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1. 发明申请

US20050009865A1 Quinoline derivative as diagnostic probe for disease with tau protein accumulation 失效
标题翻译：喹啉衍生物作为具有tau蛋白积聚的疾病的诊断探针
公开(公告)号：US20050009865A1
公开(公告)日：2005-01-13
申请号：US10494314
申请日：2003-11-28
申请人： Yukitsuka Kudo , Masako Suzuki , Takahiro Suemoto , Nobuyuki Okamura , Tsuyoshi Shiomitsu , Hiroshi Shimazu
发明人： Yukitsuka Kudo , Masako Suzuki , Takahiro Suemoto , Nobuyuki Okamura , Tsuyoshi Shiomitsu , Hiroshi Shimazu
IPC分类号： A61K31/47 , A61K31/473 , A61K51/04 , A61P25/00 , A61P25/28 , C07D215/12 , C07D215/52 , C07D221/10 , C07D215/16 , C07D215/20
CPC分类号： C07D215/52 , A61K31/47 , A61K31/473 , A61K51/0455 , A61K2123/00 , C07D215/12 , C07D221/10
摘要： The present invention provides compounds, or salts or solvates thereof, which can be used as probes for the imaging diagnosis of diseases in which tau protein accumulates, and compositions and kits comprising such compounds, or salts or solvates thereof. The present invention also provides a method for staining neurofibrillary tangles in brain samples, and a pharmaceutical composition for the treatment and/or prophylaxis of a disease in which β-sheet structure is the cause or possible cause.
摘要翻译：本发明提供可用作成像诊断tau蛋白积聚的疾病的探针的化合物或其盐或溶剂合物，以及包含这些化合物的组合物和试剂盒，或其盐或溶剂化物。本发明还提供了脑样本中神经原纤维缠结染色的方法，以及用于治疗和/或预防其中β-折叠结构是原因或可能的原因的疾病的药物组合物。

2. 发明授权

US07118730B2 Quinoline derivative as diagnostic probe for disease with tau protein accumulation 失效
标题翻译：喹啉衍生物作为具有tau蛋白积聚的疾病的诊断探针
公开(公告)号：US07118730B2
公开(公告)日：2006-10-10
申请号：US10494314
申请日：2003-11-28
申请人： Yukitsuka Kudo , Masako Suzuki , Takahiro Suemoto , Nobuyuki Okamura , Tsuyoshi Shiomitsu , Hiroshi Shimazu
发明人： Yukitsuka Kudo , Masako Suzuki , Takahiro Suemoto , Nobuyuki Okamura , Tsuyoshi Shiomitsu , Hiroshi Shimazu
IPC分类号： A61K49/00
CPC分类号： C07D215/52 , A61K31/47 , A61K31/473 , A61K51/0455 , A61K2123/00 , C07D215/12 , C07D221/10
摘要： The present invention provides compounds, or salts or solvates thereof, which can be used as probes for the imaging diagnosis of diseases in which tau protein accumulates, and compositions and kits comprising such compounds, or salts or solvates thereof. The present invention also provides a method for staining neurofibrillary tangles in brain samples, and a pharmaceutical composition for the treatment and/or prophylaxis of a disease in which β-sheet structure is the cause or possible cause.
摘要翻译：本发明提供可用作成像诊断tau蛋白积聚的疾病的探针的化合物或其盐或溶剂合物，以及包含这些化合物的组合物和试剂盒，或其盐或溶剂化物。本发明还提供了脑样本中神经原纤维缠结染色的方法，以及用于治疗和/或预防其中β-折叠结构是原因或可能的原因的疾病的药物组合物。

