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1. 发明授权

US09629571B2 Co-use of endoluminal data and extraluminal imaging 有权
公开(公告)号：US09629571B2
公开(公告)日：2017-04-25
申请号：US13228229
申请日：2011-09-08
申请人： David Tolkowsky , Ran Cohen , Eldad Klaiman , Zohar Barzelay
发明人： David Tolkowsky , Ran Cohen , Eldad Klaiman , Zohar Barzelay
IPC分类号： A61B5/05 , A61B5/06 , A61B8/12 , A61B5/00 , A61B90/00
CPC分类号： A61B5/066 , A61B5/0066 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B8/12 , A61B2090/3966 , A61B2576/00
摘要： Apparatus and methods are described for use with an endoluminal data-acquisition device configured to be moved through a lumen, the device having a radiopaque marker coupled thereto. While the device is being moved through the lumen (a) endoluminal data points of the lumen are acquired using the device, (b) contrast agent is continuously injected into the lumen, and (c) angiographic images of the device are acquired. It is determined that endoluminal data points correspond to respective locations within the lumen, by determining locations of the radiopaque marker within the angiographic images of the lumen, by performing image processing on the angiographic images, the locations of the radiopaque marker within the angiographic images of the lumen corresponding to respective endoluminal data points. Other applications are also described.

2. 发明申请

US20140140597A1 LUMINAL BACKGROUND CLEANING 有权
标题翻译：白色背景清洁
公开(公告)号：US20140140597A1
公开(公告)日：2014-05-22
申请号：US14128243
申请日：2012-06-21
申请人： Zohar Barzelay , Ran Cohen , David Tolkowsky
发明人： Zohar Barzelay , Ran Cohen , David Tolkowsky
IPC分类号： G06T5/00
CPC分类号： G06T5/001 , A61B6/481 , A61B6/504 , A61B6/52 , A61B6/5235 , A61B6/5258 , G06T5/009 , G06T5/50 , G06T2207/10116 , G06T2207/20212 , G06T2207/30101
摘要： Apparatus and methods are described for use with an input angiogram image of a device inserted inside a portion of subject's body, the angiogram image being acquired in the presence of contrast agent. At least one processor (11) includes background-image-generation functionality (13) configured to generate a background image in which a relative value is assigned to a first pixel with respect to a second pixel, at least partially based upon relative values of surroundings of the first pixel and the surroundings of the second pixel in the input image. Cleaned-image-generation functionality (14) generates a cleaned image in which visibility of the radiopaque portions of the device is increased relative to the input image, by dividing the input image by the background image. Output-generation functionality (15) drives a display (16) to display an output based upon the cleaned image. Other applications are also described.
摘要翻译：描述了与插入受试者身体的一部分内的装置的输入血管造影图像一起使用的装置和方法，在存在造影剂的情况下获取血管造影图像。至少一个处理器（11）包括背景图像生成功能（13），其被配置为生成背景图像，其中相对于第二像素将相对值分配给第一像素，至少部分地基于周围环境的相对值的第一像素和第二像素的周围。清洁图像生成功能（14）通过将输入图像除以背景图像来生成其中相对于输入图像增加设备的不透射线部分的可视性的清洁图像。输出产生功能（15）驱动显示器（16）以基于清洁的图像显示输出。还描述了其它应用。

