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1. 发明授权

US3882113A Fluoranthene derivatives 失效
标题翻译：荧蒽衍生物
公开(公告)号：US3882113A
公开(公告)日：1975-05-06
申请号：US31715072
申请日：1972-12-21
申请人： RICHARDSON MERRELL INC
发明人： ALBRECHT WILLIAM L , FLEMING ROBERT W
IPC分类号： C07C211/31 , A61K31/13 , A61K31/445 , A61K31/535 , C07C20060101 , C07C67/00 , C07C209/00 , C07D211/14 , C07D295/02 , C07D87/28
CPC分类号： C07D317/70
摘要： Novel 3,9-bis-basic alkanes of fluoranthene, their preparation and use for the prevention and inhibition of viral infections are disclosed.
摘要翻译：公开了新型荧蒽的3,9-双碱烷烃，其制备和用于预防和抑制病毒感染的用途。

2. 发明授权

US3907791A Bis-basic ketones of fluoranthene 失效
标题翻译：荧蒽的双碱性酮
公开(公告)号：US3907791A
公开(公告)日：1975-09-23
申请号：US30880672
申请日：1972-11-22
申请人： RICHARDSON MERRELL INC
发明人： ALBRECHT WILLIAM L , FLEMING ROBERT W
IPC分类号： C07D87/34
摘要： WHEREIN N IS A WHOLE INTEGER OF FROM 4 TO 6 AND R3 is hydrogen, (lower)-alkyl of from 1 to about 4 carbon atoms, phenyl, or benzyl and can be linked to any one of the carbon atoms of the heterocyclic group; or C. the group

wherein X is oxygen or NR4, and R4 is hydrogen or (lower)alkyl of from 1 to about 4 carbon atoms; or D. the group

The novel bis-basic ketones of fluoranthene of the present invention have antiviral activity when administered orally and parenterally. These compounds are represented by the following general formula:

WHEREIN EACH A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y is A. the group
wherein R1 and R2 are individually hydrogen, (lower)alkyl having from 1 to 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or B. the group

D R A W I N G
WHEREIN P IS A WHOLE INTEGER FROM 2 TO 3 AND M IS A WHOLE INTEGER FROM 1 TO 2 OR; E. the group

wherein q is a whole integer from 1 to 2, and r is a whole integer from 1 to 3 providing when r is equal to 3, q is 1; or a pharmaceutically acceptable acid addition salt of said base. These new compounds can be prepared by several different methods which are described.
摘要翻译：本发明的新颖的荧蒽的双碱式酮在口服和非肠道给药时具有抗病毒活性。这些化合物由以下通式表示：

3. 发明授权

US3707471A Fluoranthene bis-basic ethers and thioethers 失效
标题翻译：氟基双酚双酯及其衍生物
公开(公告)号：US3707471A
公开(公告)日：1972-12-26
申请号：US3707471D
申请日：1970-04-27
申请人： RICHARDSON MERRELL INC
发明人： ALBRECHT WILLIAM L , FLEMING ROBERT W
IPC分类号： C07D211/08 , C07D295/08 , C07D295/10 , C07D29/28
CPC分类号： C07D295/10 , C07D211/08 , C07D295/08
摘要： THE NOVEL BIS-BASIC ETHERS AND THIOETHERS OF FLUORANTHENE OF THE PRESENT INVENTION HAVE USEFUL ANTIVIRAL ACTIVITY. THESE NEW COMPOUNDS ARE REPRESENTED BY THE FOLLOWING FORMULA:

R2-N
BIS(X-Y-)FLUORANTHENE

WHEREIN EACH Y IS OXYGEN OR DIVALENT SULFUR; AND EACH X IS (A) THE GROUP

-A-N(-R)-R1

WHEREIN EACH A IS A STRAIGHT OR BRANCHED ALKYLENE CHAIN HAVING FROM 2 TO 8 CARBON ATOMS; R AND R1 ARE INDIVIDUALLY HYDROGEN, (LOWER)ALKYL HAVING FROM 1 TO 6 CARBON ATOMS, CYCLOALKYL OF FROM 3 TO 6 CARBON ATOMS, ALKENYL OF FROM 3 TO 6 CARBON ATOMS AND HAVING THE VINYL UNSATURATION IN OTHER THAN THE 1-POSITION OF THE ALKENYL GROUP; OR EACH SET OF R AND R1 TAKEN TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED IS A SATURATED MONOCYCLIC HETEROCYCLIC GROUP SUCH AS PYRROLIDINO, PIPERIDINO, MORPHOLINO OR N-(LOWER)ALKYLPIPERAZINO; OR (B) THE GROUP R2-N

