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1. 发明授权

US07517650B2 Method of diagnosing breast cancer and compositions therefor 有权
标题翻译：诊断乳腺癌的方法及其组成
公开(公告)号：US07517650B2
公开(公告)日：2009-04-14
申请号：US11368141
申请日：2006-03-03
申请人： Yun-sun Nam , Seung-Hak Choi , Jae-Heup Kim , Jung-joo Hwang , Yeon-Su Lee , Tae-jin Ahn
发明人： Yun-sun Nam , Seung-Hak Choi , Jae-Heup Kim , Jung-joo Hwang , Yeon-Su Lee , Tae-jin Ahn
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： A method of diagnosing breast cancer in an individual aged younger than 41 or older than 54 is provided. The method comprises obtaining a nucleic acid from the individual and determining a nucleotide at a polymorphic site of the nucleic acid. Polynucleotides specific to breast cancer, a microarray comprising the polynucleotides, and diagnostic kits are also provided.
摘要翻译：提供了一种在年龄小于41岁或以下的个体中诊断乳腺癌的方法。该方法包括从个体获得核酸并确定核酸的多态位点处的核苷酸。还提供了对乳腺癌特异性的多核苷酸，包含多核苷酸的微阵列和诊断试剂盒。

2. 发明申请

US20060211023A1 Method of diagnosing breast cancer and compositions therefor 有权
公开(公告)号：US20060211023A1
公开(公告)日：2006-09-21
申请号：US11368141
申请日：2006-03-03
申请人： Yun-sun Nam , Seung-Hak Choi , Jae-Heup Kim , Jung-Joo Hwang , Yeon-Su Lee , Tae-Jin Ahn
发明人： Yun-sun Nam , Seung-Hak Choi , Jae-Heup Kim , Jung-Joo Hwang , Yeon-Su Lee , Tae-Jin Ahn
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： A method of diagnosing breast cancer in an individual aged younger than 41 or older than 54 is provided. The method comprises obtaining a nucleic acid from the individual and determining a nucleotide at a polymorphic site of the nucleic acid. Polynucleotides specific to breast cancer, a microarray comprising the polynucleotides, and diagnostic kits are also provided.

3. 发明申请

US20060263815A1 Multiple SNP for diagnosing cardiovascular disease, microarray and kit comprising the same, and method of diagnosing cardiovascular disease using the same 有权
标题翻译：用于诊断心血管疾病的多重SNP，包含该SNP的微阵列和试剂盒以及使用该SNP诊断心血管疾病的方法
公开(公告)号：US20060263815A1
公开(公告)日：2006-11-23
申请号：US11435662
申请日：2006-05-17
申请人： Seung-Hak Choi , Yun-sun Nam , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Hyo-jeong Jeon , Ok-ryul Song , Tae-jin Ahn , Kyu-sang Lee
发明人： Seung-Hak Choi , Yun-sun Nam , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Hyo-jeong Jeon , Ok-ryul Song , Tae-jin Ahn , Kyu-sang Lee
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： A multiple single nucleotide polymorphism (multi-SNP) marker for cardiovascular disease diagnosis and a method of diagnosing cardiovascular disease are provided. Also, sets of polynucleotides, a microarray, and a kit including the microarray are provided.
摘要翻译：提供了用于心血管疾病诊断的多重单核苷酸多态性（多SNP）标记物和诊断心血管疾病的方法。此外，提供了多组核苷酸，微阵列和包含微阵列的试剂盒。

4. 发明授权

US07732139B2 Multiple SNP for diagnosing cardiovascular disease, microarray and kit comprising the same, and method of diagnosing cardiovascular disease using the same 有权
标题翻译：用于诊断心血管疾病的多重SNP，包含该SNP的微阵列和试剂盒以及使用该SNP诊断心血管疾病的方法
公开(公告)号：US07732139B2
公开(公告)日：2010-06-08
申请号：US11435662
申请日：2006-05-17
申请人： Seung-Hak Choi , Yun-sun Nam , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Hyo-jeong Jeon , Ok-ryul Song , Tae-jin Ahn , Kyu-sang Lee
发明人： Seung-Hak Choi , Yun-sun Nam , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Hyo-jeong Jeon , Ok-ryul Song , Tae-jin Ahn , Kyu-sang Lee
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , C12M1/36 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： A multiple single nucleotide polymorphism (multi-SNP) marker for cardiovascular disease diagnosis and a method of diagnosing cardiovascular disease are provided. Also, sets of polynucleotides, a microarray, and a kit including the microarray are provided.
摘要翻译：提供了用于心血管疾病诊断的多重单核苷酸多态性（多SNP）标记物和诊断心血管疾病的方法。此外，提供了多组核苷酸，微阵列和包含微阵列的试剂盒。

