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1. 发明授权

US4190589A Coriolin derivatives and process for producing the same 失效
标题翻译：科里奥林衍生物及其制备方法
公开(公告)号：US4190589A
公开(公告)日：1980-02-26
申请号：US902824
申请日：1978-05-04
申请人： Yuya Nakayama , Mamoru Kunishima , Akira Matsuda , Tomio Takeuchi , Hamao Umezawa
发明人： Yuya Nakayama , Mamoru Kunishima , Akira Matsuda , Tomio Takeuchi , Hamao Umezawa
IPC分类号： A61K31/34 , A61K31/365 , A61P31/04 , A61P35/00 , A61P35/02 , C07D493/10
CPC分类号： C07D493/10
摘要： Coriolin derivatives having antitumor activity and low toxicity represented by the following general formula: ##STR1## where R: --CO(CH.sub.2).sub.6 CH.sub.3 or --COCH(OH)(CH).sub.2).sub.5 CH.sub.3,X: .dbd.CH.sub.2 or --COOR',R': H or lower alkyl group.Y: OH or .dbd.O andZ: --OH or OCH.sub.3,as well as the process for producing the above derivatives are disclosed.
摘要翻译：其中R：-CO（CH 2）6 CH 3或-COCH（OH）（CH）2）5CH 3，X：= CH 2或-COOR'，R '：H或低级烷基。 Y：OH或= O和Z：-OH或OCH 3，以及制备上述衍生物的方法。

2. 发明授权

US4233224A Coriolin derivatives 失效
标题翻译：科里奥林衍生物
公开(公告)号：US4233224A
公开(公告)日：1980-11-11
申请号：US41904
申请日：1979-05-23
申请人： Yuya Nakayama , Mamoru Kunishima , Akira Matsuda , Tomio Takeuchi
发明人： Yuya Nakayama , Mamoru Kunishima , Akira Matsuda , Tomio Takeuchi
IPC分类号： A61K31/365 , A61P31/04 , A61P35/00 , A61P35/02 , C07D493/20 , C07D493/22
CPC分类号： C07D493/22 , C07D493/20
摘要： Anti-tumor low-toxicity coriolin derivatives represented by the following general formula: ##STR1## wherein one of X and Y is ##STR2## and the other is >C OH, >C.dbd.O or ##STR3##
摘要翻译：由下列通式表示的抗肿瘤低毒型科可因衍生物：其中X和Y之一为“IMAGE”，另一个为C OH，> C = O或“IMAGE”

3. 再颁专利

USRE30451E Novel process for producing antibiotics bleomycin 失效
标题翻译：生产抗生素博莱霉素的新方法
公开(公告)号：USRE30451E
公开(公告)日：1980-12-16
申请号：US41996
申请日：1979-05-24
申请人： Hamao Umezawa , Kenji Maeda , Tomohisa Takita , Yuya Nakayama , Akio Fujii , Nobuyoshi Shimada , Hideo Chimura
发明人： Hamao Umezawa , Kenji Maeda , Tomohisa Takita , Yuya Nakayama , Akio Fujii , Nobuyoshi Shimada , Hideo Chimura
IPC分类号： C07H15/26 , C07K9/00
CPC分类号： C07K9/003 , C07H15/26
摘要： A novel process for producing antibiotics bleomycins by innoculating and aerobically culturing in a nutrient source-containing medium a bleomycin-producing strain belonging to the actinomyces, wherein the culture is effected in the presence of an amino compound having at least one ##STR1## group and at least one basic group selected from amino, imino, guanidino, amidino and sulfonium groups and nitrogen-containing cyclic compounds, or in the presence of a compound convertible in the culture liquor to such amino compound as mentioned above, thereby selectively producing a known or novel bleomycin component corresponding to the said amino compound or to an amino compound derived from the above-mentioned compound, and then the known or novel bleomycin is recovered by known means from the culture medium.

4. 发明授权

US4607114A Novel platinum complexes 失效
标题翻译：新型铂络合物
公开(公告)号：US4607114A
公开(公告)日：1986-08-19
申请号：US661433
申请日：1984-10-16
申请人： Yuya Nakayama , Kenji Iwata , Katsutoshi Takahashi
发明人： Yuya Nakayama , Kenji Iwata , Katsutoshi Takahashi
IPC分类号： A61K31/28 , A61K31/282 , A61P35/00 , C07F15/00
CPC分类号： C07F15/0093
摘要： This invention relates to a novel platinum-diamine complexes represented by the general formula: ##STR1## wherein R.sub.1 and R.sub.2 each represents a lower alkyl group having 1 to 3 carbon atoms or jointly represent an alkylene group having 3 to 6 carbon atoms; two X's each represents a halogen atom, ##STR2## or jointly represent a group represented by ##STR3## in which R.sub.3 is a lower alkyl group or a group represented by --OM (wherein M is an atom which can become a monovalent cation); Y is --OH or a halogen atom; and n is 0 or 1, and n is 1 when R.sub.1 and R.sub.2 jointly represent an alkylene group having 5 carbon atoms and X is chlorine. The platinum-diamine complex of this invention has an excellent antitumor activity and a lower renal toxicity than cis-Platin now widely used as a carcinostatic as clinical medicine, and is expected as a carcinostatic lowered in toxicity.
摘要翻译：本发明涉及由以下通式表示的新颖的铂 - 二胺络合物：其中R 1和R 2各自表示具有1至3个碳原子的低级烷基或共同表示具有3至6个碳原子的亚烷基; 两个X各自表示卤素原子，或者共同表示由表示的基团，其中R3是低级烷基或由-OM表示的基团（其中M是可以成为单价阳离子的原子）; Y是-OH或卤素原子; 且n为0或1，当R 1和R 2共同表示具有5个碳原子的亚烷基且X为氯时，n为1。本发明的铂 - 二胺配合物与现在广泛用作制癌剂作为临床医学的顺铂具有优异的抗肿瘤活性和较低的肾毒性，并且预期其具有降低的致癌性。

5. 发明授权

US08038861B2 Laminated gas sensor element and gas sensor 有权
标题翻译：层压气体传感器元件和气体传感器
公开(公告)号：US08038861B2
公开(公告)日：2011-10-18
申请号：US12423039
申请日：2009-04-14
申请人： Shin Yoshida , Nobuo Furuta , Yuya Nakayama
发明人： Shin Yoshida , Nobuo Furuta , Yuya Nakayama
IPC分类号： G01N27/417 , G01N27/419
CPC分类号： G01N27/4077
摘要： A laminated gas sensor element extending in a longitudinal direction and having a detection part including a plate-shaped element body which has a heater layer having an embedded resistance heating body and a detection layer laminated to the heater layer and having a vertical surface along a lamination direction and a horizontal surface perpendicular to the lamination direction; and a porous protective layer coating the vertical surface and the horizontal surface of the element body constituting the detection part, wherein a thickness of the protective layer formed on the vertical surface is thicker than a thickness of the protective layer formed on the horizontal surface.
摘要翻译：一种层叠气体传感器元件，其沿纵向延伸并且具有检测部件，该检测部件包括板状元件体，该板状元件体具有加热层，该加热层具有嵌入式电阻加热体和层叠到加热器层的检测层，并且具有沿层叠体的垂直表面方向和垂直于层叠方向的水平表面; 以及涂覆构成检测部件的元件主体的垂直面和水平面的多孔保护层，其中形成在垂直表面上的保护层的厚度比形成在水平表面上的保护层的厚度厚。

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