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1. 发明申请

WO2012002964A1 METHODS AND KITS FOR DETECTING AN INFECTIOUS AGENT 审中-公开
标题翻译：检测感染性药物的方法和试剂盒
公开(公告)号：WO2012002964A1
公开(公告)日：2012-01-05
申请号：PCT/US2010/040649
申请日：2010-06-30
申请人： ZHANG, Aiguo , OKUNIEFF, Paul , ZHANG, Lurong , ZHANG, Lulu
发明人： ZHANG, Aiguo , OKUNIEFF, Paul , ZHANG, Lurong , ZHANG, Lulu
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/689 , C12Q1/682 , C12Q1/708 , C12Q2600/166 , Y02A50/54 , C12Q2525/313
摘要： The present invention provides methods and kits for determining the presence, absence, or level of an infectious agent in a sample. Specifically, the present invention provides methods and kits for detecting or quantifying certain target polynucleotides of the infectious agent. In certain embodiments, the present invention provides for such detection without the need for amplification (e.g., replication) of the target molecule and/or without the need for labor intensive purification procedures. In certain embodiments, the present invention provides positive control and housekeeping gene for normalization and quantatively detection of the copy numbers of infectious agent in a sample. In these or other embodiments, the invention allows for such detection with the desired sensitivity and/or specificity, even where the polynucleotide is present in the sample at low copy number.
摘要翻译：本发明提供了用于确定样品中感染因子的存在，不存在或水平的方法和试剂盒。具体地，本发明提供了用于检测或定量感染因子的某些靶多核苷酸的方法和试剂盒。在某些实施方案中，本发明提供了这种检测，而不需要靶分子的扩增（例如复制）和/或不需要劳动密集的纯化方法。在某些实施方案中，本发明提供用于标准化和定量检测样品中感染因子的拷贝数的阳性对照和管家基因。在这些或其它实施方案中，即使多核苷酸以低拷贝数存在于样品中，本发明允许具有期望的灵敏度和/或特异性的这种检测。

2. 发明申请

WO2010099127A2 FREE CIRCULATING DNA BIO-MARKERS AND THEIR APPLICATIONS 审中-公开
标题翻译：免费循环DNA生物标记及其应用
公开(公告)号：WO2010099127A2
公开(公告)日：2010-09-02
申请号：PCT/US2010/025114
申请日：2010-02-23
申请人： DIACARTA LLC , ZHANG, Lurong , OKUNIEFF, Paul , ZHANG, Lulu
发明人： ZHANG, Lurong , OKUNIEFF, Paul , ZHANG, Lulu
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： This invention relates generally to methods for detecting cell damage as a consequence of pathophysiological or traumatic insults such as in a nuclear accident, bioterror attack, tumorigenesis, infections or in individuals with cardiovascular disease.
摘要翻译：本发明一般涉及由于病理生理学或创伤性损伤如核事故，生物恐怖袭击，肿瘤发生，感染或心血管疾病的个体而检测细胞损伤的方法。

3. 发明申请

WO2009158238A2 FIBROBLAST GROWTH FACTOR (FGF) ANALOGS AND USES THEREOF 审中-公开
标题翻译： FIBROBLAST生长因子（FGF）模拟物及其用途
公开(公告)号：WO2009158238A2
公开(公告)日：2009-12-30
申请号：PCT/US2009/047498
申请日：2009-06-16
申请人： UNIVERSITY OF ROCHESTER , OKUNIEFF, Paul , ZHANG, Lurong
发明人： OKUNIEFF, Paul , ZHANG, Lurong
IPC分类号： A61K38/10
CPC分类号： A61K38/1825 , A61B17/1214 , A61B17/1215 , A61K38/196 , A61L27/227 , A61L27/54 , A61L29/048 , A61L29/16 , A61L31/047 , A61L31/16 , A61L2300/25 , C07K14/503 , A61K2300/00
摘要： The invention relates to novel peptide comprising FGF-P and methods of use thereof.
摘要翻译：本发明涉及包含FGF-P的新型肽及其使用方法。