3. 发明申请

US20060018825A1 Probe for diseases with amyloid accumulation, amyloid-staining agent, remedy and preventive for diseases with amyloid accumulation and diagnostic probe and staining agent for neurofibrillary change 审中-公开
标题翻译：探索具有淀粉样蛋白积聚的疾病，淀粉样蛋白染色剂，用于淀粉样蛋白积聚的疾病的补救和预防以及用于神经原纤维变化的诊断性探针和染色剂
公开(公告)号：US20060018825A1
公开(公告)日：2006-01-26
申请号：US10527398
申请日：2004-08-11
申请人： Yukitsuka Kudo , Masako Suzuki , Takahiro Suemoto , Nobuyuki Okamura , Tsuyoshi Shiomitsu , Hiroshi Shimazu
发明人： Yukitsuka Kudo , Masako Suzuki , Takahiro Suemoto , Nobuyuki Okamura , Tsuyoshi Shiomitsu , Hiroshi Shimazu
IPC分类号： A61K31/4709 , A61K51/00 , C07D417/02 , C07D413/02
CPC分类号： C07D263/32 , A61K31/4178 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4709 , A61K49/0021 , A61K49/0032 , C07D215/12 , C07D235/14 , C07D263/48 , C07D263/56 , C07D277/42 , C07D277/64 , C07D403/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06
摘要： The present invention provides compounds having high affinity for amyloid β-protein which are for the diagnosis of diseases in which amyloid β-protein accumulates, for agents for specifically staining amyloid β-protein, and for the treatment and/or prophylaxis of diseases in which amyloid β-protein accumulates. The present invention also provides probes and staining agents for neurofibrillary tangles.
摘要翻译：本发明提供对淀粉样β-蛋白具有高亲和力的化合物，其用于诊断淀粉样蛋白β蛋白积聚的疾病，用于特异性染色淀粉样蛋白β-蛋白的药剂，以及用于治疗和/或预防其中淀粉样β蛋白积累。本发明还提供了用于神经原纤维缠结的探针和染色剂。

4. 发明授权

US5826516A Squeegee for screen printing and its production method 失效
标题翻译：丝网印刷及其生产方法
公开(公告)号：US5826516A
公开(公告)日：1998-10-27
申请号：US992912
申请日：1997-12-18
申请人： Hiroshi Shimazu , Yoshihiro Kobayashi , Eiji Sakata
发明人： Hiroshi Shimazu , Yoshihiro Kobayashi , Eiji Sakata
IPC分类号： B41F15/42 , B41F15/44 , C25D1/00 , C25D5/00 , H05K3/12
CPC分类号： C25D1/00 , B41F15/42 , B41F15/44 , H05K3/1233 , C25D5/00 , H05K2203/0139
摘要： A squeegee (K1-K3) for screen printing, comprising: a squeegee body (1) which is formed by a metal sheet and has a squeegeeing face (1a) and a convexly curved pressing edge (3) on the squeegeeing face (1a); wherein when the squeegee (K1-K3) is set for squeegeeing such that the squeegeeing face (1a) is oriented in a travelling direction (X) of the squeegee (K1-K3), a center (O) of curvature of the convexly curved pressing edge (3) extends substantially horizontally.
摘要翻译：一种用于丝网印刷的刮板（K1-K3），包括：由金属板形成的刮板体（1），并且在刮板面（1a）上具有刮板面（1a）和凸曲面的加压边（3） ; 其特征在于，当所述刮板（K1-K3）被设定为用于刮板刮板使得所述刮板面（1a）在所述刮板（K1-K3）的行进方向（X）上取向时，所述凸曲面按压边缘（3）基本上水平地延伸。

5. 发明授权

US4451984A Inner blade for use in reciprocating type electric shaver 失效
标题翻译：内刀片用于往复式电动剃须刀
公开(公告)号：US4451984A
公开(公告)日：1984-06-05
申请号：US417841
申请日：1982-09-14
申请人： Hiroshi Shimazu
发明人： Hiroshi Shimazu
IPC分类号： B26B19/04 , B26B19/00 , B23B17/00 , B26B19/02
CPC分类号： B26B19/044 , Y10T29/49789
摘要： An inner blade (15) for use in a reciprocating type electric shaver, including at least two support members (17) and a plurality of inner blade elements (16) mounted on the at least two support members (17). The inner blade element (16) having a pair of a first blade tip portion (19) and a second blade tip portion (19') is formed by folding, a blank (24) having a profile symmetrical with respect to a line (L), along the line (L) into a pair of a first inner blade element portion (18) and a second inner blade element portion (18') such that the first inner blade element portion (18) is brought into close contact with the second inner blade element portion (18').
摘要翻译：一种用于往复式电动剃须刀的内刀片（15），包括安装在所述至少两个支撑构件（17）上的至少两个支撑构件（17）和多个内刀片元件（16）。具有一对第一叶片末端部分（19）和第二叶片末端部分（19'）的内部叶片元件（16）通过折叠形成，具有相对于线（L ），沿着线（L）成为一对第一内刀片元件部分（18）和第二内刀片元件部分（18'），使得第一内刃元件部分（18）与第二内刀片元件部分（18'）。

