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1. 发明申请

US20120059465A1 CAPSULAR MEMBRANE IMPLANTS TO INCREASE ACCOMMODATIVE AMPLITUDE 有权
标题翻译：囊体膜植入物增加舒张功能
公开(公告)号：US20120059465A1
公开(公告)日：2012-03-08
申请号：US13043178
申请日：2011-03-08
申请人： Daniel G. Brady , Zsolt Bor , Edward Geraghty , Brooke C. Basinger , Carina R. Reisin , Douglas S. Cali
发明人： Daniel G. Brady , Zsolt Bor , Edward Geraghty , Brooke C. Basinger , Carina R. Reisin , Douglas S. Cali
IPC分类号： A61F2/16
CPC分类号： A61F2/14 , A61F2/1624 , A61F9/00736 , A61F9/008 , A61F9/00838 , A61F2002/1681 , A61F2009/0087 , A61F2009/00889 , A61F2009/00895 , F04C2270/0421
摘要： A support is coupled to the lens capsule to increase accommodation. The support may be adjustable, such that patient refraction and accommodation can be adjusted following surgery. The support may comprise rigidity sufficient to decrease radial movement of the intermediate portion of the lens capsule. The support can be placed on the intermediate portion to decrease radial movement of the intermediate portion of the lens capsule and increase radial stretching of an outer portion of the lens capsule extending between the zonules and the intermediate portion coupled to the support, such that the amount of accommodation of the eye is increased. The support may comprise a biocompatible material capable of stable coupling to the lens capsule following implantation, such that the far vision refraction and accommodation of the eye can be stable following surgery.
摘要翻译：支撑件联接到镜片胶囊以增加调节。支撑件可以是可调节的，使得在手术后可以调整患者的折射和容纳。支撑件可以包括足以减小透镜胶囊的中间部分的径向移动的刚度。可以将支撑件放置在中间部分上以减小透镜胶囊的中间部分的径向移动，并且增加透镜胶囊的在部分与连接到支撑件的中间部分之间延伸的外部部分的径向拉伸，使得量眼睛的适应性增加。支撑体可以包括能够在植入之后稳定地耦合到晶状体囊的生物相容性材料，使得眼睛的远视力折射和适应在手术后可以是稳定的。

2. 发明授权

US09278026B2 Capsular membrane treatments to increase accommodative amplitude 有权
标题翻译：荚膜治疗增加调节幅度
公开(公告)号：US09278026B2
公开(公告)日：2016-03-08
申请号：US13043149
申请日：2011-03-08
申请人： Zsolt Bor , Daniel G. Brady , Edward Geraghty , Carina R. Reisin , Douglas S. Cali
发明人： Zsolt Bor , Daniel G. Brady , Edward Geraghty , Carina R. Reisin , Douglas S. Cali
IPC分类号： A61F2/14 , A61B18/18 , A61F9/007 , A61F9/008 , A61F2/16
CPC分类号： A61F9/013 , A61F2/16 , A61F9/00 , A61F9/0008 , A61F9/0017 , A61F9/007 , A61F9/00736 , A61F9/0079 , A61F9/008 , A61F9/00838 , A61F2009/0087 , A61F2009/00889 , A61F2009/00895
摘要： Methods and apparatus treat the lens capsule so as to increase accommodation of the eye. The treatment of the lens capsule may comprise treating a portion of the lens capsule so as to stiffen the treated portion and improve accommodation of the eye. The intermediate portion of the lens capsule may located between an optically used central portion of the lens capsule and a peripheral portion of the lens capsule connected to zonules of the eye. The stiffened intermediate portion of the lens capsule can improve coupling of the peripheral portion of the lens capsule to the central portion of the lens capsule, such that an amount of accommodation of the optically used central portion of the lens is increased. As the force of the lens capsule to a lens disposed within the lens capsule is increased, the lens may comprise the natural lens of the eye or an artificial lens such as an accommodative IOL. The treatment of the eye to stiffen the intermediate portion may comprise application of one or more of an energy or a substance to the intermediate portion.
摘要翻译：方法和装置处理晶状体囊以增加眼睛的适应性。透镜胶囊的治疗可以包括处理透镜胶囊的一部分，以便加强经处理的部分并改善眼睛的适应性。透镜胶囊的中间部分可以位于透镜胶囊的光学使用的中心部分和与眼睛的小区连接的透镜胶囊的周边部分之间。透镜胶囊的加强的中间部分可以改善透镜胶囊的周边部分与透镜胶囊的中心部分的联接，使得透镜的光学中心部分的调节量增加。当透镜胶囊对设置在透镜胶囊内的透镜的力增加时，透镜可以包括眼睛的天然晶状体或诸如调节性IOL的人造镜片。治疗眼睛以加强中间部分可以包括向中间部分施加一种或多种能量或物质。

