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1. 发明授权

US08217365B2 Double-faced ion source 有权
标题翻译：双面离子源
公开(公告)号：US08217365B2
公开(公告)日：2012-07-10
申请号：US12437044
申请日：2009-05-07
申请人： Zhiqiang Chen , Yuanjing Li , Hua Peng , Qingjun Zhang , Jin Lin , Shaoji Mao , Zhude Dai , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang , Shaofeng Wang , Hui Li
发明人： Zhiqiang Chen , Yuanjing Li , Hua Peng , Qingjun Zhang , Jin Lin , Shaoji Mao , Zhude Dai , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang , Shaofeng Wang , Hui Li
IPC分类号： H01J27/20 , H01J49/14
CPC分类号： H01J49/14 , H01J27/20
摘要： Disclosed is an ion source comprising a plate-shaped source body which has radioactivity on its both sides and allows positive and negative ions to penetrate through the source body. The present invention gives beneficial effects. First, the ion source structure can improve the ionization efficiency of sample molecules, and the generated sample ions have a centralized distribution within a flat space on both sides of the source body. Such distribution of ion cloud facilitates to improve the IMS sensitivity. Meanwhile, the source body of the present invention has a transmittance in itself. Thus, positive and negative ions generated on both sides of the source body can penetrate through the source body and be separated to the both sides of the source body. In this way, it is possible to improve the utilization efficiency of ions.
摘要翻译：公开了一种离子源，其包括在其两侧具有放射性并允许正离子和负离子穿过源体的板状源体。本发明具有有益效果。首先，离子源结构可以提高样品分子的电离效率，并且所产生的样品离子在源体的两侧的平坦空间内具有集中分布。这种离子云的分布有助于提高IMS灵敏度。同时，本发明的源体本身具有透光性。因此，源体两侧产生的正离子和负离子可以穿透源体并分离到源体的两侧。以这种方式，可以提高离子的利用效率。

2. 发明授权

US07851747B2 Electrode structure for drift tube in ion mobility spectrometer 有权
标题翻译：离子迁移谱仪中漂移管的电极结构
公开(公告)号：US07851747B2
公开(公告)日：2010-12-14
申请号：US12455029
申请日：2009-05-27
申请人： Zhiqiang Chen , Yuanjing Li , Hua Peng , Qingjun Zhang , Jin Lin , Shaoji Mao , Zhude Dai , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang , Shaofeng Wang , Hui Li
发明人： Zhiqiang Chen , Yuanjing Li , Hua Peng , Qingjun Zhang , Jin Lin , Shaoji Mao , Zhude Dai , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang , Shaofeng Wang , Hui Li
IPC分类号： H01J49/40
CPC分类号： G01N27/622
摘要： Disclosed is an electrode structure for a drift tube in IMS comprising a ring electrode, for each of two surfaces of the ring electrode, at least a part adjacent to the inner radius is formed into a cone, and the angles formed between the cones and the axis of the ring electrode are different from each other. The electrode structure of the present invention can alleviate, even eliminate, the accumulation of space charges in the drift tube. Such structure is particularly suitable when the electric field in the drift tube is low in strength or a great number of ions pass through. Meanwhile, the structure allows a significant decrease in the size of the outer radius of the electrode, while the inner radius remains constant. In this way, it is possible to effectively reduce the outline size of the drift tube and thus make the IMS compact.
摘要翻译：公开了一种用于IMS中的漂移管的电极结构，包括环形电极，对于环形电极的两个表面中的每一个，至少与内半径相邻的部分形成为锥体，并且在锥体和环电极的轴线彼此不同。本发明的电极结构可以减轻甚至消除漂移管中空间电荷的累积。当漂移管中的电场强度低或大量离子通过时，这种结构特别合适。同时，结构允许电极的外半径的大小显着减小，而内半径保持恒定。以这种方式，可以有效地减小漂移管的轮廓尺寸，从而使得IMS紧凑。

