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1. 发明授权

US06385481B1 Diagnostic system with a chair and table movable on rails provided on vertical magnets thereof 有权
公开(公告)号：US06385481B1
公开(公告)日：2002-05-07
申请号：US09218402
申请日：1998-12-22
申请人： Katsumasa Nose , Osamu Furuta , Kazuhiko Hayakawa , Masaaki Sakuma , Yujiro Hayashi
发明人： Katsumasa Nose , Osamu Furuta , Kazuhiko Hayakawa , Masaaki Sakuma , Yujiro Hayashi
IPC分类号： A61B5055
摘要： The present invention is directed to joint motion imaging and provides a vertical magnet type MRI system comprising a vertical magnet unit (10) having a pair of opposite vertical magnets (11), a movable table (20) provided with wheels (22) for traveling and a cradle (21) to carry a specimen laid down thereon, and capable of being moved into and moved out of a space between the pair of opposite vertical magnets (11), table locking devices (13) for locking the movable table (20) with the cradle (21) being in place between the pair of opposite vertical magnets (11), a movable chair (30) provided with wheels (32) for traveling and capable of being moved into and moved out of the space between the pair of opposite vertical magnets (11), and a chair locking device (14) for locking the movable chair (30) in place between the pair of opposite vertical magnets (11).

2. 发明授权

US6141580A Detecting coil for magnetic resonance diagnostic apparatus 有权
标题翻译：磁共振诊断仪检测线圈
公开(公告)号：US6141580A
公开(公告)日：2000-10-31
申请号：US209604
申请日：1998-12-11
申请人： Yujiro Hayashi , Masaaki Sakuma
发明人： Yujiro Hayashi , Masaaki Sakuma
IPC分类号： G01R33/3415 , A61B5/055 , G01R33/34
CPC分类号： G01R33/341 , G01R33/34046 , G01R33/34084
摘要： In order not to nip the clothes or skin of a subject between the joining portions of coil members when a detecting coil for a magnetic resonance diagnostic apparatus is fitted around a region of the subject such as the leg or neck, the detecting coil 100 for a magnetic resonance diagnostic apparatus, which can be separated into an upper coil member 10 and a lower coil member 20 and has an annular shape when these members 10, 20 are integrally joined, is provided at the joining portions of the lower coil member 20 with guards 27, 28 of a silicone rubber having a hardness of Hs80.
摘要翻译：为了在用于磁共振诊断装置的检测线圈安装在诸如腿部或颈部的对象的区域周围时，为了不在被卷绕在线圈部件的接合部分之间的受试者的衣服或皮肤夹持，磁共振诊断装置，在上部线圈部件10和下部线圈部件20分离的同时，在下部线圈部件20的连接部分设有保护件 27，28，硬度为Hs80的硅橡胶。

3. 发明授权

US08962889B2 Process for producing optically active β-amino aldehyde compound 有权
标题翻译：光学活性和氨基醛化合物的制备方法
公开(公告)号：US08962889B2
公开(公告)日：2015-02-24
申请号：US13880675
申请日：2011-10-09
申请人： Yujiro Hayashi
发明人： Yujiro Hayashi
IPC分类号： C07C251/12 , C07C311/06 , C07C303/40 , C07B53/00
CPC分类号： C07C303/40 , C07B53/00 , C07B2200/07 , C07C2601/14 , C07C311/16 , C07C311/17
摘要： The invention relates to a method of producing optically active β-aminoaldehyde compound (3) by reacting imine compound (1-1) or sulfone compound (1-2) with aldehyde compound (2) in the presence of an optically active pyrrolidine compound. wherein each symbol is as defined in the specification.
摘要翻译：本发明涉及通过在光学活性吡咯烷化合物存在下使亚胺化合物（1-1）或砜化合物（1-2）与醛化合物（2）反应制备光学活性的α-氨基醛化合物（3）的方法。其中每个符号如说明书中所定义。

4. 发明授权

US08729294B2 Process for producing optically active 3-substituted-3-formyl-2-hydroxypropanoic acid compound 有权
标题翻译：光学活性3-取代-3-甲酰基-2-羟基丙酸化合物的制造方法
公开(公告)号：US08729294B2
公开(公告)日：2014-05-20
申请号：US13701314
申请日：2011-05-30
申请人： Yujiro Hayashi
发明人： Yujiro Hayashi
IPC分类号： C07C69/675 , C07C69/732
CPC分类号： C07C67/343 , C07B53/00 , C07C67/31 , C07C69/708 , C07C69/716 , C07C69/732 , C07D209/48
摘要： The present invention provides a production method of optically active 3-substituted-3-formyl-2-hydroxypropanoic acid compound (4), which includes a step of reacting glyoxylic acid compound (1-1) or (1-2) with aldehyde (2) in the presence of optically active pyrrolidine compound (3); wherein each symbol is as defined in the specification.
摘要翻译：本发明提供光学活性3-取代-3-甲酰基-2-羟基丙酸化合物（4）的制备方法，该方法包括使乙醛酸化合物（1-1）或（1-2）与醛反应 2）在光学活性吡咯烷化合物（3）的存在下; 其中每个符号如说明书中所定义。

