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1. 发明授权

US08649242B2 Insonification device that includes a three-dimensional network of emitters arranged in at least two concentric spirals, which are designed to generate a beam of high-intensity focussed waves 有权
标题翻译： Insonification装置包括布置在至少两个同心螺旋中的发射器的三维网络，其被设计成产生高强度聚焦波束
公开(公告)号：US08649242B2
公开(公告)日：2014-02-11
申请号：US12742086
申请日：2008-11-12
申请人： Yves Martin , Mathieu Pernot , François Varray
发明人： Yves Martin , Mathieu Pernot , François Varray
IPC分类号： G01S15/89
CPC分类号： G01S15/89 , G01S7/52047 , G01S15/8929 , G10K11/32
摘要： The invention concerns a device (1) for the insonification of an environment or medium, which is designed to generate a beam of focussed waves around a point in a so-called focus zone (20), used for imaging the medium or changing the properties of the medium, with the insonification device (1) having an intrinsic or extrinsic support structure on which is installed a network of a predetermined number of ultrasound transducers (12) that are designed to be controlled independently for generation of the focussed wave beam.According to the invention, the transducers (12) used for the generation of the focussed wave beam are located in a homogeneous spatial distribution along at least two concentric spirals (11) that are wound onto a three-dimensional concave area (10) whose shape and size are chosen to allow optimal focusing of the beam at a predetermined focal length, and whose concave side is oriented toward the focus zone (20).
摘要翻译：本发明涉及一种用于环境或介质的固化的设备（1），其被设计成在所谓的聚焦区域（20）中的点周围产生聚焦波束，用于对介质进行成像或改变特性所述增强装置（1）具有固有或非本征支撑结构，在其上安装有预定数量的超声换能器（12）的网络，所述网络被设计为独立地被控制以产生聚焦波束。根据本发明，用于产生聚焦波束的换能器（12）沿着至少两个同心螺旋（11）位于均匀的空间分布中，所述至少两个同心螺旋（11）被卷绕到三维凹入区域（10）上，其形状并且选择尺寸以允许在预定焦距处的光束的最佳聚焦，并且其凹面朝向聚焦区域（20）定向。

2. 发明申请

US20110051554A1 INSONIFICATION DEVICE THAT INCLUDES A THREE-DIMENSIONAL NETWORK OF EMITTERS ARRANGED IN AT LEAST TWO CONCENTRIC SPIRALS, WHICH ARE DESIGNED TO GENERATE A BEAM OF HIGH-INTENSITY FOCUSSED WAVES 有权
标题翻译：包括在最初两个集中螺旋上安装的三维发射网络的设备，其被设计用于生成高强度聚焦波束的光束
公开(公告)号：US20110051554A1
公开(公告)日：2011-03-03
申请号：US12742086
申请日：2008-11-12
申请人： Francois Varray , Mathieu Pernot , Yves Martin
发明人： Francois Varray , Mathieu Pernot , Yves Martin
IPC分类号： G01S15/89
CPC分类号： G01S15/89 , G01S7/52047 , G01S15/8929 , G10K11/32
摘要： The invention concerns a device (1) for the insonification of an environment or medium, which is designed to generate a beam of focussed waves around a point in a so-called focus zone (20), used for imaging the medium or changing the properties of the medium, with the insonification device (1) having an intrinsic or extrinsic support structure on which is installed a network of a predetermined number of ultrasound transducers (12) that are designed to be controlled independently for generation of the focussed wave beam. According to the invention, the transducers (12) used for the generation of the focussed wave beam are located in a homogeneous spatial distribution along at least two concentric spirals (11) that are wound onto a three-dimensional concave area (10) whose shape and size are chosen to allow optimal focusing of the beam at a predetermined focal length, and whose concave side is oriented toward the focus zone (20).
摘要翻译：本发明涉及一种用于环境或介质的固化的设备（1），其被设计成在所谓的聚焦区域（20）中的点周围产生聚焦波束，用于对介质进行成像或改变特性所述增强装置（1）具有固有或非本征支撑结构，在其上安装有预定数量的超声换能器（12）的网络，所述网络被设计为独立地被控制以产生聚焦波束。根据本发明，用于产生聚焦波束的换能器（12）沿着至少两个同心螺旋（11）位于均匀的空间分布中，所述至少两个同心螺旋（11）被卷绕到三维凹入区域（10）上，其形状并且选择尺寸以允许在预定焦距处的光束的最佳聚焦，并且其凹面朝向聚焦区域（20）定向。