3. 发明授权

US08288718B2 Ion mobility spectrometer and detecting method using the same 有权
标题翻译：离子迁移光谱仪及其检测方法
公开(公告)号：US08288718B2
公开(公告)日：2012-10-16
申请号：US12997719
申请日：2010-06-28
申请人： Yuanjing Li , Zhiqiang Chen , Qingjun Zhang , Shiping Cao , Dexu Lin , Shaoji Mao , Qinghua Wang
发明人： Yuanjing Li , Zhiqiang Chen , Qingjun Zhang , Shiping Cao , Dexu Lin , Shaoji Mao , Qinghua Wang
IPC分类号： H01J49/26 , H01J49/00 , B01D59/44
CPC分类号： G01N27/622
摘要： An ion mobility spectrometer comprises an electrode and two storage electrodes disposed at the two opposite sides of the electrode respectively. Ions from an intermediate part between the two storage electrodes are stored and the stored ions are released from the storage electrodes by changing electric potentials of the two storage electrodes. The present invention further discloses a detecting method using an ion mobility spectrometer.
摘要翻译：离子迁移谱仪包括分别设置在电极的两个相对侧的电极和两个存储电极。存储来自两个存储电极之间的中间部分的离子，并且通过改变两个存储电极的电位而将存储的离子从存储电极释放。本发明还公开了使用离子迁移谱仪的检测方法。

4. 发明授权

US08013297B2 Ion gate for dual ion mobility spectrometer and method thereof 有权
标题翻译：双离子迁移谱仪的离子门及其方法
公开(公告)号：US08013297B2
公开(公告)日：2011-09-06
申请号：US12579719
申请日：2009-10-15
申请人： Hua Peng , Qingjun Zhang , Jin Lin , Yuanjing Li , Zhiqiang Chen , Shaoji Mao , Zhude Dai , Dai Hua, legal representative , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang
发明人： Hua Peng , Qingjun Zhang , Jin Lin , Yuanjing Li , Zhiqiang Chen , Shaoji Mao , Zhude Dai , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang
IPC分类号： G01N27/64 , H01J49/06
CPC分类号： H01J3/04 , H01J49/004 , H01J49/061
摘要： Disclosed is an ion gate for a dual IMS and method. The ion gate includes an ion source, a first gate electrode placed on one side of the ion source, a second gate electrode placed on the other side of the ion source, a third gate electrode placed on the side of the first gate electrode away from the ion source, a fourth gate electrode placed on the side of the second gate electrode away from the ion source, wherein during the ion storage, the potential at the position on the tube axis of the ion gate corresponding to the first gate electrode is different from the potentials at the positions on the tube axis corresponding to the ion source and the third gate electrode, and the potential at the position on the tube axis corresponding to the second gate electrode is different from the potentials at the positions on the tube axis corresponding to the ion source and the fourth gate electrode. According to the present invention, after sample gas enters the ion gates, charge exchange with reaction ions occurs between the first gate electrode and the second electrode, and positive and negative ions are continuously stored into the storage regions for the positive and negative ions. This leads to an improvement of utility rate of ions. Then, the ions are educed in a step-wise manner from the storage regions for the positive and negative ions by a simple control of a combination of the electrodes.
摘要翻译：公开了一种用于双重IMS和方法的离子门。离子浇口包括离子源，位于离子源一侧的第一栅电极，位于离子源另一侧的第二栅电极，位于第一栅电极侧的第三栅电极，离子源，第四栅极放置在远离离子源的第二栅电极侧，其中在离子存储期间，对应于第一栅电极的离子门的管轴上的位置的电位不同从对应于离子源和第三栅电极的管轴上的位置的电位和对应于第二栅电极的管轴上的位置的电位与管轴对应的位置的电位不同到离子源和第四栅电极。根据本发明，在样品气体进入离子浇口之后，在第一栅电极和第二电极之间产生与反应离子的电荷交换，正离子和负离子被连续地存储在正离子和负离子的存储区中。这导致了离子的利用率的提高。然后，通过简单地控制电极的组合，从正离子和负离子的存储区域逐步地排出离子。

