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1. 发明申请

WO2020081991A2 CONTROLLING BLOOD TEMPERATURE IN EXTRACORPOREAL SYSTEMS 审中-公开
公开(公告)号：WO2020081991A2
公开(公告)日：2020-04-23
申请号：PCT/US2019/057022
申请日：2019-10-18
申请人： ZOLL CIRCULATION, INC. , HELKOWSKI, Richard , BUCKLEY, John Thomas , MAZZONE, James D. , DABROWIAK, Jeremy Thomas
发明人： HELKOWSKI, Richard , BUCKLEY, John Thomas , MAZZONE, James D. , DABROWIAK, Jeremy Thomas
IPC分类号： A61M1/16 , A61M1/36
摘要： Devices, systems and methods for warming or cooling blood or other fluids as they circulate through an extracorporeal circuit.

2. 发明申请

WO2020081995A2 HEAT EXCHANGE IN EXTRACORPOREAL SYSTEMS 审中-公开
公开(公告)号：WO2020081995A2
公开(公告)日：2020-04-23
申请号：PCT/US2019/057028
申请日：2019-10-18
申请人： ZOLL CIRCULATION, INC. , HELKOWSKI, Richard , BUCKLEY, John Thomas , MAZZONE, James D. , DABROWIAK, Jeremy Thomas
发明人： HELKOWSKI, Richard , BUCKLEY, John Thomas , MAZZONE, James D. , DABROWIAK, Jeremy Thomas
IPC分类号： A61M1/16 , A61M1/36
摘要： Devices, systems and methods for warming or cooling blood or other fluids as they circulate through an extracorporeal circuit.

3. 发明申请

WO2021158775A1 DETERMINING A VALUE INDICATIVE OF A THERMOREGULATORY ACTIVTY OF A PATIENT USING A TEMPERATURE MANAGEMENT SYSTEM 审中-公开
公开(公告)号：WO2021158775A1
公开(公告)日：2021-08-12
申请号：PCT/US2021/016590
申请日：2021-02-04
申请人： ZOLL CIRCULATION, INC. , WALLS, George L. , HELKOWSKI, Richard A. , DABROWIAK, Jeremy Thomas , REYNOLDS, Byron , LEE, Iljong , DAE, Michael W. , YIP, Sean W.
发明人： WALLS, George L. , HELKOWSKI, Richard A. , DABROWIAK, Jeremy Thomas , REYNOLDS, Byron , LEE, Iljong , DAE, Michael W. , YIP, Sean W.
IPC分类号： A61F7/00
摘要： A temperature management system controls a temperature of a body of a patient and determines a value indicative of a thermoregulatory activity of the patient. The system includes a heat exchange system configured to exchange heat with a body of a patient and to record operational data while controlling the temperature of the body of the patient. The temperature management system receives temperature data from a sensor, controls the heat exchange system to maintain the temperature of the body of the patient within a target temperature range, receives, in response to the controlling, operational data, determines, based on the temperature data and the operational data, a value indicative of a thermoregulatory activity of the patient, and generates, based on the value, an alert through the user interface indicating the thermoregulatory activity of the patient.