4. 发明授权

US3929802A Bis-basic ethers of dibenzofuran 失效
标题翻译：二苯并呋喃的双碱性醚
公开(公告)号：US3929802A
公开(公告)日：1975-12-30
申请号：US44619474
申请日：1974-02-25
申请人： RICHARDSON MERRELL INC
发明人： ALBRECHT WILLIAM L , FLEMING ROBERT W
IPC分类号： C07D307/91
CPC分类号： C07D307/91
摘要： The novel bis-basic ethers of dibenzofuran of the present invention have useful antiviral properties. These new compounds are represented by the formula

WHEREIN EACH X is A. the group

WHEREIN N IS A WHOLE INTEGER OF FROM 0 TO 2, M IS 1 OR 2, AND R2 is hydrogen, lower alkyl having from 1 to 6 carbon atoms, or alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group. This invention also includes pharmaceutically acceptable acid addition salts of the base compounds represented by Formula I. These new compounds may be prepared by several different methods which are described.

wherein each A is a straight or branched alkylene chain having from 2 to 6 carbon atoms and which separates the amino nitrogen and oxygen by at least 2 carbon atoms; R and R1 are individually hydrogen, lower alkyl having from 1 to 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl having from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or each set of R and R1 taken together with the nitrogen atom to which they are attached is a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino, or N-(lower)alkylpiperazino; or B. the group
摘要翻译：本发明的二苯并呋喃的新型双碱性醚具有有用的抗病毒性质。这些新化合物由式X表示，其中X是A。R-ANGG R1，其中每个A是具有2-6个碳原子的直链或支链亚烷基链，并将氨基氮和氧分开至少2个碳原子 R和R 1分别为氢，具有1至6个碳原子的低级烷基，具有3至6个碳原子的环烷基，具有3至6个碳原子的烯基，并且在烯基的1位以外具有乙烯基不饱和度 ; 或者R和R 1与它们所连接的氮原子一起是饱和的单环杂环基如吡咯烷子基，哌啶子基，吗啉代或N-（低级）烷基哌嗪基; 或B.该基团N为0至2的全部整数，M为1或2，并且R 2为氢，具有1至6个碳原子的低级烷基或3至6个碳原子的烯基，并且具有乙烯基不饱和键除了烯基的1位。

5. 发明授权

US3906007A Bis-basic ketones of dibenzofuran 失效
标题翻译：二苯并呋喃的双碱性酮
公开(公告)号：US3906007A
公开(公告)日：1975-09-16
申请号：US7217070
申请日：1970-09-14
申请人： RICHARDSON MERRELL INC
发明人： ALBRECHT WILLIAM L , FLEMING ROBERT W
IPC分类号： C07D307/91
CPC分类号： C07D307/91
摘要： Disclosed herein as novel compounds having antiviral activity are compounds represented by the formula

WHEREIN A is a straight or branched alkylene chain of from 1 to 6 carbon atoms and each Y is the group A.

wherein R1 and R2 are each individually selected from hydrogen, lower alkyl of from 1 to 4 carbon atoms, cycloalkyl of from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or B.

wherein X is oxygen or N-R3 and R3 is hydrogen or lower alkyl of from 1 to 4 carbon atoms, OR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS OF SAID COMPOUNDS. The compounds are prepared by several different processes which are described herein.
摘要翻译：本文中公开的具有抗病毒活性的新化合物是由式WHEREIN A表示的化合物，其中A是具有1至6个碳原子的直链或支链亚烷基链，并且每个Y是基团A. R1-ANGLE R2其中R1和R2各自独立地选自氢，1至4个碳原子的低级烷基，3至6个碳原子的环烷基，3至6个碳原子的烯基，并且在烯基的1位以外具有乙烯基不饱和度; 或B.

6. 发明授权

US3903116A Bis-basic amides of dibenzofuran 失效
标题翻译：二苯并呋喃的双碱性酰胺
公开(公告)号：US3903116A
公开(公告)日：1975-09-02
申请号：US51214774
申请日：1974-10-04
申请人： RICHARDSON MERRELL INC
发明人： ALBRECHT WILLIAM L , FLEMING ROBERT W
IPC分类号： C07D307/91
CPC分类号： C07D307/91
摘要： Novel bis-basic esters and amides of dibenzofuran of the formula

WHEREIN: A. each of R1 and R2 is hydrogen, (lower)alkyl, cycloalkyl of 3 to 6 ring carbon atoms, alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position of the alkenyl group, or each set of R1 and R2 taken together with the nitrogen atom to which they are attached is pyrrolidino, piperidino, N-(lower)alkyl-piperazino, or morpholino; B. each A is alkylene of 3 to 8 carbon atoms and separates its adjacent Y and amino nitrogen by an alkylene chain of at least 3 carbon atoms; C. each Y is oxygen, or N-R wherein R is hydrogen, methyl or ethyl; or a pharmaceutically acceptable acid addition salt thereof. These compounds can be used for preventing or inhibiting viral infections.
摘要翻译：二苯并呋喃的新型双碱性酯和酰胺，式为WHEREIN：

