmaceutical compositions with hypoglycemic and diuretic properties and methods for their use are disclosed herein. The active ingredients of the compositions are compounds of the formula
摘要翻译：具有低血糖和利尿性质的药物组合物及其使用方法在本文中公开。组合物的活性成分是式WHEREIN R是1或6个碳原子的低级烷氧基的化合物，当R代表低级烷氧基时，取代基烷氧基可以在邻位，间位或对位连接的苯基; R1是氢或1至4个碳原子的低级烷基; n为3〜11的整数，或所述化合物的药学上可接受的酸加成盐和各种旋光异构体。

9. 发明授权

US3873520A 9-Fluorenyl lactamimides 失效
标题翻译： 9-芴基内酰胺
公开(公告)号：US3873520A
公开(公告)日：1975-03-25
申请号：US38699673
申请日：1973-08-09
申请人： RICHARDSON MERRELL INC
发明人： BLOHM THOMAS R , WIECH NORBERT L , ROBERTS EDWARD M
IPC分类号： C07D207/22 , C07D211/72 , C07D211/74 , C07D227/08 , C07D227/10 , C07D27/04 , C07D29/28 , C07D41/04
CPC分类号： C07D211/72 , C07C2603/18 , C07D207/22 , C07D211/74 , C07D227/08 , C07D227/10 , Y10S514/822 , Y10S514/869
摘要： Compounds possessing hypoglycemic, diuretic and platelet aggregation inhibition activities of the following formula:

WHEREIN N IS AN INTEGER OF 3 TO 11, R is hydrogen or lower alkyl of from 1 to 4 carbon atoms, R1 is hydrogen, halogen, lower alkyl of from 1 to 4 carbon atoms and X and Y are selected from hydrogen, halogen, lower alkyl of from 1 to 4 carbon atoms, lower alkoxy of from 1 to 4 carbon atoms, or nitro and may be the same or different; and the pharmaceutically acceptable acid addition salts thereof.
摘要翻译：具有以下配方的低血糖，利尿和血小板聚集抑制活性的化合物：

10. 发明授权

US3870723A 2-Azacycloalkylmethyl substituted benzhydryl ketones and carbinols 失效
标题翻译： 2-氮杂环烷基甲基取代的二苯甲基酮和甲醇
公开(公告)号：US3870723A
公开(公告)日：1975-03-11
申请号：US35431573
申请日：1973-04-25
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J MARTIN , CLAXTON GEORGE P
IPC分类号： C07D223/04 , C07C45/63 , C07D207/08 , C07D207/20 , C07D207/26 , C07D211/22 , C07D211/32 , C07D225/02 , C07D487/22 , C07D29/20
CPC分类号： C07D211/32 , C07C45/63 , C07D207/20 , C07D211/22 , Y10S514/822 , C07C49/80
摘要： Novel derivatives of 2-azacycloalkylmethyl substituted benzhydryl ketones and carbinols are described which are useful as anticoagulants.
摘要翻译：描述了可用作抗凝剂的2-氮杂环烷基甲基取代的二苯甲基酮和甲醇的新型衍生物。

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