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1. 发明申请

US20130266537A1 MOESIN MODULATORS AND USES THEREOF 有权
公开(公告)号：US20130266537A1
公开(公告)日：2013-10-10
申请号：US13878232
申请日：2011-10-08
申请人： Yue Zhang , Jun Bao , Hua Mao , Zhinan Shou , Weina Situ
发明人： Yue Zhang , Jun Bao , Hua Mao , Zhinan Shou , Weina Situ
IPC分类号： C07K7/08 , A61K38/08 , A61K38/20 , A61K45/06 , A61K38/19 , C07K7/06 , A61K38/10
CPC分类号： A61K39/3955 , A61K38/08 , A61K38/10 , A61K38/191 , A61K38/2006 , A61K38/204 , A61K38/2086 , A61K45/06 , C07K7/06 , C07K7/08 , C07K16/18 , C07K16/28 , C07K2317/73 , C07K2317/76 , A61K2300/00
摘要： The present application provides compositions and methods useful for treating and diagnosing diseases and disorders associated with moesin activation.

2. 发明授权

US09345764B2 Moesin modulators and uses thereof 有权
标题翻译：莫辛调节剂及其用途
公开(公告)号：US09345764B2
公开(公告)日：2016-05-24
申请号：US13878232
申请日：2011-10-08
申请人： Yue Zhang , Jun Bao , Hua Mao , Zhinan Shou , Weina Situ
发明人： Yue Zhang , Jun Bao , Hua Mao , Zhinan Shou , Weina Situ
IPC分类号： C07K7/08 , A61K38/08 , A61K38/20 , A61K45/06 , A61K38/19 , A61K38/10 , C07K7/06 , A61K39/395 , C07K16/18 , C07K16/28
CPC分类号： A61K39/3955 , A61K38/08 , A61K38/10 , A61K38/191 , A61K38/2006 , A61K38/204 , A61K38/2086 , A61K45/06 , C07K7/06 , C07K7/08 , C07K16/18 , C07K16/28 , C07K2317/73 , C07K2317/76 , A61K2300/00
摘要： The present application provides compositions and methods useful for treating and diagnosing diseases and disorders associated with moesin activation.
摘要翻译：本申请提供了用于治疗和诊断与moesin活化相关的疾病和病症的组合物和方法。

3. 发明授权

US09632098B2 Moesin fragments and uses thereof 有权
公开(公告)号：US09632098B2
公开(公告)日：2017-04-25
申请号：US13878230
申请日：2011-10-08
申请人： Xiaofeng Zeng , Yue Zhang , Zhinan Shou , Hua Mao , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
发明人： Xiaofeng Zeng , Yue Zhang , Zhinan Shou , Hua Mao , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
IPC分类号： G01N33/68 , C07K14/705 , C07K14/52 , C07K16/18 , G01N33/564 , A61K38/19
CPC分类号： G01N33/6893 , A61K38/19 , C07K14/52 , C07K14/705 , C07K16/18 , G01N33/564 , G01N33/6854 , G01N2800/52
摘要： The present application provides compositions and methods useful for detecting and monitoring autoimmune diseases in a human subject. The methods comprise providing a moesin fragment for binding to an anti-moesin autoantibody and contacting the moesin fragment with a sample obtained from the human subject. The moesin fragment comprises the entire N-terminal FERM domain of a human moesin protein. The human subject has or is suspected of having an autoimmune disease such as connective tissue disease, systemic sclerosis, Sjogren's syndrome, or systemic lupus erythematosus.

4. 发明申请

US20130210678A1 MOESIN FRAGMENTS AND USES THEREOF 有权
标题翻译： MOESIN片段及其用途
公开(公告)号：US20130210678A1
公开(公告)日：2013-08-15
申请号：US13878230
申请日：2011-10-08
申请人： Xiaofeng Zeng , Yue Zhang , Zhinan Shou , Hua Mao , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
发明人： Xiaofeng Zeng , Yue Zhang , Zhinan Shou , Hua Mao , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
IPC分类号： G01N33/68 , C07K14/705
CPC分类号： G01N33/6893 , A61K38/19 , C07K14/52 , C07K14/705 , C07K16/18 , G01N33/564 , G01N33/6854 , G01N2800/52
摘要： The present invention provides compositions and methods useful for detecting and monitoring autoimmune diseases.
摘要翻译：本发明提供了用于检测和监测自身免疫疾病的组合物和方法。

