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1. 发明授权

US07883705B2 Anti FGF23 antibody and a pharmaceutical composition comprising the same 有权
标题翻译：抗FGF23抗体和包含其的药物组合物
公开(公告)号：US07883705B2
公开(公告)日：2011-02-08
申请号：US12030593
申请日：2008-02-13
申请人： Yuji Yamazaki , Itaru Urakawa , Hitoshi Yoshida , Yukiko Aono , Takeyoshi Yamashita , Takashi Shimada , Hisashi Hasegawa
发明人： Yuji Yamazaki , Itaru Urakawa , Hitoshi Yoshida , Yukiko Aono , Takeyoshi Yamashita , Takashi Shimada , Hisashi Hasegawa
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/244 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： To provide an antibody against FGF23 and a pharmaceutical composition such as a preventive or therapeutic agent which can prevent or treat by suppressing an action of FGF23 by using the antibody. An antibody or its functional fragment against human FGF23 produced by hybridoma C10 (Accession No. FERM BP-10772).
摘要翻译：提供针对FGF23的抗体和通过使用抗体抑制FGF23的作用可以预防或治疗的药物组合物，例如预防或治疗剂。由杂交瘤C10（登录号FERM BP-10772）产生的针对人FGF23的抗体或其功能片段。

2. 发明申请

US20110182913A1 ANTI FGF23 ANTIBODY AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：抗FGF23抗体和包含其的药物组合物
公开(公告)号：US20110182913A1
公开(公告)日：2011-07-28
申请号：US13019557
申请日：2011-02-02
申请人： Yuji Yamazaki , Itaru Urakawa , Hitoshi Yoshida , Yukiko Aono , Takeyoshi Yamashita , Takashi Shimada , Hisashi Hasegawa
发明人： Yuji Yamazaki , Itaru Urakawa , Hitoshi Yoshida , Yukiko Aono , Takeyoshi Yamashita , Takashi Shimada , Hisashi Hasegawa
IPC分类号： A61K39/395 , A61P13/12 , A61P17/04 , A61P5/18 , A61P19/08 , A61P19/10 , A61P19/00 , A61P21/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/244 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： To provide an antibody against FGF23 and a pharmaceutical composition such as a preventive or therapeutic agent which can prevent or treat by suppressing an action of FGF23 by using the antibody. An antibody or its functional fragment against human FGF23 produced by hybridoma C10 (Accession No. FERM BP-10772).
摘要翻译：提供针对FGF23的抗体和通过使用抗体抑制FGF23的作用可以预防或治疗的药物组合物，例如预防或治疗剂。由杂交瘤C10（登录号FERM BP-10772）产生的针对人FGF23的抗体或其功能片段。

3. 发明申请

US20090148461A1 ANTI FGF23 ANTIBODY AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权
标题翻译：抗FGF23抗体和包含其的药物组合物
公开(公告)号：US20090148461A1
公开(公告)日：2009-06-11
申请号：US12030593
申请日：2008-02-13
申请人： Yuji Yamazaki , Itaru Urakawa , Hitoshi Yoshida , Yukiko Aono , Takeyoshi Yamashita , Takashi Shimada , Hisashi Hasegawa
发明人： Yuji Yamazaki , Itaru Urakawa , Hitoshi Yoshida , Yukiko Aono , Takeyoshi Yamashita , Takashi Shimada , Hisashi Hasegawa
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/64 , C12N5/06 , C12P21/00 , A61P35/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/244 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： To provide an antibody against FGF23 and a pharmaceutical composition such as a preventive or therapeutic agent which can prevent or treat by suppressing an action of FGF23 by using the antibody. An antibody or its functional fragment against human FGF23 produced by hybridoma C10 (Accession No. FERM BP-10772).
摘要翻译：提供针对FGF23的抗体和通过使用抗体抑制FGF23的作用可以预防或治疗的药物组合物，例如预防或治疗剂。由杂交瘤C10（登录号FERM BP-10772）产生的针对人FGF23的抗体或其功能片段。

