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1. 发明申请

WO1995030668A1 CYCLIC ETHER DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEM 审中-公开
标题翻译：循环醚衍生物和含有它们的药物组合物
公开(公告)号：WO1995030668A1
公开(公告)日：1995-11-16
申请号：PCT/GB1995001000
申请日：1995-05-02
申请人： ZENECA LIMITED , ZENECA-PHARMA , EDWARDS, Philip, Neil , WATERSON, David
发明人： ZENECA LIMITED , ZENECA-PHARMA
IPC分类号： C07D309/06
CPC分类号： C07D405/12 , C07D309/06 , C07D413/12
摘要： The invention concerns a cyclic ether derivative of formula (I), wherein Ar is phenyl or naphthyl, or a 9- or 10-membered bicyclic heterocyclic moiety, and Ar may be optionally substituted; A includes (1-4C)alkylene; X includes oxy; Ar includes phenylene, pyridinediyl and pyrimidinediyl which may optionally bear one or two substituents; R and R together form a group of the formula: -A -X -A - which, together with the carbon atom to which both A and A are attached, define a 5- or 6-membered ring wherein: A is (1-3C)alkylene; X includes oxy; and A is (1-3C)alkylene; and which ring may be optionally substituted; and Y includes halogeno, 2-cyanovinyl, 2-halogenovinyl, hydroxyimino-(1-4C)alkyl and (1-4C)alkoxyimino-(1-4C)alkyl; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
摘要翻译：本发明涉及式（I）的环醚衍生物，其中Ar 1是苯基或萘基，或9或10元双环杂环部分，Ar 1可以任选被取代; A 1包括（1-4C）亚烷基; X 1包括氧基; Ar 2包括可以任选地带有一个或两个取代基的亚苯基，吡啶二基和嘧啶二基; R 1和R 2一起形成下式的基团：-A 2 -X 2 -A 3，其与A 2和A“ 3>连接，定义5-或6-元环，其中：A 2是（1-3C）亚烷基; X 2包括氧基; 并且A 3为（1-3C）亚烷基; 并且哪个环可以任选被取代; 和Y包括卤代，2-氰基乙烯基，2-卤代乙烯基，羟基亚氨基 - （1-4C）烷基和（1-4C）烷氧基亚氨基 - （1-4C）烷基; 或其药学上可接受的盐; 其准备过程; 含有它们的药物组合物及其作为5-脂肪氧合酶抑制剂的用途。

2. 发明申请

WO1995030669A1 ETHER DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：其他衍生物和含有它们的药物组合物
公开(公告)号：WO1995030669A1
公开(公告)日：1995-11-16
申请号：PCT/GB1995001001
申请日：1995-05-02
申请人： ZENECA LIMITED , ZENECA-PHARMA , EDWARDS, Philip, Neil
发明人： ZENECA LIMITED , ZENECA-PHARMA
IPC分类号： C07D309/10
CPC分类号： C07D309/10
摘要： The invention concerns an ether derivative of formula (I), wherein each of A and A includes, independently, direct links; wherein X includes thio; wherein Ar includes phenylene, optionally substituted; wherein Ar includes phenylene, optionally substituted; wherein R and R independently includes hydrogen and (1-6C)alkyl; wherein R and R together, and R and R together, form a group of the formula -A -X -A -, which together with the carbon atom to which both A and A are attached define 4- to 7-membered rings, optionally substituted, wherein A and A are independently (1-4C)alkylene and X includes oxy; or wherein R and R together with the carbon atom to which both R and R are attached define cyclopentyl or cyclohexyl groups, optionally substituted; or a pharmaceutically-acceptable salt; and processes for their preparation, pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
摘要翻译：本发明涉及式（I）的醚衍生物，其中A 1和A 2各自独立地包括直链; 其中X 1包括硫代; 其中Ar 1包括任选取代的亚苯基; 其中Ar 2包括任选取代的亚苯基; 其中R 1和R 4独立地包括氢和（1-6C）烷基; 其中R 2和R 3一起并且R 5和R 6一起形成式-A 3 -X 2 -A 4 - 的基团，其与 A 3和A 4均连接的碳原子定义为任选取代的4-至7-元环，其中A 3和A 4独立地为（1-4C）亚烷基， 2>包括氧基; 或其中R 5和R 6与R 5和R 6两者所连接的碳原子一起定义为任选取代的环戊基或环己基; 或药学上可接受的盐; 及其制备方法，含有它们的药物组合物及其作为5-脂肪氧合酶抑制剂的用途。

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