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1. 发明申请

WO2004053465A2 MALE FERTILITY ASSAY METHOD AND DEVICE 审中-公开
标题翻译：男性性状测定方法与装置
公开(公告)号：WO2004053465A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/039069
申请日：2003-12-09
申请人： ADVANCED FLUIDIX LABORATORIES, LLC
发明人： ARAVANIS, Alexander, M. , PYLE, Jason, L.
IPC分类号： G01N15/14
CPC分类号： G01N15/1459 , B01L3/502715 , B01L2400/0677 , G01N15/1484 , G01N21/6428 , G01N21/645 , G01N2015/1075 , Y10S435/808
摘要： A method and device for assaying sperm motility in a forward direction and density of active sperm in a semen sample are disclosed. The device includes a microfluidics structure having a sample reservoir, a downstream collection region and a microchannel extending therebetween. The microchannel is dimensioned to confine sample sperm to single-direction movement within the channel, such that sperm in a semen sample placed in the sample reservoir enter and migrate along the microchannel toward and into the collection region. Also included is a detector for detecting the presence of labeled sperm in the microchannel or collection region, and an electronics unit operatively connected to the detector for (i) receiving detector signals, (ii) based on the detector signals received, determining sperm motility and density in the sperm sample, and (iii) displaying information related to sperm motility and density.
摘要翻译：公开了一种用于测定精液样品中活力精子向前方向精子活力和密度的方法和装置。该装置包括具有样品储存器，下游收集区域和在其间延伸的微通道的微流体结构。微通道的尺寸被确定为将样品精子限制在通道内的单向运动，使得放置在样品储存器中的精液样品中的精子进入并沿着微通道移动并进入收集区域。还包括用于检测微通道或收集区域中标记的精子的存在的检测器，以及可操作地连接到检测器的电子单元，用于（i）接收检测器信号，（ii）基于所接收的检测器信号，确定精子活力和精子样本中的密度，（iii）显示与精子活力和密度有关的信息。

2. 发明申请

WO2005037085A2 MULTILENS OPTICAL ASSEMBLY FOR A DIAGNOSTIC DEVICE 审中-公开
标题翻译：用于诊断设备的多用途光学组件
公开(公告)号：WO2005037085A2
公开(公告)日：2005-04-28
申请号：PCT/US2004/034991
申请日：2004-10-15
申请人： ADVANCED FLUIDIX LABORATORIES, LLC , ARAVANIS, Alexander, M. , HEBERT, Raymond, T. , LOUCKS, Bryan, E. , LYTLE, John, D. , PYLE, Jason, L.
发明人： ARAVANIS, Alexander, M. , HEBERT, Raymond, T. , LOUCKS, Bryan, E. , LYTLE, John, D. , PYLE, Jason, L.
IPC分类号： A61B
CPC分类号： G01N21/645 , B01L3/502715 , B01L2300/027 , B01L2400/0677 , G01N15/1459 , G01N15/1484 , G01N21/6408 , G01N21/6452 , G01N2021/6421
摘要： A diagnostics apparatus for detecting fluorescence events related to the presence of an analyte in a sample is disclosed. The apparatus includes a housing, a source of excitation light and a photodetector, and a unitary multi surface optical module. The optical module is integrally formed and composed of an upstream portion having a focusing optical surface for directing excitation light from the light source to a focal region within an analyte-detection zone in the apparatus, and a downstream portion having a second focusing powered optical surface and at least one reflecting surface for directing fluorescence-emission light produced by fluorescence events within the detection zone, in a direction substantially normal to the path of the excitation light onto the photodetector. The optical module is adaptable to a variety of assay formats, including multiplesample, sample-array, and disposable-cartridge formats.
摘要翻译：公开了一种用于检测与样品中分析物的存在有关的荧光事件的诊断装置。该装置包括壳体，激发光源和光电检测器，以及整体多表面光学模块。光学模块整体形成并由具有聚焦光学表面的上游部分组成，该聚焦光学表面用于将来自光源的激发光引导到装置内的分析物检测区域内的焦点区域，以及具有第二聚焦动力光学表面以及至少一个反射表面，用于在基本上垂直于激发光的路径到光电检测器的方向上引导在检测区内由荧光事件产生的荧光发射光。光学模块适用于多种测试格式，包括多样本，样本阵列和一次性墨盒格式。

