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1. 发明申请

US20120028263A1 METHOD FOR SCREENING A SALTY TASTE MODULATING SUBSTANCE 有权
标题翻译：筛选盐酸调味物质的方法
公开(公告)号：US20120028263A1
公开(公告)日：2012-02-02
申请号：US13190885
申请日：2011-07-26
申请人： Yutaka Ishiwatari , Yuko Kai , Takami Maekawa , Yuzuru Eto
发明人： Yutaka Ishiwatari , Yuko Kai , Takami Maekawa , Yuzuru Eto
IPC分类号： C12Q1/68 , C07H21/04 , C07K14/435 , C12Q1/02 , C12N5/00
CPC分类号： G01N33/6872 , G01N33/5008
摘要： By contacting a test substance with a cell that expresses a Kv3.2 protein, and comparing observed cation influx into the cell with cation influx into the cell observed when the test substance is not contacted with the cell, a salty taste modulating substance such as salt alternative compound, or salt perception enhancing or inhibiting compound is screened.
摘要翻译：通过使测试物质与表达Kv3.2蛋白质的细胞接触，并且当测试物质不与细胞接触时观察到阳离子进入细胞的阳离子流入细胞中观察到的阳离子流入，将盐调味物质如盐替代化合物或盐感知增强或抑制化合物被筛选。

2. 发明授权

US09222944B2 Method for screening a salty taste modulating substance 有权
标题翻译：筛选咸味调节物质的方法
公开(公告)号：US09222944B2
公开(公告)日：2015-12-29
申请号：US13190885
申请日：2011-07-26
申请人： Yutaka Ishiwatari , Yuko Kai , Takami Maekawa , Yuzuru Eto
发明人： Yutaka Ishiwatari , Yuko Kai , Takami Maekawa , Yuzuru Eto
IPC分类号： C12Q1/68 , G01N33/68 , G01N33/50
CPC分类号： G01N33/6872 , G01N33/5008
摘要： By contacting a test substance with a cell that expresses a Kv3.2 protein, and comparing observed cation influx into the cell with cation influx into the cell observed when the test substance is not contacted with the cell, a salty taste modulating substance such as salt alternative compound, or salt perception enhancing or inhibiting compound is screened.
摘要翻译：通过使测试物质与表达Kv3.2蛋白质的细胞接触，并且当测试物质不与细胞接触时观察到的阳离子进入细胞，将观察到的阳离子流入细胞与阳离子进入比较，将咸味调节物质如盐替代化合物或盐感知增强或抑制化合物被筛选。

3. 发明申请

US20130072491A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR DIABETES OR OBESITY 有权
标题翻译：糖尿病或肥胖症的预防或治疗药物
公开(公告)号：US20130072491A1
公开(公告)日：2013-03-21
申请号：US13601141
申请日：2012-08-31
申请人： Reiko YASUDA , Yuzuru Eto , Yoshiro Kitahara
发明人： Reiko YASUDA , Yuzuru Eto , Yoshiro Kitahara
IPC分类号： C07C309/51 , C07C311/32 , C07C333/08 , C07D271/10 , C07D209/14 , C07C275/42 , C07D295/192 , C07C53/18 , C07D417/04 , C07C311/51 , C07C335/16 , C07D213/75 , C07D233/61
CPC分类号： C07C309/51 , A61K31/167 , A61K31/17 , A61K31/198 , A61K31/27 , A61K31/4045 , A61K31/417 , A61K31/4245 , A61K31/4402 , A61K31/5377 , C07C53/18 , C07C275/42 , C07C311/32 , C07C311/51 , C07C333/08 , C07C335/16 , C07C2601/14 , C07C2601/18 , C07D209/14 , C07D213/74 , C07D213/75 , C07D233/61 , C07D271/10 , C07D295/16 , C07D295/192 , C07D413/04 , C07D417/04
摘要： An object is to provide a CaSR agonist agent that has excellent CaSR agonist effects, and particularly, a pharmaceutical product that can prevent or remedy diabetes or obesity by the effect of CaSR activation. The aforementioned object is achieved by a composition that contains a compound represented by the following General Formula (I) or a salt thereof (refer to the Description for the definitions of the symbols used in the formula).
摘要翻译：目的是提供具有优异的CaSR激动剂作用的CaSR激动剂，特别是可以通过CaSR活化来预防或治疗糖尿病或肥胖症的药物。上述目的通过含有由以下通式（I）表示的化合物或其盐（参考式中的符号的定义的描述）的组合物来实现。

4. 发明授权

US08173605B2 Kokumi-imparting agent 有权
标题翻译： Kokumi传授代理
公开(公告)号：US08173605B2
公开(公告)日：2012-05-08
申请号：US12117027
申请日：2008-05-08
申请人： Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
发明人： Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
IPC分类号： C07K5/06
CPC分类号： G01N33/6872 , A23L27/10 , A23L33/175 , C07K5/0215 , G01N2333/726
摘要： The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi.
摘要翻译：本发明包括使用钙受体活性作为指标筛选赋粉性物质的方法，含有通过筛选方法得到的赋予口味的物质的组合物，赋予口味的食品或饮料的制造方法，以及送给kokumi的食物或饮料。

