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1. 发明申请

WO2018191388A1 NOVEL TYPE VI CRISPR ORTHOLOGS AND SYSTEMS 审中-公开
公开(公告)号：WO2018191388A1
公开(公告)日：2018-10-18
申请号：PCT/US2018/027125
申请日：2018-04-11
申请人： ZHANG, Feng , COX, David , THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： ZHANG, Feng , COX, David
IPC分类号： C12N9/22 , C12N15/10 , C12Q1/68 , C12N15/63
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

2. 发明申请

WO2018035250A1 METHODS FOR IDENTIFYING CLASS 2 CRISPR-CAS SYSTEMS 审中-公开
标题翻译：识别2类CRISPR-CAS系统的方法
公开(公告)号：WO2018035250A1
公开(公告)日：2018-02-22
申请号：PCT/US2017/047193
申请日：2017-08-16
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： SHMAKOV, Sergey , MAKAROVA, Kira S. , WOLF, Yuri I. , SMARGON, Aaron , PYZOCHA, Neena , COX, David , YAN, Winston , SCOTT, David , SEVERINOV, Konstantin , ZHANG, Feng , KOONIN, Eugene V.
IPC分类号： G06F19/22 , C40B30/02 , C07K14/195 , C12N9/00
摘要： Disclosed here is a method of identifying novel CRISPR effectors, comprising: identifying sequences in a genomic or metagenomic database encoding a CRISPR array; identifying one or more Open Reading Frames (ORFs) in said selected sequences within 10 kb of the CRISPR array; discarding all loci encoding proteins which are assigned to known CRISPR-Cas subtypes and, optionally, all loci encoding a protein of less than 700 amino acids; and identifying putative novel CRISPR effectors, and optionally classifying them based on structure analysis.
摘要翻译：这里公开了一种鉴定新的CRISPR效应子的方法，包括：鉴定编码CRISPR阵列的基因组或宏基因组数据库中的序列; 在所述CRISPR阵列的10kb内在所述选择的序列中识别一个或多个开放阅读框（ORF）; 丢弃编码已知CRISPR-Cas亚型的编码蛋白质的所有基因座，并且任选编码小于700个氨基酸的蛋白质的所有基因座; 并鉴定推测的新型CRISPR效应物，并根据结构分析对其进行分类。

3. 发明申请

WO2018213708A1 SYSTEMS, METHODS, AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITING 审中-公开
公开(公告)号：WO2018213708A1
公开(公告)日：2018-11-22
申请号：PCT/US2018/033394
申请日：2018-05-18
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： ZHANG, Feng , COX, David , GOOTENBERG, Jonathan , ABUDAYYEH, Omar O. , ZETSCHE, Bernd , STRECKER, Jonathan
IPC分类号： C12N15/10 , C12N9/22 , C12N9/78 , C12N15/62
摘要： The invention provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a DNA-targeting Cpfl protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.

4. 发明公开

EP3610009A1 NOVEL TYPE VI CRISPR ORTHOLOGS AND SYSTEMS 审中-实审
公开(公告)号：EP3610009A1
公开(公告)日：2020-02-19
申请号：EP18725676.3
申请日：2018-04-11
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology
发明人： ZHANG, Feng , COX, David
IPC分类号： C12N9/22 , C12N15/10 , C12Q1/68 , C12N15/63

6. 发明申请

WO2006102495A2 DEVICE AND METHOD FOR TRACKING EYE GAZE DIRECTION 审中-公开
标题翻译：跟踪眼睛高度方向的装置和方法
公开(公告)号：WO2006102495A2
公开(公告)日：2006-09-28
申请号：PCT/US2006/010537
申请日：2006-03-23
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , COX, David , DICARLO, James
发明人： COX, David , DICARLO, James
IPC分类号： A61B3/14
CPC分类号： A61B3/113
摘要： Eye-tracking devices and method of operation may utilize a magnetic article associated with an eye and a sensing device to detect a magnetic field generated by the magnetic article.
摘要翻译：眼睛跟踪装置和操作方法可以利用与眼睛和感测装置相关联的磁性制品来检测由磁性制品产生的磁场。