3. 发明公开

EP1711798A2 MULTILENS OPTICAL ASSEMBLY FOR A DIAGNOSTIC DEVICE 审中-公开
标题翻译：诊断设备，包括具有多个表面的光模块
公开(公告)号：EP1711798A2
公开(公告)日：2006-10-18
申请号：EP04796053.9
申请日：2004-10-15
申请人： Advanced Fluidix Laboratories, LLC
发明人： ARAVANIS, Alexander, M. , HEBERT, Raymond, T. , LOUCKS, Bryan, E. , LYTLE, John, D. , PYLE, Jason, L.
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , B01L3/502715 , B01L2300/027 , B01L2400/0677 , G01N15/1459 , G01N15/1484 , G01N21/6408 , G01N21/6452 , G01N2021/6421
摘要： A diagnostics apparatus for detecting fluorescence events related to the presence of an analyte in a sample is disclosed. The apparatus includes a housing, a source of excitation light (66) and a photodetector (70), and a unitary multi-surface optical module (62). The optical module (62) is integrally formed and composed of an upstream (63) portion having a focusing optical surface (80) for directing excitation light from the light source (66) to a focal region (60) within an analyte-detection zone (30) in the apparatus, and a downstream portion (65) having a second focusing powered optical surface and at least one reflecting surface for directing fluorescence-emission light produced by fluorescence events within the detection zone (30), in a direction substantially normal to the path of the excitation light onto the photodetector (70). The optical module (62) is adaptable to a variety of assay formats, including multiple-sample, sample-array, and disposable-cartridge formats.

4. 发明公开

EP1581798A2 MALE FERTILITY ASSAY METHOD AND DEVICE 有权
标题翻译：装置和方法进行调查男性生育能力
公开(公告)号：EP1581798A2
公开(公告)日：2005-10-05
申请号：EP03796824.5
申请日：2003-12-09
申请人： Advanced Fluidix Laboratories, LLC
发明人： ARAVANIS, Alexander, M. , PYLE, Jason, L.
IPC分类号： G01N15/14 , B01L3/00 , G01P13/00
CPC分类号： G01N15/1459 , B01L3/502715 , B01L2400/0677 , G01N15/1484 , G01N21/6428 , G01N21/645 , G01N2015/1075 , Y10S435/808
摘要： A method and device for assaying sperm motility in a forward direction and density of active sperm in a semen sample are disclosed. The device includes a microfluidics structure having a sample reservoir, a downstream collection region and a microchannel extending therebetween. The microchannel is dimensioned to confine sample sperm to single-direction movement within the channel, such that sperm in a semen sample placed in the sample reservoir enter and migrate along the microchannel toward and into the collection region. Also included is a detector for detecting the presence of labeled sperm in the microchannel or collection region, and an electronics unit operatively connected to the detector for (i) receiving detector signals, (ii) based on the detector signals received, determining sperm motility and density in the sperm sample, and (iii) displaying information related to sperm motility and density.

5. 发明授权

EP1581798B1 MALE FERTILITY ASSAY METHOD AND DEVICE 有权
标题翻译：装置和方法进行调查男性生育能力
公开(公告)号：EP1581798B1
公开(公告)日：2009-06-03
申请号：EP03796824.5
申请日：2003-12-09
申请人： Advanced Fluidix Laboratories, LLC
发明人： ARAVANIS, Alexander, M. , PYLE, Jason, L.
IPC分类号： G01N21/64 , G01N15/14
CPC分类号： G01N15/1459 , B01L3/502715 , B01L2400/0677 , G01N15/1484 , G01N21/6428 , G01N21/645 , G01N2015/1075 , Y10S435/808
摘要： A method and device for assaying sperm motility in a forward direction and density of active sperm in a semen sample are disclosed. The device includes a microfluidics structure having a sample reservoir, a downstream collection region and a microchannel extending therebetween. The microchannel is dimensioned to confine sample sperm to single-direction movement within the channel, such that sperm in a semen sample placed in the sample reservoir enter and migrate along the microchannel toward and into the collection region. Also included is a detector for detecting the presence of labeled sperm in the microchannel or collection region, and an electronics unit operatively connected to the detector for (i) receiving detector signals, (ii) based on the detector signals received, determining sperm motility and density in the sperm sample, and (iii) displaying information related to sperm motility and density.