5. 发明申请

US20130005654A1 THERAPEUTIC AGENT FOR ACCELERATING RECOVERY OF ANIMAL UNDER MEDICAL TREATMENT 有权
标题翻译：用于加速医疗治疗动物恢复的治疗剂
公开(公告)号：US20130005654A1
公开(公告)日：2013-01-03
申请号：US13522203
申请日：2011-01-14
申请人： Noboru Murakami , Keiko Nakahara , Kenji Kangawa , Yujiro Hayashi
发明人： Noboru Murakami , Keiko Nakahara , Kenji Kangawa , Yujiro Hayashi
IPC分类号： A61K38/22 , A61P3/00
CPC分类号： A61K38/25 , A61K38/00 , A61K38/2264
摘要： An object of the present invention is to provide a therapeutic agent for accelerating recovery to accelerate a return to normal physical conditions by administering to an animal not in good health and under medical treatment, a treatment method, and the like. There is provided a therapeutic agent for accelerating recovery for animal use to accelerate the improvement of a physical condition of an animal under medical treatment which has a decreased activity (vigor) and is exhausted, which contains ghrelin or a derivative thereof or a pharmaceutically acceptable salt thereof as an active ingredient and improves one or more of evaluation parameters consisting of activity (vigor), blood cell test values, biochemical test values, body temperature, the degree of anger or anxiety, and respiratory rate.
摘要翻译：本发明的目的是提供一种治疗剂，其用于加速恢复，通过给予不良健康和医疗处理的动物，治疗方法等来加速恢复正常的身体状况。提供了用于加速动物使用恢复的治疗剂，以加速具有降低的活性（活力）并且被排出的动物的身体状况的改善，其含有生长素释放肽或其衍生物或药学上可接受的盐作为活性成分，改善由活性（活力），血细胞试验值，生化试验值，体温，愤怒或焦虑程度和呼吸频率组成的评价参数中的一种或多种。

6. 发明授权

US07279601B2 Optically active α-aminooxyketone derivatives and process for production thereof 失效
标题翻译：光学活性α-氨基氧基酮衍生物及其制备方法
公开(公告)号：US07279601B2
公开(公告)日：2007-10-09
申请号：US10569757
申请日：2004-08-20
申请人： Yujiro Hayashi , Mitsuru Shoji
发明人： Yujiro Hayashi , Mitsuru Shoji
IPC分类号： C07C239/00 , C07C259/00
CPC分类号： C07D317/72 , C07B2200/07 , C07C239/20 , C07D211/74 , C07D309/30 , C07D319/08 , C07D335/02 , C07D339/08 , C07F7/1892
摘要： The corresponding α-aminooxy ketone is manufactured with a high yield and a high enantioselectivity. A manufacturing method for an optically active α-aminooxy ketone derivative expressed by formula (1), wherein a ketone expressed by formula (2) is caused to react with a nitroso compound expressed by formula (3) in the presence of a proline derivative expressed by formula (4). In the formula, R1 and R2 respectively denote an alkyl, alkenyl or alkynyl group, and R1 and R2 may be linked to form a ring. R3 denotes an aryl, heterocyclic, alkyl, alkenyl or alkynyl group. A denotes a hydrogen atom, alkoxy group, aryloxy group, acyloxy group or silyloxy group which may have a substituent.
摘要翻译：相应的α-氨氧基酮以高产率和高对映选择性制造。由式（1）表示的光学活性α-氨基氧基酮衍生物的制造方法，其中使由式（2）表示的酮与式（3）表示的亚硝基化合物在表达的脯氨酸衍生物的存在下反应通过式（4）。在该式中，R 1和R 2分别表示烷基，烯基或炔基，R 1和R 2可以相同或不同， / SUP>可以链接形成一个戒指。 R 3表示芳基，杂环，烷基，烯基或炔基。 A表示可以具有取代基的氢原子，烷氧基，芳氧基，酰氧基或甲硅烷氧基。

