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1. 发明申请

US20110212442A1 UNIVERSAL NUCLEIC ACID PROBE SET AND METHOD FOR UTILIZATION THEREOF 审中-公开
标题翻译：通用核酸探针组及其利用方法
公开(公告)号：US20110212442A1
公开(公告)日：2011-09-01
申请号：US12737567
申请日：2009-07-30
申请人： Yuji Sekiguchi , Naohiro Noda , Ryo Miyata , Kazunori Nakamura , Shinya Kurata , Satoshi Tsuneda , Hidenori Tani
发明人： Yuji Sekiguchi , Naohiro Noda , Ryo Miyata , Kazunori Nakamura , Shinya Kurata , Satoshi Tsuneda , Hidenori Tani
IPC分类号： C12Q1/68 , C07H21/00 , C07K2/00 , C07H1/00
CPC分类号： C12Q1/6876 , C12Q1/6816 , C12Q2565/107 , C12Q2527/107 , C12Q2525/101 , C12Q2563/107 , C12Q2537/125
摘要： A nucleic acid probe set includes (A) a fluorescent probe and (B) a binding probe. The fluorescent probe (A) is formed of an oligonucleotide, which includes (a) a nucleotide unit labeled with (d) a fluorescent substance. The binding probe (B) is formed of an oligonucleotide having (b1) a fluorescent probe binding region, which can hybridize to the fluorescent probe (A), and (b2) a target nucleic acid binding region, which can hybridize to a target nucleic acid sequence (C). The fluorescent substance (d) is a fluorescent substance which changes in fluorescent character upon interaction with guanine. At least one of nucleotide units which constitute the fluorescent probe (A) is an artificial nucleotide unit having a function to raise a dissociation temperature between the probe (A) and the fluorescent probe binding region (b1). The nucleic acid probe is provided with an improved fluorescence quenching efficiency.
摘要翻译：核酸探针组包含（A）荧光探针和（B）结合探针。荧光探针（A）由寡核苷酸形成，其包括（a）用（d）荧光物质标记的核苷酸单元。结合探针（B）由具有（b1）可与荧光探针（A）杂交的荧光探针结合区域的寡核苷酸形成，（b2）可与靶核酸杂交的靶核酸结合区域酸序列（C）。荧光物质（d）是与鸟嘌呤相互作用时荧光特性变化的荧光物质。构成荧光探针（A）的核苷酸单元中的至少一个是具有提高探针（A）和荧光探针结合区域（b1）之间的解离温度的功能的人造核苷酸单元。核酸探针具有改善的荧光淬灭效率。

2. 发明申请

US20070233447A1 Circuit simulation method and circuit simulation apparatus 审中-公开
标题翻译：电路仿真方法及电路仿真装置
公开(公告)号：US20070233447A1
公开(公告)日：2007-10-04
申请号：US11730012
申请日：2007-03-29
申请人： Ryo Miyata , Hironori Sakamoto
发明人： Ryo Miyata , Hironori Sakamoto
IPC分类号： G06F17/50
CPC分类号： G06F17/5036
摘要： A circuit simulation method for estimating electrical characteristics of a semiconductor device is provided. The circuit simulation method includes: (A) generating a device model parameter of a semiconductor device model used in a circuit simulation; and (B) executing the circuit simulation by using the semiconductor device model and the generated device model parameter. The (A) step includes: (a) generating a plurality of device model parameters with respect to a plurality of different temperatures; and (b) generating the device model parameter corresponding to a specified temperature by interpolating between the plurality of device model parameters.
摘要翻译：提供了一种用于估计半导体器件的电特性的电路仿真方法。电路仿真方法包括：（A）生成电路仿真中使用的半导体器件模型的器件模型参数; 和（B）使用半导体器件模型和生成的器件模型参数执行电路仿真。（A）步骤包括：（a）产生关于多个不同温度的多个装置模型参数; 以及（b）通过在所述多个设备模型参数之间进行插值来生成对应于指定温度的设备模型参数。

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