4. 发明授权

US09290569B2 Anti FGF23 antibody and a pharmaceutical composition comprising the same 有权
标题翻译：抗FGF23抗体和包含其的药物组合物
公开(公告)号：US09290569B2
公开(公告)日：2016-03-22
申请号：US13019557
申请日：2011-02-02
申请人： Yuji Yamazaki , Itaru Urakawa , Hitoshi Yoshida , Yukiko Aono , Takeyoshi Yamashita , Takashi Shimada , Hisashi Hasegawa
发明人： Yuji Yamazaki , Itaru Urakawa , Hitoshi Yoshida , Yukiko Aono , Takeyoshi Yamashita , Takashi Shimada , Hisashi Hasegawa
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/244 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： To provide an antibody against FGF23 and a pharmaceutical composition such as a preventive or therapeutic agent which can prevent or treat by suppressing an action of FGF23 by using the antibody. An antibody or its functional fragment against human FGF23 produced by hybridoma C10 (Accession No. FERM BP-10772).
摘要翻译：提供针对FGF23的抗体和通过使用抗体抑制FGF23的作用可以预防或治疗的药物组合物，例如预防或治疗剂。由杂交瘤C10（登录号FERM BP-10772）产生的针对人FGF23的抗体或其功能片段。

5. 发明授权

US07923012B2 Antibody against fibroblast growth factor-23 有权
标题翻译：针对成纤维细胞生长因子-23的抗体
公开(公告)号：US07923012B2
公开(公告)日：2011-04-12
申请号：US10500296
申请日：2003-01-06
申请人： Yuji Yamazaki , Takashi Shimada , Takeyoshi Yamashita
发明人： Yuji Yamazaki , Takashi Shimada , Takeyoshi Yamashita
IPC分类号： A61K39/395
CPC分类号： C07K14/50 , A61K39/00 , A61K2039/505 , C07K16/22
摘要： The purpose of the present invention is to provide an antibody against fibroblast growth factor 23. The antibody is obtained by immunizing an animal with a polypeptide which comprises an amino acid sequence represented by SEQ ID NO: 1, or an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 1 by deletion, substitution, or addition of 1 or several amino acids, and has fibroblast growth factor-23 activity and activity to control phosphate metabolism or vitamin D metabolism, and is shown by the following (a), (b), or (c): (a) an antibody, which recognizes an amino acid sequence between the 180th and the 194th, or the 237th and the 251st amino acid residues represented by SEQ ID NO: 1; (b) an antibody, which is produced by a hybridoma whose accession number is FERM BP-7838, FERM BP-7839, FERM BP-7840, or FERM BP-8268; or (c) an antibody, which is competitive with the antibody produced by the hybridoma whose accession number is FERM BP-7838, FERM BP-7839, FERM BP-7840, or FERM BP-8268 upon binding with the polypeptide comprising the amino acid sequence represented by SEQ ID NO: 1.
摘要翻译：本发明的目的是提供抗成纤维细胞生长因子23的抗体。该抗体是通过用包含SEQ ID NO：1所示的氨基酸序列的多肽免疫动物，或衍生自通过缺失，取代或添加1个或几个氨基酸由SEQ ID NO：1表示的氨基酸序列，并且具有成纤维细胞生长因子-23活性和控制磷酸盐代谢或维生素D代谢的活性，并且由以下（ a），（b）或（c）：（a）识别由SEQ ID NO：1表示的第180位至第194位或第237位和第251位氨基酸残基之间的氨基酸序列的抗体; （b）由保藏号为FERM BP-7838，FERM BP-7839，FERM BP-7840或FERM BP-8268的杂交瘤产生的抗体; 或者（c）一种抗体，当与包含氨基酸的多肽结合时，其与登录号为FERM BP-7838，FERM BP-7839，FERM BP-7840或FERM BP-8268的杂交瘤产生的抗体竞争序列由SEQ ID NO：1表示。

