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1. 发明授权

US09018391B2 Inhibitors of beta-secretase 有权
标题翻译： β-分泌酶抑制剂
公开(公告)号：US09018391B2
公开(公告)日：2015-04-28
申请号：US14011183
申请日：2013-08-27
申请人： Yuri Bukhtiyarov , Salvacion Cacatian , Lawrence Wayne Dillard , Klaus Fuchs , Lanqi Jia , Deepak S. Lala , Angel Morales-Ramos , Suresh B. Singh , Shankar Venkatraman , Zhenrong Xu , Jing Yuan , Yi Zhao , Yajun Zheng , Cornelia Dorner-Ciossek , Ulrike Gross , Niklas Heine , Achim Sauer
发明人： Yuri Bukhtiyarov , Salvacion Cacatian , Lawrence Wayne Dillard , Klaus Fuchs , Lanqi Jia , Deepak S. Lala , Angel Morales-Ramos , Suresh B. Singh , Shankar Venkatraman , Zhenrong Xu , Jing Yuan , Yi Zhao , Yajun Zheng , Cornelia Dorner-Ciossek , Ulrike Gross , Niklas Heine , Achim Sauer
IPC分类号： C07D235/02 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/06 , C07D401/14 , A61K31/4184
CPC分类号： C07D235/02 , A61K31/4184 , A61K31/4439 , A61K31/506 , C07C49/747 , C07C49/755 , C07C229/50 , C07C255/59 , C07C313/06 , C07C331/26 , C07C2603/94 , C07C2603/97 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/06
摘要： The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
摘要翻译：本发明涉及螺环酰基胍及其作为分泌酶（BACE1）活性的抑制剂，含有它们的药物组合物的用途，以及将其用作治疗神经变性疾病的治疗剂的方法，其特征在于认知衰退，认知障碍，痴呆和以淀粉样蛋白聚集体生产为特征的疾病。

2. 发明申请

US20140057927A1 INHIBITORS OF BETA-SECRETASE 有权
标题翻译： BETA-SECRETASE的抑制剂
公开(公告)号：US20140057927A1
公开(公告)日：2014-02-27
申请号：US14011183
申请日：2013-08-27
申请人： Yuri Bukhtiyarov , Salvacion Cacatian , Lawrence Wayne Dillard , Klaus Fuchs , Lanqi Jia , Deepak S. Lala , Angel Morales-Ramos , Suresh B. Singh , Shankar Venkatraman , Zhenrong Xu , Jing Yuan , Yi Zhao , Yajun Zheng , Cornelia Dorner-Ciossek , Ulrike Gross , Niklas Heine , Achim Sauer
发明人： Yuri Bukhtiyarov , Salvacion Cacatian , Lawrence Wayne Dillard , Klaus Fuchs , Lanqi Jia , Deepak S. Lala , Angel Morales-Ramos , Suresh B. Singh , Shankar Venkatraman , Zhenrong Xu , Jing Yuan , Yi Zhao , Yajun Zheng , Cornelia Dorner-Ciossek , Ulrike Gross , Niklas Heine , Achim Sauer
IPC分类号： C07D405/06 , C07D401/06 , C07D401/14 , C07D235/02 , C07D403/04
CPC分类号： C07D235/02 , A61K31/4184 , A61K31/4439 , A61K31/506 , C07C49/747 , C07C49/755 , C07C229/50 , C07C255/59 , C07C313/06 , C07C331/26 , C07C2603/94 , C07C2603/97 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/06
摘要： The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
摘要翻译：本发明涉及螺环酰基胍及其作为β-分泌酶（BACE1）活性抑制剂的用途，含有它们的药物组合物及其用作治疗神经变性疾病的治疗剂的方法，其特征在于认知衰退，认知障碍，痴呆和以β-淀粉样蛋白聚集体生产为特征的疾病。

