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1. 发明授权

US08459530B2 Automatic wire feeding method for wire bonders 有权
标题翻译：线焊机自动送丝方式
公开(公告)号：US08459530B2
公开(公告)日：2013-06-11
申请号：US12608279
申请日：2009-10-29
申请人： Yue Zhang , Keng Yew James Song , Xiao Liang Chen
发明人： Yue Zhang , Keng Yew James Song , Xiao Liang Chen
IPC分类号： B23K31/00
CPC分类号： B23K20/005 , B23K2101/42 , H01L24/45 , H01L24/78 , H01L24/85 , H01L2224/45144 , H01L2224/45147 , H01L2224/48463 , H01L2224/78301 , H01L2224/786 , H01L2224/851 , H01L2224/85205 , H01L2924/00014 , H01L2924/01005 , H01L2924/01029 , H01L2924/01033 , H01L2924/01079 , H01L2924/01082 , H01L2224/48 , H01L2924/00015 , H01L2924/00
摘要： Wire is fed to a bonding tool of a wire bonder by a pneumatic device that is operative to urge the wire to feed through an outlet of the pneumatic device towards the bonding tool. A wire clamp is located adjacent to the outlet of the pneumatic device and a wire guider with a hole is located adjacent to the wire clamp between the wire clamp and the bonding tool for threading the wire through the hole before being fed to the bonding tool.
摘要翻译：电线通过气动装置供给到引线接合器的接合工具，所述气动装置可操作以促使电线通过气动装置的出口朝向接合工具进料。线夹位于气动装置的出口附近，具有孔的导线器位于线夹与接线工具之间的线夹附近，用于在馈送到接合工具之前将线穿过孔。

2. 发明授权

US11767294B2 Conjugates of cell binding molecules with cytotoxic agents 有权
公开(公告)号：US11767294B2
公开(公告)日：2023-09-26
申请号：US16407367
申请日：2019-05-09
申请人： HANGZHOU DAC BIOTECH CO., LTD. , R. Yongxin Zhao , Yue Zhang , Yourang Ma
发明人： R. Yongxin Zhao , Yue Zhang , Yourang Ma
IPC分类号： C07D207/40 , A61K45/06 , A61K47/64 , A61K47/68
CPC分类号： C07D207/40 , A61K45/06 , A61K47/64 , A61K47/6803 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6867 , Y02A50/30
摘要： A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a Formula (I), wherein T, L, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

3. 发明授权

US10920422B2 Hollow pipe-sandwiching metal plate and applications thereof 有权
公开(公告)号：US10920422B2
公开(公告)日：2021-02-16
申请号：US15774951
申请日：2017-09-26
申请人： Yue Zhang
发明人： Yue Zhang
IPC分类号： E04C2/32 , B32B15/04 , B32B3/12 , E04C2/36 , B32B15/00 , B23K1/00 , E04C2/08 , E04C2/34 , B32B3/20 , E04B1/74
摘要： Disclosed are a hollow pipe-sandwiching metal plate and applications thereof. The hollow pipe-sandwiching metal plate comprises a first panel, a second panel, and multiple hollow pipes between the first panel and the second panel; gaps are arranged among the hollow pipes, and the hollow pipes are connected to the first panel and the second panel by brazing. The present disclosure further includes the applications of the hollow pipe-sandwiching metal plate. The hollow pipe-sandwiching metal plate has advantages, such as light weight, high strength, low stress, high temperature resistance, pressure bearing, thermal insulation and vibration isolation. The metal plate will not deform due to thermal difference, thereby providing permanent service life of the metal plate.

4. 发明申请

US20180328037A1 HOLLOW PIPE-SANDWICHING METAL PLATE AND APPLICATIONS THEREOF 审中-公开
公开(公告)号：US20180328037A1
公开(公告)日：2018-11-15
申请号：US15774951
申请日：2017-09-26
申请人： Yue ZHANG
发明人： Yue Zhang
IPC分类号： E04C2/32 , B32B15/04 , B32B3/12 , E04C2/36
CPC分类号： E04C2/32 , B32B3/12 , B32B15/00 , B32B15/043 , E04B2001/748 , E04C2/30 , E04C2/365
摘要： Disclosed are a hollow pipe-sandwiching metal plate and applications thereof. The hollow pipe-sandwiching metal plate comprises a first panel, a second panel, and multiple hollow pipes between the first panel and the second panel; gaps are arranged among the hollow pipes, and the hollow pipes are connected to the first panel and the second panel by brazing. The present disclosure further includes the applications of the hollow pipe-sandwiching metal plate. The hollow pipe-sandwiching metal plate has advantages, such as light weight, high strength, low stress, high temperature resistance, pressure bearing, thermal insulation and vibration isolation. The metal plate will not deform due to thermal difference, thereby providing permanent service life of the metal plate.