5. 发明申请

US20070048751A1 Method of diagnosing type II diabetes mellitus using multilocus marker, polynucleotide including marker associated with type II diabetes mellitus, and microarray and diagnostic kit including the polynucleotide 审中-公开
标题翻译：使用多位点标记物诊断II型糖尿病的方法，包括与II型糖尿病相关的标记的多核苷酸，以及包括该多核苷酸的微阵列和诊断试剂盒
公开(公告)号：US20070048751A1
公开(公告)日：2007-03-01
申请号：US11352174
申请日：2006-02-10
申请人： Jae-Heup Kim , Seung-Hak Choi , Yun-Sun Nam , Yeon-Su Lee , Jung-joo Hwang , Kyusang Lee
发明人： Jae-Heup Kim , Seung-Hak Choi , Yun-Sun Nam , Yeon-Su Lee , Jung-joo Hwang , Kyusang Lee
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Provided are a polynucleotide including a marker associated with type II diabetes mellitus and a method of diagnosing type II diabetes mellitus in an individual, which includes determining a nucleotide of a polymorphic site of at least one polynucleotide of Table 1 in the specification.
摘要翻译：提供了包含与II型糖尿病相关的标志物的多核苷酸和个体中诊断II型糖尿病的方法，其包括确定说明书中表1的至少一种多核苷酸的多态性位点的核苷酸。

6. 发明申请

US20090215041A1 MULTIPLE SNP FOR DIAGNOSING COLORECTAL CANCER, MICROARRAY AND KIT COMPRISING THE SAME, AND METHOD OF DIAGNOSING COLORECTAL CANCER USING THE SAME 有权
标题翻译：用于诊断包括其的彩色癌，微阵列和包装的多个SNP以及使用其的诊断癌性癌的方法
公开(公告)号：US20090215041A1
公开(公告)日：2009-08-27
申请号：US11909872
申请日：2006-04-03
申请人： Seung-Hak Choi , Yun-Sun Nam , Jae-Heup Kim , Kyu-Sang Lee , Min-Sun Kim , Tae-Jin Ahn
发明人： Seung-Hak Choi , Yun-Sun Nam , Jae-Heup Kim , Kyu-Sang Lee , Min-Sun Kim , Tae-Jin Ahn
IPC分类号： C12Q1/68 , C07H21/04 , C40B40/10
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： Provided is a multiple single nucleotide polymorphism (SNP) for colorectal cancer diagnosis, a microarray and a kit including a polynucleotide having the SNP, and a method of diagnosing colorectal cancer using the SNP. Early diagnosis of incidence or possibility of colorectal cancer can be effectively performed by using the method.
摘要翻译：提供了用于结肠直肠癌诊断的多重单核苷酸多态性（SNP），微阵列和包含具有SNP的多核苷酸的试剂盒，以及使用该SNP诊断结肠直肠癌的方法。可以通过使用该方法有效地进行早期诊断发病或结肠直肠癌的可能性。

7. 发明授权

US07932368B2 Multiple SNP for diagnosing colorectal cancer, microarray and kit comprising the same, and method of diagnosing colorectal cancer using the same 有权
标题翻译：用于诊断结肠直肠癌的多重SNP，包含该结肠直肠癌的微阵列和试剂盒，以及使用该SNP诊断结肠直肠癌的方法
公开(公告)号：US07932368B2
公开(公告)日：2011-04-26
申请号：US11909872
申请日：2006-04-03
申请人： Seung-Hak Choi , Yun-Sun Nam , Jae-Heup Kim , Kyu-Sang Lee , Min-Sun Kim , Tae-Jin Ahn
发明人： Seung-Hak Choi , Yun-Sun Nam , Jae-Heup Kim , Kyu-Sang Lee , Min-Sun Kim , Tae-Jin Ahn
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： Provided is a multiple single nucleotide polymorphism (SNP) for colorectal cancer diagnosis, a microarray and a kit including a polynucleotide having the SNP, and a method of diagnosing colorectal cancer using the SNP. Early diagnosis of incidence or possibility of colorectal cancer can be effectively performed by using the method.
摘要翻译：提供了用于结肠直肠癌诊断的多重单核苷酸多态性（SNP），微阵列和包含具有SNP的多核苷酸的试剂盒，以及使用该SNP诊断结肠直肠癌的方法。可以通过使用该方法有效地进行早期诊断发病或结肠直肠癌的可能性。