3. 发明授权

US09603075B2 Method, device and system for reconfiguring aggregation cell 有权
公开(公告)号：US09603075B2
公开(公告)日：2017-03-21
申请号：US13390105
申请日：2010-09-15
申请人： Yi Zhao , Jing Liang , Jiamin Liu , Fangli Xu
发明人： Yi Zhao , Jing Liang , Jiamin Liu , Fangli Xu
IPC分类号： H04W40/00 , H04W36/28 , H04W72/02
CPC分类号： H04W36/28 , H04L5/001 , H04L5/0053 , H04L5/0096 , H04L5/0098 , H04W72/02
摘要： The present invention provides a method for reconfiguring an aggregated cell, which includes that: a network side device judges whether the aggregated cell of a user equipment (UE) needs to be changed in the cell set in which the carriers can be aggregated; when the judgment result is that the change is needed, the network side device transmits a radio resource control (RRC) connection reconfiguration message to the UE, and the RRC connection reconfiguration message carries the change information of the aggregated cell of the UE; the UE receives the RRC connection reconfiguration message, and reconfigures the aggregated cell according to the RRC connection reconfiguration message. In the present invention, for the LTE-A system, when the aggregated cell of UE which supports the carrier aggregation changes within the same cell set in which the carriers can be aggregated, the aggregated cell of the UE can be reconfigured; and the same access stratum (AS) key is used to perform the security processing procedure for the data, which enables the uninterrupted transmission for the data.

4. 发明授权

US09173922B2 Uses of IL-12 in hematopoiesis 有权
标题翻译：在造血中使用IL-12
公开(公告)号：US09173922B2
公开(公告)日：2015-11-03
申请号：US13356515
申请日：2012-01-23
申请人： Tingchao Chen , Yi Zhao , W. French Anderson
发明人： Tingchao Chen , Yi Zhao , W. French Anderson
IPC分类号： A61K38/20 , A61P35/00 , A61P7/06 , C07K14/54 , A61K45/06 , A61N5/10
CPC分类号： A61K38/208 , A61K31/675 , A61K38/193 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07K14/53 , C07K14/5434 , A61K2300/00
摘要： Methods for enhancing or stimulating hematopoiesis including the step of administering Interleukin-12 (IL-12) to yield hematopoietic recovery in a mammal in need. Preferred methods include the step of administering IL-12 as an adjuvant therapy to alleviate the hematopoietic toxicities associated with one or more treatment regimens used to combat a disease state. Other methods include administering IL-12 to ameliorate various hematopoietic deficiencies. Still other methods are directed to uses of IL-12 for in-vivo proliferation of hematopoietic repopulating cells, hematopoietic progenitor cells and hematopoietic stem cells. Other disclosed methods are directed to uses of IL-12 for bone marrow preservation or recovery.
摘要翻译：用于增强或刺激造血的方法，包括施用白细胞介素-12（IL-12）以在需要的哺乳动物中产生造血回收的步骤。优选的方法包括施用IL-12作为辅助治疗以减轻与用于对抗疾病状态的一种或多种治疗方案相关的造血毒性的步骤。其他方法包括给予IL-12以改善各种造血缺陷。还有其它方法涉及IL-12用于造血再生细胞，造血祖细胞和造血干细胞的体内增殖的用途。其他公开的方法涉及IL-12用于骨髓保存或恢复的用途。

5. 发明授权

US09106089B2 Self-adapting voltage amplifier and battery charger detection 有权
标题翻译：自适应电压放大器和电池充电器检测
公开(公告)号：US09106089B2
公开(公告)日：2015-08-11
申请号：US13958600
申请日：2013-08-04
申请人： Wenzhong Zhang , Shayan Zhang , Yi Zhao
发明人： Wenzhong Zhang , Shayan Zhang , Yi Zhao
IPC分类号： H02J7/00 , H03F3/45
CPC分类号： H02J7/0052 , H02J2007/0062 , H03F3/45183
摘要： An amplifier applies a self-adapting voltage to an output terminal. A bias circuit provides a greater bias current in a first external connection condition, in the absence of a pull-up resistance connected to the output terminal, than when such a pull-up resistance is present. The amplifier applies a different voltage to the output terminal in the absence of a pull-up resistance than when such a pull-up resistance is present. The circuit can be used in a portable device for receiving charging current from a battery charger through a connector having a D+ pin for connection to the battery charger and connected to the amplifier output terminal for battery charger detection. The portable device can meet the USB battery charger specification rev. 1.2.
摘要翻译：放大器将自适应电压施加到输出端子。在不存在连接到输出端子的上拉电阻的情况下，偏置电路在第一外部连接状态下提供更大的偏置电流，而不是存在这样的上拉电阻。在不存在上拉电阻的情况下，放大器对输出端子施加不同的电压，而不是存在这样的上拉电阻。该电路可以用在便携式设备中，用于通过具有用于连接到电池充电器的D +引脚的连接器从电池充电器接收充电电流，并连接到用于电池充电器检测的放大器输出端子。便携式设备可以满足USB电池充电器规格的修改。 1.2。