7. 发明申请

US20050209463A1 Novel compound having antitumor activity and process for producing the same 失效
标题翻译：具有抗肿瘤活性的新型化合物及其制造方法
公开(公告)号：US20050209463A1
公开(公告)日：2005-09-22
申请号：US10516743
申请日：2003-06-06
申请人： Hiroyuki Osada , Hideaki Kakeya , Yujiro Hayashi
发明人： Hiroyuki Osada , Hideaki Kakeya , Yujiro Hayashi
IPC分类号： C07D301/14 , A61K31/407 , A61P35/00 , C07D303/48 , C07D491/02 , C07D491/04 , C07D491/044
CPC分类号： C07D491/04 , A61K31/407
摘要： A compound represented by the general formula (I): (I) wherein R represents linear, branched, or cyclic alkyl or aryl; a process for producing the compound; and an antitumor agent containing the compound as an active ingredient.
摘要翻译：由通式（I）表示的化合物：（I）其中R表示直链，支链或环状的烷基或芳基; 一种制备该化合物的方法; 和含有该化合物作为活性成分的抗肿瘤剂。

8. 发明授权

US5724947A Fuel pump unit 失效
标题翻译：燃油泵单元
公开(公告)号：US5724947A
公开(公告)日：1998-03-10
申请号：US816505
申请日：1997-03-13
申请人： Hiroshi Takaki , Yujiro Hayashi
发明人： Hiroshi Takaki , Yujiro Hayashi
IPC分类号： F02M37/10 , F02M37/04
CPC分类号： F02M37/10 , Y10T137/2569 , Y10T137/86043
摘要： In a fuel pump unit, to solve (1) the problem of a valve of a reserver opening unnecessarily due to vibrations from outside or the like and (2) the problem of it not being possible to supply to an engine remaining fuel having fallen to below a minimum intake level, a main tank valve and a reserve valve respectively close from above a main fuel inlet connecting with a fuel intake passage of the fuel pump unit and an auxiliary fuel inlet connecting with the fuel intake passage and a rocking member having a force point pivotally attached to the main tank valve and having the action of pushing up the reserve valve with an action point and thereby opening the auxiliary fuel inlet when the main tank valve closes the main fuel inlet is provided and a sub-float for descending and pushing down the reserve valve from above when excess fuel in the reserver runs out is disposed in the reserver.
摘要翻译：在燃料泵单元中，解决（1）由于外部振动等引起的储存器开口的阀门的问题，以及（2）不能向发动机供给剩余燃料的问题分别靠近与燃料泵单元的燃料进入通道连接的主燃料入口和与燃料进入通道连接的辅助燃料入口的主容器阀和备用阀，以及具有与燃料泵单元连接的辅助燃料入口的摇动构件，力点枢转地附接到主油箱阀，并且具有用动作点推动备用阀的动作，并且由此在主油箱阀关闭主燃料入口时打开辅助燃料入口，并且提供用于下降和储备者中的多余燃料用完时，将储备阀从上方推下。

9. 发明授权

US08742176B2 Process for producing optically active 4-chloro-3-hydroxybutanal compound 有权
标题翻译：光学活性4-氯-3-羟基丁醛化合物的制备方法
公开(公告)号：US08742176B2
公开(公告)日：2014-06-03
申请号：US13880640
申请日：2011-10-19
申请人： Yujiro Hayashi
发明人： Yujiro Hayashi
IPC分类号： C07C47/02
CPC分类号： C07C45/00 , C07B53/00 , C07B2200/07 , C07C41/01 , C07C41/56 , C07C45/72 , C07C67/00 , C07C67/343 , C07D301/26 , C07D303/12 , C07D303/16 , C07C69/732 , C07C47/195 , C07C43/315 , C07C47/273
摘要： The invention relates to a method of producing optically active 4-chloro-3-hydroxybutanal compound (2) by reacting chloroacetaldehyde with aldehyde compound (1) in the presence of optically active pyrrolidine compound (5). wherein each symbol is as defined in the specification.
摘要翻译：本发明涉及通过在光学活性吡咯烷化合物（5）的存在下使氯乙醛与醛化合物（1）反应制备光学活性的4-氯-3-羟基丁醛化合物（2）的方法。其中每个符号如说明书中所定义。

10. 发明授权

US07612213B2 Compound having antitumor activity and process for producing the same 失效
标题翻译：具有抗肿瘤活性的化合物及其制备方法
公开(公告)号：US07612213B2
公开(公告)日：2009-11-03
申请号：US10516743
申请日：2003-06-06
申请人： Hiroyuki Osada , Hideaki Kakeya , Yujiro Hayashi
发明人： Hiroyuki Osada , Hideaki Kakeya , Yujiro Hayashi
IPC分类号： C07D207/00 , C07D209/32 , C07D303/38 , C07D491/02
CPC分类号： C07D491/04 , A61K31/407
摘要： A compound represented by the general formula (I): (I) wherein R represents linear, branched, or cyclic alkyl or aryl; a process for producing the compound; and an antitumor agent containing the compound as an active ingredient.
摘要翻译：由通式（I）表示的化合物：（I）其中R表示直链，支链或环状的烷基或芳基; 一种制备该化合物的方法; 和含有该化合物作为活性成分的抗肿瘤剂。

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