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1. 发明授权

US09260391B2 Hypoglycemic dihydropyridones 有权
标题翻译：低血糖二氢吡啶酮
公开(公告)号：US09260391B2
公开(公告)日：2016-02-16
申请号：US13058142
申请日：2009-08-07
申请人： Yuli Xie , Shixian Deng , Donald W. Landry , Paul Harris , Antonella Maffei
发明人： Yuli Xie , Shixian Deng , Donald W. Landry , Paul Harris , Antonella Maffei
IPC分类号： A61K31/45 , A61K31/351 , C07D211/74 , C07D309/30 , C07D211/94 , C07D211/76 , C07D211/88 , C07D309/32 , C07D471/04
CPC分类号： C07D211/94 , C07D211/76 , C07D211/88 , C07D309/32 , C07D471/04
摘要： The present invention provides, inter alia, a compound of formula I: wherein the substituent designations are indicated in the Specification. The present invention also provides pharmaceutical compositions comprising a compound of formula I, and methods of treatment or prevention of diabetes or hyperglycemia in a patient, and of normalizing blood glucose levels in a subject, by administering an effective amount of a compound of formula I.
摘要翻译：本发明尤其提供式I化合物：其中取代基名称在说明书中指出。本发明还提供了包含式I化合物的药物组合物，以及通过施用有效量的式I化合物来治疗或预防患者中的糖尿病或高血糖并使受试者血糖水平正常化的方法。

2. 发明申请

US20110294800A1 HYPOGLYCEMIC DIHYDROPYRIDONES 有权
标题翻译：高分子二氢吡啶
公开(公告)号：US20110294800A1
公开(公告)日：2011-12-01
申请号：US13058142
申请日：2009-08-07
申请人： Yuli Xie , Shixian Deng , Donald W. Landry , Paul Harris , Antonella Maffei
发明人： Yuli Xie , Shixian Deng , Donald W. Landry , Paul Harris , Antonella Maffei
IPC分类号： A61K31/4418 , C07D211/46 , C07D455/06 , C07D413/14 , C07D309/32 , A61P3/08 , A61K31/451 , A61K31/473 , A61K31/5377 , A61K31/366 , A61P3/10 , C07D211/86 , C07D211/76
CPC分类号： C07D211/94 , C07D211/76 , C07D211/88 , C07D309/32 , C07D471/04
摘要： The present invention provides, inter alia, a compound of formula I: wherein the substituent designations are indicated in the Specification. The present invention also provides pharmaceutical compositions comprising a compound of formula I, and methods of treatment or prevention of diabetes or hyperglycemia in a patient, and of normalizing blood glucose levels in a subject, by administering an effective amount of a compound of formula I.
摘要翻译：本发明尤其提供式I化合物：其中取代基名称在说明书中指出。本发明还提供了包含式I化合物的药物组合物，以及通过施用有效量的式I化合物来治疗或预防患者中的糖尿病或高血糖并使受试者血糖水平正常化的方法。

3. 发明授权

US09012471B2 Glucose metabolism modulating compounds 有权
标题翻译：葡萄糖代谢调节化合物
公开(公告)号：US09012471B2
公开(公告)日：2015-04-21
申请号：US12937177
申请日：2009-04-10
申请人： Paul Harris , Antonella Maffei , Yuli Xie , Donald Landry
发明人： Paul Harris , Antonella Maffei , Yuli Xie , Donald Landry
IPC分类号： A61K31/4375 , C07D455/06 , C07D211/86
CPC分类号： C07D211/88 , C07D211/46 , C07D211/86 , C07D471/04
摘要： The present invention provides, inter alia, dihydropyridone compounds and compositions, including analogs of a vesicular monoamine transporter type 2 (VMAT2) antagonist. The present invention also provides methods of using such compounds/analogs for modulating glucose levels, and/or preventing, treating, or ameliorating the effects of diabetes and hyper-glycemia.
摘要翻译：本发明尤其提供二氢吡啶酮化合物和组合物，包括囊泡单胺转运蛋白2型（VMAT2）拮抗剂的类似物。本发明还提供了使用这些化合物/类似物来调节葡萄糖水平和/或预防，治疗或改善糖尿病和高血糖症的作用的方法。