6. 发明授权

US09518306B2 Top-firing hot blast stove 有权
标题翻译：顶级热风炉
公开(公告)号：US09518306B2
公开(公告)日：2016-12-13
申请号：US14005019
申请日：2012-03-13
申请人： Norimasa Maekawa , Koya Inoue , Hiroshi Shimazu , Shunji Koya , Naoki Kunishige , Nobuhiro Ohshita
发明人： Norimasa Maekawa , Koya Inoue , Hiroshi Shimazu , Shunji Koya , Naoki Kunishige , Nobuhiro Ohshita
IPC分类号： C21B9/14 , C21B9/10 , F23D14/22
CPC分类号： C21B9/14 , C21B9/10 , F23D14/22 , F23D2209/20 , F23D2900/14241 , F23D2900/21001
摘要： There is provided a top-firing hot blast stove including a burner and a burner duct capable of stabilizing an ignition point at a desired position inside the burner duct and suppressing occurrence of blinking phenomenon so as to achieve high combustion efficiency.A top-firing hot blast stove 10 includes a checker chamber 4 and a combustion chamber 3 which includes a burner system and placed above the checker chamber 4. The burner system includes: a burner 1 provided with a fuel gas pipe 1c and combustion air pipes 1b, 1d; and a burner duct 2 communicating with a burner exit 1a of the burner 1, the burner duct 2 communicating with the combustion chamber 3 through a burner duct outlet 2b, wherein an aperture enlarged portion 2c where an aperture D1 of the burner duct 2 is enlarged is provided over a section from a middle of the burner duct 2 to the burner duct outlet 2b, so that an eddy current ED of the mixed gas MG flowing toward the combustion chamber 3 through the burner duct 2 is formed in the aperture enlarged portion 2c.
摘要翻译：顶烧式热风炉10包括检验室4和燃烧室3，其包括燃烧器系统并且放置在检验室4的上方。燃烧器系统包括：燃烧器1，其设有燃料气管1c和燃烧空气管 1b，1d; 以及与燃烧器1的燃烧器出口1a连通的燃烧器管道2，燃烧器管道2通过燃烧器管道出口2b与燃烧室3连通，其中扩大燃烧器管道2的孔径D1的孔径扩大部分2c 设置在从燃烧器管道2的中部到燃烧器管道出口2b的部分上，使得通过燃烧器管道2流向燃烧室3的混合气体MG的涡流ED形成在孔径扩大部分2c中。