3. 发明申请

US20120059363A1 CAPSULAR MEMBRANE TREATMENTS TO INCREASE ACCOMMODATIVE AMPLITUDE 有权
标题翻译： CAPSULAR膜治疗增加舒张功能
公开(公告)号：US20120059363A1
公开(公告)日：2012-03-08
申请号：US13043149
申请日：2011-03-08
申请人： Zsolt Bor , Daniel G. Brady , Edward Geraghty , Carina R. Reisin , Douglas S. Cali
发明人： Zsolt Bor , Daniel G. Brady , Edward Geraghty , Carina R. Reisin , Douglas S. Cali
IPC分类号： A61B18/20
CPC分类号： A61F9/013 , A61F2/16 , A61F9/00 , A61F9/0008 , A61F9/0017 , A61F9/007 , A61F9/00736 , A61F9/0079 , A61F9/008 , A61F9/00838 , A61F2009/0087 , A61F2009/00889 , A61F2009/00895
摘要： Methods and apparatus treat the lens capsule so as to increase accommodation of the eye. The treatment of the lens capsule may comprise treating a portion of the lens capsule so as to stiffen the treated portion and improve accommodation of the eye. The intermediate portion of the lens capsule may located between an optically used central portion of the lens capsule and a peripheral portion of the lens capsule connected to zonules of the eye. The stiffened intermediate portion of the lens capsule can improve coupling of the peripheral portion of the lens capsule to the central portion of the lens capsule, such that an amount of accommodation of the optically used central portion of the lens is increased. As the force of the lens capsule to a lens disposed within the lens capsule is increased, the lens may comprise the natural lens of the eye or an artificial lens such as an accommodative IOL. The treatment of the eye to stiffen the intermediate portion may comprise application of one or more of an energy or a substance to the intermediate portion.
摘要翻译：方法和装置处理晶状体囊以增加眼睛的适应性。透镜胶囊的治疗可以包括处理透镜胶囊的一部分，以便加强经处理的部分并改善眼睛的适应性。透镜胶囊的中间部分可以位于透镜胶囊的光学使用的中心部分和与眼睛的小区连接的透镜胶囊的周边部分之间。透镜胶囊的加强中间部分可以改善透镜胶囊的周边部分与透镜胶囊的中心部分的联接，使得透镜的光学中心部分的调节量增加。当透镜胶囊对设置在透镜胶囊内的透镜的力增加时，透镜可以包括眼睛的天然晶状体或诸如调节性IOL的人造镜片。治疗眼睛以加强中间部分可以包括向中间部分施加一种或多种能量或物质。

4. 发明授权

US09445889B2 Capsular membrane implants to increase accommodative amplitude 有权
标题翻译：胶囊植入物增加调节幅度
公开(公告)号：US09445889B2
公开(公告)日：2016-09-20
申请号：US13043178
申请日：2011-03-08
申请人： Daniel G. Brady , Zsolt Bor , Edward Geraghty , Brooke C. Basinger , Carina R. Reisin , Douglas S. Cali
发明人： Daniel G. Brady , Zsolt Bor , Edward Geraghty , Brooke C. Basinger , Carina R. Reisin , Douglas S. Cali
IPC分类号： A61F9/008 , A61F2/14 , A61F9/007 , A61F2/16
CPC分类号： A61F2/14 , A61F2/1624 , A61F9/00736 , A61F9/008 , A61F9/00838 , A61F2002/1681 , A61F2009/0087 , A61F2009/00889 , A61F2009/00895 , F04C2270/0421
摘要： A support is coupled to the lens capsule to increase accommodation. The support may be adjustable, such that patient refraction and accommodation can be adjusted following surgery. The support may comprise rigidity sufficient to decrease radial movement of the intermediate portion of the lens capsule. The support can be placed on the intermediate portion to decrease radial movement of the intermediate portion of the lens capsule and increase radial stretching of an outer portion of the lens capsule extending between the zonules and the intermediate portion coupled to the support, such that the amount of accommodation of the eye is increased. The support may comprise a biocompatible material capable of stable coupling to the lens capsule following implantation, such that the far vision refraction and accommodation of the eye can be stable following surgery.
摘要翻译：支撑件联接到镜片胶囊以增加调节。支撑件可以是可调节的，使得在手术后可以调整患者的折射和容纳。支撑件可以包括足以减小透镜胶囊的中间部分的径向移动的刚度。可以将支撑件放置在中间部分上以减小透镜胶囊的中间部分的径向移动，并且增加透镜胶囊的在部分与连接到支撑件的中间部分之间延伸的外部部分的径向拉伸，使得量眼睛的适应性增加。支撑体可以包括能够在植入之后稳定地耦合到晶状体囊的生物相容性材料，使得眼睛的远视力折射和适应在手术后可以是稳定的。

