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1. 发明授权

US6051428A Rapid production of autologous tumor vaccines 失效
标题翻译：快速生产自体肿瘤疫苗
公开(公告)号：US6051428A
公开(公告)日：2000-04-18
申请号：US45476
申请日：1998-01-20
申请人： Yuman Fong , Howard Federoff , Joseph D. Rosenblatt
发明人： Yuman Fong , Howard Federoff , Joseph D. Rosenblatt
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , A61P37/04 , C12N5/10 , C12N15/12 , C12N15/869 , C12N15/63 , A61K39/245 , C12N15/38
CPC分类号： C12N15/86 , A61K39/0011 , A61K2039/5156 , A61K2039/55516 , A61K48/00 , C12N2710/16643 , C12N2830/00 , C12N2830/60 , C12N2840/203
摘要： An autologous vaccine to tumor cells is produced by transducing the tumor cells with a herpes simplex virus amplicon containing the gene for an immunomodulatory protein to provide transient expression of the immunomodulatory protein by the cells. The tumor cells may transduced with the herpes simplex amplicons ex vivo or in vivo. Suitable immunomodulatory proteins include cytokines, for example, interleukins, interferons, and chemokines such as RANTES; intercellular adhesion molecules, for example ICAM-1 and costimulatory factors such as B7.1. The tumor cells may also be transduced with one or more species of amplicon containing genes for two or more different immunomodulatory proteins.
摘要翻译：通过用包含免疫调节蛋白的基因的单纯疱疹病毒扩增子转导肿瘤细胞来产生肿瘤细胞的自体疫苗，以提供细胞的免疫调节蛋白的瞬时表达。肿瘤细胞可以离体或体内用单纯疱疹病毒扩增子转导。合适的免疫调节蛋白包括细胞因子，例如白介素，干扰素和趋化因子，例如RANTES; 细胞间粘附分子，例如ICAM-1和共刺激因子如B7.1。肿瘤细胞还可以用含有两种或多种不同免疫调节蛋白的含有一个或多个含扩增子的基因转导。

2. 发明申请

US20120244068A1 Microorganisms for imaging and/or treatment of tumors 有权
标题翻译：用于成像和/或治疗肿瘤的微生物
公开(公告)号：US20120244068A1
公开(公告)日：2012-09-27
申请号：US13506738
申请日：2012-05-10
申请人： Nanhai Chen , Aladar A. Szalay , Yong A. Yu , Qian Zhang , Yuman Fong
发明人： Nanhai Chen , Aladar A. Szalay , Yong A. Yu , Qian Zhang , Yuman Fong
IPC分类号： A61K35/76 , A61K49/08 , A61K51/02 , A61P35/00 , C12N7/01 , A61K49/00
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
摘要翻译：提供了编码转运蛋白的修饰病毒和用于制备修饰病毒的方法。提供含有病毒的疫苗。病毒也可用于诊断方法，如肿瘤的检测和成像。病毒也可用于治疗诸如增殖性和炎症性疾病的疾病的方法，包括作为抗肿瘤剂。

3. 发明申请

US20120058141A1 CHIMERIC NEWCASTLE DISEASE VIRUSES AND USES THEREOF 有权
标题翻译： CHIMERIC NEWCASTLE病毒病毒及其用途
公开(公告)号：US20120058141A1
公开(公告)日：2012-03-08
申请号：US13147842
申请日：2010-02-05
申请人： Peter Palese , Adolfo Garcia-Sastre , Dmitriy Zamarin , Yuman Fong
发明人： Peter Palese , Adolfo Garcia-Sastre , Dmitriy Zamarin , Yuman Fong
IPC分类号： A61K35/76 , A61P37/04 , A61P35/00 , A61K39/00 , C12N7/01 , C12N7/02
CPC分类号： C12N7/00 , A61K35/13 , A61K39/0011 , A61K39/17 , C07K14/005 , C12N2760/16122 , C12N2760/18121 , C12N2760/18122 , C12N2760/18132 , C12N2760/18143 , C12N2760/18171
摘要： Described herein are chimeric Newcastle disease viruses engineered to express a heterologous interferon antagonist and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer.
摘要翻译：本文描述了工程化以表达异源干扰素拮抗剂的嵌合型新城疫病毒和包含这种病毒的组合物。嵌合的新城疫病毒和组合物可用于治疗癌症。

4. 发明申请

US20130129614A9 Microorganisms for imaging and/or treatment of tumors 有权
公开(公告)号：US20130129614A9
公开(公告)日：2013-05-23
申请号：US13506738
申请日：2012-05-10
申请人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang , Yuman Fong
发明人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang , Yuman Fong
IPC分类号： A61K35/76 , A61K49/08 , A61K51/02 , A61P35/00 , C12N7/01 , A61K49/00
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.

