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1. 发明申请

US20060052318A1 Tyrosinase activity cntrolling agent, process for producing the same and external preparations containing the same 有权
标题翻译：酪氨酸酶活性调节剂，制备含有相同的外用制剂的方法
公开(公告)号：US20060052318A1
公开(公告)日：2006-03-09
申请号：US10530789
申请日：2003-10-10
申请人： Yutaka Tokiwa , Masaru Kitagawa , Kenji Yoshino , Shusaku Yanagidani , Takao Raku , Tetsuzo Totani , Hiromi Shimakawa
发明人： Yutaka Tokiwa , Masaru Kitagawa , Kenji Yoshino , Shusaku Yanagidani , Takao Raku , Tetsuzo Totani , Hiromi Shimakawa
IPC分类号： A61K31/704 , C07H15/00
CPC分类号： C07H15/203 , A61K8/602 , A61K31/201 , A61K31/375 , A61K31/7024 , A61K31/7034 , A61K2800/782 , A61Q5/08 , A61Q19/02 , A61Q19/08 , C07H13/06 , C12P19/46
摘要： Disclosed is a tyrosinase activity controlling agent comprising, as an active ingredient, a compound that has tyrosinase inhibiting or promoting activity, an external preparation comprising the controlling agent, and a process for producing the compound.
摘要翻译：公开了一种酪氨酸酶活性控制剂，其包含具有酪氨酸酶抑制或促进活性的化合物作为活性成分，包含所述控制剂的外用制剂及其制备方法。

2. 发明授权

US07754864B2 Tyrosinase activity controlling agent, process for producing the same and external preparation containing the same 有权
标题翻译：酪氨酸酶活性控制剂，其制备方法和含有其的外用制剂
公开(公告)号：US07754864B2
公开(公告)日：2010-07-13
申请号：US10530789
申请日：2003-10-10
申请人： Yutaka Tokiwa , Masaru Kitagawa , Kenji Yoshino , Shusaku Yanagidani , Takao Raku , Tetsuzo Totani , Hiromi Shimakawa
发明人： Yutaka Tokiwa , Masaru Kitagawa , Kenji Yoshino , Shusaku Yanagidani , Takao Raku , Tetsuzo Totani , Hiromi Shimakawa
IPC分类号： C07G3/00 , C07H15/00 , C07H17/00 , A61K31/70 , A01N43/04 , A61K8/18 , A61Q5/08 , A61Q19/02
CPC分类号： C07H15/203 , A61K8/602 , A61K31/201 , A61K31/375 , A61K31/7024 , A61K31/7034 , A61K2800/782 , A61Q5/08 , A61Q19/02 , A61Q19/08 , C07H13/06 , C12P19/46
摘要： Disclosed is a tyrosinase activity controlling agent comprising, as an active ingredient, a compound that has tyrosinase inhibiting or promoting activity, an external preparation comprising the controlling agent, and a process for producing the compound.
摘要翻译：公开了一种酪氨酸酶活性控制剂，其包含具有酪氨酸酶抑制或促进活性的化合物作为活性成分，包含所述控制剂的外用制剂及其制备方法。

3. 发明授权

US07264955B2 α1-6 fucosyltransferase 有权
标题翻译： α1-6岩藻糖基转移酶
公开(公告)号：US07264955B2
公开(公告)日：2007-09-04
申请号：US10844432
申请日：2004-05-13
申请人： Naoyuki Taniguchi , Naofumi Uozumi , Tetsuo Shiba , Shusaku Yanagidani
发明人： Naoyuki Taniguchi , Naofumi Uozumi , Tetsuo Shiba , Shusaku Yanagidani
IPC分类号： C12N9/10 , C07H21/04 , C12P21/06
CPC分类号： C12N9/1051
摘要： An isolated, porcine α1-6 fucosyltransferase having the following physico-chemical properties: (1) action: transferring fucose from guanosine diphosphate-fucose to a hydroxy group at 6-position of GluNAc closest to R of a receptor (GlcNAcβ1-2Manα1-6)(GlcNAcβ1-2Manα1-3)Manβ1-4GlcNAcβ1-4GlucNAc-R wherein R is an asparagine residue or a peptide chain carrying said residue, whereby to form (GlcNAcβ1-2Manα1-6)-(GlcNAcβ1-2Manα1-3)Manα1-4GlcNAcβ1-4(Fucα1-6)GlucNAc-R (2) optimum pH: about 7.0 (3) pH stability: retains activity after 5 hours of treatment at 4° C. at a pH range of 4.0-10.0 (4) optimum temperature: about 30-37° C. (5) inhibition or activation: no requirement for divalent metal for expression of activity; no inhibition of activity in the presence of 5 mM EDTA (6) molecular weight: about 60,000 by SDS-polyacrylamide gel electrophoresis is provided. An isolated polynucleotide encoding porcine α1-6 fucosyltransferase is also provided. Expression vectors comprising a polynucleotide encoding porcine α1-6 fucosyltransferase are also provided.
摘要翻译：具有以下物理化学性质的分离的猪α1-6岩藻糖基转移酶：（1）作用：将岩藻糖从鸟苷二磷酸 - 岩藻糖转移到最接近受体R的GluNAc的6-位的羟基（GlcNAcbeta1-2Manalpha1-6 ）（GlcNAcbeta1-2Manalpha1-3）Manbeta1-4GlcNAcbeta1-4GlucNAc-R其中R是携带所述残基的天冬酰胺残基或肽链，由此形成（GlcNAcbeta1-2Manalpha1-6） - （GlcNAcbeta1-2Manalpha1-3）Manalpha1-4GlcNAcbeta1 -4（Fucalpha1-6）GlucNAc-R（2）最适pH：约7.0（3）pH稳定性：在4.0〜1.0.0的pH范围内，4℃下处理5小时后保持活性（4）最适温度：约30-37℃。（5）抑制或活化：不需要二价金属来表达活性; 提供了通过SDS-聚丙烯酰胺凝胶电泳在5mM EDTA（6）分子量：约60,000存在下的活性抑制。还提供了编码猪α1-6岩藻糖基转移酶的分离的多核苷酸。还提供了包含编码猪α1-6岩藻糖基转移酶的多核苷酸的表达载体。