6. 发明申请

US20130343319A1 INDICATION METHOD FOR ACCESSING A CELL, METHOD FOR SELECTING A CELL, AND DEVICE 审中-公开
标题翻译：用于获取细胞的指示方法，选择细胞的方法和装置
公开(公告)号：US20130343319A1
公开(公告)日：2013-12-26
申请号：US14003113
申请日：2011-12-30
申请人： Haiyang Quan , Jiayi Fang , Yi Zhao
发明人： Haiyang Quan , Jiayi Fang , Yi Zhao
IPC分类号： H04W48/08
CPC分类号： H04W48/08 , H04W4/70 , H04W48/02
摘要： An indication method for accessing a cell, a method for selecting a cell and devices. The indication method for accessing a cell includes: broadcasting, by a base station, network access control information; wherein the network access control information is to indicate whether a cell of the base station permits access of a user equipment (UE) with a specific UE category, or access of a UE with a specific access class, or access of a UE supporting a specific service. When the examples of the present invention are employed, the access of a MTC device can be controlled, and thus system overhead is reduced.
摘要翻译：用于访问小区的指示方法，用于选择小区和设备的方法。用于接入小区的指示方法包括：由基站广播网络接入控制信息; 其中所述网络访问控制信息是指示所述基站的小区是否允许具有特定UE类别的用户设备（UE）的访问，或具有特定接入类别的UE的接入，或者支持特定接入类型的UE的接入服务。当采用本发明的示例时，可以控制MTC设备的接入，从而降低系统开销。

7. 发明申请

US20130232002A1 System and Method for Managing Requests for Service 审中-公开
标题翻译：管理服务请求的系统和方法
公开(公告)号：US20130232002A1
公开(公告)日：2013-09-05
申请号：US13780227
申请日：2013-02-28
申请人： Yong Zhao , Yi Zhao , McEvan Baum
发明人： Yong Zhao , Yi Zhao , McEvan Baum
IPC分类号： G06Q30/06
CPC分类号： G06Q30/0613 , G06Q30/0239 , G06Q30/0611
摘要： A present invention embodiment provides a system for connecting service seekers with service providers in order for the service providers to perform a desired service. The system handles service requests and comprises a computer system including at least one processor. The system receives one or more service requests from service seekers requesting performance of a service. Service providers that provide the requested services are identified based on at least the current location of the service providers relative to the location for performing the requested service. The system further facilitates communication between the service seekers and the identified service providers. Embodiments of the present invention further include a method and computer program product for handling service requests in substantially the same manner described above.
摘要翻译：本发明实施例提供了一种用于将服务寻求者与服务提供商相连接的系统，以便服务提供商执行所需的服务。该系统处理服务请求并且包括包括至少一个处理器的计算机系统。系统从请求执行服务的服务请求者接收一个或多个服务请求。提供所请求服务的服务提供者至少基于服务提供者相对于用于执行所请求服务的位置的当前位置被识别。该系统进一步促进了服务寻求者与所识别的服务提供者之间的通信。本发明的实施例还包括用于以基本相同的方式处理服务请求的方法和计算机程序产品。

8. 发明授权

US08217579B2 Device and method for controlling DC bias of RF discharge system 有权
标题翻译：控制射频放电系统直流偏置的装置和方法
公开(公告)号：US08217579B2
公开(公告)日：2012-07-10
申请号：US12746480
申请日：2008-02-03
申请人： Yi Zhao
发明人： Yi Zhao
IPC分类号： H03F3/04 , H05B31/26
CPC分类号： H03F1/0211 , H03F1/0277 , H03F3/20
摘要： The present invention provides a device and a method for controlling a DC bias of a RF discharge system. Said device comprises a DC bias detection module (302), a mode selection module (301), a DC bias controlling module (303) and a RF power providing module (304). The mode selection module (301) receives a parameter and a type of the parameter. If the type of the parameter is representative of voltage, the DC bias controlling module (303) calculates a power value according to the voltage-related representative parameter and the detected DC bias value, and the RF power providing module (304) provides power according to the calculated power value. If the type of the parameter is representative of power, the RF power providing module (304) provides power according to the power-related representative parameter.
摘要翻译：本发明提供一种用于控制RF放电系统的直流偏压的装置和方法。所述装置包括DC偏压检测模块（302），模式选择模块（301），DC偏压控制模块（303）和RF功率提供模块（304）。模式选择模块（301）接收参数和参数的类型。如果参数的类型代表电压，则直流偏置控制模块（303）根据与电压相关的代表参数和检测到的直流偏压值来计算功率值，并且RF功率提供模块（304）根据到计算的功率值。如果参数的类型代表功率，则RF功率提供模块（304）根据功率相关的代表性参数提供功率。

