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1. 发明授权

US07347988B2 Synthesis, uses and compositions of crystal hydrogels 失效
标题翻译：水凝胶的合成，用途和组成
公开(公告)号：US07347988B2
公开(公告)日：2008-03-25
申请号：US10295484
申请日：2002-11-15
申请人： Zhibing Hu , Xihua Lu , Jun Gao , Tong Cai , Gang Huang , Bo Zhou
发明人： Zhibing Hu , Xihua Lu , Jun Gao , Tong Cai , Gang Huang , Bo Zhou
IPC分类号： A61K7/021
CPC分类号： G02B1/04 , C08F220/56 , C08J3/075 , G01N2021/7723
摘要： A method is disclosed for creating hydrogels with ordered crystalline structures that exhibit a characteristic colored opalescence. In addition to the unique optical properties, these materials contain a large amount of water in their crosslinked networks. The manufacturing processes include synthesizing monodispersed hydrogel nanoparticles containing specific reactive functional groups, self-assembly of these particles to form a crystalline structure, and subsequent crosslinking neighboring spheres to stabilize the entire network. Polymerizing a hydrogel monomeric composition around the crystalline structure can enhance the mechanical strength. The resulting network is dimensionally and thermodynamically stabile under various pH and temperature conditions. The color and volume of these crystalline hydrogel networks can reversibly change in response to external stimuli such as temperature, pH and other environmental conditions. These new materials may lead to a variety of technological and artistic applications, ranging from sensors, displays, controlled drug delivery devices, jewelry and decorative consumer products.
摘要翻译：公开了一种用于产生具有有色晶体结构的水凝胶的方法，其具有特征性的着色乳光。除了独特的光学性能之外，这些材料在其交联网络中含有大量的水。制造方法包括合成包含特定反应性官能团的单分散水凝胶纳米颗粒，这些颗粒的自组装形成晶体结构，随后交联相邻球体以稳定整个网络。在晶体结构周围聚合水凝胶单体组合物可以增强机械强度。所得到的网络在各种pH和温度条件下在尺寸和热力学上是稳定的。这些结晶水凝胶网络的颜色和体积可以响应于诸如温度，pH和其他环境条件的外部刺激而可逆地改变。这些新材料可能导致各种技术和艺术应用，从传感器，显示器，受控药物输送装置，首饰和装饰消费品。

2. 发明申请

US20080044472A1 Photoresponsive Hydrogels 审中-公开
标题翻译：光反应性水凝胶
公开(公告)号：US20080044472A1
公开(公告)日：2008-02-21
申请号：US10587229
申请日：2005-01-24
申请人： Antonio Garcia , Rohit Rosario , John Gust , Mark Hayes , Manuel Marquez , Zhibing Hu , Tong Cai
发明人： Antonio Garcia , Rohit Rosario , John Gust , Mark Hayes , Manuel Marquez , Zhibing Hu , Tong Cai
IPC分类号： A61K31/407 , A61K31/711 , A61K45/00 , A61K9/14 , A61P29/00
CPC分类号： C08F2/50 , A61K47/34
摘要： Disclosed are photoresponsive hydrogels. The compositions disclosed herein can be prepared by polymerizing a hydrogel precursor and a spiropyran. The properties of the disclosed compositions can be changed by exposure to light, pH, and temperature. Methods of using the disclosed compositions to deliver pharmaceutical actives are also disclosed.
摘要翻译：公开了光响应水凝胶。本文公开的组合物可以通过聚合水凝胶前体和螺吡喃来制备。所公开的组合物的性质可以通过暴露于光，pH和温度而改变。还公开了使用所公开的组合物递送药物活性物质的方法。

