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1. 发明专利

JP2010207619A Heat exchange catheter with discrete heat exchange element 审中-公开
标题翻译：带有离散换热元件的热交换器
公开(公告)号：JP2010207619A
公开(公告)日：2010-09-24
申请号：JP2010132357
申请日：2010-06-09
申请人： Zoll Circulation Inc , ゾールサーキュレイションインコーポレイテッドZOLL Circulation,Inc.
发明人： KELLER WADE E , MACHOLD TIMOTHY R , SAAB MARK A
IPC分类号： A61F7/00 , A61M25/00 , A61F7/12
CPC分类号： A61F7/12 , A61F2007/126
摘要： PROBLEM TO BE SOLVED: To provide a heat exchange catheter with discrete heat exchange elements. SOLUTION: This catheter (50) includes a shaft (52), and a heat exchange region (56) having a plurality of heat exchange elements (58) each having a fixed length, with at least one of its opposing ends connected to the shaft, so that when inserted in a fluid body cavity with fluid, the body fluid may circumferentially surround each heat exchange element. The catheter includes a fluid circulation path therein, which desirably includes a hollow lumen within each of the heat exchange elements. The heat exchange elements may be connected at two points along the shaft using manifolds (70, 72). Alternatively, the heat exchange elements may be connected at only one point and be permitted to float. An insulating member, such as a balloon (204), may be provided along the shaft, and ribs (204) may be provided on each of the heat exchange elements. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供具有分立的热交换元件的热交换导管。解决方案：该导管（50）包括轴（52）和热交换区（56），热交换区（56）具有多个具有固定长度的热交换元件（58），其相对端中的至少一个连接使得当以流体插入流体体腔时，体液可以周向地围绕每个热交换元件。导管包括其中的流体循环路径，其期望地包括在每个热交换元件内的中空腔。热交换元件可以使用歧管（70,72）沿着轴在两个点连接。或者，热交换元件可以仅在一点连接并被允许浮动。可以沿着轴设置绝缘构件，例如球囊（204），并且可以在每个热交换元件上设置肋（204）。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2010158531A Catheter apparatus and system having the same 有权
标题翻译：导管装置和具有该装置的系统
公开(公告)号：JP2010158531A
公开(公告)日：2010-07-22
申请号：JP2010025861
申请日：2010-02-08
申请人： Zoll Circulation Inc , ゾールサーキュレイションインコーポレイテッドZOLL Circulation,Inc.
发明人： GINSBURG ROBERT , MACHOLD TIMOTHY R , DINEEN MICHAEL T
IPC分类号： A61F7/12 , A61M25/00 , A61B6/00 , A61B6/12 , A61B17/00 , A61B17/22 , A61B18/00 , A61B18/08 , A61B18/24 , A61F2/958 , A61F7/00 , A61F7/10 , A61M39/00
CPC分类号： A61F7/12 , A61B18/00 , A61B18/082 , A61B18/245 , A61B2017/00084 , A61B2017/22051 , A61B2018/00095 , A61F7/007 , A61F7/0097 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0056 , A61F2007/0086 , A61F2007/0093 , A61F2007/0095 , A61F2007/0096 , A61F2007/126 , A61M25/00 , A61M25/1011 , A61M2025/0078 , A61M2025/1072 , A61M2025/1086 , A61M2205/366 , A61M2206/10 , A61M2230/50
摘要： PROBLEM TO BE SOLVED: To provide a catheter apparatus which can exchange heat by using a body fluid on site for modifying a temperature at a target region in a body, and a system including the catheter apparatus. SOLUTION: The catheter apparatus 420 comprises a spindly flexible catheter, at least one fluid lumen, a heat exchange instrument 440 located on the catheter, and a body fluid-inducing sleeve 422 formed around a segment of the catheter. The catheter apparatus can modify the temperature at the target region in the body by using the body fluid on site. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：解决的问题：提供一种能够通过使用现场体液来改变体内目标区域的温度来进行热交换的导管装置，以及包括该导管装置的系统。解决方案：导管装置420包括柔性导管，至少一个流体腔，位于导管上的热交换器械440，以及围绕导管部分形成的体液引导套筒422。导管装置可以通过现场使用体液来改变体内目标区域的温度。版权所有（C）2010，JPO＆INPIT

