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1. 发明申请

WO2015070019A1 MICROPOROUS ZIRCONIUM SILICATE FOR THE TREATMENT OF HYPERKALEMIA 审中-公开
标题翻译：用于治疗高血压的微量硅酸锌
公开(公告)号：WO2015070019A1
公开(公告)日：2015-05-14
申请号：PCT/US2014/064548
申请日：2014-11-07
申请人： ZS PHARMA, INC.
发明人： KEYSER, Donald Jeffrey , GUILLEM, Alvaro F.
IPC分类号： A61K9/14 , B01J39/14 , A61K33/24 , C07F7/02
CPC分类号： A61K33/24 , A61K9/14 , A61K9/20 , A61K9/2054 , B01J20/10 , B01J39/14
摘要： The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects. The preferred composition has at least 95% ZS-9. These compositions are particularly useful in the therapeutic treatment of hyperkalemia. These compositions are also useful in the treatment of chronic kidney disease, coronary vascular disease, diabetes mellitus, and transplant rejection.
摘要翻译：本发明涉及配制成去除毒素的新型微孔硅酸锆组合物，例如，钾离子，来自胃肠道以升高的速率，而不引起不期望的副作用。优选的组合物具有至少95％的ZS-9。这些组合物特别可用于治疗高钾血症。这些组合物也可用于治疗慢性肾脏疾病，冠状动脉血管疾病，糖尿病和移植排斥。

2. 发明申请

WO2017066128A1 EXTENDED USE ZIRCONIUM SILICATE COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：延伸使用的硅酸锆硅酸盐组合物及其使用方法
公开(公告)号：WO2017066128A1
公开(公告)日：2017-04-20
申请号：PCT/US2016/056286
申请日：2016-10-10
申请人： ZS PHARMA, INC.
发明人： KEYSER, Donald Jeffrey , GUILLEM, Alvaro F.
IPC分类号： C07F7/02
CPC分类号： A61K33/24 , A61K9/0053 , A61K9/14 , A61K9/16 , B01J39/02 , B01J39/14 , C01B39/02
摘要： The present invention relates to zirconium silicate compositions having a lead content that is below 0.6 ppm and methods of manufacturing zirconium silicate at reactor volumes exceeding 200-L with a lead content below 1.1 ppm. The lead content of the zirconium silicate of this invention are within the levels that are considered acceptable for extended use given the dose requirements for zirconium silicate.
摘要翻译：本发明涉及铅含量低于0.6ppm的硅酸锆组合物和在反应器体积超过200-L且铅含量低于1.1ppm的情况下制造硅酸锆的方法。考虑到硅酸锆的剂量要求，本发明的硅酸锆的铅含量在被认为可以接受的延长使用水平内。

3. 发明申请

WO2015070015A1 MICROPOROUS ZIRCONIUM SILICATE FOR THE TREATMENT OF HYPERKALEMIA 审中-公开
标题翻译：用于治疗高血压的微量硅酸锌
公开(公告)号：WO2015070015A1
公开(公告)日：2015-05-14
申请号：PCT/US2014/064542
申请日：2014-11-07
申请人： ZS PHARMA, INC.
发明人： KEYSER, Donald Jeffrey , GUILLEM, Alvaro F.
IPC分类号： A61K9/14 , A61K33/24 , C07F7/02
CPC分类号： A61K33/24 , A61K9/0095 , A61K9/16 , A61K9/2054 , A61K33/00 , B01J39/14
摘要： The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects. The preferred formulations are designed avoid increase in pH of urine in patients and/or avoid potential entry of particles into the bloodstream of the patient. Also disclosed is a method for preparing high purity crystals of ZS-9 exhibiting an enhanced level of potassium exchange capacity. These compositions are particularly useful in the therapeutic treatment of hyperkalemia. These compositions are also useful in the treatment of chronic kidney disease, coronary vascular disease, diabetes mellitus, and transplant rejection.
摘要翻译：本发明涉及配制成去除毒素的新型微孔硅酸锆组合物，例如，钾离子，来自胃肠道以升高的速率，而不引起不期望的副作用。设计优选的制剂避免了患者尿液pH值的增加和/或避免颗粒潜在地进入患者的血液中。还公开了一种制备表现出提高钾交换容量水平的ZS-9的高纯度晶体的方法。这些组合物特别可用于治疗高钾血症。这些组合物也可用于治疗慢性肾脏疾病，冠状动脉血管疾病，糖尿病和移植排斥。

