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1. 发明专利

ITMI20010779D0 未知
公开(公告)号：ITMI20010779D0
公开(公告)日：2001-04-12
申请号：ITMI20010779
申请日：2001-04-12
申请人： ZOPPETTI GIORGIO , UNI DEGLI STUDI BRESCIA , ORESTE PASQUA ANNA
发明人： ZOPPETTI GIORGIO , PRESTA MARCO , ORESTE PASQUA ANNA
IPC分类号： A61K31/737 , A61P17/06 , A61P29/00 , A61P35/00

2. 发明专利

ITMI20010779A1 未知
公开(公告)号：ITMI20010779A1
公开(公告)日：2002-10-14
申请号：ITMI20010779
申请日：2001-04-12
申请人： ZOPPETTI GIORGIO , UNI DEGLI STUDI BRESCIA , ORESTE PASQUA ANNA
发明人： ZOPPETTI GIORGIO , PRESTA MARCO , ORESTE PASQUA ANNA
IPC分类号： A61K31/737 , A61P17/06 , A61P29/00 , A61P35/00

3. 发明申请

WO03106505A9 PROCESS FOR THE MANUFACTURE OF N-ACYL-(EPI)K5-AMINE-O-SULFATE-DERIVATIVES AND PRODUCTS THUS OBTAINED 审中-公开
标题翻译：制备N-亚氨基 - （EPI）K5-氨基-O-硫酸酯衍生物和获得的产品的方法
公开(公告)号：WO03106505A9
公开(公告)日：2004-02-26
申请号：PCT/IB0302339
申请日：2003-06-17
申请人： ORESTE PASQUA ANNA , ZOPPETTI GIORGIO
发明人： ORESTE PASQUA ANNA , ZOPPETTI GIORGIO
IPC分类号： A61K8/60 , A61K8/72 , A61K8/73 , A61K31/726 , A61K31/727 , A61K31/737 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/00 , A61P17/06 , A61P17/16 , A61P19/02 , A61P27/02 , A61P27/06 , A61P31/12 , A61P35/00 , A61P35/04 , A61P39/06 , A61P43/00 , C07H1/00 , C08B37/00 , C08B37/10 , C08B37/08
CPC分类号： A61K31/726 , A61K31/727 , A61K31/737 , C07H1/00 , C08B37/006 , C08B37/0075 , C08B37/0078
摘要： A new method is described for the oversulfation of (epi)KS-N-sulfates to obtain (epi)K5-amine-O-oversulfates at extremely high degree of sulfation and for the transformation of these intermediates into new Nacyl-(epi)K5-amine-O-oversulfates basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are pharmaceutical compositions containing, as one of their active ingredients, an (epi)K5-amine-O-oversulfate.
摘要翻译：描述了一种用于（epi）KS-N-硫酸盐过硫酸盐以获得（epi）极高硫酸化程度的（表面）K 5 - 胺 - O-硫酸盐和将这些中间体转化成新的Nacyl-（epi）K5的新方法 - 胺 - 过硫酸盐基本上没有凝血参数的活性，并且在化妆品或制药领域中有用。还描述了含有作为其活性成分之一的（epi）K5-胺-O-过硫酸盐的药物组合物。

4. 发明申请

WO2005058976A3 LOW MOLECULAR POLYSACCHARIDES HAVING ANTITHROMBOTIC ACTIVITY 审中-公开
标题翻译：具有抗血栓活性的低分子多糖
公开(公告)号：WO2005058976A3
公开(公告)日：2005-08-04
申请号：PCT/IB2004004128
申请日：2004-12-15
申请人： GLYCORES 2000 SRL , ORESTE PASQUA ANNA , ZOPPETTI GIORGIO
发明人： ORESTE PASQUA ANNA , ZOPPETTI GIORGIO
IPC分类号： A61K31/726 , A61K31/727 , A61K31/737 , C08B37/00 , C08B37/10
CPC分类号： C08B37/0063
摘要： depolymerized-LMWepiK5-N,O-sulfates obtainable starting from a LMWepiK5-N-sulfate prepared by nitrous depolymerization of an epiK5-N-sulfate or by C5-epimerization of a LMW-K5-N-sulfate obtained by nitrous depolymerization of a K5-N-sulfate. A process consists of submitting the starting depolymerized-LMW-epiK5-N-sulfate to four steps: an O-oversulfation, a partial 0-desulfation, a 6-0-sulfation and a N-sulfation. The depolymerizedLMWepiK5-N,O-sulfates present a di- or trisulfated 2,5-anhydromannitol unit at the reducing end of the majority of its chains, have a content of iduronic acid of 40-60%, a sulfation degree of from 2.3 to 2.9 and a mean molecular weight of from about 1,500 to about 12,000. They exhibit a good antithrombotic activity with a low pro-hemorrhagic risk.
摘要翻译：解聚的LMWepiK5-N，O-硫酸盐，可从通过epiK5-N-硫酸盐的亚硝解聚制备的LMWepiK5-N-硫酸盐或通过K5的亚硝解聚得到的LMW-K5-N-硫酸盐的C5差向异构体 -N-硫酸盐。一个过程包括将起始解聚的LMW-epiK5-N-硫酸盐提交到四个步骤：O-过硫酸盐，部分O-脱硫，6-0-硫酸化和N-硫酸化。解聚的MWepiK5-N，O-硫酸盐在其大部分链的还原末端呈现二硫酸化或三硫酸化的2,5-脱水甘露糖醇单元，其具有40-60％的艾杜糖醛酸含量，硫酸化度为2.3至 2.9，平均分子量为约1,500至约12,000。它们具有良好的抗血栓形成活性，具有低的出血性风险。