3. 发明授权

US09305334B2 Luminal background cleaning 有权
标题翻译：腔内背景清洁
公开(公告)号：US09305334B2
公开(公告)日：2016-04-05
申请号：US14128243
申请日：2012-06-21
申请人： Zohar Barzelay , Ran Cohen , David Tolkowsky
发明人： Zohar Barzelay , Ran Cohen , David Tolkowsky
IPC分类号： G06K9/00 , G06T5/00 , G06T5/50 , A61B6/00
CPC分类号： G06T5/001 , A61B6/481 , A61B6/504 , A61B6/52 , A61B6/5235 , A61B6/5258 , G06T5/009 , G06T5/50 , G06T2207/10116 , G06T2207/20212 , G06T2207/30101
摘要： Apparatus and methods are described for use with an input angiogram image of a device inserted inside a portion of subject's body, the angiogram image being acquired in the presence of contrast agent. At least one processor (11) includes background-image-generation functionality (13) configured to generate a background image in which a relative value is assigned to a first pixel with respect to a second pixel, at least partially based upon relative values of surroundings of the first pixel and the surroundings of the second pixel in the input image. Cleaned-image-generation functionality (14) generates a cleaned image in which visibility of the radiopaque portions of the device is increased relative to the input image, by dividing the input image by the background image. Output-generation functionality (15) drives a display (16) to display an output based upon the cleaned image. Other applications are also described.
摘要翻译：描述了与插入受试者身体的一部分内的装置的输入血管造影图像一起使用的装置和方法，在存在造影剂的情况下获取血管造影图像。至少一个处理器（11）包括背景图像生成功能（13），其被配置为生成背景图像，其中相对于第二像素将相对值分配给第一像素，至少部分地基于周围环境的相对值的第一像素和第二像素的周围。清洁图像生成功能（14）通过将输入图像除以背景图像来生成其中相对于输入图像增加设备的不透射线部分的可视性的清洁图像。输出产生功能（15）驱动显示器（16）以基于清洁的图像显示输出。还描述了其它应用。

4. 发明申请

US20100161023A1 AUTOMATIC TRACKING OF A TOOL UPON A VASCULAR ROADMAP 审中-公开
标题翻译：自动跟踪一个工具在一个VASCULAR ROADMAP
公开(公告)号：US20100161023A1
公开(公告)日：2010-06-24
申请号：US12650152
申请日：2009-12-30
申请人： Ran COHEN , David Tolkowsky
发明人： Ran COHEN , David Tolkowsky
IPC分类号： A61B6/00 , A61F2/84 , A61F2/24
CPC分类号： A61B5/0044 , A61B5/7285 , A61B5/7289 , A61B6/12 , A61B6/469 , A61B6/481 , A61B6/501 , A61B6/503 , A61B6/504 , A61B6/5217 , A61B6/5247 , A61B6/541 , A61B8/0883 , A61B8/0891 , A61B8/543 , A61B17/12036 , A61B17/1204 , A61B17/12136 , A61B18/02 , A61B18/1492 , A61B18/24 , A61B34/10 , A61B34/20 , A61B34/25 , A61B2017/00252 , A61B2017/00694 , A61B2017/00703 , A61B2017/1205 , A61B2017/22044 , A61B2017/22094 , A61B2034/105 , A61B2034/107 , A61B2034/254 , A61B2090/365 , A61F2/958 , G06K9/00369 , G06K2209/057 , G06T5/001 , G06T7/0012 , G06T7/0014 , G06T7/13 , G06T7/246 , G06T7/62 , G06T11/60 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： Apparatus and methods are described including generating a road map of a blood vessel in a portion of a subject's body. A given feature that is within the portion of the subject's body is identified in the road map, the given feature being visible even in images of the portion the generation of which does not include use of a contrast agent. A tool is inserted into the blood vessel, and a current location of a portion of the tool is determined with respect to the given feature, by imaging the tool and the feature. In response to the determined current location, a current position of the tool within the road map is determined. In response to determining the current position of the tool within the road map, the current position of the tool with respect to the road map is displayed. Other embodiments are also described.
摘要翻译：描述的装置和方法包括在受试者身体的一部分中产生血管的路线图。在路线图中标识在被摄体的身体部分内的给定特征，即使在生成不包括使用造影剂的部分的图像中，给定特征也是可见的。将工具插入到血管中，并且通过对工具和特征进行成像来确定工具的一部分相对于给定特征的当前位置。响应于确定的当前位置，确定道路地图内的工具的当前位置。响应于在道路图中确定工具的当前位置，显示工具相对于路线图的当前位置。还描述了其它实施例。