7. 发明申请

US20140011152A1 TOP-FIRING HOT BLAST STOVE 有权
标题翻译：顶级热火炉
公开(公告)号：US20140011152A1
公开(公告)日：2014-01-09
申请号：US14005616
申请日：2012-03-19
申请人： Norimasa Maekawa , Koya Inoue , Hiroshi Shimazu , Shunji Koya , Naoki Kunishige , Nobuhiro Ohshita
发明人： Norimasa Maekawa , Koya Inoue , Hiroshi Shimazu , Shunji Koya , Naoki Kunishige , Nobuhiro Ohshita
IPC分类号： C21B9/14
CPC分类号： C21B9/14 , C21B9/10 , F23D14/24 , F23D2900/21001 , F27B17/0083 , F27B2017/0091
摘要： There is provided a top-firing hot blast stove capable of enhancing combustion efficiency in burner system, supplying high-temperature combustion gas to an entire checker chamber, and suppressing damage on a refractory material on an inner wall of a burner duct.A top-firing hot blast stove 10 has a burner system including: a burner 1 for passing fuel gas or combustion air to each of three or more pipe lines in a multiple pipe line structure; and a burner duct 2. A core pipe line 1b and a central pipe line 1c include a swirling flow generating means provided for generating a swirling flow of the fuel gas or the combustion air, while an outermost pipe line 1d carries a linear flow of the fuel gas or the combustion air, so that combustion gas HG including a linear component HG″ and a swirling component HG′ is generated in the burner duct 2. The combustion gas HG is supplied to a combustion chamber 3 from at least one or more of the burner systems in an inflow direction which does not pass through a center position of the combustion chamber 3.
摘要翻译：提供了能够提高燃烧器系统的燃烧效率，向整个检验室供给高温燃烧气体并抑制对燃烧器管道的内壁上的耐火材料的损害的顶烧式热风炉。顶烧式热风炉10具有燃烧器系统，其包括：燃烧器1，用于使燃料气体或燃烧空气通过多管道结构中的三条或更多条管线中的每一条; 核心管线1b和中心管线1c包括设置用于产生燃料气体或燃烧空气的回旋流的旋流产生装置，而最外管线1d承载线性流燃料气体或燃烧空气，使得在燃烧器管道2中产生包括线性部件HG“和旋转部件HG'的燃烧气体HG。燃烧气体HG从至少一个或多个的燃烧器系统在不通过燃烧室3的中心位置的流入方向上。

8. 发明申请

US20140004475A1 TOP-FIRING HOT BLAST STOVE 有权
标题翻译：顶级热火炉
公开(公告)号：US20140004475A1
公开(公告)日：2014-01-02
申请号：US14005019
申请日：2012-03-13
申请人： Norimasa Maekawa , Koya Inoue , Hiroshi Shimazu , Shunji Koya , Naoki Kunishige , Nobuhiro Ohshita
发明人： Norimasa Maekawa , Koya Inoue , Hiroshi Shimazu , Shunji Koya , Naoki Kunishige , Nobuhiro Ohshita
IPC分类号： C21B9/14
CPC分类号： C21B9/14 , C21B9/10 , F23D14/22 , F23D2209/20 , F23D2900/14241 , F23D2900/21001
摘要： There is provided a top-firing hot blast stove including a burner and a burner duct capable of stabilizing an ignition point at a desired position inside the burner duct and suppressing occurrence of blinking phenomenon so as to achieve high combustion efficiency.A top-firing hot blast stove 10 includes a checker chamber 4 and a combustion chamber 3 which includes a burner system and placed above the checker chamber 4. The burner system includes: a burner 1 provided with a fuel gas pipe 1c and combustion air pipes 1b, 1d; and a burner duct 2 communicating with a burner exit 1a of the burner 1, the burner duct 2 communicating with the combustion chamber 3 through a burner duct outlet 2b, wherein an aperture enlarged portion 2c where an aperture D1 of the burner duct 2 is enlarged is provided over a section from a middle of the burner duct 2 to the burner duct outlet 2b, so that an eddy current ED of the mixed gas MG flowing toward the combustion chamber 3 through the burner duct 2 is formed in the aperture enlarged portion 2c.
摘要翻译：提供一种具有燃烧器和燃烧器管道的顶部放热热风炉，其能够使燃烧器管道内的期望位置处的点火点稳定并且抑制闪烁现象的发生，从而实现高燃烧效率。顶烧式热风炉10包括检验室4和燃烧室3，其包括燃烧器系统并且放置在检验室4的上方。燃烧器系统包括：燃烧器1，其设有燃料气管1c和燃烧空气管 1b，1d; 以及与燃烧器1的燃烧器出口1a连通的燃烧器管道2，燃烧器管道2通过燃烧器管道出口2b与燃烧室3连通，其中扩大燃烧器管道2的孔径D1的孔径扩大部分2c 设置在从燃烧器管道2的中部到燃烧器管道出口2b的部分上，使得通过燃烧器管道2流向燃烧室3的混合气体MG的涡流ED形成在孔径扩大部分2c中。

