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1. 发明授权

US08668933B2 Polyion complex of double-stranded ribonucleic acid 有权
标题翻译：双链核糖核酸的Polyion复合物
公开(公告)号：US08668933B2
公开(公告)日：2014-03-11
申请号：US13259961
申请日：2010-03-31
申请人： Yuichi Hori , Kazunori Kataoka , Toshiro Fujita , Hideki Shimizu , Shinya Kaname , Satoru Matsumoto , Nobuhiro Nishiyama , Kanjiro Miyata , Makoto Oba
发明人： Yuichi Hori , Kazunori Kataoka , Toshiro Fujita , Hideki Shimizu , Shinya Kaname , Satoru Matsumoto , Nobuhiro Nishiyama , Kanjiro Miyata , Makoto Oba
IPC分类号： A61K9/14 , C07H21/02 , C12N15/11
CPC分类号： C12N15/87 , C12N15/111 , C12N2320/32 , Y10T428/2982
摘要： Provided are a delivery system that is useful in delivering a double-stranded ribonucleic acid that functions in gene silencing in glomeruli, particularly in mesangial cells and the like, to the tissue or cells, and the like. A polyion complex in the form of a non-polymeric micelle consisting of a double-stranded ribonucleic acid and a block copolymer represented by the formula (I) or (II) below, which are electrostatically bound together, wherein the polyion complex has an average particle diameter of less than 100 nm as measured by a dynamic light scattering measuring method: wherein each symbol is as defined in the specification.
摘要翻译：提供了一种递送系统，其可用于递送在肾小球，特别是肾小球系膜细胞等中的基因沉默中起作用的组织或细胞等的双链核糖核酸。由双链核糖核酸和由下式（I）或（II）表示的嵌段共聚物组成的非聚合胶束形式的聚离子络合物，其静电结合在一起，其中聚离子络合物具有平均值通过动态光散射测量方法测量的小于100nm的粒径：其中每个符号如说明书中所定义。

2. 发明申请

US20120076836A1 POLYION COMPLEX OF DOUBLE-STRANDED RIBONUCLEIC ACID 有权
标题翻译：双链抗坏血酸的多重复合物
公开(公告)号：US20120076836A1
公开(公告)日：2012-03-29
申请号：US13259961
申请日：2010-03-31
申请人： Yuichi Hori , Kazunori Kataoka , Toshiro Fujita , Hideki Shimizu , Shinya Kaname , Satoru Matsumoto , Nobuhiro Nishiyama , Kanjiro Miyata , Makoto Oba
发明人： Yuichi Hori , Kazunori Kataoka , Toshiro Fujita , Hideki Shimizu , Shinya Kaname , Satoru Matsumoto , Nobuhiro Nishiyama , Kanjiro Miyata , Makoto Oba
IPC分类号： A61K9/14 , C08L71/00 , C07H21/02 , A61K31/80 , A61P13/12 , B82Y5/00
CPC分类号： C12N15/87 , C12N15/111 , C12N2320/32 , Y10T428/2982
摘要： Provided are a delivery system that is useful in delivering a double-stranded ribonucleic acid that functions in gene silencing in glomeruli, particularly in mesangial cells and the like, to the tissue or cells, and the like. A polyion complex in the form of a non-polymeric micelle consisting of a double-stranded ribonucleic acid and a block copolymer represented by the formula (I) or (II) below, which are electrostatically bound together, wherein the polyion complex has an average particle diameter of less than 100 nm as measured by a dynamic light scattering measuring method: wherein each symbol is as defined in the specification.
摘要翻译：提供了一种递送系统，其可用于递送在肾小球，特别是肾小球系膜细胞等中的基因沉默中起作用的组织或细胞等的双链核糖核酸。由双链核糖核酸和由下式（I）或（II）表示的嵌段共聚物组成的非聚合胶束形式的聚离子络合物，其静电结合在一起，其中聚离子络合物具有平均值通过动态光散射测量方法测量的小于100nm的粒径：其中每个符号如说明书中所定义。

3. 发明授权

US08673470B2 Secondary cell 失效
标题翻译：二次电池
公开(公告)号：US08673470B2
公开(公告)日：2014-03-18
申请号：US13022038
申请日：2011-02-07
申请人： Kinya Aota , Toshiro Fujita , Kouichi Kajiwara , Masaaki Iwasa
发明人： Kinya Aota , Toshiro Fujita , Kouichi Kajiwara , Masaaki Iwasa
IPC分类号： H01M6/10
CPC分类号： H01M10/052 , H01M2/0217 , H01M2/263 , H01M10/0431 , H01M10/0587 , Y02T10/7011
摘要： A secondary cell includes: an electrode roll in which a positive foil on which a positive-electrode material is coated and a negative foil on which a negative-electrode material is coated are winded through a separator into a flat shape around a winding core; a case in which the electrode roll is housed; a cover which seals the case; a positive terminal and a negative terminal provided on the cover; a positive electrode current collector plate that is electrically connected to the positive foil of the electrode roll and the positive terminal and held by the cover; and a negative electrode current collector plate that is electrically connected to the negative foil of the electrode roll and the negative terminal and held by the cover. The positive electrode current collector plate and the negative electrode current collector plate are each connected to the winding core.
摘要翻译：二次电池包括：其上涂覆有正极材料的正极箔和其上涂覆有负极材料的负极箔的电极辊绕隔板卷绕成绕芯的扁平形状; 容纳电极辊的情况; 一个封盖的封面; 设置在盖上的正极端子和负极端子; 与电极辊的正极和正极端子电连接并由盖保持的正极集电板; 以及负极集电板，其与电极辊和负极端子的负极箔电连接并由盖保持。正极集电板和负极集电板分别与卷芯连接。