7. 发明申请

WO2015040485A1 WHEEL BARROW WITH IMPROVED STRUCTURE FOR LOADING AND UNLOADING 审中-公开
标题翻译：具有改进的装载和卸载结构的车轮轨道
公开(公告)号：WO2015040485A1
公开(公告)日：2015-03-26
申请号：PCT/IB2014/002134
申请日：2014-09-17
申请人： COX, David
发明人： COX, David
IPC分类号： B62B1/18
CPC分类号： B62B1/24 , B62B1/20 , B62B5/0485 , B62B5/067
摘要： The invention disclosed relates to an improved structure for a wheel barrow to provide efficient loading and unloading. The additional method of loading that separates it from existing designs is the ability to load the wheel barrow tub at ground level and then raise the tub to the standard position while maintaining the base of the tub largely horizontal. The movement of the tub is made possible by a parallel linkage to the frame consisting of two arms on each side of the tub. Through geometrical constraints, the arms keep the tub substantially horizontal throughout the entire movement. The ability to remove or rotate the back panel of the tub allows the tub to be loaded at ground level without having to raise the load over the sides of the tub.
摘要翻译：所公开的发明涉及一种改进的轮式推土机结构，以提供有效的装载和卸载。将其与现有设计分开的附加加载方法是将手推车盆装载在地面水平上的能力，然后将浴缸升高到标准位置，同时将浴缸的底部保持在很大程度上水平。通过与由桶的每一侧上的两个臂构成的框架的平行连接，可以实现桶的移动。通过几何约束，臂在整个运动中保持桶基本上水平。移除或旋转洗手盆的后面板的能力允许桶被装载在地面水平，而不必提高桶的两侧的负荷。

8. 发明申请

WO2013022978A2 HAPTIC DIRECTIONAL FEEDBACK HANDLES FOR LOCATION DEVICES 审中-公开
标题翻译：定位设备的方向性反馈手柄
公开(公告)号：WO2013022978A2
公开(公告)日：2013-02-14
申请号：PCT/US2012/050004
申请日：2012-08-08
申请人： OLSSON, Mark , NEWBY, Garrett , WARREN, Alexander , COX, David
发明人： OLSSON, Mark , NEWBY, Garrett , WARREN, Alexander , COX, David
IPC分类号： G01V3/12
CPC分类号： G08B6/00 , G01V3/081 , G01V3/12 , G01V3/165
摘要： Locating devices and systems providing haptic tactile feedback are disclosed. In one embodiment, a locator includes a haptic handle configured to provide directional signals through an operator's sense of touch to aid in locating and tracing a buried conductor or other object such as a pipe or cable.
摘要翻译：公开了提供触觉触觉反馈的定位设备和系统。在一个实施例中，定位器包括触觉手柄，该触觉手柄被配置成通过操作者的触觉提供定向信号以帮助定位和追踪掩埋导体或其他物体，例如管道或电缆。

9. 发明申请

WO2007064776A2 MARKERS FOR BREAST CANCER 审中-公开
标题翻译：乳腺癌标志物
公开(公告)号：WO2007064776A2
公开(公告)日：2007-06-07
申请号：PCT/US2006/045812
申请日：2006-11-29
申请人： PERLEGEN SCIENCES, INC. , UNIVERSITY OF CAMBRIDGE , COX, David , BALLINGER, Dennis , PONDER, Bruce , EASTON, Doug
发明人： COX, David , BALLINGER, Dennis , PONDER, Bruce , EASTON, Doug
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/16
摘要： Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.
摘要翻译：提供多态性与乳腺癌的相关性。提供诊断，预后和治疗乳腺癌的方法。提供用于乳腺癌诊断，预后和治疗的系统和试剂盒。还描述了确定乳腺癌调节剂的方法。

10. 发明申请

WO2008149061A3 INTERNAL COMBUSTION ENGINES 审中-公开
公开(公告)号：WO2008149061A3
公开(公告)日：2008-12-11
申请号：PCT/GB2008/001798
申请日：2008-05-28
申请人： COX POWERTRAIN LTD , COX, David
发明人： COX, David
IPC分类号： F01B1/08 , F01B7/04 , F01B9/02 , F02B75/24 , F02B75/28 , F02B25/08 , F16H21/36 , F02B75/02 , F02B75/18 , F02F1/22 , F01B7/10 , F02F3/00
摘要： The invention provides a 2-stroke internal combustion engine comprising two opposed cylinders, each cylinder housing two opposed pistons and having at least one exhaust port and at least one intake port, and a crankshaft having asymmetrically arranged journals and scotch-yoke mechanisms for driving the journals from the pistons. The pistons in each cylinder operate to open its exhaust port or ports before its intake port or ports and to close its exhaust port or ports before its intake port or ports.

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