8. 发明申请

US20060286589A1 Method of screening multiple single nucleotide polymorphisms associated with susceptibility to specific disease or drug response 审中-公开
标题翻译：筛选与特异性疾病或药物反应易感性相关的多个单核苷酸多态性的方法
公开(公告)号：US20060286589A1
公开(公告)日：2006-12-21
申请号：US11454336
申请日：2006-06-16
申请人： Yun-sun Nam , Seung-Hak Choi , Jae-Heup Kim
发明人： Yun-sun Nam , Seung-Hak Choi , Jae-Heup Kim
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6883 , C12Q2600/156 , G16B20/00 , G16B30/00
摘要： Provided is a method of screening multiple single nucleotide polymorphisms (SNPs) having significance with a case group, the method comprising: selecting one or more SNPs from nucleic acid sequences of the case group and a control group; generating all combinable genotype patterns of multiple SNPs comprised of two or more of the selected SNPs; determining frequencies of the genotype patterns from the case group and the control group; and determining and choosing genotype patterns having statistical significance with the case group using the frequencies. According to the method of screening multiple SNPs, multiple SNPs associated with a specific disease or drug can be effectively selected from the entire genome of an individual. Methods of identifying susceptibility of an individual to development of Type II diabetes are also disclosed.
摘要翻译：提供了筛选与病例组具有重要意义的多个单核苷酸多态性（SNP）的方法，所述方法包括：从病例组和对照组的核酸序列中选择一个或多个SNP; 产生由两个或更多个所选SNP组成的多个SNP的所有可组合基因型模式; 从病例组和对照组确定基因型模式的频率; 并使用这些频率确定和选择具有统计学显着性的病例组的基因型模式。根据筛选多个SNP的方法，可以从个体的整个基因组中有效地选择与特定疾病或药物相关的多个SNP。还公开了确定个体对II型糖尿病发展的易感性的方法。

9. 发明申请

US20090311712A1 METHOD OF SCREENING MULTIPLE SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH SUSCEPTIBILITY TO SPECIFIC DISEASE OR DRUG RESPONSE 审中-公开
标题翻译：筛选与特异性疾病或药物反应不相关的多种单核苷酸多态性相关的方法
公开(公告)号：US20090311712A1
公开(公告)日：2009-12-17
申请号：US12543249
申请日：2009-08-18
申请人： Yun-Sun Nam , Seung-Hak Choi , Jae-Heup Kim
发明人： Yun-Sun Nam , Seung-Hak Choi , Jae-Heup Kim
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , G16B20/00 , G16B30/00
摘要： Provided is a method of screening multiple single nucleotide polymorphisms (SNPs) having significance with a case group, the method comprising: selecting one or more SNPs from nucleic acid sequences of the case group and a control group; generating all combinable genotype patterns of multiple SNPs comprised of two or more of the selected SNPs; determining frequencies of the genotype patterns from the case group and the control group; and determining and choosing genotype patterns having statistical significance with the case group using the frequencies. According to the method of screening multiple SNPs, multiple SNPs associated with a specific disease or drug can be effectively selected from the entire genome of an individual. Methods of identifying susceptibility of an individual to development of Type II diabetes are also disclosed.
摘要翻译：提供了筛选与病例组具有重要意义的多个单核苷酸多态性（SNP）的方法，所述方法包括：从病例组和对照组的核酸序列中选择一个或多个SNP; 产生由两个或更多个所选SNP组成的多个SNP的所有可组合基因型模式; 从病例组和对照组确定基因型模式的频率; 并使用这些频率确定和选择具有统计学显着性的病例组的基因型模式。根据筛选多个SNP的方法，可以从个体的整个基因组中有效地选择与特定疾病或药物相关的多个SNP。还公开了确定个体对II型糖尿病发展的易感性的方法。

10. 发明授权

US08554487B2 Method and apparatus for analyzing genotype data 有权
标题翻译：分析基因型数据的方法和装置
公开(公告)号：US08554487B2
公开(公告)日：2013-10-08
申请号：US11326164
申请日：2006-01-04
申请人： Ki-eun Kim , Kyung-Hee Park , Jung-joo Hwang , Jae-Heup Kim , Yeon-Su Lee , Kyusang Lee
发明人： Ki-eun Kim , Kyung-Hee Park , Jung-joo Hwang , Jae-Heup Kim , Yeon-Su Lee , Kyusang Lee
IPC分类号： G01N33/50
CPC分类号： G06F19/18 , G06F19/26
摘要： Provided are a method and apparatus for analyzing genotype data plotted in a two-dimensional space. The method includes: connecting points representing the genotype data to a predetermined point to form straight lines and obtaining angles between adjacent straight lines; extracting the two largest angles from the obtained angles; and analyzing the plotted genotype data using three groups of the genotype data separated by the two extracted largest angles. According to the present invention, when the experimental results of classifying genotype are to be analyzed, the two largest angles from the angles obtained by connecting straight lines between points representing each of the genotype data and a predetermined point plotted in a two-dimensional space are detected, and three data regions separated by the detected two largest angles are used to analyze the genotype data. Thus, a large amount of the experimental data for classifying the genotype can be analyzed rapidly and conveniently.
摘要翻译：提供了用于分析绘制在二维空间中的基因型数据的方法和装置。该方法包括：将表示基因型数据的点连接到预定点以形成直线并获得相邻直线之间的角度; 从所获得的角度提取两个最大角度; 并使用由两个提取的最大角度分离的三组基因型数据分析绘制的基因型数据。根据本发明，当分析基因型分类的实验结果时，通过连接表示各基因型数据的点和在二维空间中绘制的预定点之间的直线连接获得的角度的两个最大角度为检测到的三个数据区域被检测到的两个最大角度分开，以分析基因型数据。因此，可以快速方便地分析大量用于分类基因型的实验数据。

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