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    • 6. 发明授权
    • Optical system for measuring metabolism in a body and imaging method
    • 用于测量身体代谢的光学系统和成像方法
    • US06282438B1
    • 2001-08-28
    • US09203610
    • 1998-12-02
    • Atsushi MakiHideaki KoizumiFumio KawaguchiYuichi YamashitaYoshitoshi Ito
    • Atsushi MakiHideaki KoizumiFumio KawaguchiYuichi YamashitaYoshitoshi Ito
    • A61B600
    • A61B5/0059A61B5/0042A61B5/055A61B5/14552A61B5/14553A61B5/18A61B5/6814A61B5/7207A61B5/7228A61B6/03A61B6/507A61B2562/0219A61B2562/0233A61B2562/046
    • Light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. After completion of the measurement or during the measurement, changes in concentration values of absorbers in the living body are determined from the living body transmitting light intensity levels of the plurality of wavelengths detected at the respective detection points and a measuring point is set on a perpendicular extending through an intermediate point between the incident point and each detection point so as to image a function of the living body. In living body optical measurement system and method, the measuring time is shortened by estimating fluctuation attributable to the living body, the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time, and a local change in. hemodynamic movement can be measured by detecting light rays transmitting through the interior of the living body by the two light detectors disposed at different two sites (equidistant from the light incident point) on a subject and by separating only the local change in hemodynamic movement from an overall change in hemodynamic movement in the living body in accordance with a logarithmic difference between the two detection signals.
    • 以多个不同频率强度调制的多个波长的光线照射在生物体的表面上的多个照射位置上,并且生物体的时间变化透射与各个相对应的光强度水平 波长和各个照射位置在生物体的表面上的不同位置处被测量。 在测量完成之后或在测量期间,生物体中的吸收体的浓度值的变化是根据在各个检测点处检测到的多个波长的光强度水平来发射的,并且将测量点设定在垂直方向 延伸穿过入射点和每个检测点之间的中间点,以便对活体的功能进行成像。 在生物体光学测量系统和方法中,通过估计归因于生物体的波动来缩短测量时间,通过一次显示估计信号和测量信号可以容易地确定测量信号的变化是否存在, 并且可以通过检测设置在被摄体上不同的两个位置(等于光入射点的位置)的两个光检测器检测通过生物体的内部的光线,并且仅分离本地 根据两个检测信号之间的对数差异,从生物体的血液动力学运动的总体变化中改变血流动力学运动。