5. 发明授权

US10716528B2 Automatic display of previously-acquired endoluminal images 有权
公开(公告)号：US10716528B2
公开(公告)日：2020-07-21
申请号：US13228185
申请日：2011-09-08
申请人： David Tolkowsky , Ran Cohen , Eldad Klaiman
发明人： David Tolkowsky , Ran Cohen , Eldad Klaiman
IPC分类号： A61B6/00 , G06F3/14 , G06T1/00 , G09G5/36 , G06T7/00 , G06T19/20 , A61B1/00 , A61B6/12 , A61F2/82 , A61B17/22 , A61B17/00 , A61F2/958 , A61B8/08 , A61B5/00 , A61B90/00
摘要： Apparatus and methods are provided for use with an endoluminal data-acquisition device that acquires a set of endoluminal data-points of a lumen of a subject's body at respective locations inside the lumen, a second endoluminal device, and a display configured to display images. At least one processor includes location-association functionality that associates a given data point acquired by the endoluminal data-acquisition device with a given location within the lumen. Location-determination functionality determines, by means of image processing, in an extraluminal image of the second endoluminal device, a current location of at least a portion of the second endoluminal device. Display-driving functionality drives the display to display an indication of the endoluminal data point associated with the location, in response to determining that the portion of the second device is currently at the location. Other applications are also described.

6. 发明授权

US10499814B2 Automatic generation and utilization of a vascular roadmap 有权
公开(公告)号：US10499814B2
公开(公告)日：2019-12-10
申请号：US12648913
申请日：2009-12-29
申请人： Alexander Steinberg , Sagiv Philipp , Ran Cohen , David Tolkowsky
发明人： Alexander Steinberg , Sagiv Philipp , Ran Cohen , David Tolkowsky
IPC分类号： G06K9/00 , A61B5/00 , A61B34/10 , A61B34/20 , A61B6/12 , A61B6/00 , G06T7/00 , A61B17/12 , G06T11/60 , G06T5/00 , G06T7/13 , G06T7/246 , G06T7/62 , A61B8/08 , A61B8/00 , A61B17/00 , A61B17/22 , A61F2/958 , A61B18/02 , A61B18/14 , A61B18/24 , A61B34/00 , A61B90/00
CPC分类号： A61B5/0044 , A61B6/12 , A61B6/469 , A61B6/481 , A61B6/501 , A61B6/504 , A61B6/5217 , A61B6/541 , A61B17/1204 , A61B17/12036 , A61B17/12136 , A61B34/10 , A61B34/20 , G06K9/00369 , G06T5/001 , G06T7/0012 , G06T7/0014 , G06T7/13 , G06T7/246 , G06T7/62 , G06T11/60 , A61B5/7285 , A61B5/7289 , A61B6/503 , A61B6/5247 , A61B8/0883 , A61B8/0891 , A61B8/543 , A61B18/02 , A61B18/1492 , A61B18/24 , A61B34/25 , A61B2017/00252 , A61B2017/00694 , A61B2017/00703 , A61B2017/1205 , A61B2017/22044 , A61B2017/22094 , A61B2034/105 , A61B2034/107 , A61B2034/254 , A61B2090/365 , A61F2/958 , G06K2209/057 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： Apparatus and methods are described for receiving into at least one processor a set of images of blood vessels of a subject. A road map of the subject's blood vessels is generated, by automatically (a) deriving at least one image from the set of images of the blood vessels, based upon visibility of at least a portion of the blood vessels in the set of images, and (b) in the derived image, determining a location of edge lines of at least some of the portion of the blood vessels in the image. An output is generated by the processor, based on the road map. Other embodiments are also described.