3. 发明授权

US08310132B2 Insonification device having an internal cooling chamber 有权
标题翻译：具有内部冷却室的胰岛素化装置
公开(公告)号：US08310132B2
公开(公告)日：2012-11-13
申请号：US12922966
申请日：2009-03-17
申请人： Yves Martin , Mathieu Pernot
发明人： Yves Martin , Mathieu Pernot
IPC分类号： F25D31/00
CPC分类号： G10K11/004
摘要： The invention relates to an insonification device (100) comprising a plurality of elementary ultrasonic transducers (110) each comprising at least one electro-acoustic element (111) and distributed on a chassis (120, 140) so that the electro-acoustic elements (111) are distributed on a so-called front surface (120′) of the device (100) intended to be placed facing the medium to be insonified. According to the invention, as each transducer (110) comprises a longitudinal body (113) made in a heat conducting material at the so-called front end of which the electro-acoustic element (111) is placed, the chassis (120, 140) comprises a sealed cooling chamber (130) placed behind the front surface (120′), crossed by the bodies of the transducers (113) and intended to be gone through by a coolant fluid flow.
摘要翻译：本发明涉及一种包括多个基本超声换能器（110）的增音装置（100），每个基本超声波换能器包括至少一个电声元件（111）并分布在底架（120,140）上，使得电声元件 111）分布在设备（100）的所谓的正面（120'）上，用于面向要被增强的介质放置。根据本发明，由于每个换能器（110）包括在导电材料制成的纵向本体（113），所述导体材料位于所述电声元件（111）的所谓前端，所述底架（120,140））包括放置在前表面（120'）后面的密封冷却室（130），其通过换能器（113）的主体穿过并且旨在通过冷却剂流体流动。

4. 发明申请

US20110011111A1 INSONIFICATION DEVICE HAVING AN INTERNAL COOLING CHAMBER 有权
标题翻译：具有内部冷却室的断开装置
公开(公告)号：US20110011111A1
公开(公告)日：2011-01-20
申请号：US12922966
申请日：2009-03-17
申请人： Yves Martin , Mathieu Pernot
发明人： Yves Martin , Mathieu Pernot
IPC分类号： F25D31/00 , F28D15/00
CPC分类号： G10K11/004
摘要： The invention relates to an insonification device (100) comprising a plurality of elementary ultrasonic transducers (110) each comprising at least one electro-acoustic element (111) and distributed on a chassis (120, 140) so that the electro-acoustic elements (111) are distributed on a so-called front surface (120′) of the device (100) intended to be placed facing the medium to be insonified. According to the invention, as each transducer (110) comprises a longitudinal body (113) made in a heat conducting material at the so-called front end of which the electro-acoustic element (111) is placed, the chassis (120, 140) comprises a sealed cooling chamber (130) placed behind the front surface (120′), crossed by the bodies of the transducers (113) and intended to be gone through by a coolant fluid flow.
摘要翻译：本发明涉及一种包括多个基本超声换能器（110）的增音装置（100），每个基本超声波换能器包括至少一个电声元件（111）并分布在底架（120,140）上，使得电声元件 111）分布在设备（100）的所谓的正面（120'）上，用于面向要被增强的介质放置。根据本发明，由于每个换能器（110）包括在导电材料制成的纵向本体（113），所述导体材料位于所述电声元件（111）的所谓前端，所述底架（120,140））包括放置在前表面（120'）后面的密封冷却室（130），其通过换能器（113）的主体穿过并且旨在通过冷却剂流体流动。