3. 发明专利

AU2013222017B2 Heat exchanger catheter for controlling body temperature 未知
公开(公告)号：AU2013222017B2
公开(公告)日：2016-04-14
申请号：AU2013222017
申请日：2013-08-30
申请人： ZOLL CIRCULATION INC
发明人： BLOOM NICOLE DENISE , ROTH ALEX T , MACHOLD TIMOTHY R , KELLER WADE A
IPC分类号： A61B17/00 , A61B18/02 , A61B18/04 , A61F7/12 , A61M25/00
摘要： H:\tld\Intrwovn\NRPortbl\DCC\TLD\5431482_I.doc-30/08/2013 Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of local hypothermia of the brain region for 5 neuroprotection. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. Various disposable heat exchange cassettes are attached to the circulatory flow lines of the catheter, the heat exchange cassettes being sized to engage cavities within various re-usable control units. The control units include a heater/cooler device, a 10 user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up and down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages 15 with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature. WO 02/07793 PCT/USOI/23009 co - - - - - - - - - - - - - z U) ri -------------- ---- ------- 5 _j -:L. > "2D- 0 m y C) CL lil M 0 ------------------ 0 IL C) Ir C) cc cc) a--L Z) (No) ro) w a- V- CL 1 0 0 T 1 0-::) CL C) - ------- --- ----w :z) U) W w m D U)

4. 发明专利

AU2011201173B2 Heat exchanger catheter for controlling body temperature 未知
公开(公告)号：AU2011201173B2
公开(公告)日：2013-05-30
申请号：AU2011201173
申请日：2011-03-16
申请人： ZOLL CIRCULATION INC
发明人： ROTH ALEX T , BLOOM NICOLE DENISE , MACHOLD TIMOTHY R , KELLER WADE A
IPC分类号： A61B17/00 , A61B18/02 , A61B18/04 , A61F7/12 , A61M25/00
摘要： C\NRPonbDCC\KXM\X 345979_DI OC-I6/0D/2IIi Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of local hypothermia of the brain region for 5 neuroprotection. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. Various disposable heat exchange cassettes are attached to the circulatory flow lines of the catheter, the heat exchange cassettes being sized to engage cavities within various re-usable control units. The control units include a heater/cooler device, a 10 user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up and down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages 15 with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the .desired target temperature. WO 02/07793 PCT[USOI/23009 C~ cn o Do Is C') Cc W Cv

5. 发明专利

AU2007201161B2 Heat exchanger catheter for controlling body temperature 未知
公开(公告)号：AU2007201161B2
公开(公告)日：2010-12-16
申请号：AU2007201161
申请日：2007-03-16
申请人： ZOLL CIRCULATION INC
发明人： MACHOLD TIMOTHY R , ROTH ALEX T , KELLER WADE A , BLOOM NICOLE DENISE
IPC分类号： A61B17/00 , A61B18/02 , A61B18/04 , A61F7/12 , A61M25/00
摘要： C\NRPonbDCC\KXM\X 345979_DI OC-I6/0D/2IIi Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of local hypothermia of the brain region for 5 neuroprotection. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. Various disposable heat exchange cassettes are attached to the circulatory flow lines of the catheter, the heat exchange cassettes being sized to engage cavities within various re-usable control units. The control units include a heater/cooler device, a 10 user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up and down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages 15 with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the .desired target temperature. WO 02/07793 PCT[USOI/23009 C~ cn o Do Is C') Cc W Cv

6. 发明专利

AU2016204932A1 Heat exchanger catheter for controlling body temperature 未知
公开(公告)号：AU2016204932A1
公开(公告)日：2016-07-28
申请号：AU2016204932
申请日：2016-07-14
申请人： ZOLL CIRCULATION INC
发明人： BLOOM NICOLE DENISE , ROTH ALEX T , MACHOLD TIMOTHY R , KELLER WADE A
IPC分类号： A61B17/00 , A61B18/02 , A61B18/04 , A61F7/12 , A61M25/00
摘要： H:\td\lnterwoven\NRPortbl\DCC\TLD\10494939 _docx-14/07/2016 -68 Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of local hypothermia of the brain region 5 for neuroprotection. The temperature modification is accomplished using an in dwelling heat exchange catheter within which a fluid heat exchange medium circulates. Various disposable heat exchange cassettes are attached to the circulatory flow lines of the catheter, the heat exchange cassettes being sized to engage cavities within various re-usable control units. The control units include a 10 heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up and down without overshoot is provided. The disposable heat exchange cassettes may 15 include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.

7. 发明专利

AU2011201173C1 Heat exchanger catheter for controlling body temperature 未知
公开(公告)号：AU2011201173C1
公开(公告)日：2013-10-03
申请号：AU2011201173
申请日：2011-03-16
申请人： ZOLL CIRCULATION INC
发明人： ROTH ALEX T , BLOOM NICOLE DENISE , MACHOLD TIMOTHY R , KELLER WADE A
IPC分类号： A61B17/00 , A61B18/02 , A61B18/04 , A61F7/12 , A61M25/00
摘要： C\NRPonbDCC\KXM\X 345979_DI OC-I6/0D/2IIi Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of local hypothermia of the brain region for 5 neuroprotection. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. Various disposable heat exchange cassettes are attached to the circulatory flow lines of the catheter, the heat exchange cassettes being sized to engage cavities within various re-usable control units. The control units include a heater/cooler device, a 10 user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up and down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages 15 with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the .desired target temperature. WO 02/07793 PCT[USOI/23009 C~ cn o Do Is C') Cc W Cv