4. 发明申请

US20110118300A1 GLUCOSE METABOLISM MODULATING COMPOUNDS 有权
标题翻译：葡萄糖代谢调节化合物
公开(公告)号：US20110118300A1
公开(公告)日：2011-05-19
申请号：US12937177
申请日：2009-04-10
申请人： Paul Harris , Antonella Maffei , Yuli Xie , Donald Landry
发明人： Paul Harris , Antonella Maffei , Yuli Xie , Donald Landry
IPC分类号： A61K31/4375 , C07D455/06 , C07D213/69 , C07D211/74 , A61K31/4412 , A61K31/44 , A61P3/10
CPC分类号： C07D211/88 , C07D211/46 , C07D211/86 , C07D471/04
摘要： The present invention provides, inter alia, dihydropyridone compounds and compositions, including analogs of a vesicular monoamine transporter type 2 (VMAT2) antagonist. The present invention also provides methods of using such compounds/analogs for modulating glucose levels, and/or preventing, treating, or ameliorating the effects of diabetes and hyper-glycemia.
摘要翻译：本发明尤其提供二氢吡啶酮化合物和组合物，包括囊泡单胺转运蛋白2型（VMAT2）拮抗剂的类似物。本发明还提供了使用这些化合物/类似物来调节葡萄糖水平和/或预防，治疗或改善糖尿病和高血糖症的作用的方法。

5. 发明申请

US20100204258A1 METHODS AND COMPOSITIONS FOR MODULATING INSULIN SECRETION AND GLUCOSE METABOLISM 审中-公开
标题翻译：用于调节胰岛素分泌和葡萄糖代谢的方法和组合物
公开(公告)号：US20100204258A1
公开(公告)日：2010-08-12
申请号：US12450100
申请日：2008-03-12
申请人： Paul Harris , Yuli Xie , Donald Landry , Shi-Xian Deng , Antonella Maffei
发明人： Paul Harris , Yuli Xie , Donald Landry , Shi-Xian Deng , Antonella Maffei
IPC分类号： A61K31/4375 , A61K31/137 , A61P5/48 , A61P3/10
CPC分类号： A61K31/473 , A61K31/00 , A61K31/05 , A61K31/4741 , A61K31/4745 , A61K31/475
摘要： The present invention relates to methods and compositions for treating or ameliorating the effects of diabetes. In addition, the present invention relates to methods and compositions for treating or preventing hyperglycemia, as well as modulating monoamine levels, islet β-cell insulin secretion, insulin and/or glucagon levels in a patient. In certain preferred embodiments, such methods include administering to a patient an effective amount of a vesicular monoamine transporter type 2 (VMAT2) antagonist, such as tetrabenazine (TBZ), dihydrotetrabenazine (DTBZ), tetrahydroberberine (THB), reserpine, emetine, Compound 6, or enantiomers, optical isomers, diastereomers, N-oxides, crystalline forms, hydrates, metabolites or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及用于治疗或改善糖尿病的作用的方法和组合物。此外，本发明涉及用于治疗或预防高血糖的方法和组合物，以及调节患者体内单胺水平，胰岛素和细胞胰岛素分泌，胰岛素和/或胰高血糖素水平。在某些优选的实施方案中，这些方法包括向患者施用有效量的2型（VMAT2）囊泡单胺转运蛋白拮抗剂，如丁苯那嗪（TBZ），二氢丁苯那嗪（DTBZ），四氢小檗碱（THB），利血平，，或对映体，旋光异构体，非对映异构体，N-氧化物，结晶形式，水合物，代谢物或药学上可接受的盐。

6. 发明申请

US20090202428A1 Use of Dtbz for Imaging Endocrine Pancreas and Beta Cell Mass In Type 1 Diabetes 审中-公开
标题翻译：在1型糖尿病中使用Dtbz成像内分泌胰腺和β细胞
公开(公告)号：US20090202428A1
公开(公告)日：2009-08-13
申请号：US11988040
申请日：2006-06-21
申请人： Paul Harris , Antonella Maffei , Ronald Van Heertum
发明人： Paul Harris , Antonella Maffei , Ronald Van Heertum
IPC分类号： A61K51/00
CPC分类号： A61K51/0455
摘要： The present invention provides non-invasive methods for determining the beta cell mass in the pancreas of a subject by administering to the subject an effective amount of a vesicular monoamine transporter type 2 (VMAT2)-specific radioligand; obtaining at least one computerized image of at least a portion of the pancreas of the subject; and quantitatively analyzing the computerized image in order to determine the beta cell mass in the pancreas of the subject. The present invention additionally provides methods for diagnosing a metabolic neuroendocrine disorder in a subject including insulinoma, diabetes and preclinical diabetes, as well as methods for determining the efficacy of treatment for a metabolic disorder. The present invention further provides methods for assessing the prognosis of a subject at risk for developing diabetes, and methods for managing the treatment or prevention of diabetes. The present invention also provides kits for use in determining the beta cell mass in the pancreas of a subject, as well as diagnosing metabolic or neuroendocrine disorders in a subject.
摘要翻译：本发明提供了通过向受试者施用有效量的2型（VMAT2）特异性囊泡单体转运蛋白来确定受试者胰腺中的β细胞团的非侵入性方法; 获得所述受试者的胰脏的至少一部分的至少一个计算机化图像; 并定量分析计算机化图像，以确定受试者胰腺中的β细胞量。本发明另外提供了用于诊断包括胰岛素瘤，糖尿病和临床前糖尿病的受试者中的代谢神经内分泌障碍的方法以及用于确定治疗代谢紊乱的功效的方法。本发明还提供了评估患有糖尿病风险的受试者的预后的方法，以及用于治疗或预防糖尿病的方法。本发明还提供了用于确定受试者胰腺中的β细胞群以及诊断受试者中代谢或神经内分泌障碍的试剂盒。

