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1. 发明授权

US07202043B2 Detecting cell membrane protein endocytosis 有权
标题翻译：检测细胞膜蛋白内吞
公开(公告)号：US07202043B2
公开(公告)日：2007-04-10
申请号：US11244256
申请日：2005-10-04
申请人： Yun-Jung Choi , Kun Peng , Linda Kauffman , Rajendra Singh
发明人： Yun-Jung Choi , Kun Peng , Linda Kauffman , Rajendra Singh
IPC分类号： G01N33/53
CPC分类号： C12Q1/37 , G01N33/5005 , G01N33/567 , G01N2333/924 , G01N2333/976 , Y10S435/962 , Y10S435/963
摘要： Methods and reagents are provided for determining endocytosis, using a cell expressing an externally polypeptide labeled cell membrane receptor, and as a reagent an antibody to said label conjugated to a fragment of an enzyme fragment complementation pair. Compounds are tested for their effect on endocytosis by complexing the reagent with said cells, adding the test compound at any time in relation to the complexing, allowing any endocytosis to occur, proteolytically degrading external enzyme fragment, adding protease inhibitor and the complementary member of the enzyme fragment complementation pair and substrate. The product provides a detectable signal related to the amount of endocytosis that occurred. The method is readily automated as all steps can occur in a single vessel without separations and washings.
摘要翻译：提供了用于确定内吞作用的方法和试剂，使用表达外部多肽标记的细胞膜受体的细胞，以及作为与所述酶标记片段互补对的片段缀合的所述标记的抗体作为试剂。通过使试剂与所述细胞络合来测试化合物对内吞作用的影响，在任何时间加入测试化合物与复合相关，允许发生任何内吞作用，蛋白水解降解外部酶片段，加入蛋白酶抑制剂和补体成员酶片段互补对和底物。该产品提供与发生的胞吞作用量相关的可检测信号。该方法易于自动化，因为所有步骤都可以发生在没有分离和洗涤的单个容器中。

2. 发明申请

US20060073523A1 Detecting cell membrane protein endocytosis 有权
标题翻译：检测细胞膜蛋白内吞
公开(公告)号：US20060073523A1
公开(公告)日：2006-04-06
申请号：US11244256
申请日：2005-10-04
申请人： Yun-Jung Choi , Kun Peng , Linda Kauffman , Rajendra Singh
发明人： Yun-Jung Choi , Kun Peng , Linda Kauffman , Rajendra Singh
IPC分类号： G01N33/567 , G01N33/53
CPC分类号： C12Q1/37 , G01N33/5005 , G01N33/567 , G01N2333/924 , G01N2333/976 , Y10S435/962 , Y10S435/963
摘要： Methods and reagents are provided for determining endocytosis, using a cell expressing an externally polypeptide labeled cell membrane receptor, and as a reagent an antibody to said label conjugated to a fragment of an enzyme fragment complementation pair. Compounds are tested for their effect on endocytosis by complexing the reagent with said cells, adding the test compound at any time in relation to the complexing, allowing any endocytosis to occur, proteolytically degrading external enzyme fragment, adding protease inhibitor and the complementary member of the enzyme fragment complementation pair and substrate. The product provides a detectable signal related to the amount of endocytosis that occurred. The method is readily automated as all steps can occur in a single vessel without separations and washings.
摘要翻译：提供了用于确定内吞作用的方法和试剂，使用表达外部多肽标记的细胞膜受体的细胞，以及作为与所述酶标记片段互补对的片段缀合的所述标记的抗体作为试剂。通过使试剂与所述细胞络合来测试化合物对内吞作用的影响，在任何时间加入测试化合物与复合相关，允许发生任何内吞作用，蛋白水解降解外部酶片段，加入蛋白酶抑制剂和补体成员酶片段互补对和底物。该产品提供与发生的胞吞作用量相关的可检测信号。该方法易于自动化，因为所有步骤都可以发生在没有分离和洗涤的单个容器中。

3. 发明申请

US20100152295A1 METHODS OF REDUCING SMALL, DENSE LDL PARTICLES 审中-公开
标题翻译：减少小，密度低密度脂蛋白颗粒的方法
公开(公告)号：US20100152295A1
公开(公告)日：2010-06-17
申请号：US12579996
申请日：2009-10-15
申请人： David Karpf , Ronald M. Krauss , Yun-Jung Choi , Xueyan Wang , Francine M. Gregoire
发明人： David Karpf , Ronald M. Krauss , Yun-Jung Choi , Xueyan Wang , Francine M. Gregoire
IPC分类号： A61K31/192 , A61P3/06
CPC分类号： A61K31/192 , A61K31/09 , A61K31/4015
摘要： The present invention provides methods for increasing LDL particle size.
摘要翻译：本发明提供了增加LDL粒径的方法。