7. 发明授权

US09008754B2 Automatic correction and utilization of a vascular roadmap comprising a tool 有权
标题翻译：包括工具的血管路线图的自动校正和利用
公开(公告)号：US09008754B2
公开(公告)日：2015-04-14
申请号：US12650156
申请日：2009-12-30
申请人： Alexander Steinberg , David Tolkowsky , Ran Cohen , Sagiv Philipp
发明人： Alexander Steinberg , David Tolkowsky , Ran Cohen , Sagiv Philipp
IPC分类号： A61B6/00 , A61B19/00 , A61B6/12 , G06K9/00 , G06T7/00 , A61B17/12 , G06T7/20 , G06T7/60 , A61B5/00 , G06T11/60 , G06T5/00 , A61B8/08 , A61B8/00 , A61B17/00 , A61B17/22 , A61F2/958 , A61B18/02 , A61B18/14 , A61B18/24
CPC分类号： A61B5/0044 , A61B5/7285 , A61B5/7289 , A61B6/12 , A61B6/469 , A61B6/481 , A61B6/501 , A61B6/503 , A61B6/504 , A61B6/5217 , A61B6/5247 , A61B6/541 , A61B8/0883 , A61B8/0891 , A61B8/543 , A61B17/12036 , A61B17/1204 , A61B17/12136 , A61B18/02 , A61B18/1492 , A61B18/24 , A61B34/10 , A61B34/20 , A61B34/25 , A61B2017/00252 , A61B2017/00694 , A61B2017/00703 , A61B2017/1205 , A61B2017/22044 , A61B2017/22094 , A61B2034/105 , A61B2034/107 , A61B2034/254 , A61B2090/365 , A61F2/958 , G06K9/00369 , G06K2209/057 , G06T5/001 , G06T7/0012 , G06T7/0014 , G06T7/13 , G06T7/246 , G06T7/62 , G06T11/60 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： Apparatus and methods are described including generating a road map of a blood vessel. Subsequent to the generation of the road map, a tool is inserted into the blood vessel. While the tool is inside the blood vessel, the position of the tool is determined. The road map is modified to account for the determined position of the tool. Other embodiments are also described.
摘要翻译：描述了包括产生血管路线图的装置和方法。在生成路线图之后，将工具插入血管。当工具在血管内时，确定工具的位置。修改路线图以说明确定的工具位置。还描述了其它实施例。

8. 发明授权

US08781193B2 Automatic quantitative vessel analysis 有权
标题翻译：自动定量血管分析
公开(公告)号：US08781193B2
公开(公告)日：2014-07-15
申请号：US12666879
申请日：2009-11-18
申请人： Alexander Steinberg , Sagiv Philipp , David Tolkowsky , Ran Cohen
发明人： Alexander Steinberg , Sagiv Philipp , David Tolkowsky , Ran Cohen
IPC分类号： G06K9/00 , A61B5/02
CPC分类号： A61B5/0044 , A61B5/7285 , A61B5/7289 , A61B6/12 , A61B6/469 , A61B6/481 , A61B6/501 , A61B6/503 , A61B6/504 , A61B6/5217 , A61B6/5247 , A61B6/541 , A61B8/0883 , A61B8/0891 , A61B8/543 , A61B17/12036 , A61B17/1204 , A61B17/12136 , A61B18/02 , A61B18/1492 , A61B18/24 , A61B34/10 , A61B34/20 , A61B34/25 , A61B2017/00252 , A61B2017/00694 , A61B2017/00703 , A61B2017/1205 , A61B2017/22044 , A61B2017/22094 , A61B2034/105 , A61B2034/107 , A61B2034/254 , A61B2090/365 , A61F2/958 , G06K9/00369 , G06K2209/057 , G06T5/001 , G06T7/0012 , G06T7/0014 , G06T7/13 , G06T7/246 , G06T7/62 , G06T11/60 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： Apparatus and methods are described for use with an image of blood vessels of a subject. In response to a user designating a single point on the image (a) a target portion of a blood vessel is automatically identified in the vicinity of the designated point, and (b) quantitative vessel analysis is performed on the target portion of the blood vessel. An output is generated based upon the quantitative vessel analysis. Other embodiments are also described.
摘要翻译：描述了与受试者的血管图像一起使用的装置和方法。响应于用户指定图像上的单个点（a），在指定点附近自动识别血管的目标部分，并且（b）对血管的目标部分进行定量血管分析。基于定量血管分析产生输出。还描述了其它实施例。

