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1. 发明申请

US20070053903A1 Methods of using pHHLA2 to co-stimulate T-cells 审中-公开
标题翻译：使用pHHLA2共同刺激T细胞的方法
公开(公告)号：US20070053903A1
公开(公告)日：2007-03-08
申请号：US11433269
申请日：2006-05-12
申请人： Zeren Gao , Brian Fox , Steven Levin , Frederick Ramsdell , Edward Howard , Janine Bilsborough
发明人： Zeren Gao , Brian Fox , Steven Levin , Frederick Ramsdell , Edward Howard , Janine Bilsborough
IPC分类号： A61K48/00 , C07H21/04 , C12P21/06 , A61K39/395 , C07K16/28 , C07K14/74
CPC分类号： C07K14/47 , A61K38/00 , C07K16/2827 , C07K2317/73 , C07K2319/00 , C07K2319/30
摘要： The invention provides pHHLA2 co-receptor polypeptides and functional fragments, antibodies to same, isolated polynucleotides encoding same, vectors containing the polynucleotides, cells containing the vectors. Methods of making and using these co-stimulatory pHHLA2 co-receptors molecules are also disclosed.
摘要翻译：本发明提供pHHLA2辅助受体多肽和功能片段，对相同的编码相同的分离的多核苷酸的抗体，含有多核苷酸的载体，含有载体的细胞。还公开了制备和使用这些共刺激性pHHLA2共受体分子的方法。

2. 发明申请

US20070054360A1 Compositions and methods for modulating immune responses 审中-公开
标题翻译：用于调节免疫应答的组合物和方法
公开(公告)号：US20070054360A1
公开(公告)日：2007-03-08
申请号：US11433276
申请日：2006-05-12
申请人： Zeren Gao , Steven Levin , Janine Bilsborough , James West , Cameron Brandt , Frederick Ramsdell , Edward Howard , Erick Chadwick
发明人： Zeren Gao , Steven Levin , Janine Bilsborough , James West , Cameron Brandt , Frederick Ramsdell , Edward Howard , Erick Chadwick
IPC分类号： C12P21/06 , C07H21/04 , C07K14/705 , C07K16/30
CPC分类号： C07K16/2827 , A61K38/00 , A61K2039/507 , C07K14/47 , C07K14/70532 , C07K16/2803 , C07K16/2818 , C07K2317/34 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C12Q1/66 , G01N33/505 , G01N33/56972 , G01N2333/70532
摘要： The present invention provides a newly identified B7 receptor, zB7R1 that functions as lymphocyte inhibitory receptor, which is a PD-1-like molecule and is expressed on T cells. The present invention also provides the discovery of zB7R1's ability to bind to CD155. Methods and compositions for modulating zB7R1-mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic and research purposes are also provided.
摘要翻译：本发明提供新鉴定的B7受体，作为淋巴细胞抑制性受体的zB7R1，其是PD-1样分子，并在T细胞上表达。本发明还提供了zB7R1与CD155结合的能力的发现。还提供了用于调节zB7R1介导的负信号并干扰其反受体相互作用用于治疗，诊断和研究目的的方法和组合物。

3. 发明申请

US20070280942A1 COMPOSITIONS AND METHODS FOR MODULATING IMMUNE RESPONSES 审中-公开
标题翻译：用于调节免疫应答的组合物和方法
公开(公告)号：US20070280942A1
公开(公告)日：2007-12-06
申请号：US11748370
申请日：2007-05-14
申请人： Steven Levin , Frederick Ramsdell , Zeren Gao , Edward Howard , David Taft , Janet Johnston , Mark Rixon , LuAnne Hebb
发明人： Steven Levin , Frederick Ramsdell , Zeren Gao , Edward Howard , David Taft , Janet Johnston , Mark Rixon , LuAnne Hebb
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K38/00 , C07K14/70503 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention provides a newly identified CD28 family member that functions as lymphocyte inhibitory receptor termed pG6b, which is expressed on T cells. Methods and compositions for modulating pG6b-mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic, and research purposes are also provided.
摘要翻译：本发明提供了新鉴定的CD28家族成员，其作为在T细胞上表达的称为pG6b的淋巴细胞抑制性受体起作用。还提供了用于调节pG6b介导的负信号并干扰其用于治疗，诊断和研究目的的反向受体相互作用的方法和组合物。