5. 发明申请

US20090093724A1 METHOD FOR OPTIMISING THE FOCUSSING OF WAVES THROUGH AN ABERRATION-INDUCING ELEMENT 有权
标题翻译：通过诱导诱导元素优化波形聚焦的方法
公开(公告)号：US20090093724A1
公开(公告)日：2009-04-09
申请号：US12282625
申请日：2008-02-20
申请人： Mathieu Pernot , Mathias Fink , Mickael Tanter , Gabriel Montaldo , Jean-Francois Aubry , Ralph Sinkus
发明人： Mathieu Pernot , Mathias Fink , Mickael Tanter , Gabriel Montaldo , Jean-Francois Aubry , Ralph Sinkus
IPC分类号： A61B8/14
CPC分类号： G01S7/52049 , A61B8/0808 , A61N7/02 , A61N2007/0078 , A61N2007/0095 , G01S15/8909
摘要： The invention concerns a method for optimizing the focusing of waves in a zone of interest of a medium, with the waves being emitted by a network of sources to the medium through an aberration-inducing element that introduces an initially indeterminate phase shift. The method according to the invention proposes to use M−1 successive modifications of the emitted wave, each giving rise to a perturbation. According to the invention, the M perturbations are measured in the zone of interest at each modification of the phase and/or amplitude distributions, and these measurements are used to deduce optimal focusing characteristics to maximize the perturbation induced in the zone of interest.
摘要翻译：本发明涉及一种用于优化介质感兴趣区域中的波的聚焦的方法，其中波被源网络通过引入初始不确定相移的像差诱导元件发射到介质。根据本发明的方法提出使用发射波的M-1个连续修改，每个引起扰动。根据本发明，在相位和/或幅度分布的每个修改时，在感兴趣的区域中测量M扰动，并且这些测量用于推导最佳聚焦特性，以使感兴趣区域中诱导的扰动最大化。

6. 发明授权

US08037766B2 Method for generation mechanical waves by generation of interfacial acoustic radiation force 有权
标题翻译：通过产生界面声辐射力产生机械波的方法
公开(公告)号：US08037766B2
公开(公告)日：2011-10-18
申请号：US12092406
申请日：2007-10-25
申请人： Jérémy Bercoff , Claude Cohen-Bacrie , Mathieu Pernot , David Savery
发明人： Jérémy Bercoff , Claude Cohen-Bacrie , Mathieu Pernot , David Savery
IPC分类号： G01N29/06 , G01N29/28
CPC分类号： G10K11/30
摘要： The present invention relates to a method for generating mechanical waves within a viscoelastic medium (11) comprising a step of generating an acoustic radiation force (15) within the viscoelastic medium (11) by application of acoustic waves focused on an interface (13) delimiting two zones (11, 14) having distinct acoustic properties.
摘要翻译：本发明涉及一种用于在粘弹性介质（11）内产生机械波的方法，包括通过施加聚焦在界面（13）上的声波在声粘弹介质（11）内产生声辐射力（15）的步骤具有不同声学特性的两个区域（11,14）。

7. 发明授权

US08858441B2 System and method for electromechanical wave imaging of body structures 有权
标题翻译：身体结构机电波成像的系统和方法
公开(公告)号：US08858441B2
公开(公告)日：2014-10-14
申请号：US11433510
申请日：2006-05-12
申请人： Elisa E. Konofagou , Mathieu Pernot
发明人： Elisa E. Konofagou , Mathieu Pernot
IPC分类号： A61B8/00
CPC分类号： A61B8/0883 , A61B8/08 , A61B8/463 , A61B8/485 , A61B8/5223 , G01S7/52042 , G01S7/52087 , G01S15/8956 , G01S15/8977
摘要： A system and method for detecting electromechanical wave propagation within a body structure of a patient in a series of image frames representing movement the body structure. Image data is acquired comprising a series of image frames corresponding to the movement of a body structure. A correlation calculation is performed on the image frames to generate a displacement map representing the relative displacement between the first and second image frames. A video is generated comprising a series of displacement maps. The parameters of movement of the body structure are detected by analysis of the displacement maps. The image acquisition may detect the movement of the body structure without inducing such movement.
摘要翻译：一种系统和方法，用于检测表示运动身体结构的一系列图像帧中患者的身体结构内的机电波传播。获取包括对应于身体结构的移动的一系列图像帧的图像数据。对图像帧执行相关计算，以生成表示第一和第二图像帧之间的相对位移的位移图。生成包括一系列位移图的视频。通过对位移图的分析来检测身体结构的运动参数。图像采集可以在不引起这种移动的情况下检测身体结构的运动。