6. 发明申请

US20050048058A1 Antibody against fibroblast growth factor-23 有权
标题翻译：针对成纤维细胞生长因子-23的抗体
公开(公告)号：US20050048058A1
公开(公告)日：2005-03-03
申请号：US10500296
申请日：2003-01-06
申请人： Yuji Yamazaki , Takashi Shimada , Takeyoshi Yamashita
发明人： Yuji Yamazaki , Takashi Shimada , Takeyoshi Yamashita
IPC分类号： A61K39/00 , A61P19/08 , C07K14/50 , C07K16/22 , C12P21/08 , A61K39/395 , C07K16/30
CPC分类号： C07K14/50 , A61K39/00 , A61K2039/505 , C07K16/22
摘要： The purpose of the present invention is to provide an antibody against fibroblast growth factor 23. The antibody is obtained by immunizing an animal with a polypeptide which comprises an amino acid sequence represented by SEQ ID NO: 1, or an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 1 by deletion, substitution, or addition of 1 or several amino acids, and has fibroblast growth factor-23 activity and activity to control phosphate metabolism or vitamin D metabolism, and is shown by the following (a), (b), or (c): (a) an antibody, which recognizes an amino acid sequence between the 180th and the 194th, or the 237th and the 251st amino acid residues represented by SEQ ID NO: 1; (b) an antibody, which is produced by a hybridoma whose accession number is FERM BP-7838, FERM BP-7839, FERM BP-7840, or FERM BP-8268; or (c) an antibody, which is competitive with the antibody produced by the hybridoma whose accession number is FERM BP-7838, FERM BP-7839, FERM BP-7840, or FERM BP-8268 upon binding with the polypeptide comprising the amino acid sequence represented by SEQ ID NO: 1.
摘要翻译：本发明的目的是提供抗成纤维细胞生长因子23的抗体。该抗体是通过用包含SEQ ID NO：1所示的氨基酸序列的多肽免疫动物，或衍生自通过缺失，取代或添加1个或几个氨基酸由SEQ ID NO：1表示的氨基酸序列，并且具有成纤维细胞生长因子-23活性和控制磷酸盐代谢或维生素D代谢的活性，并且由以下（ a），（b）或（c）：（a）识别180和194之间的氨基酸序列或第237和第251位氨基酸的抗体由SEQ ID NO：1表示的酸残基; （b）由保藏号为FERM BP-7838，FERM BP-7839，FERM BP-7840或FERM BP-8268的杂交瘤产生的抗体; 或者（c）一种抗体，当与包含氨基酸的多肽结合时，其与登录号为FERM BP-7838，FERM BP-7839，FERM BP-7840或FERM BP-8268的杂交瘤产生的抗体竞争序列由SEQ ID NO：1表示。

7. 发明授权

US07981419B2 Method for treating hypophosphatemic bone diseases using FGF-23 antibody 有权
标题翻译：使用FGF-23抗体治疗低磷血症性骨病的方法
公开(公告)号：US07981419B2
公开(公告)日：2011-07-19
申请号：US12325551
申请日：2008-12-01
申请人： Takeyoshi Yamashita , Takashi Shimada , Satoru Mizutani , Seiji Fukumoto
发明人： Takeyoshi Yamashita , Takashi Shimada , Satoru Mizutani , Seiji Fukumoto
IPC分类号： A61K39/395 , C07K16/22
CPC分类号： C07K14/50 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/705
摘要： A method for treating a hypophosphatemic bone disease, such as X-linked hypophosphatemia (XLH). The method entails administering to a subject a pharmaceutical composition, which contains an antibody that binds to an FGF-23 polypeptide and a pharmaceutically acceptable carrier.
摘要翻译：用于治疗低磷血症性骨病的方法，例如X连接的低磷血症（XLH）。该方法需要向受试者施用药物组合物，其含有与FGF-23多肽和药学上可接受的载体结合的抗体。

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