4. 发明申请

US20070190166A1 Processes for making selectively permeable laminates 失效
标题翻译：制备选择性渗透层压板的方法
公开(公告)号：US20070190166A1
公开(公告)日：2007-08-16
申请号：US11593777
申请日：2006-11-07
申请人： Edward Howard , Ralph Lloyd , Ronald McKinney , Bryan Sauer , Mark Weinberg
发明人： Edward Howard , Ralph Lloyd , Ronald McKinney , Bryan Sauer , Mark Weinberg
IPC分类号： A61K35/64
CPC分类号： B23B27/12 , A61K31/722 , A62D5/00 , B32B5/022 , B32B5/024 , B32B9/00 , B32B9/02 , B32B9/047 , B32B27/12 , B32B2262/0261 , B32B2262/0269 , B32B2262/062 , B32B2307/714 , B32B2307/7145 , B32B2307/724 , B32B2437/00 , C08J5/18 , C08J2305/08 , Y02A50/471
摘要： Processes for fabricating selectively permeable laminates are provided. In various embodiments, the laminates are useful for fabrication as a protective article and are substantially impermeable to hazardous chemical and biological agents, but sufficiently permeable to water vapor that, if worn as protective apparel, it is both protective and comfortable to wear.
摘要翻译：提供了制造选择性渗透层压板的方法。在各种实施方案中，层压体可用作制造为保护制品，并且对于危险的化学和生物制剂基本上是不可渗透的，但是对于水蒸汽充分渗透，如果作为保护性服装穿着，则它既保护又舒适。

5. 发明申请

US20050119357A1 Compositions containing particles of highly fluorinated ion exchange polymer 失效
公开(公告)号：US20050119357A1
公开(公告)日：2005-06-02
申请号：US11032779
申请日：2005-01-11
申请人： Dennis Curtin , Edward Howard
发明人： Dennis Curtin , Edward Howard
IPC分类号： C08J7/04 , B01J39/16 , C08J3/03 , C08J3/09 , C08J3/16 , C08J5/18 , C08L27/18 , D01F6/32 , C08J5/20
CPC分类号： C08J3/16 , C08J5/18 , C08J2327/12 , C08J2327/18 , D01F6/32
摘要： Solid and liquid compositions containing particles of highly fluorinated ion-exchange polymer having sulfonate functional groups with an ion exchange ratio of less than about 33. The compositions contain at least about 25% by weight of polymer particles having a particle size of about 2 nm to about 30 nm.

6. 发明申请

US20060205893A1 Barrier films of polyurethane/polyalkylamine polymer compositions and processes for making same 审中-公开
标题翻译：聚氨酯/聚烷基胺聚合物组合物的阻隔膜及其制备方法
公开(公告)号：US20060205893A1
公开(公告)日：2006-09-14
申请号：US11079561
申请日：2005-03-14
申请人： Edward Howard , Ralph Lloyd , Ronald McKinney , Bryan Sauer
发明人： Edward Howard , Ralph Lloyd , Ronald McKinney , Bryan Sauer
IPC分类号： C08G69/48 , C08F283/04
CPC分类号： C08L75/04 , C08L79/02 , C08L2666/20
摘要： This invention relates to a barrier film useful in protective apparel and structures, and a process for making said film; the film comprising a polyurethane network having a polyalkylamine incorporated therein, wherein the film, after contact with boiling water for 5 minutes, has less than a 50 percent loss in weight of the polyalkylamine.
摘要翻译：本发明涉及可用于保护性服装和结构的阻挡膜及其制造方法。所述膜包含其中并入有聚烷基胺的聚氨酯网络，其中所述膜在与沸水接触5分钟后具有少于多烷基胺重量损失的50％。