5. 发明授权

US09632098B2 Moesin fragments and uses thereof 有权
公开(公告)号：US09632098B2
公开(公告)日：2017-04-25
申请号：US13878230
申请日：2011-10-08
申请人： Xiaofeng Zeng , Yue Zhang , Zhinan Shou , Hua Mao , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
发明人： Xiaofeng Zeng , Yue Zhang , Zhinan Shou , Hua Mao , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
IPC分类号： G01N33/68 , C07K14/705 , C07K14/52 , C07K16/18 , G01N33/564 , A61K38/19
CPC分类号： G01N33/6893 , A61K38/19 , C07K14/52 , C07K14/705 , C07K16/18 , G01N33/564 , G01N33/6854 , G01N2800/52
摘要： The present application provides compositions and methods useful for detecting and monitoring autoimmune diseases in a human subject. The methods comprise providing a moesin fragment for binding to an anti-moesin autoantibody and contacting the moesin fragment with a sample obtained from the human subject. The moesin fragment comprises the entire N-terminal FERM domain of a human moesin protein. The human subject has or is suspected of having an autoimmune disease such as connective tissue disease, systemic sclerosis, Sjogren's syndrome, or systemic lupus erythematosus.

6. 发明申请

US20170023554A1 P-PHENYLENE ETHYNYLENE COMPOUNDS AS BIOACTIVE AND DETECTION AGENTS 审中-公开
标题翻译：作为生物和检测剂的对苯乙烯乙烯化合物
公开(公告)号：US20170023554A1
公开(公告)日：2017-01-26
申请号：US15125896
申请日：2015-03-13
申请人： David G. Whitten , Harry Pappas , Eric H. Hill , Yue Zhang , Eva Yung Hua Chi , Arjun Thapa , Ying wang , Patrick L. Donabedian , Kiran Bhaskar
发明人： David G. Whitten , Harry Pappas , Eric H. Hill , Yue Zhang , Eva Yung Hua Chi , Arjun Thapa , Ying wang , Patrick L. Donabedian , Kiran Bhaskar
IPC分类号： G01N33/52 , C12Q1/46 , C12Q1/44 , C12N1/20
摘要： Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.
摘要翻译：各种实施方案涉及作为生物活性和检测剂的对亚苯基亚乙炔化合物。在各种实施方案中，本发明提供诱导微生物孢子发芽的方法，包括使微生物孢子与对亚苯基亚乙炔基化合物接触。在各种实施方案中，本发明提供了检测酶的方法，蛋白质分析方法或检测化学试剂的方法，包括将对亚苯基亚乙烯基化合物引入到包含酶底物的组合物中，并分析荧光的对亚苯基亚乙炔基化合物。各种实施方案提供包括对亚苯基亚乙炔化合物和酶底物的传感器。

7. 发明授权

US09173852B2 Glycyrrhetinic acid-mediated nanoparticles of hepatic targeted drug delivery system, process for preparing the same and use thereof 有权
标题翻译：甘草次酸介导的肝靶向药物递送系统的纳米颗粒，其制备方法及其用途
公开(公告)号：US09173852B2
公开(公告)日：2015-11-03
申请号：US12338966
申请日：2008-12-18
申请人： Zhi Yuan , Wei Huang , Qin Tian , Chuangnian Zhang , Liang Han , Tong Liu , Yue Zhang , Yue Chen
发明人： Zhi Yuan , Wei Huang , Qin Tian , Chuangnian Zhang , Liang Han , Tong Liu , Yue Zhang , Yue Chen
IPC分类号： A61K9/51 , A61K47/36 , A61K47/48
CPC分类号： A61K9/5146 , A61K9/5161 , A61K9/5192 , A61K47/593 , A61K47/60 , A61K47/61 , A61K47/645 , A61K47/6935 , Y10S977/773 , Y10S977/906
摘要： Disclosed are a hepatic targeted drug delivery system and a process for preparing the same. Also disclosed is a method for treating liver cancer.
摘要翻译：公开了肝靶向药物递送系统及其制备方法。还公开了一种治疗肝癌的方法。