5. 发明申请

US20100136197A1 Kokumi- imparting agent 有权
标题翻译： Kokumi传授代理
公开(公告)号：US20100136197A1
公开(公告)日：2010-06-03
申请号：US12121969
申请日：2008-05-16
申请人： Yuzuru Eto , Yusuke Amino
发明人： Yuzuru Eto , Yusuke Amino
IPC分类号： A23L1/228 , C07K5/083 , C07K5/062
CPC分类号： C07K5/0215 , A23L23/00 , A23L27/10 , A23L27/21 , A23L33/175 , G01N2333/726
摘要： The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi.
摘要翻译：本发明包括使用钙受体活性作为指标筛选赋粉性物质的方法，含有通过筛选方法得到的赋予口味的物质的组合物，赋予口味的食品或饮料的制造方法，以及送给kokumi的食物或饮料。

6. 发明授权

US08454978B2 Immunostimulating agent 有权
标题翻译：免疫刺激剂
公开(公告)号：US08454978B2
公开(公告)日：2013-06-04
申请号：US12899045
申请日：2010-10-06
申请人： Tomohiro Kodera , Yuzuru Eto , Yoshinori Mine
发明人： Tomohiro Kodera , Yuzuru Eto , Yoshinori Mine
IPC分类号： A61K38/05
CPC分类号： A61K31/132 , A23L33/10 , A23L33/18 , A61K31/135 , A61K38/03 , A61K38/17 , Y02A50/473
摘要： An immunostimulating agent, which can stimulate immunity effectively, is described. The immunostimulating agent contains an active ingredient including a calcium receptor activator such as γ-Glu-X-Gly [wherein X represents an amino acid or a derivative thereof other than Cys], γ-Glu-Val-Y [wherein Y represents an amino acid or a derivative thereof], γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Met, γ-Glu-Thr, γ-Glu-Val, γ-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, γ-Glu-Met(O), γ-Glu-γ-Glu-Val, γ-Glu-Val-NH2, γ-Glu-Val-ol, γ-Glu-Ser, γ-Glu-Tau, γ-Glu-Cys(S-Me)(O), γ-Glu-Leu, γ-Glu-Ile, γ-Glu-t-Leu, γ-Glu-Cys(S-Me), a cation having a valency of 2 or more, protamine, polylysine, spermine, spermidine, putrescine, cinacalcet, a cinacalcet analogue compound, and a salt of any one of the aforementioned components.
摘要翻译：描述了可以有效地刺激免疫的免疫刺激剂。免疫刺激剂含有活性成分，包括钙受体激活剂如γ-Glu-X-Gly [其中X表示除Cys之外的氨基酸或其衍生物]，γ-Glu-Val-Y [其中Y表示氨基酸或其衍生物]，γ-Glu-Ala，γ-Glu-Gly，γ-Glu-Met，γ-Glu-Thr，γ-Glu-Val，γ-Glu-Orn，Asp-Gly，Cys-Gly ，Cys-Met，Glu-Cys，Gly-Cys，Leu-Asp，γ-Glu-Met（O），γ-Glu-γ-Glu-Val，γ-Glu-Val-NH2，（S-Me）（O），γ-Glu-Leu，γ-Glu-Ile，γ-Glu-t-Leu，γ-Glu-Leu， Glu-Cys（S-Me），2价以上的阳离子，鱼精蛋白，聚赖氨酸，精胺，亚精胺，腐胺，西那卡塞，西那卡塞类似物化合物和上述成分中的任一种的盐。

7. 发明授权

US08420144B2 Kokumi-imparting agent, method of using, and compositions containing same 有权
标题翻译：赋形剂，使用方法和含有它们的组合物
公开(公告)号：US08420144B2
公开(公告)日：2013-04-16
申请号：US12121969
申请日：2008-05-16
申请人： Yuzuru Eto , Yusuke Amino
发明人： Yuzuru Eto , Yusuke Amino
IPC分类号： A23L1/228
CPC分类号： C07K5/0215 , A23L23/00 , A23L27/10 , A23L27/21 , A23L33/175 , G01N2333/726
摘要： The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi.
摘要翻译：本发明包括使用钙受体活性作为指标筛选赋粉性物质的方法，含有通过筛选方法得到的赋予口味的物质的组合物，赋予口味的食品或饮料的制造方法，以及送给kokumi的食物或饮料。