4. 发明申请

WO2014165670A1 MICROPOROUS ZIRCONIUM SILICATE AND DIURETICS FOR THE REDUCTION OF POTASSIUM AND TREATMENT OF CHRONIC KIDNEY AND/OR CHRONIC HEART DISEASE 审中-公开
标题翻译：用于减少钾肥和治疗慢性寄生虫和/或慢性心脏疾病的微生物硅酸锌和抗微生物剂
公开(公告)号：WO2014165670A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/032815
申请日：2014-04-03
申请人： ZS PHARMA, INC.
发明人： KEYSER, Donald Jeffrey , GUILLEM, Alvaro F.
IPC分类号： A61K33/24
CPC分类号： A61K33/24 , A61K9/16 , A61K31/4184 , A61K38/06 , A61K45/06 , C01B39/00 , Y02A50/471 , Y02A50/475 , Y02A50/483 , A61K2300/00
摘要： The present invention relates to novel methods of using microporous zirconium silicate to reduce the risk of hyperkalemia and to lower aldosterone levels in the treatment of chronic kidney disease and/or chronic heart disease with therapies comprising diuretics. The invention provides a safe way to reduce the risk of hyperkalemia and to lower aldosterone. The invention also relates to treatment of other conditions that can occur either alone or in connection with hyperkalemia, chronic kidney disease, and/or chronic heart disease.
摘要翻译：本发明涉及使用微孔硅酸锆降低高钾血症风险的新方法，并且通过包含利尿剂的疗法来治疗慢性肾脏疾病和/或慢性心脏病方面降低醛固酮水平。本发明提供了降低高钾血症和降低醛固酮的风险的安全方法。本发明还涉及可以单独或与高钾血症，慢性肾脏疾病和/或慢性心脏病有关的其它病症的治疗。

5. 发明申请

WO2015089174A1 ZIRCONIUM SILICATE FOR TREATING HYPERKALEMIA WITHOUT CO-ADMINISTERING LITHIUM 审中-公开
标题翻译：用于处理没有共同施用锂离子的高锰酸钡的硅酸锌
公开(公告)号：WO2015089174A1
公开(公告)日：2015-06-18
申请号：PCT/US2014/069524
申请日：2014-12-10
申请人： ZS PHARMA, INC.
发明人： KEYSER, Donald Jeffrey , GUILLEM, Alvaro F.
IPC分类号： A61K33/24 , A61M1/36 , B01J39/02
CPC分类号： A61K33/24 , A61K9/0095 , A61K9/10 , B01J39/14
摘要： The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects. The preferred formulations are designed avoid increase in pH of urine in patients and/or avoid potential entry of particles into the bloodstream of the patient. The present invention also relates to the use of the microporous zirconium silicate compositions in the treatment of diseases, where the subject is not concurrently receiving lithium based drugs. Also disclosed is a method for preparing high purity crystals of ZS-9 exhibiting an enhanced level of potassium exchange capacity. These compositions are particularly useful in the therapeutic treatment of hyperkalemia.
摘要翻译：本发明涉及配制成去除毒素的新型微孔硅酸锆组合物，例如，钾离子，来自胃肠道以升高的速率，而不引起不期望的副作用。设计优选的制剂避免了患者尿液pH值的增加和/或避免颗粒潜在地进入患者的血液中。本发明还涉及微孔硅酸锆组合物在治疗疾病中的用途，其中受试者不同时接受锂基药物。还公开了一种制备表现出提高钾交换容量水平的ZS-9的高纯度晶体的方法。这些组合物特别可用于治疗高钾血症。

6. 发明申请

WO2014066407A1 MICROPOROUS ZIRCONIUM SILICATE FOR TREATING HYPERKALEMIA 审中-公开
标题翻译：用于处理HYPERKALEMIA的微波硅酸锌
公开(公告)号：WO2014066407A1
公开(公告)日：2014-05-01
申请号：PCT/US2013/066207
申请日：2013-10-22
申请人： ZS PHARMA, INC.
发明人： KEYSER, Donald Jeffrey , GUILLEM, Alvaro F.
IPC分类号： A61K33/24 , B01J19/18 , C01B33/24
CPC分类号： A61K33/24 , A61K9/143 , A61K33/00 , A61K45/06 , B01J19/0013 , B01J19/006 , B01J19/18 , B01J39/02 , B01J39/14 , B01J2219/00063 , B01J2219/00094 , B01J2219/00768 , C01B33/20 , C01B39/00 , C07F7/025 , Y02A50/471 , Y02A50/475 , Y02A50/483 , A61K2300/00
摘要： The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects. The preferred formulations are designed avoid increase in pH of urine in patients and/or avoid potential entry of particles into the bloodstream of the patient. Also disclosed is a method for preparing high purity crystals of ZS-9 exhibiting an enhanced level of potassium exchange capacity. These compositions are particularly useful in the therapeutic treatment of hyperkalemia.
摘要翻译：本发明涉及配制成去除毒素的新型微孔硅酸锆组合物，例如，钾离子，来自胃肠道以升高的速率，而不引起不期望的副作用。设计优选的制剂避免了患者尿液pH值的增加和/或避免颗粒潜在地进入患者的血液中。还公开了一种制备表现出提高钾交换容量水平的ZS-9的高纯度晶体的方法。这些组合物特别可用于治疗高钾血症。