8. 发明申请

US20090005711A1 Systems and methods for opening of the blood-brain barrier of a subject using ultrasound 审中-公开
标题翻译：使用超声波打开受试者血脑屏障的系统和方法
公开(公告)号：US20090005711A1
公开(公告)日：2009-01-01
申请号：US12077612
申请日：2008-03-19
申请人： Elisa E. Konofagou , James J. Choi , Mathieu Pernot , Scott A. Small
发明人： Elisa E. Konofagou , James J. Choi , Mathieu Pernot , Scott A. Small
IPC分类号： A61N7/00
CPC分类号： A61M37/0092 , A61B8/0816
摘要： A system and method for opening the blood-brain barrier in the brain of a subject is disclosed. In some embodiments, a region of the brain of a subject is targeted for opening; and a focused ultrasound beam is applied through the skull of the subject to the targeted region to open the blood-brain barrier in the brain of the subject.
摘要翻译：公开了一种用于打开受试者脑中的血脑屏障的系统和方法。在一些实施方案中，受试者的脑区域被打开; 并且将聚焦超声波束通过对象的头骨施加到目标区域以打开受试者的脑中的血脑屏障。

9. 发明申请

US20070049824A1 System and method for electromechanical wave imaging of body structures 有权
标题翻译：身体结构机电波成像的系统和方法
公开(公告)号：US20070049824A1
公开(公告)日：2007-03-01
申请号：US11433510
申请日：2006-05-12
申请人： Elisa Konofagou , Mathieu Pernot
发明人： Elisa Konofagou , Mathieu Pernot
IPC分类号： A61B8/00
CPC分类号： A61B8/0883 , A61B8/08 , A61B8/463 , A61B8/485 , A61B8/5223 , G01S7/52042 , G01S7/52087 , G01S15/8956 , G01S15/8977
摘要： A system and method for detecting electromechanical wave propagation within a body structure of a patient in a series of image frames representing movement the body structure. Image data is acquired comprising a series of image frames corresponding to the movement of a body structure. A correlation calculation is performed on the image frames to generate a displacement map representing the relative displacement between the first and second image frames. A video is generated comprising a series of displacement maps. The parameters of movement of the body structure are detected by analysis of the displacement maps. The image acquisition may detect the movement of the body structure without inducing such movement.
摘要翻译：一种系统和方法，用于检测表示运动身体结构的一系列图像帧中患者的身体结构内的机电波传播。获取包括对应于身体结构的移动的一系列图像帧的图像数据。对图像帧执行相关计算，以生成表示第一和第二图像帧之间的相对位移的位移图。生成包括一系列位移图的视频。通过对位移图的分析来检测身体结构的运动参数。图像采集可以在不引起这种移动的情况下检测身体结构的运动。

10. 发明授权

US10172527B2 Method and apparatus for measuring a physical parameter in mammal soft tissues by propagating shear waves 有权
公开(公告)号：US10172527B2
公开(公告)日：2019-01-08
申请号：US12533546
申请日：2009-07-31
申请人： Mathieu Pernot , Mickael Tanter , Mathieu Couade , Jean-Luc Gennisson , Mathias Fink
发明人： Mathieu Pernot , Mickael Tanter , Mathieu Couade , Jean-Luc Gennisson , Mathias Fink
IPC分类号： A61B8/00 , A61B5/021 , A61B5/00 , A61B5/01 , A61B5/02 , A61B8/08 , G01N29/06 , A61B18/02 , A61B18/18
摘要： Method for measuring a physical parameter in soft tissues of a mammal, in which a mechanical shear wave is propagated through the soft tissues and observation of the propagation leads to determine values of a shear wave propagation parameter. The physical parameter is computed on the basis of these values.

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