9. 发明授权

US09017068B2 Top-firing hot blast stove 有权
标题翻译：顶级热风炉
公开(公告)号：US09017068B2
公开(公告)日：2015-04-28
申请号：US14005616
申请日：2012-03-19
申请人： Norimasa Maekawa , Koya Inoue , Hiroshi Shimazu , Shunji Koya , Naoki Kunishige , Nobuhiro Ohshita
发明人： Norimasa Maekawa , Koya Inoue , Hiroshi Shimazu , Shunji Koya , Naoki Kunishige , Nobuhiro Ohshita
IPC分类号： C21B9/00 , C21B9/14 , C21B9/10 , F23D14/24 , F27B17/00
CPC分类号： C21B9/14 , C21B9/10 , F23D14/24 , F23D2900/21001 , F27B17/0083 , F27B2017/0091
摘要： There is provided a top-firing hot blast stove capable of enhancing combustion efficiency in burner system, supplying high-temperature combustion gas to an entire checker chamber, and suppressing damage on a refractory material on an inner wall of a burner duct.A top-firing hot blast stove 10 has a burner system including: a burner 1 for passing fuel gas or combustion air to each of three or more pipe lines in a multiple pipe line structure; and a burner duct 2. A core pipe line 1b and a central pipe line 1c include a swirling flow generating means provided for generating a swirling flow of the fuel gas or the combustion air, while an outermost pipe line 1d carries a linear flow of the fuel gas or the combustion air, so that combustion gas HG including a linear component HG″ and a swirling component HG′ is generated in the burner duct 2. The combustion gas HG is supplied to a combustion chamber 3 from at least one or more of the burner systems in an inflow direction which does not pass through a center position of the combustion chamber 3.
摘要翻译：提供了能够提高燃烧器系统的燃烧效率，向整个检验室供给高温燃烧气体并抑制对燃烧器管道的内壁上的耐火材料的损害的顶烧式热风炉。顶烧式热风炉10具有燃烧器系统，其包括：燃烧器1，用于使燃料气体或燃烧空气通过多管道结构中的三条或更多条管线中的每一条; 核心管线1b和中心管线1c包括设置用于产生燃料气体或燃烧空气的回旋流的旋流产生装置，而最外管线1d承载线性流燃料气体或燃烧空气，使得在燃烧器管道2中产生包括线性部件HG“和旋转部件HG'的燃烧气体HG。燃烧气体HG从至少一个或多个燃烧器系统处于不通过燃烧室3的中心位置的流入方向。

10. 发明授权

US5775219A Squeegee for screen printing 失效
标题翻译：刮刀用于丝网印刷
公开(公告)号：US5775219A
公开(公告)日：1998-07-07
申请号：US764625
申请日：1996-12-11
申请人： Hiroshi Shimazu , Yoshihiro Kobayashi , Eiji Sakata
发明人： Hiroshi Shimazu , Yoshihiro Kobayashi , Eiji Sakata
IPC分类号： B41F15/42 , B41F15/44 , C25D1/00 , C25D5/00 , H05K3/12
CPC分类号： C25D1/00 , B41F15/42 , B41F15/44 , H05K3/1233 , C25D5/00 , H05K2203/0139
摘要： A squeegee (K1-K3) for screen printing, comprising: a squeegee body (1) which is formed by a metal sheet and has a squeegeeing face (1a) and a convexly curved pressing edge (3) on the squeegeeing face (1a); wherein when the squeegee (K1-K3) is set for squeegeeing such that the squeegeeing face (1a) is oriented in a travelling direction (X) of the squeegee (K1-K3), a center (O) of curvature of the convexly curved pressing edge (3) extends substantially horizontally.
摘要翻译：一种用于丝网印刷的刮板（K1-K3），包括：由金属板形成的刮板体（1），并且在刮板面（1a）上具有刮板面（1a）和凸曲面的加压边（3） ; 其特征在于，当所述刮板（K1-K3）被设定为用于刮板刮板使得所述刮板面（1a）在所述刮板（K1-K3）的行进方向（X）上取向时，所述凸曲面按压边缘（3）基本上水平地延伸。

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