7. 发明申请

US20060205300A1 Laminates made from polyurethane/polyalkylamine polymer compositions and processes for making same 审中-公开
标题翻译：由聚氨酯/聚烷基胺聚合物组合物制成的层压板及其制造方法
公开(公告)号：US20060205300A1
公开(公告)日：2006-09-14
申请号：US11079124
申请日：2005-03-14
申请人： Edward Howard , Ralph Lloyd , Ronald McKinney , Bryan Sauer
发明人： Edward Howard , Ralph Lloyd , Ronald McKinney , Bryan Sauer
IPC分类号： B32B5/02 , B32B27/12 , B32B3/00
CPC分类号： B32B27/281 , B32B5/022 , B32B5/024 , B32B27/12 , B32B27/40 , B32B2255/10 , B32B2255/26 , B32B2262/0269 , B32B2270/00 , B32B2307/554 , B32B2307/734 , B32B2437/00 , B32B2459/00 , Y10T442/20 , Y10T442/273
摘要： This invention relates to a laminate useful in protective apparel and structures, and processes for making said laminate, the laminate comprising i) a polymer barrier layer comprising a polyurethane network having a polyalkylamine incorporated therein; and ii) a support substrate; wherein the laminate, after contact with boiling water for 5 minutes, has less than a 20 percent loss in weight of the polyalkylamine.
摘要翻译：本发明涉及可用于保护性服装和结构的层压材料，以及制造所述层压材料的方法，所述层压体包含i）聚合物阻挡层，其包含聚合物网络，其中并入有多烷基胺; 和ii）支撑衬底; 其中层压体在与沸水接触5分钟后具有少于20重量％的多烷基胺重量损失。

8. 发明授权

US07534516B2 Solid polymer membrane for fuel cell with polyamine imbibed therein for reducing methanol permeability 失效
标题翻译：用于燃料电池的固体聚合物膜，其中吸收多胺以降低甲醇渗透性
公开(公告)号：US07534516B2
公开(公告)日：2009-05-19
申请号：US10488910
申请日：2002-10-15
申请人： Edward Howard
发明人： Edward Howard
IPC分类号： H01M8/10
CPC分类号： B01D67/0088 , B01D69/141 , B01D71/32 , B01J35/065 , C08J5/2237 , C08J5/2281 , C08J5/2293 , C08J2327/18 , H01M4/8605 , H01M4/881 , H01M4/8817 , H01M4/921 , H01M4/926 , H01M8/04197 , H01M8/1004 , H01M8/1009 , H01M8/1023 , H01M8/103 , H01M8/1039 , H01M8/1044 , H01M2300/0082 , H01M2300/0091
摘要： The present invention provides for a solid polymer electrolyte membrane having a fluorinated ionomer having imbibed therein a non-fluorinated, non-ionomeric polymer, wherein the fluorinated ionomer comprises at least 6 mole % of monomer units having a fluorinated pendant group with a terminal ionic group, and wherein the non-ionomeric polymer is selected from the group consisting of a polyamine, a polyvinyl amine, and derivatives thereof. The invention also provides a catalyst coated membrane and a fuel cell having this solid polymer electrolyte membrane.
摘要翻译：本发明提供了一种固体聚合物电解质膜，其具有在其中吸收非氟化非离聚物聚合物的氟化离聚物，其中氟化离聚物包含至少6摩尔％的带有末端离子基团的氟化侧基的单体单元，并且其中所述非离聚物聚合物选自多胺，聚乙烯胺及其衍生物。本发明还提供一种催化剂涂覆膜和具有该固体聚合物电解质膜的燃料电池。