3. 发明申请

US20100261814A1 Synthesis of columnar hydrogel colloidal crystals in water-organic solvent mixture 失效
标题翻译：在水 - 有机溶剂混合物中合成柱状水凝胶胶体晶体
公开(公告)号：US20100261814A1
公开(公告)日：2010-10-14
申请号：US11524703
申请日：2006-09-21
申请人： Zhibing Hu , Jun Zhou , Tong Cai , Shijun Tang , Manuel Marquez
发明人： Zhibing Hu , Jun Zhou , Tong Cai , Shijun Tang , Manuel Marquez
IPC分类号： C08K5/02 , C08L33/24
CPC分类号： C30B5/00 , C30B29/58
摘要： The compositions of hydrogel colloidal crystals are made from mixing an aqueous suspension of poly-N-isopropylacrylamide (“PNIPAM”)-co-allylamine microgels with dichloromethane, forming a PNIPAM-co-allylamine/dichloromethane mixture. The PNIPAM-co-allylamine/dichloromethane mixture is incubated for a period of time at a given temperature, forming the colloidal crystal material. The colloidal crystals can be stabilized by diffusing a glutaric dialdehyde solution into the colloidal crystal material. The concentration of polymer matrix microgels can determine the orientation of random or columnar crystals.
摘要翻译：水凝胶胶体晶体的组成通过将聚-N-异丙基丙烯酰胺（“PNIPAM”） - 共 - 烯丙基胺微凝胶的水悬浮液与二氯甲烷混合，形成PNIPAM-共 - 烯丙基胺/二氯甲烷混合物来制备。将PNIPAM-共 - 烯丙基胺/二氯甲烷混合物在给定温度下温育一段时间，形成胶体晶体材料。可以通过将戊二醛溶液扩散到胶体晶体材料中来稳定胶体晶体。聚合物基质微凝胶的浓度可以确定随机或柱状晶体的取向。

4. 发明申请

US20100076105A1 MONODISPERSE THERMO-RESPONSIVE MICROGELS OF POLY(ETHYLENE GLYCOL) ANALOGUE-BASED BIOPOLYMERS, THEIR MANUFACTURE, AND THEIR APPLICATIONS 审中-公开
标题翻译：聚乙二醇（乙烯甘油）基于模拟物的生物聚合物的单体热响应微胶囊，其制备及其应用
公开(公告)号：US20100076105A1
公开(公告)日：2010-03-25
申请号：US12502842
申请日：2009-07-14
申请人： Zhibing Hu , Tong Cai , Chenglin Chi , Manuel Marquez
发明人： Zhibing Hu , Tong Cai , Chenglin Chi , Manuel Marquez
IPC分类号： C08L33/10 , C08F2/48
CPC分类号： C08F2/48 , C08L33/02 , C08L33/26 , C08L2666/04
摘要： Composition, processes, techniques, and apparatus for synthesizing monodisperse microgels based on poly(ethylene glycol) (PEG) derivative polymers by using precipitation polymerization. These microgels are hydrophilic and have the adjustable volume phase transition temperature in aqueous environment. Microgels can be added with various functional groups. These microgels in water can self-assemble into various phases, including a crystalline phase. Hydrogel films with iridescent colors were formed using these microgels as crosslinkers to connect poly(ethylene glycol) chains. The colors of these hydrogel films change with changes of environment such temperature, pH, salt concentration, etc.
摘要翻译：通过使用沉淀聚合法合成基于聚（乙二醇）（PEG）衍生物聚合物的单分散微凝胶的组合物，方法，技术和装置。这些微凝胶是亲水性的，并且在水性环境中具有可调节的体积相转变温度。微凝胶可以加入各种官能团。水中的这些微凝胶可以自组装成各种相，包括结晶相。使用这些微凝胶作为交联剂形成具有彩虹色的水凝胶膜以连接聚（乙二醇）链。这些水凝胶膜的颜色随温度，pH，盐浓度等环境变化而变化。