5. 发明申请

US20090012609A1 MULTIFOCAL ACCOMMODATING INTRAOCULAR LENS 有权
标题翻译：多功能摄影镜片
公开(公告)号：US20090012609A1
公开(公告)日：2009-01-08
申请号：US11966365
申请日：2007-12-28
申请人： Edward Geraghty , Daniel G. Brady , Timothy R. Bumbalough , Douglas S. Cali
发明人： Edward Geraghty , Daniel G. Brady , Timothy R. Bumbalough , Douglas S. Cali
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1618 , A61F2/1624 , A61F2/1635 , A61F2/164 , A61F2/1645 , A61F2/1654 , A61F2002/1681 , A61F2250/0014
摘要： An intraocular lens for providing accommodative visions to a subject includes an adjustable optic and a haptic that is operably coupled to the optic. The adjustable optic comprises an optical axis, a central zone disposed about the optical axis, and an annular zone surrounding the central zone. The optic may also comprise additional annular zones disposed about the central zone and the first annular zone. The haptic comprises a transparent portion protruding into the adjustable optic. The intraocular lens has a disaccommodative configuration in which the central zone has a base optical power and an accommodative configuration in which the central zone has an add optical power that is at least about 1 Diopter greater than the base optical power, preferably at least about 2 Diopters greater than the base optical power. In some embodiments, the add optical power is at least 3 Diopters, or even 4 Diopters, greater than the base optical power. The central zone and the annular zone have different optical powers when the adjustable intraocular lens is in the accommodative configuration and/or when the adjustable intraocular lens is in the disaccommodative configuration.
摘要翻译：用于向受试者提供调节视力的眼内透镜包括可操作地耦合到光学元件的可调光学元件和触觉件。可调节光学元件包括光轴，围绕光轴设置的中心区域和围绕中心区域的环形区域。光学元件还可以包括围绕中心区域和第一环形区域设置的附加环形区域。触觉包括突出到可调节光学元件中的透明部分。眼内透镜具有不利的配置，其中中心区域具有基本光焦度和调节结构，其中中心区域具有比基本光功率大至少约1屈光度的添加光焦度，优选至少约2 屈光度大于基础光功率。在一些实施例中，添加光功率大于基本光功率的至少3屈光度，或甚至4屈光度。当可调节眼内透镜处于调节构型和/或当可调节眼内透镜处于不利配置时，中心区域和环形区域具有不同的光焦度。