7. 外观设计

USD1045865S1 Touch panel control interface 有权
公开(公告)号：USD1045865S1
公开(公告)日：2024-10-08
申请号：US29855676
申请日：2022-10-06
申请人： Paul Harris
设计人： Paul Harris
摘要： FIG. 1 is a perspective view of the touch panel control interface in accordance with the present invention;
FIG. 2 is a front elevation view thereof;
FIG. 3 is a rear elevation view thereof;
FIG. 4 is a top plan view thereof;
FIG. 5 is a bottom plan view thereof;
FIG. 6 is a right side elevation view thereof; and,
FIG. 7 is a left side elevation view thereof.
The broken lines in the drawings depict portions of the touch panel control interface that form no part of the claimed design.

8. 外观设计

USD985576S1 Adjustable monitor stand 有权
公开(公告)号：USD985576S1
公开(公告)日：2023-05-09
申请号：US29784353
申请日：2021-05-19
申请人： Paul Harris
设计人： Paul Harris
摘要： FIG. 1 is a perspective view of an adjustable monitor stand.
FIG. 2 is a front elevational view of the adjustable monitor stand.
FIG. 3 is a rear elevational view thereof.
FIG. 4 is a top plan view thereof.
FIG. 5 is a bottom plan view thereof.
FIG. 6 is a left side elevational view thereof; and,
FIG. 7 is a right side elevational view thereof.
The broken lines in the drawings depict portions of the adjustable monitor stand that form no part of the claimed design.

9. 发明授权

US09561482B1 Static mixer assembly suitable for use with injected gas in SCR and/or other applications 有权
标题翻译：适用于SCR和/或其他应用中的注入气体的静态混合器组件
公开(公告)号：US09561482B1
公开(公告)日：2017-02-07
申请号：US14048380
申请日：2013-10-08
申请人： Paul Harris , Robert Mudry , Peikang Jin
发明人： Paul Harris , Robert Mudry , Peikang Jin
IPC分类号： B01F5/06
CPC分类号： B01F5/0602 , B01F3/04049 , B01F5/0451 , B01F5/0456 , B01F5/0611 , B01F5/0618 , B01F15/00136 , B01F15/00337
摘要： A static mixer is described in which rows of mixing plates are used in a combination with nozzles that are located with respect to the mixing plates in a manner that is designed to produce a high level of mixing without significantly impeding the flow of flue gas passing through the rows of mixer plates. In various embodiments, the static mixer includes rows of tilted plates, and the injection lance nozzles are positioned to align with row boundaries corresponding to the boundaries between consecutive rows of mixing plates. In some embodiments, there are N rows of mixing plates and N-1 rows of nozzles. In some embodiments the nozzles are positioned to coincide with the boundaries between rows. The mixer assembly including injection nozzles and/or lances can be implemented in a relatively compact manner allowing for it to be placed in a shorter length of flue than many other mixer assemblies.
摘要翻译：描述了一种静态混合器，其中混合板行与以相对于混合板定位的喷嘴组合使用，其设计成可以产生高水平的混合，而不会显着阻碍通过的烟道气的流动搅拌板排。在各种实施例中，静态混合器包括一排倾斜板，并且喷射喷枪喷嘴被定位成与对应于连续排混合板之间的边界的行边界对齐。在一些实施例中，存在N排混合板和N-1排喷嘴。在一些实施例中，喷嘴被定位成与行之间的边界重合。包括注射喷嘴和/或喷枪的混合器组件可以以相对紧凑的方式实现，使其能够被放置在比许多其它混合器组件更短的烟道长度上。

10. 发明授权

US08569581B2 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same 有权
公开(公告)号：US08569581B2
公开(公告)日：2013-10-29
申请号：US12883549
申请日：2010-09-16
申请人： Suchindra Maiyuran , Randall Kramer , Paul Harris
发明人： Suchindra Maiyuran , Randall Kramer , Paul Harris
IPC分类号： C12P21/02 , C12N15/56 , C12N15/82 , C12N9/42
CPC分类号： C12N9/2437 , C11D3/386 , C11D3/38645 , C11D3/3869 , C12P19/02 , C12P19/14 , C12Y302/01 , Y02E50/16
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

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