7. 发明授权

US3867409A Bis-basic esters of dibenzofuran 失效
标题翻译： DIBENZOFURAN的BIS基础研究
公开(公告)号：US3867409A
公开(公告)日：1975-02-18
申请号：US83371769
申请日：1969-06-16
申请人： RICHARDSON MERRELL INC
发明人： ALBRECHT WILLIAM L , FLEMING ROBERT W
IPC分类号： C07D307/91 , C07C5/42
CPC分类号： C07D307/91
摘要： Novel bis-basic esters and amides of dibenzofuran of the formula

WHEREIN: A. each of R1 and R2 is hydrogen, (lower)alkyl, cycloalkyl of 3 to 6 ring carbon atoms, alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position of the alkenyl group, or each set of R1 and R2 taken together with the nitrogen atom to which they are attached is pyrrolidino, piperidino, N-(lower)alkyl-piperazino, or morpholino; B. each A is alkylene of 3 to 8 carbon atoms and separates its adjacent Y and aminio nitrogen by an alkylene chain of at least 3 carbon atoms; C. each Y is oxygen, or N-R wherein R is hydrogen, methyl or ethyl; or a pharmaceutically acceptable acid addition salt thereof. These compounds can be used for preventing or inhibiting viral infections.
摘要翻译：二苯并呋喃的新型双碱性酯和酰胺，式为WHEREIN：

8. 发明授权

US3673191A Bis-basic ethers and thioethers of dibenzothiophene 失效
标题翻译：二苯并噻吩的双酚A基和二苯醚
公开(公告)号：US3673191A
公开(公告)日：1972-06-27
申请号：US3673191D
申请日：1970-02-18
申请人： RICHARDSON MERRELL INC
发明人： ALBRECHT WILLIAM L , FLEMING ROBERT W , HORGAN STEPHEN W
IPC分类号： C07D333/76 , C07D29/36
CPC分类号： C07D333/76
摘要： The novel bis-basic ethers and thioethers of dibenzothiophene of the present invention have useful antiviral properties. These new compounds are represented by the formula WHEREIN EACH Y is oxygen or divalent sulfur; and each X is WHEREIN EACH A is a straight or branched alkylene chain having from two to eight carbon atoms and which separates the amino nitrogen and Y by at least two carbon atoms; R and R1 are individually hydrogen, (lower)alkyl having from one to six carbon atoms, cycloalkyl having from three to six carbon atoms, alkenyl having from three to six carbon atoms and having the vinyl unsaturation in other that the 1-position of the alkenyl group; or each set of R and R1 taken together with the nitrogen atom to which they are attached is a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino, or N(lower)alkylpiperazino; or WHEREIN N IS A WHOLE INTEGER OF FROM 0 TO 2, M IS 1 OR 2, AND R2 is hydrogen, (lower)alkyl having from one to six carbon atoms, or alkenyl of from three to six carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group. This invention also includes pharmaceutically acceptable acid addition salts of the bases represented by Formula I. These new compounds may be prepared by several different methods which are described.
摘要翻译：本发明的二苯并噻吩的新型双碱性醚和硫醚具有有用的抗病毒性质。这些新化合物以下式表示：其中Y是Y或Y是二价硫; 并且每个X是每个A是具有2至8个碳原子并且将氨基氮和Y分开至少两个碳原子的直链或支链亚烷基链; R和R 1分别是氢，具有1至6个碳原子的（低级）烷基，具有3至6个碳原子的环烷基，具有3至6个碳原子的烯基，并且具有乙烯基不饱和键，烯基; 或者R和R 1与它们所连接的氮原子一起是饱和的单环杂环基如吡咯烷子基，哌啶子基，吗啉代或N-（低级）烷基哌嗪基; 或其中N为0至2的全部整数，M为1或2，并且R 2为氢，具有1至6个碳原子的（低级）烷基或3至6个碳原子的烯基并且具有乙烯基不饱和度除了烯基的1位以外。

9. 发明授权

US3531489A Bis-basic esters and thioesters of fluoranthene 失效
标题翻译： BIS基础产品和荧光素酶
公开(公告)号：US3531489A
公开(公告)日：1970-09-29
申请号：US3531489D
申请日：1968-10-18
申请人： RICHARDSON MERRELL INC
发明人： ALBRECHT WILLIAM L , FLEMING ROBERT W
IPC分类号： C07D295/08 , A61K31/13 , A61K31/135 , A61P31/12 , C07C67/00 , C07C213/00 , C07C219/14 , C07C325/00 , C07C327/32 , C07D211/22 , C07D211/46 , C07D51/70
CPC分类号： C07D211/22

10. 发明专利

DE3031320A1 未知
公开(公告)号：DE3031320A1
公开(公告)日：1981-03-26
申请号：DE3031320
申请日：1980-08-20
申请人： RICHARDSON MERRELL INC
发明人： ALBRECHT WILLIAM L , JONES JUN WINTON D
IPC分类号： A61K31/41 , A61P1/04 , C07D209/48 , C07D249/12

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