9. 发明申请

US20110206635A1 USES OF IL-12 IN HEMATOPOIESIS 审中-公开
标题翻译： IL-12在HEMATOPOIESIS中的应用
公开(公告)号：US20110206635A1
公开(公告)日：2011-08-25
申请号：US13076365
申请日：2011-03-30
申请人： Tingchao CHEN , Yi Zhao , W. French Anderson
发明人： Tingchao CHEN , Yi Zhao , W. French Anderson
IPC分类号： A61K38/20 , A61P31/12
CPC分类号： A61K38/208 , A61K31/675 , A61K38/193 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07K14/53 , C07K14/5434 , A61K2300/00
摘要： Methods for enhancing or stimulating hematopoiesis including the step of administering Interleukin-12 (IL-12) to yield hernatopoietic recovery in a mammal in need. Preferred methods include the step of administering IL-12 as an adjuvant therapy to alleviate the hematopoietic toxicities associated with one or more treatment regimens used to combat a disease state. Other methods include administering IL-12 to ameliorate various hematopoietic deficiencies. Still other methods are directed to uses of IL-12 for in-vivo proliferation of hematopoietic repopulating cells, hematopoietic progenitor cells and hematopoietic stem cells. Other disclosed methods are directed to uses of IL-12 for bone marrow preservation or recovery.
摘要翻译：用于增强或刺激造血的方法，包括施用白细胞介素-12（IL-12）以在需要的哺乳动物中产生愈伤组织的恢复的步骤。优选的方法包括施用IL-12作为辅助治疗以减轻与用于对抗疾病状态的一种或多种治疗方案相关的造血毒性的步骤。其他方法包括给予IL-12以改善各种造血缺陷。还有其它方法涉及IL-12用于造血再生细胞，造血祖细胞和造血干细胞的体内增殖的用途。其他公开的方法涉及IL-12用于骨髓保存或恢复的用途。

10. 发明申请

US20070026422A1 Vaccine-induced hepatitis B viral strain and uses thereof 审中-公开
标题翻译：疫苗诱导的乙型肝炎病毒株及其用途
公开(公告)号：US20070026422A1
公开(公告)日：2007-02-01
申请号：US11385013
申请日：2006-03-20
申请人： Chong Oon , Gek Lim , Ai Leong , Yi Zhao , Wei Chen
发明人： Chong Oon , Gek Lim , Ai Leong , Yi Zhao , Wei Chen
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/5764 , A61K39/12 , A61K39/29 , C07K14/005 , C07K14/71 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12Q1/706
摘要： This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-‘S’-145 Singapore Strain (Glycine to Arginine) which constituent viral genome is deposited under Accession Nos. P97121504, P97121505 and P97121506 with the European Collection of Cell Culture on 15th Dec. 1997. This invention also provides an isolated nucleic acid encoding a polypeptide which is a mutant major surface antigen of a strain of hepatitis B virus, such polypeptide having an amino acid sequence which differs from the amino acid sequence of a major surface antigen of a wild type hepatitis B virus in that the amino acid at position number 145 of such polypeptide is an arginine rather than a glycine, and the purified peptide This invention further provides an isolated nucleic acid which encodes a peptide, wherein the peptide is encoded by a nucleic acid molecule comprising nucleotides 527 through 595 of SEQ. I.D. No. 1, and the purified peptide. This invention also provides various methods using the disclosed isolated nucleic acids and polypeptides.
摘要翻译：本发明提供了一种分离的乙型肝炎病毒株，命名为人类乙型肝炎病毒表面抗原-''-145新加坡菌株（Glycine to Arginine），构成病毒基因组以保藏号P97121504，P97121505和P97121506保藏在欧洲集合细胞培养在15日/ 12月12日。本发明还提供了编码多肽的分离核酸，其是乙型肝炎病毒株的突变型主要表面抗原，该多肽具有不同于野生型主要表面抗原的氨基酸序列的氨基酸序列因为这种多肽的位置编号145的氨基酸是精氨酸而不是甘氨酸，纯化的肽本发明还提供了编码肽的分离的核酸，其中肽由核酸编码包含SEQ ID NO：527至595的分子。 ID。 1和纯化肽。本发明还提供了使用公开的分离的核酸和多肽的各种方法。

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