5. 发明专利

AU2002236118B2 Highly sulfated derivatives of K5 polysaccharide and their preparation 未知
公开(公告)号：AU2002236118B2
公开(公告)日：2007-05-10
申请号：AU2002236118
申请日：2002-02-26
申请人： ORESTE PASQUA ANNA , ZOPPETTI GIORGIO
发明人： ORESTE PASQUA ANNA , ZOPPETTI GIORGIO
IPC分类号： A61K8/60 , A61K8/73 , A61K31/737 , A61P35/04 , C08B37/00
摘要： The purification of the E. coli K5 polysaccharide by treatment with isopropyl alcohol and elimination of lipophilic substances is described. The purified product can be used to prepare, after N-deacetylation, new N,O-sulfated polysaccharides with high degree of sulfation.

6. 发明专利

ITMI20011633D0 未知
公开(公告)号：ITMI20011633D0
公开(公告)日：2001-07-27
申请号：ITMI20011633
申请日：2001-07-27
申请人： SAN RAFFAELE CENTRO FOND , ZOPPETTI GIORGIO , ORESTE PASQUA ANNA
发明人： ZOPPETTI GIORGIO , ORESTE PASQUA ANNA , POLI GUIDO , VICENZI ELISA
IPC分类号： A61K31/737 , A61P31/18 , A61P37/04 , C08B37/00
摘要： The present invention relates to the use of N,O oversulfated K5 derivatives having a degree of sulfation higher than 3.2 or of their pharmaceutically acceptable salts for the preparation of pharmaceutical compositions for treating the infection and the consequent HIV/ADS disease.

7. 发明专利

CA2454945A1 USE OF OVERSULFATED POLYSACCHARIDES AS INHIBITORS OF HIV 未知
公开(公告)号：CA2454945A1
公开(公告)日：2003-02-13
申请号：CA2454945
申请日：2002-07-26
申请人： SAN RAFFAELE CENTRO FOND , ORESTE PASQUA ANNA , ZOPPETTI GIORGIO
发明人： VICENZI ELISA , POLI GUIDO , ORESTE PASQUA ANNA , ZOPPETTI GIORGIO
IPC分类号： A61K31/737 , A61P31/18 , A61P37/04 , C08B37/00
摘要： The present invention relates to the use of N,O oversulfated K5 derivatives having a degree of sulfation higher than 3.2 or of their pharmaceutically acceptable salts for the preparation of pharmaceutical composition s for treating the infection and the consequent HIV/AIDS disease.

8. 发明专利

CA2439337C HIGHLY SULFATED DERIVATIVES OF K5 POLYSACCHARIDE AND THEIR PREPARATION 未知
公开(公告)号：CA2439337C
公开(公告)日：2011-04-26
申请号：CA2439337
申请日：2002-02-26
申请人： ZOPPETTI GIORGIO , ORESTE PASQUA ANNA
发明人： ZOPPETTI GIORGIO , ORESTE PASQUA ANNA
IPC分类号： A61K8/60 , C08B37/00 , A61K8/73 , A61K31/715 , A61K31/737 , A61P35/04
摘要： The purification of the E.coli K5 polysaccharide by treatment with isopropyl alcohol and elimination of lipophilic substances is described. The purified product can be used to prepare, after N-deacetylation, new N,O-sulfated polysaccharides with high degree of sulfation.

9. 发明专利

CA2439337A1 HIGHLY SULFATED DERIVATIVES OF K5 POLYSACCHARIDE AND THEIR PREPARATION 未知
公开(公告)号：CA2439337A1
公开(公告)日：2002-09-06
申请号：CA2439337
申请日：2002-02-26
申请人： ZOPPETTI GIORGIO , ORESTE PASQUA ANNA
发明人： ZOPPETTI GIORGIO , ORESTE PASQUA ANNA
IPC分类号： A61K8/60 , A61K8/73 , A61K31/737 , A61P35/04 , C08B37/00 , A61K31/715
摘要： The purification of the E.coli K5 polysaccharide by treatment with isopropyl alcohol and elimination of lipophilic substances is described. The purified product can be used to prepare, after N-deacetylation, new N,O-sulfated polysaccharides with high degree of sulfation.

10. 发明专利

ITMI20010397A1 未知
公开(公告)号：ITMI20010397A1
公开(公告)日：2002-08-27
申请号：ITMI20010397
申请日：2001-02-27
申请人： ZOPPETTI GIORGIO , ORESTE PASQUA ANNA
发明人： ZOPPETTI GIORGIO , ORESTE PASQUA ANNA
IPC分类号： A61K8/60 , A61K8/73 , A61K31/737 , A61P35/04 , C08B37/00
摘要： The purification of the E. coli K5 polysaccharide by treatment with isopropyl alcohol and elimination of lipophilic substances is described. The purified product can be used to prepare, after N-deacetylation, new N,O-sulfated polysaccharides with high degree of sulfation.

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