4. 发明申请

WO2009023357A3 CURCUMIN DERIVATIVES AND THEIR USE AS RADIOPROTECTORS 审中-公开
公开(公告)号：WO2009023357A3
公开(公告)日：2009-02-19
申请号：PCT/US2008/064872
申请日：2008-05-27
申请人： UNIVERSITY OF ROCHESTER , OKUNIEFF, Paul , ZHANG, Lurong , LIU, Chaomei , SUN, Weimin , YANG, Shanmin , SWARTS, Steven
发明人： OKUNIEFF, Paul , ZHANG, Lurong , LIU, Chaomei , SUN, Weimin , YANG, Shanmin , SWARTS, Steven
IPC分类号： A01N43/20
摘要： Disclosed are compositions relating to analogues, derivatives, and metabolites of curcumin, methods of synthesis thereof, and methods for use of said compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

5. 发明申请

WO2006055875A3 METHODS AND COMPOSITIONS RELATED TO ESCULENTOSIDE A 审中-公开
公开(公告)号：WO2006055875A3
公开(公告)日：2006-05-26
申请号：PCT/US2005/042063
申请日：2005-11-18
申请人： UNIVERSITY OF ROCHESTER , OKUNIEFF, Paul , ZHANG, Lurong , XIAO, Zhenyu
发明人： OKUNIEFF, Paul , ZHANG, Lurong , XIAO, Zhenyu
IPC分类号： A01N43/04 , A61K31/70
摘要： Disclosed are compositions related to water soluble selective COX-2 inhibitors and methods of using the inhibitors (including Esculentoside A and derivatives thereof).

6. 发明申请

WO2012040707A2 MATERIALS AND METHODS FOR IMPROVING GASTROINTESTINAL FUNCTION 审中-公开
标题翻译：用于改善胃肠功能的材料和方法
公开(公告)号：WO2012040707A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/053265
申请日：2011-09-26
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , VIDYASAGAR, Sadasivan , OKUNIEFF, Paul , ZHANG, Lurong
发明人： VIDYASAGAR, Sadasivan , OKUNIEFF, Paul , ZHANG, Lurong
IPC分类号： A61K31/198 , A61K31/195 , A61P1/04 , A61P1/00
CPC分类号： A61K31/405 , A61K9/0095 , A61K31/197 , A61K31/198 , A61K31/7004 , A61K31/7016 , A61K47/183 , A61K2300/00
摘要： The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of injury to small intestine mucosa. In preferred embodiments, the composition comprises one or more nutrients and/or electrolytes that acquire or retain considerable absorptive capacity.
摘要翻译：本发明提供治疗组合物及其用于治疗或改善对小肠粘膜损伤的用途。在优选的实施方案中，组合物包含获得或保持相当大的吸收能力的一种或多种营养物和/或电解质。

7. 发明申请

WO2009017874A2 NOVEL CURCUMIN DERIVATIVES AND THEIR PHARMAEUTICAL USES THEREOF 审中-公开
标题翻译：新型CURCUMIN衍生物及其药物用途
公开(公告)号：WO2009017874A2
公开(公告)日：2009-02-05
申请号：PCT/US2008/064877
申请日：2008-05-27
申请人： UNIVERSITY OF ROCHESTER , OKUNIEFF, Paul , LIU, Chaomei , ZHANG, Lurong
发明人： OKUNIEFF, Paul , LIU, Chaomei , ZHANG, Lurong
IPC分类号： A61K31/415
CPC分类号： A61K31/415
摘要： Disclosed are methods relating to analogues, derivatives, and metabolites of curcumin. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：公开了与姜黄素的类似物，衍生物和代谢物相关的方法。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不是限制本发明。

8. 发明申请

WO2009143475A9 METHODS AND COMPOSITIONS RELATED TO AGLYCOSIDIC ESCULENTOSIDE A 审中-公开
公开(公告)号：WO2009143475A9
公开(公告)日：2009-11-26
申请号：PCT/US2009/045056
申请日：2009-05-22
申请人： UNIVERSITY OF ROCHESTER , OKUNIEFF, Paul , LURONG, Zhang , SHANMIN, Yang , MEI, Zhang , LIU, Chaomei
发明人： OKUNIEFF, Paul , LURONG, Zhang , SHANMIN, Yang , MEI, Zhang , LIU, Chaomei
IPC分类号： A01N43/42
摘要： Disclosed are compositions related to water soluble selective COX-2 inhibitors and methods of using the inhibitors (including h-EsA and derivatives thereof.)