8. 发明申请

US20080249001A1 AGENTS THAT ALLEVIATE SIDE-EFFECTS CAUSED BY CHEMOTHERAPY AGENTS 审中-公开
标题翻译：由化疗药剂引起的副作用的药剂
公开(公告)号：US20080249001A1
公开(公告)日：2008-10-09
申请号：US11924080
申请日：2007-10-25
申请人： Akiko Onuki , Kazumi Tashiro , Yuzuru Eto , Tomoyuki Konda
发明人： Akiko Onuki , Kazumi Tashiro , Yuzuru Eto , Tomoyuki Konda
IPC分类号： A61K38/14 , C07C53/00 , A61K31/195 , A61P35/00
CPC分类号： A61K31/198 , A61K38/1816 , A61K2300/00
摘要： The present invention provides improving agents of side-effects of chemotherapy agents. Though the erythroid progenitor cells decrease due to the side-effect of chemotherapy agents, such side-effect can be improved by chemotherapy agents which comprise arginine as the active ingredient.
摘要翻译：本发明提供了化疗剂副作用的改善剂。尽管红细胞祖细胞由于化疗药物的副作用而降低，但可以通过包含精氨酸作为活性成分的化疗剂来改善这种副作用。

9. 发明授权

US07375085B1 Melanocyte-stimulating hormone inhibitors 有权
标题翻译：促黑细胞激素抑制剂
公开(公告)号：US07375085B1
公开(公告)日：2008-05-20
申请号：US09926391
申请日：2000-04-25
申请人： Eiji Shiojiri , Yoshinobu Takino , Hiromi Chujou , Kazutami Sakamoto , Chiori Ijichi , Yuzuru Eto , Keiji Iwasaki
发明人： Eiji Shiojiri , Yoshinobu Takino , Hiromi Chujou , Kazutami Sakamoto , Chiori Ijichi , Yuzuru Eto , Keiji Iwasaki
IPC分类号： C07K5/08 , A61K38/00
CPC分类号： C07K5/0812 , A61K38/00
摘要： In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl group or the salts thereof, or a melanocyte-stimulating hormone inhibitory compound having a 50% inhibitory concentration of cAMP production (IC50) of 100 nM or less, which composition can prevent pigmentation, or can prevent, improve or recover from immune abnormality or immunodeficiency, or regulate body weight by appetite control, and also can be used as cosmetics or external preparations for the skin, and in addition, can be produced easily, and are excellent in the stability during storage.
摘要翻译：在本说明书中公开了一种黑素细胞刺激激素抑制组合物，其包含作为活性成分的具有某个萘基的二肽或三肽衍生物或其盐，或具有50％抑制性的黑素细胞刺激激素抑制化合物 cAMP产生浓度（IC 50）为100nM以下，该组合物可以防止色素沉积，或者可以防止，改善或恢复免疫异常或免疫缺陷，或通过食欲控制来调节体重，并且还可以用作化妆品或外用制剂并且另外可以容易地制造，并且在保存期间的稳定性优异。

10. 发明申请

US20050266498A1 Method for screening biomolecule activity regulator 审中-公开
标题翻译：筛选生物分子活性调节剂的方法
公开(公告)号：US20050266498A1
公开(公告)日：2005-12-01
申请号：US11135414
申请日：2005-05-24
申请人： Satoru Okamoto , Kiyoshi Miwa , Yuzuru Eto
发明人： Satoru Okamoto , Kiyoshi Miwa , Yuzuru Eto
IPC分类号： C07K1/04 , C07K7/06 , C07K7/08 , C07K14/00 , C12N9/04 , C12N15/10 , C12P7/60 , C12Q1/02 , C40B40/02 , G01N33/50 , G01N33/53 , C12P21/06
CPC分类号： C40B40/02 , C07K1/047 , C07K7/06 , C07K7/08 , C07K14/00 , C12N9/0006 , C12N15/1037 , C12P7/60 , C12Q1/025 , G01N33/50
摘要： A method for screening a low molecular weight substance which binds to a specific site of a biomolecule and may be usable as a starting material in drug development. This method comprises screening a substance that interacts with a specific region of a biomolecule having an activity, to regulate the activity, by the following steps: (a) a step of selecting a recombinant organism that interacts with the biomolecule, from a peptide library composed of a collection of recombinant organisms each presenting at least one of various peptides on its surface; and (b) a step of selecting a substance inhibiting the interaction between the selected recombinant organism or a peptide presented by the recombinant organism and the biomolecule.
摘要翻译：用于筛选结合生物分子的特定部位并可用作药物开发中的起始材料的低分子量物质的方法。该方法包括通过以下步骤筛选与具有活性的生物分子的特定区域相互作用以调节活性的物质：（a）从组成的肽文库中选择与生物分子相互作用的重组生物体的步骤的重组生物的集合，每个在其表面上呈现各种肽中的至少一种; 和（b）选择抑制所选择的重组生物或由重组生物呈递的肽与生物分子之间的相互作用的物质的步骤。

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