5. 发明授权

US09354241B2 Moesin fragments associated with aplastic anemia 有权
标题翻译：与再生障碍性贫血相关的Moesin片段
公开(公告)号：US09354241B2
公开(公告)日：2016-05-31
申请号：US13878235
申请日：2011-10-08
申请人： Yue Zhang , Jun Bao , Hua Mao , Fei Xiang , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
发明人： Yue Zhang , Jun Bao , Hua Mao , Fei Xiang , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
IPC分类号： G01N33/68 , A61K38/19 , C07K14/52 , G01N33/564
CPC分类号： G01N33/6893 , A61K38/19 , C07K14/52 , G01N33/564 , G01N2800/22
摘要： The present application provides compositions and methods useful for detecting and monitoring acquired aplastic anemia.
摘要翻译：本申请提供了用于检测和监测获得性再生障碍性贫血的组合物和方法。

6. 发明申请

US20130203091A1 MOESIN FRAGMENTS ASSOCIATED WITH APLASTIC ANEMIA 有权
标题翻译：与APLASTIC ANEMIA相关的MOESIN片段
公开(公告)号：US20130203091A1
公开(公告)日：2013-08-08
申请号：US13878235
申请日：2011-10-08
申请人： Yue Zhang , Jun Bao , Hua Mao , Fei Xiang , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
发明人： Yue Zhang , Jun Bao , Hua Mao , Fei Xiang , Hongbin Sun , Jie Qian , Yongjun Han , Weina Situ
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , A61K38/19 , C07K14/52 , G01N33/564 , G01N2800/22
摘要： The present application provides compositions and methods useful for detecting and monitoring acquired aplastic anemia.
摘要翻译：本申请提供了用于检测和监测获得性再生障碍性贫血的组合物和方法。

7. 发明授权

US07390621B2 Methods and compositions for detecting telomerase activity 有权
标题翻译：检测端粒酶活性的方法和组合物
公开(公告)号：US07390621B2
公开(公告)日：2008-06-24
申请号：US10534978
申请日：2003-11-12
申请人： Zhunagwu Li , Jun Bao , Hua Mao , Wenbin Ma , Lina Li
发明人： Zhunagwu Li , Jun Bao , Hua Mao , Wenbin Ma , Lina Li
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q1/68 , C12Q1/6841 , C12Q1/6851 , C12Q1/686 , C12Q2561/113 , C12Q2547/107 , C12Q2521/113 , C12Q2547/101 , C12Q2545/113
摘要： A method for determining telomerase activity using primer extension followed with real time PCR quantification is disclosed. The method of the present invention provides a rapid, sensitive and accurate measurement for telomerase activity in a biological sample. In one embodiment, the method includes the steps of: adding the biological sample to a reaction tube containing a first reaction mixture having a first primer and nucleoside triphosphates, a second reaction mixture having a second primer and a DNA polymerase, and a wax layer that separates the first reaction mixture from the second reaction mixture; incubating the biological sample with the first reaction mixture; admixing the extension product with the second reaction mixture; amplifying and quantifying the extension product using real-time PCR and a control template. In another embodiment, the detection method includes an in situ primer extension step that allows the production of the extension product within an intact cell. In this embodiment, the extension product can be preserved under appropriate conditions for an extended time before the completion of the quantification step.
摘要翻译：公开了使用引物延伸测定端粒酶活性的方法，随后进行实时PCR定量。本发明的方法提供对生物样品中端粒酶活性的快速，灵敏和准确的测量。在一个实施方案中，该方法包括以下步骤：将生物样品加入到含有具有第一引物和核苷三磷酸的第一反应混合物的反应管中，具有第二引物和DNA聚合酶的第二反应混合物和蜡层，将第一反应混合物与第二反应混合物分离; 用第一反应混合物孵育生物样品; 将延伸产物与第二反应混合物混合; 使用实时PCR扩增和定量扩增产物和对照模板。在另一个实施方案中，检测方法包括原位引物延伸步骤，其允许在完整细胞内产生延伸产物。在本实施例中，扩展产品可以在适当的条件下在量化步骤完成之前延长一段时间。

8. 发明授权

US06998494B2 Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives 失效
标题翻译：反式熔融的3,3a，8,12b-四氢-2h-二苯并[3,4：6,7]环庚并[1,2-b]呋喃衍生物的制备
公开(公告)号：US06998494B2
公开(公告)日：2006-02-14
申请号：US10496279
申请日：2002-12-02
申请人： Yolande Lydia Lang , Bart Petrus Anna Maria Jozef Medaer , Georges Joseph Cornelius Hoornaert , Thierry Brossette , Frans Josef Cornelius Compernolle , Michel Joseph Maurice André Guillaume , Hua Mao , Tomasz Kozlecki
发明人： Yolande Lydia Lang , Bart Petrus Anna Maria Jozef Medaer , Georges Joseph Cornelius Hoornaert , Thierry Brossette , Frans Josef Cornelius Compernolle , Michel Joseph Maurice André Guillaume , Hua Mao , Tomasz Kozlecki
IPC分类号： C07D307/93
CPC分类号： C07D307/93
摘要： The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I) in stereochemically pure form from either of two enantiomerically pure precursors. The tetracyclic ringsystem having trans-fused five and seven membered rings is formed in an acid-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates, the methanamine end-products, the methanamine end-products for use as a medicine, in particular as CNS active medicines.
摘要翻译：本发明涉及制备式（I）的四种非对映异构体中的每一种的方法，化学式id =“CHEM-US-00001”num =“000