8. 发明专利

AU2011201173A1 Heat exchanger catheter for controlling body temperature 未知
公开(公告)号：AU2011201173A1
公开(公告)日：2011-04-07
申请号：AU2011201173
申请日：2011-03-16
申请人： ZOLL CIRCULATION INC
发明人： ROTH ALEX T , BLOOM NICOLE DENISE , MACHOLD TIMOTHY R , KELLER WADE A
IPC分类号： A61B17/00 , A61B18/02 , A61B18/04 , A61F7/12 , A61M25/00

9. 发明专利

AU2005222530B9 Method of controlling body temperature while reducing shivering 未知
公开(公告)号：AU2005222530B9
公开(公告)日：2009-07-23
申请号：AU2005222530
申请日：2005-10-12
申请人： ZOLL CIRCULATION INC
发明人： MACHOLD TIMOTHY R , KELLER WADE A , DAE MICHAEL W
IPC分类号： A61B17/00 , A61F7/00 , A61F7/02 , A61F7/12 , A61K31/00 , A61K31/13 , A61K31/135 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/439 , A61K31/451 , A61K31/4515 , A61K31/454 , A61K31/472 , A61K31/485 , A61K31/496 , A61K31/506 , A61K31/553 , A61K45/00 , A61K45/06 , A61M25/00 , A61P25/00 , A61P25/04 , A61P29/00 , A61P41/00 , A61P43/00
摘要： A method and apparatus for lowering the body temperature of a patient while reducing shivering by using a heat exchange device in combination with an alpha2-adrenoreceptor agonist, a non-opiod analgesic monoamine uptake inhibitor or neuropeptide that temporarily reduces shivering. The devices disclosed include a catheter having a heat exchange balloon thereon with heat exchange fluid circulating through the interior of the balloon. The heat exchange balloon is placed in the vasculature of a patient, and heat exchange fluid at a temperature other than the temperature of the blood in the vasculature is circulated through the interior of the balloon to add or remove heat from the blood of the patient. Various alpha2-adrenoreceptor agonistalpha2-adrenoreceptor agonists, non-opiod analgesic monoamine uptake inhibitors and neuropeptides are disclosed including dexmedetomidine, nefopam, neurotensin and anticonvulsant medications and pharmaceutically acceptable salts thereof. A control system for the control of the patient's temperature is disclosed for controlling the patient's temperature in conjunction with administering the alpha2-adrenoreceptor agonist, non-opiod analgesic monoamine uptake inhibitor or neuropeptide.

10. 发明专利

AU2005222530B2 Method of controlling body temperature while reducing shivering 未知
公开(公告)号：AU2005222530B2
公开(公告)日：2009-06-04
申请号：AU2005222530
申请日：2005-10-12
申请人： ZOLL CIRCULATION INC
发明人： MACHOLD TIMOTHY R , KELLER WADE A , DAE MICHAEL W
IPC分类号： A61B17/00 , A61F7/00 , A61F7/02 , A61F7/12 , A61K31/00 , A61K31/13 , A61K31/135 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/439 , A61K31/451 , A61K31/4515 , A61K31/454 , A61K31/472 , A61K31/485 , A61K31/496 , A61K31/506 , A61K31/553 , A61K45/00 , A61K45/06 , A61M25/00 , A61P25/00 , A61P25/04 , A61P29/00 , A61P41/00 , A61P43/00
摘要： A method and apparatus for lowering the body temperature of a patient while reducing shivering by using a heat exchange device in combination with an alpha2-adrenoreceptor agonist, a non-opiod analgesic monoamine uptake inhibitor or neuropeptide that temporarily reduces shivering. The devices disclosed include a catheter having a heat exchange balloon thereon with heat exchange fluid circulating through the interior of the balloon. The heat exchange balloon is placed in the vasculature of a patient, and heat exchange fluid at a temperature other than the temperature of the blood in the vasculature is circulated through the interior of the balloon to add or remove heat from the blood of the patient. Various alpha2-adrenoreceptor agonistalpha2-adrenoreceptor agonists, non-opiod analgesic monoamine uptake inhibitors and neuropeptides are disclosed including dexmedetomidine, nefopam, neurotensin and anticonvulsant medications and pharmaceutically acceptable salts thereof. A control system for the control of the patient's temperature is disclosed for controlling the patient's temperature in conjunction with administering the alpha2-adrenoreceptor agonist, non-opiod analgesic monoamine uptake inhibitor or neuropeptide.

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