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1. 发明授权

US08416416B2 Measuring method for SPR and system thereof 失效
标题翻译： SPR测量方法及其系统
公开(公告)号：US08416416B2
公开(公告)日：2013-04-09
申请号：US12745444
申请日：2007-11-29
申请人： Zheng Zheng , Yuhang Wan , Xin Zhao , Jinsong Zhu , Jiangfeng Fan
发明人： Zheng Zheng , Yuhang Wan , Xin Zhao , Jinsong Zhu , Jiangfeng Fan
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： The invention provides an SPR measuring method and a measuring system thereof. According to the measuring method, first, a linear-polarized coherent broadband pulsed light beam is incident onto a surface of a sample under detection of a SPR sensing device to cause reflection; next, a time-domain monotonous chirp is performed on the incident coherent broadband pulsed light and/or the SPR reflected light; finally, the time-domain monotonically chirped SPR reflected light beam is detected, and information of the SPR effect is obtained according to the detected signal. According to the invention, the spectrum detection method used in conventional slow wavelength interrogation is converted into the high-speed real-time detection of time-domain pulse shape signals. Thus, the procedure of the SPR reaction may be monitored closely, and dynamical curves with very high time resolution may be obtained, in that case, fast biochemical reaction procedures may be monitored. As each part of the measuring system may remain fixed during the measurement, a compact, miniature and portable system may be realized. The interrogation part of the sensing system is easy-to-realize, of low cost and compatible with various SPR devices and components.
摘要翻译：本发明提供一种SPR测量方法及其测量系统。根据测量方法，首先，线性偏振相干宽带脉冲光束在SPR感测装置的检测下入射到样品的表面上以引起反射; 接下来，对入射相干宽带脉冲光和/或SPR反射光执行时域单调啁啾; 最后，检测到时域单调啁啾的SPR反射光束，并根据检测到的信号获得SPR效应的信息。根据本发明，在常规慢波询问中使用的频谱检测方法被转换成时域脉冲形状信号的高速实时检测。因此，可以密切监测SPR反应的过程，并且可以获得具有非常高的时间分辨率的动力学曲线，在这种情况下，可以监测快速的生化反应程序。由于测量系统的每个部分在测量期间都可能保持固定，因此可以实现紧凑，微型和便携式系统。传感系统的询问部分易于实现，成本低廉，与各种SPR设备和组件兼容。

2. 发明申请

US20100321697A1 MEASURING METHOD FOR SPR AND SYSTEM THEREOF 失效
标题翻译： SPR及其系统的测量方法
公开(公告)号：US20100321697A1
公开(公告)日：2010-12-23
申请号：US12745444
申请日：2007-11-29
申请人： Zheng Zheng , Yuhang Wan , Xin Zhao , Jinsong Zhu , Jiangfeng Fan
发明人： Zheng Zheng , Yuhang Wan , Xin Zhao , Jinsong Zhu , Jiangfeng Fan
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： The invention provides an SPR measuring method and a measuring system thereof. According to the measuring method, first, a linear-polarized coherent broadband pulsed light beam is incident onto a surface of a sample under detection of a SPR sensing device to cause reflection; next, a time-domain monotonous chirp is performed on the incident coherent broadband pulsed light and/or the SPR reflected light; finally, the time-domain monotonically chirped SPR reflected light beam is detected, and information of the SPR effect is obtained according to the detected signal. According to the invention, the spectrum detection method used in conventional slow wavelength interrogation is converted into the high-speed real-time detection of time-domain pulse shape signals. Thus, the procedure of the SPR reaction may be monitored closely, and dynamical curves with very high time resolution may be obtained, in that case, fast biochemical reaction procedures may be monitored. As each part of the measuring system may remain fixed during the measurement, a compact, miniature and portable system may be realized. The interrogation part of the sensing system is easy-to-realize, of low cost and compatible with various SPR devices and components.
摘要翻译：本发明提供一种SPR测量方法及其测量系统。根据测量方法，首先，线性偏振相干宽带脉冲光束在SPR感测装置的检测下入射到样品的表面上以引起反射; 接下来，对入射相干宽带脉冲光和/或SPR反射光执行时域单调啁啾; 最后，检测到时域单调啁啾的SPR反射光束，并根据检测到的信号获得SPR效应的信息。根据本发明，在常规慢波询问中使用的频谱检测方法被转换成时域脉冲形状信号的高速实时检测。因此，可以密切监测SPR反应的过程，并且可以获得具有非常高的时间分辨率的动力学曲线，在这种情况下，可以监测快速的生化反应程序。由于测量系统的每个部分在测量期间都可能保持固定，因此可以实现紧凑，微型和便携式系统。传感系统的询问部分易于实现，成本低廉，与各种SPR设备和组件兼容。

3. 发明申请

US20130114079A1 OPTICAL PHASE DEVICE, METHOD AND SYSTEM. 审中-公开
标题翻译：光相装置，方法与系统。
公开(公告)号：US20130114079A1
公开(公告)日：2013-05-09
申请号：US13809061
申请日：2011-10-12
申请人： Zheng Zheng , Yuhang Wan , Xin Zhao , Zhiting Lu , Jingyi Guan
发明人： Zheng Zheng , Yuhang Wan , Xin Zhao , Zhiting Lu , Jingyi Guan
IPC分类号： G02B5/30
CPC分类号： G02B5/3083 , G01N21/552 , G02B5/0833 , G02B27/283
摘要： The invention provides an optical phase device, method and system. The optical phase device consists of a transparent dielectric substrate, a multilayer stack of dielectrics and a buffer layer. The refractive index of the transparent dielectric substrate, the multilayer stack of dielectrics and the buffer layer are all larger than that of the external medium. For the wavelength of the incident beam, the optical phase device has a phase variation in the angular range [α, β] and the critical angle for total reflection on the interface between the buffer layer and the external medium adjacent to the buffer layer is γ, γ
摘要翻译：本发明提供一种光学相位装置，方法和系统。光学相位装置由透明电介质基底，多层电介质和缓冲层构成。透明电介质基板的折射率，多层电介质和缓冲层都大于外部介质的折射率。对于入射光束的波长，光学相位装置在角度范围[α，β]中具有相位变化，并且缓冲层和与缓冲层相邻的外部介质之间的界面上的全反射的临界角为γ ，γ<β。光学器件具有低损耗和较大的相位变化，导致Goos-Hanchen移位较大。作为色散补偿元件，它可以产生更大的可调分散体，通过调整结构中的操作角度或参数可以获得不同的色散补偿。

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