4. 发明授权

US08507118B2 Secondary battery and fabrication method thereof 有权
标题翻译：二次电池及其制造方法
公开(公告)号：US08507118B2
公开(公告)日：2013-08-13
申请号：US13211401
申请日：2011-08-17
申请人： Kinya Aota , Toshiro Fujita
发明人： Kinya Aota , Toshiro Fujita
IPC分类号： H01M4/00 , H01M6/00
CPC分类号： H01M2/0217 , B23K35/365 , H01M2/0426 , H01M2/0473 , H01M2/06 , H01M2/26 , H01M2/263 , H01M2/30 , H01M2/365 , H01M4/667 , H01M10/0431 , H01M10/0587 , Y10T29/4911
摘要： A secondary battery includes: a jelly roll that includes a positive and a negative electrode wound via a separator; a case; a lid; and electrically conductive input/output members, wherein: the electrically conductive input/output members include, at least; a positive and a negative electrode current collector plate with one end thereof connected to the positive and the negative electrode respectively; a positive and a negative electrode external conductive member with one end thereof connected to another end of the positive and the negative electrode current collector plate respectively and another end thereof extending to an outer side of the lid; the one end of the positive and the negative electrode external conductive member are respectively swage-fused to the other end of the positive and the negative electrode current collector plate; and an oxide layer is formed at a surface of each swage-fused area.
摘要翻译：二次电池包括：果冻卷，其包括经由隔膜缠绕的正极和负极; 一个案例; 盖子和导电输入/输出构件，其中：所述导电输入/输出构件至少包括：正极和负极集电板，其一端分别连接到正极和负极; 正极和负极外部导电构件，其一端分别连接到正极集电板和负极集电板的另一端，另一端延伸到盖的外侧; 正极和负极外部导电构件的一端分别与正极集电板和负极集电板的另一端模压熔接; 并且在每个熔接区域的表面上形成氧化物层。

5. 发明申请

US20110195286A1 Secondary Cell 失效
标题翻译：二次电池
公开(公告)号：US20110195286A1
公开(公告)日：2011-08-11
申请号：US13022038
申请日：2011-02-07
申请人： Kinya AOTA , Toshiro Fujita , Kouichi Kajiwara , Masaaki Iwasa
发明人： Kinya AOTA , Toshiro Fujita , Kouichi Kajiwara , Masaaki Iwasa
IPC分类号： H01M10/36
CPC分类号： H01M10/052 , H01M2/0217 , H01M2/263 , H01M10/0431 , H01M10/0587 , Y02T10/7011
摘要： A secondary cell includes: an electrode roll in which a positive foil on which a positive-electrode material is coated and a negative foil on which a negative-electrode material is coated are winded through a separator into a flat shape around a winding core; a case in which the electrode roll is housed; a cover which seals the case; a positive terminal and a negative terminal provided on the cover; a positive electrode current collector plate that is electrically connected to the positive foil of the electrode roll and the positive terminal and held by the cover; and a negative electrode current collector plate that is electrically connected to the negative foil of the electrode roll and the negative terminal and held by the cover. The positive electrode current collector plate and the negative electrode current collector plate are each connected to the winding core.
摘要翻译：二次电池包括：其上涂覆有正极材料的正极箔和其上涂覆有负极材料的负极箔的电极辊绕隔板卷绕成绕芯的扁平形状; 容纳电极辊的情况; 一个封盖的封面; 设置在盖上的正极端子和负极端子; 与电极辊的正极和正极端子电连接并由盖保持的正极集电板; 以及负极集电板，其与电极辊和负极端子的负极箔电连接并由盖保持。正极集电板和负极集电板分别与卷芯连接。

6. 发明申请

US20110152223A1 THERAPEUTIC AGENT FOR ANCA-RELATED VASCULITIS 审中-公开
标题翻译：与ANCA相关的血管瘤的治疗药物
公开(公告)号：US20110152223A1
公开(公告)日：2011-06-23
申请号：US13059789
申请日：2009-08-21
申请人： Junichi Hirahashi , Makoto Arita , Keiichi Hishikawa , Toshiro Fujita , Masanori Nakakuki
发明人： Junichi Hirahashi , Makoto Arita , Keiichi Hishikawa , Toshiro Fujita , Masanori Nakakuki
IPC分类号： A61K31/616 , A61K31/232 , A61K31/202 , A61P11/00 , A61P13/12
CPC分类号： A61K31/202 , A61K31/232 , A61K31/616 , A61K2300/00
摘要： Disclosed is an agent for preventing/treating ANCA-related vasculitis and/or preventing the recurrence of ANCA-related vasculitis. Also disclosed is a therapeutic method using the agent. Specifically disclosed is a pharmaceutical composition comprising at least one member selected from the group consisting of eicosapentaenoic acid, a pharmaceutically acceptable salt thereof and an ester thereof as an active ingredient. The pharmaceutical composition is useful for the prevention of recurrence of ANCA-related vasculitis, the treatment of chronic ANCA-related vasculitis, and the prevention and treatment of rapidly progressive glomerulonephritis (RPGN).
摘要翻译：公开了用于预防/治疗ANCA相关性血管炎和/或预防ANCA相关性血管炎复发的药剂。还公开了使用该药剂的治疗方法。具体公开了包含选自二十碳五烯酸，其药学上可接受的盐和其酯作为活性成分的组中的至少一种的药物组合物。该药物组合物可用于预防ANCA相关性血管炎复发，治疗慢性ANCA相关性血管炎以及预防和治疗快速进展性肾小球肾炎（RPGN）。

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