5. 发明授权

US07989505B2 Synthesis of columnar hydrogel colloidal crystals in water-organic solvent mixture 失效
标题翻译：在水 - 有机溶剂混合物中合成柱状水凝胶胶体晶体
公开(公告)号：US07989505B2
公开(公告)日：2011-08-02
申请号：US11524703
申请日：2006-09-21
申请人： Zhibing Hu , Jun Zhou , Tong Cai , Shijun Tang , Manuel Marquez
发明人： Zhibing Hu , Jun Zhou , Tong Cai , Shijun Tang , Manuel Marquez
IPC分类号： C08J3/05 , C08J3/075 , B01F3/12
CPC分类号： C30B5/00 , C30B29/58
摘要： The compositions of hydrogel colloidal crystals are made from mixing an aqueous suspension of poly-N-isopropylacrylamide (“PNIPAM”)-co-allylamine microgels with dichloromethane, forming a PNIPAM-co-allylamine/dichloromethane mixture. The PNIPAM-co-allylamine/dichloromethane mixture is incubated for a period of time at a given temperature, forming the colloidal crystal material. The colloidal crystals can be stabilized by diffusing a glutaric dialdehyde solution into the colloidal crystal material. The concentration of polymer matrix microgels can determine the orientation of random or columnar crystals.
摘要翻译：水凝胶胶体晶体的组成通过将聚-N-异丙基丙烯酰胺（“PNIPAM”） - 共 - 烯丙基胺微凝胶的水悬浮液与二氯甲烷混合，形成PNIPAM-共 - 烯丙基胺/二氯甲烷混合物来制备。将PNIPAM-共 - 烯丙基胺/二氯甲烷混合物在给定温度下温育一段时间，形成胶体晶体材料。可以通过将戊二醛溶液扩散到胶体晶体材料中来稳定胶体晶体。聚合物基质微凝胶的浓度可以确定随机或柱状晶体的取向。

6. 发明申请

US20070116765A1 Aqueous dispersion of hydrogel nanoparticles with inverse thermoreversible gelation 失效
标题翻译：具有逆热反应凝胶化的水凝胶纳米颗粒的水分散体
公开(公告)号：US20070116765A1
公开(公告)日：2007-05-24
申请号：US10581678
申请日：2004-12-09
申请人： Zhibing Hu , Xiaohu Xia
发明人： Zhibing Hu , Xiaohu Xia
IPC分类号： C12N15/09 , A61K9/14
CPC分类号： A61K9/0024 , A61K9/06 , A61K9/10 , A61K9/1635 , A61K9/5138 , A61K9/5161 , A61K9/5192 , Y10S977/702 , Y10S977/897 , Y10S977/906
摘要： An aqueous dispersion of hydrogel nanoparticles and methods of making the aqueous dispersion of hydrogel nanoparticless having an interpenetrating polymer network (“IPN”) are described. The uniformed sized mono-disperse IPN nanoparticles have inverse thermo gelation properties that allow therapeutic medications to be uniformly distributed in a liquid form of the aqueous dispersion of hydrogel nanoparticles. Such medications can then be released from a solid form of the aqueous dispersion of hydrogel nanoparticles in time dependant manor.
摘要翻译：描述了水凝胶纳米颗粒的水分散体和制备具有互穿聚合物网络（“IPN”）的纳米级水凝胶的水性分散体的方法。均匀尺寸的单分散IPN纳米颗粒具有逆热凝胶化性质，其允许治疗性药物均匀分布在液体形式的水凝胶纳米颗粒的水分散体中。然后可以从固体形式的时间依赖性的水凝胶纳米颗粒的水分散体中释放这些药物。

7. 发明授权

US06858222B2 Fabrication of drug loaded biodegradable polymer fibers 有权
公开(公告)号：US06858222B2
公开(公告)日：2005-02-22
申请号：US10428354
申请日：2003-05-02
申请人： Kevin D Nelson , Andres A. Romero-Sanchez , George M. Smith , Nadir Alikacem , Delia Radulescu , Paula Waggoner , Zhibing Hu
发明人： Kevin D Nelson , Andres A. Romero-Sanchez , George M. Smith , Nadir Alikacem , Delia Radulescu , Paula Waggoner , Zhibing Hu
IPC分类号： A61K9/00 , A61K9/70 , A61K31/7088 , A61K38/00 , A61K47/34 , A61K47/36 , A61L27/00 , A61L27/54 , A61L27/58 , A61P7/00 , A61P35/00 , A61P37/02 , D01F1/10 , D01F6/62 , D01F8/14 , D06M15/03 , D06M16/00 , A61F2/02 , A61K47/30
CPC分类号： D01F1/10 , A61B17/1128 , A61K9/0024 , A61K9/0051 , A61K9/70 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/426 , A61L2300/604 , D01F6/625 , D01F8/14 , D06M15/03 , D06M16/00 , Y10T428/30 , Y10T442/2525
摘要： The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal distribution of released therapeutic agents is controlled by use of defined nonhomogeneous patterns of therapeutic agents in the matrices.