6. 发明申请

US20120253458A1 MULTIFOCAL ACCOMMODATING INTRAOCULAR LENS 有权
标题翻译：多功能摄影镜片
公开(公告)号：US20120253458A1
公开(公告)日：2012-10-04
申请号：US13243196
申请日：2011-09-23
申请人： Edward Geraghty , Daniel G. Brady , Timothy R. Bumbalough , Douglas S. Cali
发明人： Edward Geraghty , Daniel G. Brady , Timothy R. Bumbalough , Douglas S. Cali
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1618 , A61F2/1624 , A61F2/1635 , A61F2/164 , A61F2/1645 , A61F2/1654 , A61F2002/1681 , A61F2250/0014
摘要： An intraocular lens for providing accommodative vision includes an adjustable optic and a haptic that is operably coupled to the optic. The adjustable optic comprises a central zone and an annular zone surrounding the central zone. The optic may also comprise additional annular zones. The haptic comprises a transparent portion protruding into the adjustable optic. The intraocular lens has a disaccommodative configuration in which the central zone has a base optical power and an accommodative configuration in which the central zone has an add optical power that is at least about 1 Diopter greater than the base optical power. The central zone and the annular zone have different optical powers when the adjustable intraocular lens is in the accommodative configuration and/or when the adjustable intraocular lens is in the disaccommodative configuration.
摘要翻译：用于提供调节视力的眼内透镜包括可操作地耦合到光学元件的可调光学元件和触觉件。可调光学元件包括中心区域和围绕中心区域的环形区域。光学元件还可以包括附加的环形区域。触觉包括突出到可调节光学元件中的透明部分。眼内透镜具有不利的配置，其中中心区域具有基本光功率和调节配置，其中中心区域具有比基本光功率大至少约1屈光度的添加光功率。当可调节眼内透镜处于调节构型和/或当可调节眼内透镜处于不利配置时，中心区域和环形区域具有不同的光焦度。

7. 发明授权

US08048156B2 Multifocal accommodating intraocular lens 有权
标题翻译：多焦点适应人工晶状体
公开(公告)号：US08048156B2
公开(公告)日：2011-11-01
申请号：US11966365
申请日：2007-12-28
申请人： Edward Geraghty , Daniel G. Brady , Timothy R. Bumbalough , Douglas S. Cali
发明人： Edward Geraghty , Daniel G. Brady , Timothy R. Bumbalough , Douglas S. Cali
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1618 , A61F2/1624 , A61F2/1635 , A61F2/164 , A61F2/1645 , A61F2/1654 , A61F2002/1681 , A61F2250/0014
摘要： An intraocular lens for providing accommodative visions to a subject includes an adjustable optic and a haptic that is operably coupled to the optic. The adjustable optic comprises an optical axis, a central zone disposed about the optical axis, and an annular zone surrounding the central zone. The optic may also comprise additional annular zones disposed about the central zone and the first annular zone. The haptic comprises a transparent portion protruding into the adjustable optic. The intraocular lens has a disaccommodative configuration in which the central zone has a base optical power and an accommodative configuration in which the central zone has an add optical power that is at least about 1 Diopter greater than the base optical power, preferably at least about 2 Diopters greater than the base optical power. In some embodiments, the add optical power is at least 3 Diopters, or even 4 Diopters, greater than the base optical power. The central zone and the annular zone have different optical powers when the adjustable intraocular lens is in the accommodative configuration and/or when the adjustable intraocular lens is in the disaccommodative configuration.
摘要翻译：用于向受试者提供调节视力的眼内透镜包括可操作地耦合到光学元件的可调光学元件和触觉件。可调节光学元件包括光轴，围绕光轴设置的中心区域和围绕中心区域的环形区域。光学元件还可以包括围绕中心区域和第一环形区域设置的附加环形区域。触觉包括突出到可调节光学元件中的透明部分。眼内透镜具有不利的配置，其中中心区域具有基本光焦度和调节结构，其中中心区域具有比基本光功率大至少约1屈光度的添加光焦度，优选至少约2 屈光度大于基础光功率。在一些实施例中，添加光功率大于基本光功率的至少3屈光度，或甚至4屈光度。当可调节眼内透镜处于调节构型和/或当可调节眼内透镜处于不利配置时，中心区域和环形区域具有不同的光焦度。