7. 发明公开

EP3065709A1 MICROPOROUS ZIRCONIUM SILICATE FOR THE TREATMENT OF HYPERKALEMIA 无效转让
标题翻译：琉璃苣
公开(公告)号：EP3065709A1
公开(公告)日：2016-09-14
申请号：EP14860097.6
申请日：2014-11-07
申请人： ZS Pharma, Inc
发明人： KEYSER, Donald Jeffrey , GUILLEM, Alvaro F.
IPC分类号： A61K9/14 , A61K33/24 , C07F7/02
CPC分类号： A61K33/24 , A61K9/0095 , A61K9/16 , A61K9/2054 , A61K33/00 , B01J39/14
摘要： The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects. The preferred formulations are designed avoid increase in pH of urine in patients and/or avoid potential entry of particles into the bloodstream of the patient. Also disclosed is a method for preparing high purity crystals of ZS-9 exhibiting an enhanced level of potassium exchange capacity. These compositions are particularly useful in the therapeutic treatment of hyperkalemia. These compositions are also useful in the treatment of chronic kidney disease, coronary vascular disease, diabetes mellitus, and transplant rejection.
摘要翻译：本发明涉及新型微孔硅酸锆组合物，其被配制成去除毒素，例如，钾离子，以升高的速率来自胃肠道，而不引起不期望的副作用。优选的制剂被设计为避免了患者尿液pH值的增加和/或避免了颗粒进入患者血液中的可能性。还公开了一种制备表现出提高的钾交换容量水平的ZS-9的高纯度晶体的方法。这些组合物特别可用于治疗高钾血症。这些组合物也可用于治疗慢性肾脏疾病，冠状动脉血管疾病，糖尿病和移植排斥。

8. 发明公开

EP3362456A1 EXTENDED USE ZIRCONIUM SILICATE COMPOSITIONS AND METHODS OF USE THEREOF 审中-实审
公开(公告)号：EP3362456A1
公开(公告)日：2018-08-22
申请号：EP16856007.6
申请日：2016-10-10
申请人： ZS Pharma, Inc.
发明人： KEYSER, Donald Jeffrey , GUILLEM, Alvaro F.
IPC分类号： C07F7/02
CPC分类号： A61K33/24 , A61K9/0053 , A61K9/14 , A61K9/16 , B01J39/02 , B01J39/14 , C01B39/02
摘要： The present invention relates to zirconium silicate compositions having a lead content that is below 0.6 ppm and methods of manufacturing zirconium silicate at reactor volumes exceeding 200-L with a lead content below 1.1 ppm. The lead content of the zirconium silicate of this invention are within the levels that are considered acceptable for extended use given the dose requirements for zirconium silicate.

9. 发明公开

EP3079706A1 ZIRCONIUM SILICATE FOR TREATING HYPERKALEMIA WITHOUT CO-ADMINISTERING LITHIUM 无效
标题翻译：硅酸锆用于治疗高钾血症无锂同时给予
公开(公告)号：EP3079706A1
公开(公告)日：2016-10-19
申请号：EP14869060.5
申请日：2014-12-10
申请人： ZS Pharma, Inc
发明人： KEYSER, Donald Jeffrey , GUILLEM, Alvaro F.
IPC分类号： A61K33/24 , A61M1/16 , B01J39/02
CPC分类号： A61K33/24 , A61K9/0095 , A61K9/10 , B01J39/14
摘要： The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects. The preferred formulations are designed avoid increase in pH of urine in patients and/or avoid potential entry of particles into the bloodstream of the patient. The present invention also relates to the use of the microporous zirconium silicate compositions in the treatment of diseases, where the subject is not concurrently receiving lithium based drugs. Also disclosed is a method for preparing high purity crystals of ZS-9 exhibiting an enhanced level of potassium exchange capacity. These compositions are particularly useful in the therapeutic treatment of hyperkalemia.

10. 发明公开

EP3065710A1 MICROPOROUS ZIRCONIUM SILICATE FOR THE TREATMENT OF HYPERKALEMIA 无效
标题翻译：微孔硅酸锆用于治疗高血压
公开(公告)号：EP3065710A1
公开(公告)日：2016-09-14
申请号：EP14860387.1
申请日：2014-11-07
申请人： ZS Pharma, Inc
发明人： KEYSER, Donald Jeffrey , GUILLEM, Alvaro F.
IPC分类号： A61K9/14 , B01J39/14 , A61K33/24 , C07F7/02
CPC分类号： A61K33/24 , A61K9/14 , A61K9/20 , A61K9/2054 , B01J20/10 , B01J39/14
摘要： The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects. The preferred composition has at least 95% ZS-9. These compositions are particularly useful in the therapeutic treatment of hyperkalemia. These compositions are also useful in the treatment of chronic kidney disease, coronary vascular disease, diabetes mellitus, and transplant rejection.
摘要翻译：本发明涉及新的微孔硅酸锆组合物，其被配制成去除毒素，来自胃肠道的钾离子以升高的速率而不引起不希望的副作用。优选的组合物具有至少95％的ZS-9。这些组合物在高钾血症的治疗性治疗中特别有用。这些组合物还可用于治疗慢性肾病，冠状血管疾病，糖尿病和移植排斥。

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