4. 发明授权

US07848425B2 Method and apparatus for encoding and decoding stereoscopic video 失效
标题翻译：用于对立体视频进行编码和解码的方法和装置
公开(公告)号：US07848425B2
公开(公告)日：2010-12-07
申请号：US10540891
申请日：2003-01-22
申请人： Suk-Hee Cho , Yun-Jung Choi , Kug-Jin Yun , Jin-Hwan Lee , Young-Kwon Hahm , Chieteuk Ahn , Yong-Han Kim
发明人： Suk-Hee Cho , Yun-Jung Choi , Kug-Jin Yun , Jin-Hwan Lee , Young-Kwon Hahm , Chieteuk Ahn , Yong-Han Kim
IPC分类号： H04N7/12 , H04N11/02 , H04N11/04
CPC分类号： H04N19/20 , G06T9/20 , H04N19/186 , H04N19/46 , H04N19/597 , H04N19/61 , H04N19/70
摘要： Stereoscopic video is encoded and decoded by using the MAC defined by the existing MPEG-4 standard. The stereoscopic video is divided into one image as a single video object, and another image as auxiliary information for the image established as the video object. The auxiliary information includes a horizontal disparity map, a vertical disparity map, luminance residual texture, and chrominance residual texture, which are respectively allocated to auxiliary components of the MAC according to importance and complexity of the images, encoded, and then output as a single encoding stream.
摘要翻译：通过使用由现有MPEG-4标准定义的MAC来对立体视频进行编码和解码。将立体视频分为一个图像作为单个视频对象，另一个图像作为用于作为视频对象建立的图像的辅助信息。辅助信息包括根据图像的重要性和复杂度分别分配给MAC的辅助部件的水平视差图，垂直视差图，亮度残差纹理和色度残余纹理，然后作为单个输出编码流。

5. 发明申请

US20100216827A1 ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF 审中-公开
标题翻译： ARYL GPR120受体激动剂及其用途
公开(公告)号：US20100216827A1
公开(公告)日：2010-08-26
申请号：US12582610
申请日：2009-10-20
申请人： Jingyuan Ma , Aaron Novack , Imad Nashashibi , Phuongly Pham , Christopher J. Rabbat , Jiangao Song , Dong Fang Shi , Zuchun Zhao , Yun-Jung Choi , Xin Chen
发明人： Jingyuan Ma , Aaron Novack , Imad Nashashibi , Phuongly Pham , Christopher J. Rabbat , Jiangao Song , Dong Fang Shi , Zuchun Zhao , Yun-Jung Choi , Xin Chen
IPC分类号： A61K31/506 , C07D231/12 , A61K31/415 , C07D285/06 , A61K31/433 , C07D233/54 , A61K31/4164 , C07D403/04 , A61P3/10
CPC分类号： C07D231/12 , C07D233/64 , C07D249/06 , C07D261/08 , C07D263/32 , C07D277/24 , C07D285/06 , C07D307/42 , C07D333/16 , C07D409/04
摘要： Aryl GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
摘要翻译：提供Aryl GPR120激动剂。这些化合物可用于治疗代谢疾病，包括II型糖尿病和与血糖控制不良相关的疾病。

6. 发明申请

US20060133493A1 Method and apparatus for encoding and decoding stereoscopic video 失效
标题翻译：用于对立体视频进行编码和解码的方法和装置
公开(公告)号：US20060133493A1
公开(公告)日：2006-06-22
申请号：US10540891
申请日：2003-01-22
申请人： Suk-Hee Cho , Yun-Jung Choi , Kug-Jin Yun , Jin-Hwan Lee , Young-Kwon Hahm , Cheiteuk Ahn , Yong-Han Kim
发明人： Suk-Hee Cho , Yun-Jung Choi , Kug-Jin Yun , Jin-Hwan Lee , Young-Kwon Hahm , Cheiteuk Ahn , Yong-Han Kim
IPC分类号： H04N11/02 , H04N13/00 , H04N11/04 , H04N7/12 , H04N15/00 , H04B1/66
CPC分类号： H04N19/20 , G06T9/20 , H04N19/186 , H04N19/46 , H04N19/597 , H04N19/61 , H04N19/70
摘要： Stereoscopic video is encoded and decoded by using the MAC defined by the existing MPEG-4 standard. The stereoscopic video is divided into one image as a single video object, and another image as auxiliary information for the image established as the video object. The auxiliary information includes a horizontal disparity map, a vertical disparity map, luminance residual texture, and chrominance residual texture, which are respectively allocated to auxiliary components of the MAC according to importance and complexity of the images, encoded, and then output as a single encoding stream.
摘要翻译：通过使用由现有MPEG-4标准定义的MAC来对立体视频进行编码和解码。将立体视频分为一个图像作为单个视频对象，另一个图像作为用于作为视频对象建立的图像的辅助信息。辅助信息包括根据图像的重要性和复杂度分别分配给MAC的辅助部件的水平视差图，垂直视差图，亮度残差纹理和色度残余纹理，然后作为单个输出编码流。

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