9. 发明申请

US20060205299A1 Polyurethane/polyalkylamine polymer compositions and process for making same 审中-公开
标题翻译：聚氨酯/聚烷基胺聚合物组合物及其制备方法
公开(公告)号：US20060205299A1
公开(公告)日：2006-09-14
申请号：US11079121
申请日：2005-03-14
申请人： Edward Howard , Ralph Lloyd , Ronald McKinney , Bryan Sauer
发明人： Edward Howard , Ralph Lloyd , Ronald McKinney , Bryan Sauer
IPC分类号： B32B5/02
CPC分类号： C08L75/04 , B32B5/02 , B32B5/022 , B32B5/024 , B32B27/08 , B32B27/12 , B32B27/281 , B32B27/34 , B32B27/40 , B32B2255/10 , B32B2255/26 , B32B2262/0269 , B32B2270/00 , B32B2307/554 , B32B2307/734 , B32B2437/00 , B32B2459/00 , C08L79/02 , C09D5/02 , C09D175/04 , Y10T442/20 , C08L2666/14 , C08L2666/20
摘要： This invention relates to a polymer composition useful as a chemical barrier, and films, laminates, and articles comprising the polymer composition and methods for making the polymer composition; the polymer composition comprising: a polyurethane network having a polyalkylamine incorporated therein, wherein the polymer composition, after contact with boiling water for 5 minutes, has less than a 50 percent loss in weight of the polyalkylamine.
摘要翻译：本发明涉及可用作化学屏障的聚合物组合物，以及包含聚合物组合物和制备聚合物组合物的方法的膜，层压材料和制品; 所述聚合物组合物包含：聚氨酯网络，其中并入有聚烷基胺，其中所述聚合物组合物在与沸水接触5分钟后具有少于所述聚烷基胺重量的50％的损失。

10. 发明授权

US4831889A Conical worm gear for a multi-speed bicycle drive mechanism 失效
标题翻译：用于多速自行车驱动机构的锥形蜗轮
公开(公告)号：US4831889A
公开(公告)日：1989-05-23
申请号：US194972
申请日：1988-05-17
申请人： Edward Howard
发明人： Edward Howard
IPC分类号： B62M17/00 , F16H3/06
CPC分类号： B62M17/00 , F16H3/06 , Y10T74/1934 , Y10T74/19833
摘要： A multi-speed chainless drive mechanism for a cycle-type vehicle comprises a drive shaft rotatably driven by a pedal actuated gear train. The drive shaft, which includes a universal joint, extends away from the gear train. The drive mechanism also comprises a first support provided intermediate the gear train and the universal joint for rotatably supporting the drive shaft to a frame of the vehicle. An elongated shaft extends from the universal joint opposite the gear train. A variable ratio worm gear, more particularly a cone-shaped worm gear, has an opening defined centrally and longitudinally therethrough. The worm gear is slidably mounted on the elongated shaft and is adapted for rotation therewith. The worm gear meshes with a drive gear mounted to a drive wheel of the vehicle. Different gear ratios are thus provided in relation to the longitudinal position of the worm gear on the elongated shaft. The drive mechanism also comprises a gear shifting device for moving the worm gear along the elongated shaft and for constantly maintaining the worm gear and the drive gear in a mesh.
摘要翻译：用于循环型车辆的多速无链驱动机构包括由踏板致动齿轮系可旋转地驱动的驱动轴。包括万向接头的传动轴远离齿轮系。驱动机构还包括设置在齿轮系中间的第一支撑件和用于将驱动轴可旋转地支撑到车辆框架的万向接头。细长轴从与齿轮系相对的万向接头延伸。可变比蜗杆，更具体地是锥形蜗轮具有中心并纵向穿过其中的开口。蜗轮可滑动地安装在细长轴上并适于与其一起旋转。蜗轮与安装在车辆驱动轮上的驱动齿轮啮合。因此，相对于细长轴上的蜗轮的纵向位置提供不同的齿轮比。驱动机构还包括用于沿着细长轴移动蜗轮并且用于将蜗轮和驱动齿轮恒定地保持在网中的换档装置。

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