4. 发明授权

US06291219B1 &agr;1-6 fucosyltransferase 失效
标题翻译： α1-6岩藻糖基转移酶
公开(公告)号：US06291219B1
公开(公告)日：2001-09-18
申请号：US09442629
申请日：1999-11-18
申请人： Naoyuki Taniguchi , Naofumi Uozumi , Tetsuo Shiba , Shusaku Yanagidani
发明人： Naoyuki Taniguchi , Naofumi Uozumi , Tetsuo Shiba , Shusaku Yanagidani
IPC分类号： C12N900
CPC分类号： C12N9/1051
摘要： Porcine- or human-derived &agr;1-6 fucosyltransferases having the following action: action: transferring fucose from guanosine diphosphate-fucose to the hydroxy group at 6-position of GluNAc closest to R of a receptor (GlcNAc&bgr;1-2Man&agr;1-6) (GlcNAc&bgr;1-2Man&agr;1-3) Man&bgr;1-4GlcNAc&bgr;1-4GlucNAc-R wherein R is an asparagine residue or a peptide chain carrying said residue, whereby to form (GlcNAc&bgr;1-2Man&agr;1-6)-(GlcNAc&bgr;1-2Man&agr;1-3)Man&bgr;1-4GlcNAc&bgr;1-4(Fuc&agr;1-6)GlucNAc-R; a gene encoding these enzymes; an expression vector containing the gene; a transformant prepared by using this expression vector; and a method for producing a recombinant &agr;1-6 fucosyltransferase, by culturing the transformant.
摘要翻译：具有以下作用的猪或人来源的α1-6岩藻糖基转移酶：作用：将岩藻糖从鸟苷二磷酸岩藻糖转移到最接近受体R的GluNAc的6位羟基（GlcNAcbeta1-2Manalpha1-6）（GlcNAcβ1- 2Manalpha1-3）Manbeta1-4GlcNAcbeta1-4GlucNAc-R其中R是携带所述残基的天冬酰胺残基或肽链，由此形成（GlcNAcbeta1-2Manalpha1-6） - （GlcNAcbeta1-2Manalpha1-3）Manbeta1-4GlcNAcbeta1-4（Fucalpha1 -6）GlucNAc-R; 编码这些酶的基因; 含有该基因的表达载体; 通过使用该表达载体制备的转化体; 以及通过培养转化体来制备重组α1-6岩藻糖基转移酶的方法。

5. 发明授权

US6054304A .alpha.1-6 fucosyltransferase 失效
标题翻译： α1-岩藻糖基转移酶
公开(公告)号：US6054304A
公开(公告)日：2000-04-25
申请号：US913805
申请日：1998-01-07
申请人： Naoyuki Taniguchi , Naofumi Uozumi , Tetsuo Shiba , Shusaku Yanagidani
发明人： Naoyuki Taniguchi , Naofumi Uozumi , Tetsuo Shiba , Shusaku Yanagidani
IPC分类号： C12N9/10 , C12N15/54 , A23J1/00 , C12N1/20 , C12N5/00
CPC分类号： C12N9/1051
摘要： Porcine- or human-derived .alpha.1-6 fucosyltransferases having the following action:action: transferring fucose from guanosine adiphosphate-fucose to the hydroxy group at 6-position of GlcNAc closest to R of a receptor (GlcNAc.beta.1-2Man.alpha.1-6)(GlcNAc.beta.1-2Man.alpha.1-3)Man.beta.1-4GlcNAc.beta.1-4GlcNAc-R wherein R is an asparagine residue or a peptide chain carrying said residue, whereby to form (GlcNAc.beta.1-2Man.alpha.1-6)-(GlcNAc.beta.1-2Man.alpha.1-3)Man.beta.1-4GlcNAc.beta.1-4(Fuc.alpha.1-6)GlcNAc-R; a gene encoding these enzymes; an expression vector containing the gene; a transformant prepared by using this expression vector; and a method for producing a recombinant .alpha.1-6 fucosyltransferase, by culturing the transformant.
摘要翻译： PCT No.PCT / JP97 / 00171 Sec。 371日期：1998年1月7日 102（e）1998年1月7日PCT PCT 1997年1月23日PCT公布。公开号WO97 / 27303 日期1997年7月31日具有以下作用的雄激素或人源α1-岩藻糖基转移酶：作用：将岩藻糖从鸟苷酸岩藻糖转移到最接近受体R的GlcNAc的6位的羟基（GlcNAcβ1 -2Manα1-6）（GlcNAcβ1-2Manα1-3）Manβ1-4GlcNAcβ1-4GlcNAc-R其中R是携带所述残基的天冬酰胺残基或肽链，由此形成（GlcNAcβ1 -2Manα1-6） - （GlcNAcβ1-2Manα1-3）Manβ1-4GlcNAcβ1-4（Fucα1-6）GlcNAc-R; 编码这些酶的基因; 含有该基因的表达载体; 通过使用该表达载体制备的转化体; 以及通过培养转化体来产生重组α1-6岩藻糖基转移酶的方法。

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