4. 发明申请

WO2015122937A1 FLUID CASSETTE WITH POLYMERIC MEMBRANCES AND INTEGRAL INLET AND OUTLET TUBES FOR PATIENT HEAT EXCHANGE SYSTEM 审中-公开
标题翻译：具有聚合物膜的流体CASSETTE和用于患者热交换系统的整体入口和出口管
公开(公告)号：WO2015122937A1
公开(公告)日：2015-08-20
申请号：PCT/US2014/059006
申请日：2014-10-03
申请人： ZOLL CIRCULATION, INC.
发明人： PISTOR, Christop Matthias , DABROWIAK, Jeremy Thomas , PENDRY, Craig Wendell , PAMICHEV, Christo
IPC分类号： A61F7/12 , A61M25/01
CPC分类号： A61F7/0085 , A61F7/02 , A61F7/10 , A61F2007/0056 , A61F2007/126 , A61M1/369 , A61M19/00 , A61M2205/127 , A61M2205/366 , Y10T29/4935
摘要： A working fluid cassette (50) for an intravascular heat exchange catheter (12) includes a frame (52) holding two closely spaced, square polymeric membranes (66, 68) along the sides of which are disposed inlet (58) and outlet (62) tubes. Working fluid from the catheter is directed from the inlet tube (58) between the membranes (66, 68) to the outlet tube (62). The cassette (50) is closely received between two refrigerant cold plates (30, 32) to exchange heat with the working fluid, which is circulated back to the catheter (12).
摘要翻译：用于血管内热交换导管（12）的工作流体盒（50）包括框架（52），其保持两个紧密间隔的正方形的聚合物膜（66,68），其侧面设置有入口（58）和出口（62））管。来自导管的工作流体从膜（66,68）之间的入口管（58）引导到出口管（62）。盒（50）紧密地接收在两个制冷剂冷板（30,32）之间，以与工作流体交换热量，工作流体循环回到导管（12）。

5. 发明申请

WO2015122936A1 FLUID CASSETTE WITH TENSIONED POLYMERIC MEMBRANES FOR PATIENT HEAT EXCHANGE SYSTEM 审中-公开
标题翻译：用于患者热交换系统的拉伸聚合物膜的流体盒
公开(公告)号：WO2015122936A1
公开(公告)日：2015-08-20
申请号：PCT/US2014/058996
申请日：2014-10-03
申请人： ZOLL CIRCULATION, INC.
发明人： DABROWIAK, Jeremy Thomas , PISTOR, Christop Matthias , PENDRY, Craig Wendell , PAMICHEV, Christo
IPC分类号： A61F7/12 , A61M25/01
CPC分类号： A61F7/0085 , A61F7/10 , A61F2007/0056 , A61F2007/126 , A61M5/44 , A61M2205/12 , A61M2205/127 , A61M2205/366 , Y10T29/4935
摘要： A working fluid cassette for an intravascular heat exchange catheter (12) includes a frame (52) holding two closely spaced, square polymeric membranes (66, 68) in tension. Working fluid from the catheter (12) is directed between the membranes (66, 68). The cassette is closely received between two refrigerant cold plates (30, 32) to exchange heat with the working fluid, which is circulated back to the catheter (12).
摘要翻译：一种用于血管内热交换导管（12）的工作流体盒包括一个框架（52），该框架（52）在张力下保持两个紧密间隔的方形聚合物膜（66,68）。来自导管（12）的工作流体被引导在膜（66,68）之间。盒子紧密地接收在两个制冷剂冷板（30,32）之间，以与工作流体交换热量，工作流体循环回到导管（12）。