5. 发明申请

US20100102219A1 ION GATE FOR DUAL ION MOBILITY SPECTROMETER AND METHOD THEREOF 有权
标题翻译：用于双离子移动光谱仪的离子通道及其方法
公开(公告)号：US20100102219A1
公开(公告)日：2010-04-29
申请号：US12579719
申请日：2009-10-15
申请人： Hua Peng , Qingjun Zhang , Jin Lin , Yuanjing Li , Zhiqiang Chen , Shaoji Mao , Zhude Dai , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang , Zhang Qing Jun
发明人： Hua Peng , Qingjun Zhang , Jin Lin , Yuanjing Li , Zhiqiang Chen , Shaoji Mao , Zhude Dai , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang , Zhang Qing Jun
IPC分类号： H01J49/02 , B01D59/44
CPC分类号： H01J3/04 , H01J49/004 , H01J49/061
摘要： Disclosed is an ion gate for a dual IMS and method. The ion gate includes an ion source, a first gate electrode placed on one side of the ion source, a second gate electrode placed on the other side of the ion source, a third gate electrode placed on the side of the first gate electrode away from the ion source, a fourth gate electrode placed on the side of the second gate electrode away from the ion source, wherein during the ion storage, the potential at the position on the tube axis of the ion gate corresponding to the first gate electrode is different from the potentials at the positions on the tube axis corresponding to the ion source and the third gate electrode, and the potential at the position on the tube axis corresponding to the second gate electrode is different from the potentials at the positions on the tube axis corresponding to the ion source and the fourth gate electrode. According to the present invention, after sample gas enters the ion gates, charge exchange with reaction ions occurs between the first gate electrode and the second electrode, and positive and negative ions are continuously stored into the storage regions for the positive and negative ions. This leads to an improvement of utility rate of ions. Then, the ions are educed in a step-wise manner from the storage regions for the positive and negative ions by a simple control of a combination of the electrodes.
摘要翻译：公开了一种用于双重IMS和方法的离子门。离子浇口包括离子源，位于离子源一侧的第一栅电极，位于离子源另一侧的第二栅电极，位于第一栅电极侧的第三栅电极，离子源，第四栅极放置在远离离子源的第二栅电极侧，其中在离子存储期间，对应于第一栅电极的离子门的管轴上的位置的电位不同从对应于离子源和第三栅电极的管轴上的位置的电位和对应于第二栅电极的管轴上的位置的电位与管轴对应的位置的电位不同到离子源和第四栅电极。根据本发明，在样品气体进入离子浇口之后，在第一栅电极和第二电极之间产生与反应离子的电荷交换，正离子和负离子被连续地存储在正离子和负离子的存储区中。这导致了离子的利用率的提高。然后，通过简单地控制电极的组合，从正离子和负离子的存储区域逐步地排出离子。

6. 发明申请

US20090309013A1 Electrode structure for drift tube in ion mobility spectrometer 有权
标题翻译：离子迁移谱仪中漂移管的电极结构
公开(公告)号：US20090309013A1
公开(公告)日：2009-12-17
申请号：US12455029
申请日：2009-05-27
申请人： Zhiqiang Chen , Yuanjing Li , Hua Peng , Qingjun Zhang , Jin Lin , Shaoji Mao , Zhude Dai , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang , Shaofeng Wang , Hui Li
发明人： Zhiqiang Chen , Yuanjing Li , Hua Peng , Qingjun Zhang , Jin Lin , Shaoji Mao , Zhude Dai , Shiping Cao , Zhongxia Zhang , Yangtian Zhang , Dexu Lin , Qinghua Wang , Shaofeng Wang , Hui Li
IPC分类号： H01J49/00
CPC分类号： G01N27/622
摘要： Disclosed is an electrode structure for a drift tube in IMS comprising a ring electrode, for each of two surfaces of the ring electrode, at least a part adjacent to the inner radius is formed into a cone, and the angles formed between the cones and the axis of the ring electrode are different from each other. The electrode structure of the present invention can alleviate, even eliminate, the accumulation of space charges in the drift tube. Such structure is particularly suitable when the electric field in the drift tube is low in strength or a great number of ions pass through. Meanwhile, the structure allows a significant decrease in the size of the outer radius of the electrode, while the inner radius remains constant. In this way, it is possible to effectively reduce the outline size of the drift tube and thus make the IMS compact.
摘要翻译：公开了一种用于IMS中的漂移管的电极结构，包括环形电极，对于环形电极的两个表面中的每一个，至少与内半径相邻的部分形成为锥体，并且在锥体和环电极的轴线彼此不同。本发明的电极结构可以减轻甚至消除漂移管中空间电荷的累积。当漂移管中的电场强度低或大量离子通过时，这种结构特别合适。同时，结构允许电极的外半径的大小显着减小，而内半径保持恒定。以这种方式，可以有效地减小漂移管的轮廓尺寸，从而使得IMS紧凑。