8. 发明授权

US08062362B2 Accommodating intraocular lens 有权
标题翻译：容纳人工晶状体
公开(公告)号：US08062362B2
公开(公告)日：2011-11-22
申请号：US12703350
申请日：2010-02-10
申请人： Daniel G. Brady , Tuyet Hoc Nguyen , Hendrik A. Weeber , Douglas S. Cali
发明人： Daniel G. Brady , Tuyet Hoc Nguyen , Hendrik A. Weeber , Douglas S. Cali
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2002/1681 , A61F2002/169 , A61F2230/0095 , A61F2250/0018
摘要： An intraocular lens for implantation in a capsular bag of an eye includes an optic disposed about an optical axis and a haptic including a protruding portion disposed inside the optic. The optic has an anterior face and an opposing posterior face that are configured to provide a lens power. In response to an ocular force of the eye, the haptic transmits a force that alters one or more of a shape of the optic and an axial thickness of the optic. The protruding portion of the haptic has a refractive index that is equal to a refraction index of the optic for at least one wavelength within the visible spectrum.
摘要翻译：用于植入眼袋的眼内透镜包括围绕光轴设置的光学元件和包括设置在光学元件内部的突出部分的触觉件。光学元件具有被配置为提供透镜光焦度的前表面和相对的后表面。响应于眼睛的眼力，触觉件透射改变光学元件的形状和光学元件的轴向厚度中的一个或多个的力。触觉件的突出部分具有等于可见光谱内的至少一个波长的光学器件的折射率的折射率。

9. 发明申请

US20080161913A1 HAPTIC FOR ACCOMMODATING INTRAOCULAR LENS 有权
标题翻译：适合摄入镜片
公开(公告)号：US20080161913A1
公开(公告)日：2008-07-03
申请号：US11618325
申请日：2006-12-29
申请人： Daniel G. Brady , Tuyet Hoc Nguyen , Hendrik A. Weeber , Douglas S. Cali
发明人： Daniel G. Brady , Tuyet Hoc Nguyen , Hendrik A. Weeber , Douglas S. Cali
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2002/1681 , A61F2002/169 , A61F2230/0095 , A61F2250/0018
摘要： An intraocular lens is disclosed, with an optic that changes shape in response to a deforming force exerted by the zonules of the eye. A haptic supports the optic around its equator and couples the optic to the capsular bag of the eye. The region of contact between the optic and the haptic extends into the edge of the optic, similar to the interface between a bicycle tire and the rim that holds it in place. The haptic may be stiffer than the optic. The haptic may have the same refractive index as the optic. The haptic may include a saddle-shaped portion in contact with the adjustable optic, with a convex profile along an optical axis; and a concave profile in a plane perpendicular to the optical axis.
摘要翻译：公开了一种眼内透镜，其具有响应于由眼睛的小环施加的变形力而改变形状的光学元件。触觉件支持其赤道周围的光学器件，并将光学元件耦合到眼睛的囊袋。光学元件和触觉件之间的接触区域延伸到光学元件的边缘，类似于自行车轮胎和将其保持在适当位置的边缘之间的界面。触觉可能比光学元件更硬。触觉可以具有与光学元件相同的折射率。触觉件可以包括与可调节光学元件接触的鞍形部分，具有沿着光轴的凸形轮廓; 以及在垂直于光轴的平面中的凹形轮廓。

10. 发明申请

US20120016473A1 ACCOMMODATING INTRAOCULAR LENS 有权
标题翻译：住院镜片
公开(公告)号：US20120016473A1
公开(公告)日：2012-01-19
申请号：US13243577
申请日：2011-09-23
申请人： Daniel G. Brady , Tuyet Hoc Nguyen , Hendrik A. Weeber , Douglas S. Cali , Timothy R. Bumbalough , Edward P. Geraghty
发明人： Daniel G. Brady , Tuyet Hoc Nguyen , Hendrik A. Weeber , Douglas S. Cali , Timothy R. Bumbalough , Edward P. Geraghty
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2002/1681 , A61F2002/169 , A61F2230/0095 , A61F2250/0018
摘要： An intraocular lens for implantation in a capsular bag of an eye includes an optic disposed about an optical axis and a haptic including a protruding portion disposed inside the optic. The optic has an anterior face and an opposing posterior face that are configured to provide a lens power. In response to an ocular force of the eye, the haptic transmits a force that alters one or more of a shape of the optic and an axial thickness of the optic. The protruding portion of the haptic has a refractive index that is equal to a refraction index of the optic for at least one a wavelength within the visible spectrum.
摘要翻译：用于植入眼袋的眼内透镜包括围绕光轴设置的光学元件和包括设置在光学元件内部的突出部分的触觉件。光学元件具有被配置为提供透镜光焦度的前表面和相对的后表面。响应于眼睛的眼力，触觉件透射改变光学元件的形状和光学元件的轴向厚度中的一个或多个的力。触觉件的突出部分具有等于可见光谱内的至少一个波长的光学器件的折射率的折射率。

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