9. 发明申请

US20050228043A1 Preparation of trans-fused 3,3a,8,12b-tetrahydro-2H-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives 审中-公开
标题翻译：反式熔融的3,3a，8,12b-四氢-2H-二苯并[3,4：6,7]环庚并[1,2-b]呋喃衍生物的制备
公开(公告)号：US20050228043A1
公开(公告)日：2005-10-13
申请号：US11141612
申请日：2005-05-31
申请人： Yolande Lang , Bart Petrus Anna Medaer , Georges Hoornaert , Thierry Brossette , Frans Compernolle , Michel Joseph Guillaume , Hua Mao , Tomasz Kozlecki
发明人： Yolande Lang , Bart Petrus Anna Medaer , Georges Hoornaert , Thierry Brossette , Frans Compernolle , Michel Joseph Guillaume , Hua Mao , Tomasz Kozlecki
IPC分类号： A61K31/34 , A61K31/343 , A61P25/06 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D307/93
CPC分类号： C07D307/93
摘要： The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I) in stereochemically pure form from either of two enantiomerically pure precursors. The tetracyclic ringsystem having trans-fused five and seven membered rings is formed in an acid-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates, the methanamine end-products, the methanamine end-products for use as a medicine, in particular as CNS active medicines.
摘要翻译：本发明涉及从两种对映异构体纯的前体中的任何一种以立体化学纯的形式制备式（I）的4种非对映异构体中的每一种的方法。在酸催化的环化反应中形成具有反式稠合的五元和七元环的四环体系。本发明还涉及由此获得的顺式稠合四环醇中间体，甲胺终产物，用作药物的甲胺最终产物，特别是CNS活性药物。

10. 发明授权

US09296774B2 Halogenated dideoxy sugar derivates, preparation method and application thereof 有权
标题翻译：卤代二脱氧糖衍生物及其制备方法及应用
公开(公告)号：US09296774B2
公开(公告)日：2016-03-29
申请号：US13540609
申请日：2012-07-02
申请人： Hua Mao
发明人： Hua Mao
IPC分类号： A01N43/04 , A61K31/70 , A01N43/16 , A61K31/35 , C07H5/04 , C07H5/06 , C08B37/00 , C07H11/04 , C07H5/02 , C07D493/04
CPC分类号： C07H11/04 , C07D493/04 , C07H5/02
摘要： A halogenated dideoxy sugar derivative, having the following general structure I wherein X is halogen, R1 and R2 are H or Br; R3 and R4 are OH or OAc. The compounds 1-14 of the current invention has strong inhibition effect on human nasopharyngeal cancer CNE-2Z cells, human lung cancer A549 cells. human colon cancer HT-29 cells, human liver cancer Bel-7402 cells, human rectum cancer cells HCE 8693, human stomach cancer BGC-803 cells, human esophagus cancer CaEs-17 cells, human breast cancer cells MCF-7, human ovarian cancer cells A2780, pancreatic cancer cells PC-3, human bladder cells EJ, human brain glia cells TG-905, human leukemia cells K562, human melanoma M 14 cells and human anaplastic thyroid carcinoma TA-K cells. They can be used to prepare anti-tumor medicament and have significant clinic value.
摘要翻译：具有以下一般结构I的卤代双脱氧糖衍生物，其中X是卤素，R 1和R 2是H或Br; R3和R4是OH或OAc。本发明化合物1-14对人鼻咽癌CNE-2Z细胞，人肺癌A549细胞具有强烈的抑制作用。人结肠癌HT-29细胞，人肝癌Bel-7402细胞，人直肠癌细胞HCE 8693，人胃癌BGC-803细胞，人食管癌CaEs-17细胞，人乳腺癌细胞MCF-7，人卵巢癌细胞A2780，胰腺癌细胞PC-3，人膀胱细胞EJ，人脑胶质细胞TG-905，人白血病细胞K562，人黑素瘤M14细胞和人间变性甲状腺癌TA-K细胞。它们可用于制备抗肿瘤药物，具有显着的临床价值。

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