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    • 1. 发明申请
    • Urogenital or anorectal transmucosal vaccine delivery system
    • 泌尿生殖或肛门直肠经粘膜疫苗递送系统
    • US20090311290A1
    • 2009-12-17
    • US12583219
    • 2009-08-17
    • Zsolt Istvan HertelendyMurray WeinerMichael HowellJoseph Thomas
    • Zsolt Istvan HertelendyMurray WeinerMichael HowellJoseph Thomas
    • A61K39/245A61P31/22
    • A61K9/0034A61K9/0031A61K9/02A61K39/12A61K39/245A61K2039/53A61K2039/541C12N2710/16622C12N2710/16634
    • The invention is directed to a suppository based vaccine delivery system for immunizing against urogenital and anorectally transmitted infectious disease in humans and animals and a method for treating the same. More particularly, this invention is directed to a suppository based vaccine delivery system for the prophylaxis against or treatment of urogenital or anorectal transmitted infectious diseases, such as from viral or microbial pathogens. The suppository based delivery system comprises vaccine and/or vaccine adjuvant(s) comprised of whole or fractionated viral or other microbial pathogens, or their purified cellular constituents, whether native, mutated, synthetic, cloned or recombinantly expressed, that consists of nucleic acids, proteins, lipids or other antigenic determinants capable of producing humoral or cellular-mediated immunity in humans or animals; and a polyethylene glycol base; wherein the suppository is adapted to be inserted into a bodily orifice of a human or animal so as to allow the suppository to be in contact with tissue of the bodily orifice to facilitate transfer of vaccine or vaccine adjuvant(s) material therethrough.
    • 本发明涉及一种用于在人类和动物中免疫泌尿生殖和肛门直肠传播的传染病的基于栓剂的疫苗递送系统及其治疗方法。 更具体地,本发明涉及一种基于栓剂的疫苗递送系统,用于预防或治疗泌尿生殖或肛门直肠传播的传染病,例如病毒或微生物病原体。 基于栓剂的递送系统包括由全部或分馏的病毒或其他微生物病原体组成的疫苗和/或疫苗佐剂,或其纯化的细胞成分,无论是天然的,突变的,合成的,克隆的或重组表达的,由核酸组成, 能够在人或动物中产生体液或细胞介导的免疫的蛋白质,脂质或其它抗原决定簇; 和聚乙二醇碱; 其中栓剂适于插入人或动物的身体孔中,以便使栓剂与身体孔的组织接触以促进疫苗或疫苗佐剂材料通过其传送。