7. 发明申请

US20150073763A1 OIL OR GAS PRODUCTION USING COMPUTER SIMULATION OF OIL OR GAS FIELDS AND PRODUCTION FACILITIES 审中-公开
标题翻译：使用计算机模拟油气田和生产设施进行油气生产
公开(公告)号：US20150073763A1
公开(公告)日：2015-03-12
申请号：US14395738
申请日：2012-05-30
申请人： Qinghua Wang , Graham Christopher Fleming , Qin Lu
发明人： Qinghua Wang , Graham Christopher Fleming , Qin Lu
IPC分类号： E21B43/00
CPC分类号： E21B43/00 , G06Q10/04
摘要： Oil or gas fields and associated facilities are computer simulated by solving linear algebraic equations using a Schwarz method with at least one well node included in the overlap. According to another aspect, equations for the wellbore nodes are processed to eliminate some non-pressure variables, e.g. component compositions. Other features are also provided.
摘要翻译：通过使用包含在重叠中的至少一个井节点的Schwarz方法求解线性代数方程式来计算油气田和相关设施。根据另一方面，对井眼节点的等式进行处理以消除一些非压力变量，例如，组分组成。还提供其他功能。

8. 发明申请

US20140188722A1 SELF-TRANSACTION AUTOMATIC OPTIMIZATION SERVICE CONTROL SYSTEM 审中-公开
标题翻译：自动交易自动优化服务控制系统
公开(公告)号：US20140188722A1
公开(公告)日：2014-07-03
申请号：US13882991
申请日：2012-07-04
申请人： Fei Xie , Qinghua Wang , Yunpei Chen , Xingfeng Xie , Pinde Tao
发明人： Fei Xie , Qinghua Wang , Yunpei Chen , Xingfeng Xie , Pinde Tao
IPC分类号： G06Q20/32
CPC分类号： G06Q20/3223 , G06Q20/18 , G07C11/00 , G07F9/02
摘要： A self-service transaction automatic optimization service control system is provided, which includes a time-slicing service mode generating module, a service interrupting signal generating module and a self-service terminal control module. Wherein, the time-slicing service mode generating module is configured to detect the current user queue of the self-service terminal and identify whether the user queue is in a long queue state, convert the self-service terminal from a general service mode to a time-slicing service mode if the user queue is in a long queue state, otherwise maintain the self-service terminal maintain in the general service mode, wherein the time-slicing service mode provides business service of specific time or specific number of times to the user currently in operation of the self-service terminal.
摘要翻译：提供一种自助交易自动优化服务控制系统，其中包括一个时间分片服务模式生成模块，一个业务中断信号生成模块和一个自助终端控制模块。其中，时分服务模式生成模块被配置为检测自服务终端的当前用户队列，并识别用户队列是否处于长队列状态，将自助终端从一般服务模式转换为如果用户队列处于长队列状态，则维持时间片服务模式，否则维护自助终端维护在一般服务模式，其中时间分片服务模式向特定时间或特定次数提供业务服务用户目前正在运营的自助终端。