6. 发明申请

WO2016073721A1 HEAT EXCHANGE SYSTEM FOR PATIENT TEMPERATURE CONTROL WITH EASY LOADING HIGH PERFORMANCE PERISTALTIC PUMP 审中-公开
标题翻译：用于患者温度控制的热交换系统，轻松加载高性能超声波泵
公开(公告)号：WO2016073721A1
公开(公告)日：2016-05-12
申请号：PCT/US2015/059244
申请日：2015-11-05
申请人： ZOLL CIRCULATION, INC.
发明人： HENDRICKS, Austin Reid , PAMICHEV, Christo Petrov , GURUKULA, Venkata Vishnu , DABROWIAK, Jeremy Thomas
IPC分类号： A61F7/00 , F04B43/12 , F04B43/08
CPC分类号： A61F7/0085 , A61F2007/0054 , A61F2007/0056 , A61F2007/126 , F04B43/0081 , F04B43/1253 , F04B43/1276 , F04B2201/1208
摘要： A peristaltic pump has an arcuate raceway (32, 130) with a partially concave inner surface (36, 136) extending through an arc of at least one hundred eighty degrees (180). The arc defines a midpoint (38/138), and a rotor (34/134) faces the inner surface of the raceway (32, 130) and is both rotatable relative to the raceway (32, 130) and translationally movable relative to the raceway (32, 130) between a pump position, wherein the rotor (34/134) is spaced from the midpoint (38/138) a first distance, and a tube load position, wherein the rotor (34/134) is spaced from the midpoint (38/138) a second distance greater than the first distance. A rotor motor (58) is coupled to the rotor (34/134) to rotate the rotor and rollers (46, 48) are arranged on the rotor to contact tubing disposed between the rotor (34/134) and the raceway (32, 130) when the rotor (34, 134) is in the pump position. A manual positioning mechanism (70) or a loading motor (140) can move the rotor (34 or 134) toward and away from the raceway (32, 130).
摘要翻译：蠕动泵具有弓形滚道（32,130），其具有延伸通过至少一百八十度（180）的圆弧的部分凹入的内表面（36,136）。圆弧限定中点（38/138），转子（34/134）面向滚道（32,130）的内表面，并且可相对于滚道（32,130）旋转，并且可相对于滚道在泵位置之间，其中所述转子（34/134）与所述中点（38/138）间隔开第一距离的泵位置（32,130）和管装载位置，其中所述转子（34/134）与所述中点（38/138）的第二距离大于所述第一距离。转子电动机（58）联接到转子（34/134）以使转子旋转并且转子（46,48）布置在转子上以接触设置在转子（34/134）和滚道 130）当转子（34,134）处于泵位置时。手动定位机构（70）或加载马达（140）可以使转子（34或134）朝向和远离滚道（32,130）移动。

7. 发明申请

WO2015122938A1 PATIENT HEAT EXCHANGE SYSTEM WITH TWO AND ONLY TWO FLUID LOOPS 审中-公开
标题翻译：患者热交换系统，两只和两只流体动物
公开(公告)号：WO2015122938A1
公开(公告)日：2015-08-20
申请号：PCT/US2014/059010
申请日：2014-10-03
申请人： ZOLL CIRCULATION, INC.
发明人： DABROWIAK, Jeremy Thomas , PENDRY, Craig Wendell , PISTOR, Christop Matthias
IPC分类号： A61F7/12
CPC分类号： A61F7/0085 , A61F7/02 , A61F2007/0056 , A61F2007/126 , A61M5/44 , A61M2205/12 , A61M2205/127 , A61M2205/366 , F25B39/02
摘要： A heat exchange system for exchanging heat with working fluid from an intravascular heat exchange catheter (12) or an external heat exchange pad (18) includes a working fluid that circulates between the catheter (12) or pad (18) and a fluid cassette (50), and a refrigerant that flows against the outer sides of cold plates (30, 32) between which the cassette (50) is disposed.
摘要翻译：用于与来自血管内热交换导管（12）或外部热交换垫（18）的工作流体进行热交换的热交换系统包括在导管（12）或垫（18）和流体盒（18）之间循环的工作流体 50），以及冷却板（30,32）的外侧流过所述盒（50）的制冷剂。

8. 发明申请

WO2016161002A1 WORKING FLUID CASSETTE WITH HINGED PLENUM OR ENCLOSURE FOR INTERFACING HEAT EXCHANGER WITH INTRAVASCULAR TEMPERATURE MANAGEMENT CATHETER 审中-公开
标题翻译：工作流体箱与铰链式热交换器与内部温度管理导管接口
公开(公告)号：WO2016161002A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/025030
申请日：2016-03-30
申请人： ZOLL CIRCULATION, INC.
发明人： PAMICHEV, Christo Petrov , DABROWIAK, Jeremy Thomas
IPC分类号： A61F7/00 , A61F7/12 , A61M25/00
CPC分类号： A61F7/12 , A61F7/0085 , A61F2007/0054 , A61F2007/0056 , A61F2007/126
摘要： An enclosure or plenum (50) that supports a looped pump tube (44) is hingedly connected to a framed thin-walled heat exchange bag (54) through which working fluid from an intravascular heat exchange catheter (12) flows. The frame with bag can be inserted between cold plates (31) to exchange heat with the working fluid flowing through the bag. With the framed bag between the plates, the looped pump tube (44) from the enclosure or plenum is receivable in the raceway (32) of a peristaltic pump (30), which pumps working fluid through the system.
摘要翻译：支撑环形泵管（44）的外壳或增压室（50）铰接地连接到框架式薄壁热交换袋（54），来自血管内热交换导管（12）的工作流体通过所述框架的薄壁热交换袋（54）流动。具有袋子的框架可以插入冷板（31）之间以与流过袋的工作流体交换热量。通过在板之间的框架袋，来自外壳或增压室的环形泵管（44）可接收在蠕动泵（30）的滚道（32）中，该蠕动泵将工作流体泵送通过系统。