8. 发明申请

US20140377380A1 METHODS AND COMPOSITIONS FOR TREATING NEPHROGENIC DIABETES INSIPIDUS 有权
标题翻译：用于治疗肾上腺皮质糖尿病的方法和组合物
公开(公告)号：US20140377380A1
公开(公告)日：2014-12-25
申请号：US14241720
申请日：2012-08-29
申请人： Bellamkonda K. Kishore , Noel G. Carlson , Yue Zhang
发明人： Bellamkonda K. Kishore , Noel G. Carlson , Yue Zhang
IPC分类号： A61K31/4365 , A61K33/00
CPC分类号： A61K31/4365 , A61K31/519 , A61K31/64 , A61K31/7076 , A61K33/00 , A61K45/06 , A61K2300/00
摘要： Disclosed is a treatment of diabetes insipidus. Methods of treating diabetes insipidus disorders associated with P2Y receptors using the compounds and compositions are also disclosed.
摘要翻译：披露了治疗尿崩症。还公开了使用该化合物和组合物治疗与P2Y受体相关的尿崩症的方法。

9. 发明申请

US20130323264A1 DIAGNOSTIC AND THERAPEUTIC USES OF MOESIN FRAGMENTS 有权
标题翻译：糖蛋白片的诊断和治疗用途
公开(公告)号：US20130323264A1
公开(公告)日：2013-12-05
申请号：US13878239
申请日：2011-10-08
申请人： Yue Zhang , Jun Bao
发明人： Yue Zhang , Jun Bao
IPC分类号： A61K39/395 , A61K38/17
CPC分类号： A61K39/3955 , A61K38/1703 , A61K38/1709 , C07K16/18 , C07K2317/76 , G01N33/564 , G01N33/6854 , G01N2800/10 , G01N2800/52
摘要： The present application provides compositions and methods for modulating the activity and quantity of platelets and preventing and treating disorders or diseases associated with abnormal activity and quantity of platelets.
摘要翻译：本申请提供调节血小板的活性和量的组合物和方法，并预防和治疗与血小板的异常活性和数量相关的疾病或疾病。

10. 发明授权

US08380755B2 Electronic reader capable of recording comments and amendments and method thereof 失效
标题翻译：能够记录评论和修改的电子阅读器及其方法
公开(公告)号：US08380755B2
公开(公告)日：2013-02-19
申请号：US12862718
申请日：2010-08-24
申请人： Hai-Sheng Li , Shang-Hui Pi , Jie Guo , Yue Zhang , Chih-San Chiang
发明人： Hai-Sheng Li , Shang-Hui Pi , Jie Guo , Yue Zhang , Chih-San Chiang
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30
摘要： An electronic reader includes a storage unit configured for storing files and a processor. The processor includes a file display control module, a first file creating module and a second file creating module. The file display control module is configured for obtaining and displaying the files opened by user input. The first file creating module is configured for creating temporary files recording the comments and the amended sections of the opened files in response to user input. Each of the temporary files corresponds to one of the opened files. The second file creating module is configured for combining contents of the temporary files into a file. The contents of the temporary files are arranged in the file according to a predetermined rule if the formats of the temporary files are the same.
摘要翻译：电子阅读器包括被配置为存储文件的存储单元和处理器。处理器包括文件显示控制模块，第一文件创建模块和第二文件创建模块。文件显示控制模块被配置为获取和显示用户输入打开的文件。第一个文件创建模块被配置为创建临时文件，以响应用户输入记录注释和已打开文件的修改部分。每个临时文件对应于其中一个打开的文件。第二文件创建模块被配置为将临时文件的内容组合成文件。如果临时文件的格式相同，则临时文件的内容按照预定规则排列在文件中。

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