9. 发明授权

US09790266B2 Growth hormone secretagogue receptor based protein 有权
公开(公告)号：US09790266B2
公开(公告)日：2017-10-17
申请号：US14776318
申请日：2014-03-14
申请人： Qinghua Wang
发明人： Qinghua Wang , Younes Anini
IPC分类号： C07K14/72 , A61K48/00
CPC分类号： C07K14/723 , A61K48/00 , C07K14/72 , C07K2319/30 , C07K2319/32
摘要： Ghrelin is a peptide hormone that binds its receptor, growth hormone secretatgogue receptor 1a (GHS-R1 a, ghrelin receptor), to promote adiposity and obesity in mammals. Ghrelin and its receptor are targets for therapeutic intervention to treat obesity-related disease and cancer. A soluble decoy GHS-R1 a receptor is developed that binds ghrelin in the periphery, preventing ghrelin from binding GHS-R1 on cells, thereby antagonizing ghrelin to treat obesity-related pathological conditions and cancer. GHS-R1 a is a transmembrane protein comprising an N-terminal extracellular domain (Nt), seven transmembrane regions and three extracellular loops (EC1, EC2 and EC3). The Nt, EC1 and EC2 are linked together, in the absence of the transmembrane regions, and fused to a Fc from an immunoglobulin, to create the decoy GHS-R1 a fusion protein, GHSR-Fc. The GHSR-Fc inhibits adiposity and weight gain in mice on a high fat diet (HFD), while the Nt and ECs on their own have no significant effect.

10. 发明授权

US09062509B2 Forced cooling circulation system for drilling mud 有权
标题翻译：用于钻井泥浆的强制冷却循环系统
公开(公告)号：US09062509B2
公开(公告)日：2015-06-23
申请号：US13575941
申请日：2010-04-15
申请人： Youhong Sun , Jiangpeng Zhao , Wei Guo , Huiwen Xu , Qinghua Wang , Chen Chen , Guosheng Li , Rui Jia , Jianguo Zhao , Jun Xue
发明人： Youhong Sun , Jiangpeng Zhao , Wei Guo , Huiwen Xu , Qinghua Wang , Chen Chen , Guosheng Li , Rui Jia , Jianguo Zhao , Jun Xue
IPC分类号： E21B36/00 , E21B21/01 , F25D29/00 , F25D17/02
CPC分类号： E21B36/001 , E21B21/01 , F25D17/02 , F25D29/00
摘要： A forced cooling circulation system for drilling mud, which includes a refrigeration unit (1), a secondary refrigerant tank (4), a coaxial convection heat exchanger (12) for mud and a mud pond (17), is disclosed. The refrigeration unit (1) is in connection with the secondary refrigerant tank (4) and the coaxial convection heat exchanger (12) for mud via a pump (2), and the coaxial convection heat exchanger (12) for mud is in connection with the mud pond (17) via a pump (15) and pipelines. Heat exchange tubes of the coaxial convection heat exchanger (12) for mud are disposed as a double-layer structure or a multi-layer structure, and the inner heat exchange tubes (23) are mounted inside of the outer heat exchange tubes (25). The secondary refrigerant or the mud is circulated in the annular space between the inner heat exchange tubes (23) and the outer heat exchange tubes (25), and the mud or the secondary refrigerant is circulated in the inner tubes (23). The flow of the circulated mud is opposite to that of the circulated secondary refrigerant, and insulation material (24) is painted on the external wall of the outer tubes (25).
摘要翻译：公开了一种用于钻井泥浆的强制冷却循环系统，其包括制冷单元（1），二次制冷剂罐（4），用于泥浆的同轴对流热交换器（12）和泥浆池（17）。制冷单元（1）通过泵（2）与二级制冷剂罐（4）和用于泥浆的同轴对流热交换器（12）连接，用于泥浆的同轴对流热交换器（12）与泥浆池（17）通过泵（15）和管道。用于泥浆的同轴对流换热器（12）的换热管被设置为双层结构或多层结构，并且内部换热管（23）安装在外部换热管（25）的内部，。二次制冷剂或泥浆在内部热交换管23和外部热交换管25之间的环形空间中循环，泥浆或二次制冷剂在内管23中循环。循环泥浆的流动与循环的二次制冷剂的流动相反，绝缘材料（24）涂在外管（25）的外壁上。

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