5. 发明申请

US20090117034A1 Microorganisms for imaging and/or treatment of tumors 审中-公开
标题翻译：用于成像和/或治疗肿瘤的微生物
公开(公告)号：US20090117034A1
公开(公告)日：2009-05-07
申请号：US12157960
申请日：2008-06-13
申请人： Nanhai Chen , Aladar A. Szalay , Yong A. Yu , Qian Zhang , Yuman Fong
发明人： Nanhai Chen , Aladar A. Szalay , Yong A. Yu , Qian Zhang , Yuman Fong
IPC分类号： A61K51/02 , C12N7/01 , A61K35/76 , A61K49/04 , A61K39/395 , A61P35/00 , A61P35/04 , A61P35/02 , A61B10/00 , A61K49/00 , A61K49/06 , A61K39/285
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
摘要翻译：提供了编码转运蛋白的修饰病毒和用于制备修饰病毒的方法。提供含有病毒的疫苗。病毒也可用于诊断方法，如肿瘤的检测和成像。病毒也可用于治疗诸如增殖性和炎症性疾病的疾病的方法，包括作为抗肿瘤剂。

6. 发明授权

US08591881B2 Chimeric Newcastle disease viruses and uses thereof 有权
公开(公告)号：US08591881B2
公开(公告)日：2013-11-26
申请号：US13147842
申请日：2010-02-05
申请人： Peter Palese , Adolfo Garcia-Sastre , Dmitriy Zamarin , Yuman Fong
发明人： Peter Palese , Adolfo Garcia-Sastre , Dmitriy Zamarin , Yuman Fong
IPC分类号： A61K39/15 , A61K39/00
CPC分类号： C12N7/00 , A61K35/13 , A61K39/0011 , A61K39/17 , C07K14/005 , C12N2760/16122 , C12N2760/18121 , C12N2760/18122 , C12N2760/18132 , C12N2760/18143 , C12N2760/18171
摘要： Described herein are chimeric Newcastle disease viruses engineered to express a heterologous interferon antagonist and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer.

7. 发明申请

US20090311664A1 Method for Detection of Cancer Cells Using Virus 审中-公开
标题翻译：使用病毒检测癌细胞的方法
公开(公告)号：US20090311664A1
公开(公告)日：2009-12-17
申请号：US12086805
申请日：2006-12-21
申请人： Yuman Fong , Prasad Adusumilli
发明人： Yuman Fong , Prasad Adusumilli
IPC分类号： C12Q1/70
CPC分类号： C12Q1/6897 , A61K35/13 , C12N2710/16611 , C12N2710/24111 , G01N33/574
摘要： The invention relates to compositions and methods for cancer cell detection in bodily samples wherein a cancer cell can be detected within a mixed population of cancer cells and non-cancer cells. The invention also relates to compositions and methods that may be used in cancer cell detection, specifically viruses that are replication-competent conditional to a cancer cell, in particular an oncolytic herpes virus, such as NV 1066 and a vaccinia virus, such as GLV-1h68. Provided are methods and kits for using these viruses that preferentially replicate in cancer cells and may also preferentially infect cancer cells for specific identification of such cancer cells, even when a cancer cell is present, for example, at a ratio of one infected cancer cell in a background often thousand non-cancer cells, thus further providing a reproducible and sensitive screening method for cancer detection, monitoring and prognosis.
摘要翻译：本发明涉及用于在体内样品中癌细胞检测的组合物和方法，其中可以在癌细胞和非癌细胞的混合群体内检测癌细胞。本发明还涉及可用于癌细胞检测的组合物和方法，特别是对癌细胞，特别是溶瘤性疱疹病毒如NV 1066和痘苗病毒如GLV- 1h68。提供了使用这些在癌细胞中优先复制的病毒的方法和试剂盒，并且即使当存在癌细胞时，例如以一种感染的癌细胞的比例，也可以优先感染癌细胞用于特异性鉴定这样的癌细胞背景经常是千个非癌细胞，因此进一步提供了可重复和敏感的癌症检测，监测和预后筛选方法。

8. 发明申请

US20050255085A1 Prevention of recurrence and metastasis of cancer 审中-公开
标题翻译：预防癌症的复发和转移
公开(公告)号：US20050255085A1
公开(公告)日：2005-11-17
申请号：US10505375
申请日：2003-03-03
申请人： Yuman Fong , Richard Wong
发明人： Yuman Fong , Richard Wong
IPC分类号： A61B17/00 , A61K31/7088 , A61K35/76 , A61K35/763 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , A61P35/04 , C12N7/04 , C12N15/86 , C12N15/869
CPC分类号： C12N7/00 , A61K35/763 , A61K38/00 , A61K39/395 , A61K45/06 , A61K2039/5254 , C12N15/86 , C12N2710/16061 , C12N2710/16632 , C12N2710/16643 , A61K2300/00
摘要： The invention provides methods of preventing and treating cancer, involving the use of attenuated, replication-com-petent, oncolytic herpes viruses.
摘要翻译：本发明提供了预防和治疗癌症的方法，其涉及使用减毒，复制，溶瘤性疱疹病毒。

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