8. 发明授权

US06596296B1 Drug releasing biodegradable fiber implant 有权
公开(公告)号：US06596296B1
公开(公告)日：2003-07-22
申请号：US09632457
申请日：2000-08-04
申请人： Kevin D. Nelson , Andres A. Romero-Sanchez , George M. Smith , Nadir Alikacem , Delia Radulescu , Paula Waggoner , Zhibing Hu
发明人： Kevin D. Nelson , Andres A. Romero-Sanchez , George M. Smith , Nadir Alikacem , Delia Radulescu , Paula Waggoner , Zhibing Hu
IPC分类号： A61F202
CPC分类号： D01F1/10 , A61B17/1128 , A61K9/0024 , A61K9/0051 , A61K9/70 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/426 , A61L2300/604 , D01F6/625 , D01F8/14 , D06M15/03 , D06M16/00 , Y10T428/30 , Y10T442/2525
摘要： The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal distribution of released therapeutic agents is controlled by use of defined nonhomogeneous patterns of therapeutic agents in the matrices.

9. 发明授权

US07514095B2 Fabrication of drug loaded biodegradable polymer fibers 有权
标题翻译：装载药物的可生物降解聚合物纤维的制造
公开(公告)号：US07514095B2
公开(公告)日：2009-04-07
申请号：US11019801
申请日：2004-12-21
申请人： Kevin D Nelson , Andres A. Romero-Sanchez , George M. Smith , Nadir Alikacem , Delia Radulescu , Paula Waggoner , Zhibing Hu
发明人： Kevin D Nelson , Andres A. Romero-Sanchez , George M. Smith , Nadir Alikacem , Delia Radulescu , Paula Waggoner , Zhibing Hu
IPC分类号： A61F2/02 , A61K47/30
CPC分类号： D01F1/10 , A61B17/1128 , A61K9/0024 , A61K9/0051 , A61K9/70 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/426 , A61L2300/604 , D01F6/625 , D01F8/14 , D06M15/03 , D06M16/00 , Y10T428/30 , Y10T442/2525
摘要： The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal distribution of released therapeutic agents is controlled by use of defined nonhomogeneous patterns of therapeutic agents in the matrices.
摘要翻译：本发明提供组织工程组合物和方法，其中制备用于生长细胞的三维基质用于体外和体内使用。该基质包括能够控制递送治疗剂的可生物降解的聚合物纤维。释放的治疗剂的空间和时间分布通过使用矩阵中定义的非均匀模式的治疗剂来控制。

10. 发明授权

US06194073B1 Synthesis and use of heterogeneous polymer gels 有权
标题翻译：异构聚合物凝胶的合成与使用
公开(公告)号：US06194073B1
公开(公告)日：2001-02-27
申请号：US09432137
申请日：1999-11-02
申请人： Yong Li , Zhibing Hu , Xiaomin Zhang
发明人： Yong Li , Zhibing Hu , Xiaomin Zhang
IPC分类号： C08F624
CPC分类号： F03G7/06 , F03G7/005 , Y10S524/916 , Y10T428/1328 , Y10T428/1352 , Y10T428/1393 , Y10T428/31536 , Y10T428/31909 , Y10T428/31913
摘要： Disclosed is a heterogeneous polymer gel comprising at least two gel networks. One embodiment of the present invention concerns a heterogeneous polymer gel comprising a first gel network comprising an environmentally-stable gel and a second gel network comprising an environmentally-unstable gel wherein the first gel network interpenetrates the second gel network. The heterogeneous polymer gel exhibits controlled changes in volume in response to environmental changes in condition, such as of temperature or of chemical composition.
摘要翻译：公开了包含至少两个凝胶网络的多相聚合物凝胶。本发明的一个实施方案涉及包含第一凝胶网络的非均相聚合物凝胶，其包含环境稳定的凝胶和包含环境不稳定凝胶的第二凝胶网络，其中所述第一凝胶网络穿透所述第二凝胶网络。异质聚合物凝胶响应于诸如温度或化学组成的条件的环境变化而显示出体积的受控变化。

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