6. 发明申请

US20050130122A1 Male fertility assay method and device 失效
公开(公告)号：US20050130122A1
公开(公告)日：2005-06-16
申请号：US10985102
申请日：2004-11-09
申请人： Alexander Aravanis , Jason Pyle
发明人： Alexander Aravanis , Jason Pyle
IPC分类号： B01L3/00 , C12M1/26 , G01N15/14 , G01N21/64 , C12Q1/00
CPC分类号： G01N15/1459 , B01L3/502715 , B01L2400/0677 , G01N15/1484 , G01N21/6428 , G01N21/645 , G01N2015/1075 , Y10S435/808
摘要： A method and device for assaying sperm motility in a forward direction and density of active sperm in a semen sample are disclosed. The device includes a microfluidics structure having a sample reservoir, a downstream collection region and a microchannel extending therebetween. The microchannel is dimensioned to confine sample sperm to single-direction movement within the channel, such that sperm in a semen sample placed in the sample reservoir enter and migrate along the microchannel toward and into the collection region. Also included is a detector for detecting the presence of labeled sperm in the microchannel or collection region, and an electronics unit operatively connected to the detector for (i) receiving detector signals, (ii) based on the detector signals received, determining sperm motility and density in the sperm sample, and (iii) displaying information related to sperm motility and density.

7. 发明授权

US06929945B2 Male fertility assay method and device 失效
标题翻译：男性生育力测定方法和装置
公开(公告)号：US06929945B2
公开(公告)日：2005-08-16
申请号：US10705162
申请日：2003-11-06
申请人： Alexander M. Aravanis , Jason L. Pyle
发明人： Alexander M. Aravanis , Jason L. Pyle
IPC分类号： B01L3/00 , C12M1/26 , G01N15/14 , G01N21/64 , C12M1/34
CPC分类号： G01N15/1459 , B01L3/502715 , B01L2400/0677 , G01N15/1484 , G01N21/6428 , G01N21/645 , G01N2015/1075 , Y10S435/808
摘要： A method and device for assaying sperm motility in a forward direction and density of active sperm in a semen sample are disclosed. The device includes a microfluidics structure having a sample reservoir, a downstream collection region and a microchannel extending therebetween. The microchannel is dimensioned to confine sample sperm to single-direction movement within the channel, such that sperm in a semen sample placed in the sample reservoir enter and migrate along the microchannel toward and into the collection region. Also included is a detector for detecting the presence of labeled sperm in the microchannel or collection region, and an electronics unit operatively connected to the detector for (i) receiving detector signals, (ii) based on the detector signals received, determining sperm motility and density in the sperm sample, and (iii) displaying information related to sperm motility and density.
摘要翻译：公开了一种用于测定精液样品中活力精子向前方向精子活力和密度的方法和装置。该装置包括具有样品储存器，下游收集区域和在其间延伸的微通道的微流体结构。微通道的尺寸被确定为将样品精子限制在通道内的单向运动，使得放置在样品储存器中的精液样品中的精子进入并沿着微通道移动并进入收集区域。还包括用于检测微通道或收集区域中标记的精子的存在的检测器，以及可操作地连接到检测器的电子单元，用于（i）接收检测器信号，（ii）基于所接收的检测器信号，确定精子活力和精子样本中的密度，（iii）显示与精子活力和密度有关的信息。

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