9. 发明申请

US20100290693A1 LOCATION-SENSITIVE CURSOR CONTROL AND ITS USE FOR VESSEL ANALYSIS 有权
标题翻译：位置敏感光标控制及其用于船舶分析
公开(公告)号：US20100290693A1
公开(公告)日：2010-11-18
申请号：US12781414
申请日：2010-05-17
申请人： Ran COHEN , Alexander Steinberg , Sagiv Philipp , Yoav Stein , Eldad Klaiman , David Tolkowsky
发明人： Ran COHEN , Alexander Steinberg , Sagiv Philipp , Yoav Stein , Eldad Klaiman , David Tolkowsky
IPC分类号： G06K9/00
CPC分类号： A61B5/0044 , A61B5/7285 , A61B5/7289 , A61B6/12 , A61B6/469 , A61B6/481 , A61B6/501 , A61B6/503 , A61B6/504 , A61B6/5217 , A61B6/5247 , A61B6/541 , A61B8/0883 , A61B8/0891 , A61B8/543 , A61B17/12036 , A61B17/1204 , A61B17/12136 , A61B18/02 , A61B18/1492 , A61B18/24 , A61B34/10 , A61B34/20 , A61B34/25 , A61B2017/00252 , A61B2017/00694 , A61B2017/00703 , A61B2017/1205 , A61B2017/22044 , A61B2017/22094 , A61B2034/105 , A61B2034/107 , A61B2034/254 , A61B2090/365 , A61F2/958 , G06K9/00369 , G06K2209/057 , G06T5/001 , G06T7/0012 , G06T7/0014 , G06T7/13 , G06T7/246 , G06T7/62 , G06T11/60 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： Apparatus and methods are provided, including displaying an image of one or more lumens of a subject. A processor includes lumen-identification functionality configured to automatically identify one or more lumens in the image. Envelope-designation functionality of the processor designates as lumen envelopes, portions of the image in vicinities of respective lumens. In response to the user designating a location inside a lumen envelope of a given lumen, via an input device, the location corresponding to a given longitudinal location within the given lumen, feature-generation functionality of the processor generates a feature on the image that corresponds to the given longitudinal location. An output is displayed in response to the generated feature. Other embodiments are also described.
摘要翻译：提供了装置和方法，包括显示受试者的一个或多个流明的图像。处理器包括被配置为自动识别图像中的一个或多个流明的管腔识别功能。处理器的信封指定功能指定为流明封套，图像的相应腔室附近的部分。响应于用户通过输入设备指定给定内腔的管腔封套内的位置，对应于给定内腔内的给定纵向位置的位置，处理器的特征生成功能在对应于图像的图像上产生特征到给定的纵向位置。响应于生成的特征显示输出。还描述了其它实施例。

10. 发明授权

US09717415B2 Automatic quantitative vessel analysis at the location of an automatically-detected tool 有权
公开(公告)号：US09717415B2
公开(公告)日：2017-08-01
申请号：US12649944
申请日：2009-12-30
申请人： Ran Cohen , Eldad Klaiman , Alexander Steinberg , Sagiv Philipp , David Tolkowsky
发明人： Ran Cohen , Eldad Klaiman , Alexander Steinberg , Sagiv Philipp , David Tolkowsky
IPC分类号： A61B5/00 , A61B34/20 , A61B6/12 , A61B6/00 , G06K9/00 , G06T7/00 , A61B17/12 , G06T11/60 , G06T5/00 , G06T7/13 , G06T7/246 , G06T7/62 , A61B34/10 , A61B8/08 , A61B8/00 , A61B17/00 , A61B17/22 , A61F2/958 , A61B18/02 , A61B18/14 , A61B18/24 , A61B34/00 , A61B90/00
CPC分类号： A61B5/0044 , A61B5/7285 , A61B5/7289 , A61B6/12 , A61B6/469 , A61B6/481 , A61B6/501 , A61B6/503 , A61B6/504 , A61B6/5217 , A61B6/5247 , A61B6/541 , A61B8/0883 , A61B8/0891 , A61B8/543 , A61B17/12036 , A61B17/1204 , A61B17/12136 , A61B18/02 , A61B18/1492 , A61B18/24 , A61B34/10 , A61B34/20 , A61B34/25 , A61B2017/00252 , A61B2017/00694 , A61B2017/00703 , A61B2017/1205 , A61B2017/22044 , A61B2017/22094 , A61B2034/105 , A61B2034/107 , A61B2034/254 , A61B2090/365 , A61F2/958 , G06K9/00369 , G06K2209/057 , G06T5/001 , G06T7/0012 , G06T7/0014 , G06T7/13 , G06T7/246 , G06T7/62 , G06T11/60 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： Apparatus and methods are described including inserting a tool into a blood vessel, and, while the tool is within the blood vessel, acquiring an extraluminal image of the blood vessel. In the extraluminal image of the blood vessel, a location of a portion of the tool with respect to the blood vessel is detected automatically. In response to detecting the location of the portion of the tool, a target portion of the blood vessel that is in a vicinity of the portion of the tool is designated automatically. Using the extraluminal image, quantitative vessel analysis is performed on the target portion of the blood vessel. Other embodiments are also described.

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