9. 发明申请

WO2016160960A1 COLD PLATE DESIGN IN HEAT EXCHANGER FOR INTRAVASCULAR TEMPERATURE MANAGEMENT CATHETER AND/OR HEAT EXCHANGE PAD 审中-公开
标题翻译：热交换器的冷板设计用于血管温度管理导管和/或热交换垫
公开(公告)号：WO2016160960A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/024970
申请日：2016-03-30
申请人： ZOLL CIRCULATION, INC.
发明人： DABROWIAK, Jeremy Thomas , PENDRY, Craig Wendell , PISTOR, Christoph Matthias
IPC分类号： A61F7/12 , A61M5/44 , A61M25/10
CPC分类号： A61F7/12 , A61F7/0085 , A61F7/02 , A61F2007/0056 , A61F2007/126
摘要： Cold plates (30, 32) through which refrigerant flows define a slot (34) between them that can receive a cassette (50) through which sterile working fluid with a relatively low flow rate flows from an intravascular heat exchange catheter (12) or external pad (18). The slot (34) may have bulge cavities (R1, R2) along the edges to permit the membrane of the cassette to expand and thus establish fluid supply and return passageways.
摘要翻译：制冷剂流过的冷板（30,32）在它们之间限定一个槽（34），其可以容纳一个盒（50），通过该盒（50），具有较低流量的无菌工作流体从血管内热交换导管（12）或外部垫（18）。狭槽（34）可以沿着边缘具有凸起腔（R1，R2），以允许盒的膜膨胀，从而建立流体供应和返回通道。

10. 发明申请

WO2015119671A1 PATIENT HEAT EXCHANGE SYSTEM WITH TRANSPARENT WALL FOR VIEWING CIRCULATING REFRIGERANT 审中-公开
标题翻译：带透明壁的患者热交换系统用于观察循环制冷剂
公开(公告)号：WO2015119671A1
公开(公告)日：2015-08-13
申请号：PCT/US2014/059029
申请日：2014-10-03
申请人： ZOLL CIRCULATION, INC.
发明人： DABROWIAK, Jeremy Thomas , PETERSON, Eric
IPC分类号： A61F7/12
CPC分类号： F28F3/12 , A61F7/0085 , A61F7/02 , A61F2007/0056 , A61F2007/126 , F25B39/02 , F28D9/0043
摘要： A heat exchange system for exchanging heat with working fluid from an intravascular heat exchange catheter (12) or an external heat exchange pad (18) includes a working fluid that circulates between the catheter (12) or pad (18) and a fluid cassette (50), and a refrigerant system that flows against the outer sides of cold plates (30, 32) between which the cassette (50) is disposed. An outer wall (32a) of the system is transparent so that a person can view the refrigerant as it circulates, ensuring proper operation.
摘要翻译：用于与来自血管内热交换导管（12）或外部热交换垫（18）的工作流体进行热交换的热交换系统包括在导管（12）或垫（18）和流体盒（18）之间循环的工作流体 50），以及制冷剂系统，其流过设置有盒（50）的冷板（30,32）的外侧。系统的外壁（32a）是透明的，使得人们可以在制冷剂循环时观察制冷剂，确保正确的操作。

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