9. 发明申请

WO2003072050A2 PREVENTION OF AND THERAPY FOR RADIATION TOXICITY OF NORMAL TISSUES USING DRUGS WHICH BLOCK IL-1 ACTIVITY 审中-公开
标题翻译：使用块IL-1活性的药物对正常组织的放射性毒性进行预防和治疗
公开(公告)号：WO2003072050A2
公开(公告)日：2003-09-04
申请号：PCT/US2003/005624
申请日：2003-02-25
申请人： UNIVERSITY OF ROCHESTER MEDICAL CENTER , OKUNIEFF, Paul , DING, Ivan , CHEN, Yuhchyau
发明人： OKUNIEFF, Paul , DING, Ivan , CHEN, Yuhchyau
IPC分类号： A61K
CPC分类号： A61K38/2006 , A61K31/00 , A61K31/635 , A61K38/20
摘要： A method for the prevention of and therapy for radiation pneumonitis, dermatitis, soft tissue fibrosis and central nervous system toxicity in patients undergoing therapeutic radiation. In addition, the invention provides for pre-treatment of those responding to nuclear bio terrorism or other nuclear or radiological accidents. Thus, with the present invention, subjects may be treated in order to prevent toxicity from nuclear bio terrorism or other nuclear or radiological accidents. More particularly, we have discovered a method for prophylactically treating radiation toxicity in normal tissue of a subject comprising administering an anti-radiation toxicity effective amount of a cytokine blocking agent through the subject. More specifically, we have discovered a method for prophylactically treating radiation pneumonitis, dermatitis, soft tissue fibrosis or central nervous system toxicity in a subject comprising administering an anti-radiation pneumonitis, dermatitis, soft tissue fibrosis or central nervous system toxicity effective amount of a cytokine blocking agent to the subject.
摘要翻译：一种在接受治疗性放射治疗的患者中预防和治疗放射性肺炎，皮炎，软组织纤维化和中枢神经系统毒性的方法。此外，本发明还规定了应对核生物恐怖主义或其他核或放射性事故的人员的预处理。因此，通过本发明，可以对受试者进行治疗，以防止核生物恐怖主义或其他核或放射学事故的毒性。更具体地，我们已经发现了预防性治疗受试者正常组织中的放射线毒性的方法，其包括通过受试者施用抗辐射毒性有效量的细胞因子阻断剂。更具体地，我们已经发现一种用于预防性治疗受试者的放射性肺炎，皮炎，软组织纤维化或中枢神经系统毒性的方法，包括施用抗辐射性肺炎，皮炎，软组织纤维化或中枢神经系统毒性有效量的细胞因子阻断剂到受试者。

10. 发明申请

WO2008014340A3 PREDICTION AND TREATMENT OF BRAIN TUMOR SPREAD USING MRI AND EXTERNAL BEAM RADIATION 审中-公开
公开(公告)号：WO2008014340A3
公开(公告)日：2008-01-31
申请号：PCT/US2007/074354
申请日：2007-07-25
申请人： UNIVERSITY OF ROCHESTER , O'DELL, Walter G. , OKUNIEFF, Paul , KRISHNAN, Anitha Priya , ASHER, Isaac
发明人： O'DELL, Walter G. , OKUNIEFF, Paul , KRISHNAN, Anitha Priya , ASHER, Isaac
IPC分类号： A61B5/05
摘要： The invention is based on the realization that brain cancer cells spread preferentially along paths of elevated water diffusion, such as along nerve fiber bundles, that can be measured by magnetic resonance (MR) diffusion-weighted imaging (DWI) and the migration of cancer cells away from the primary tumor can be predicted using computational models that incorporate DWI information. The invention therefore applies DWI and models cell migration to develop appropriate non-symmetric margins for radiation treatment of malignant brain tumors.

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