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1. 发明授权

US07502106B2 SERS analyzer 失效
标题翻译： SERS分析仪
公开(公告)号：US07502106B2
公开(公告)日：2009-03-10
申请号：US11533984
申请日：2006-09-21
申请人： Yuandong Gu , James A. Cox , Barrett E. Cole
发明人： Yuandong Gu , James A. Cox , Barrett E. Cole
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658
摘要： A surface enhanced Raman scatter (SERS) analyte analyzer. The analyzer has floating surfaces for enhancement of the Raman scattered light from sample molecules. An injector may provide a spray of charged nanoparticles suspended in droplets of an evaporable solution into a chamber. When the solution quickly evaporates, droplets of nanoparticles are left without a supporting solution. These droplets or cloud of charged nanoparticles may then explode into a dispersion or aerosol. The charged nanoparticles may attract molecules of a sample for attachment to their surfaces. A laser light may impinge the attached molecules which may result in surface enhanced Raman scattered light received by a detector or a light spectrometer. Wavelength signatures may then be obtained from the spectrometer. The signatures may provide information about the molecules.
摘要翻译：表面增强拉曼散射（SERS）分析仪。分析仪具有用于增强样品分子的拉曼散射光的浮动表面。注射器可以将悬浮在可蒸发溶液的液滴中的带电荷的纳米颗粒的喷雾提供到室中。当溶液快速蒸发时，留下纳米颗粒液滴而没有支撑溶液。这些液滴或带电的纳米颗粒云可能会爆炸成分散体或气溶胶。带电的纳米颗粒可以吸引样品的分子以附着到它们的表面。激光可以撞击附着的分子，这可能导致由检测器或光谱仪接收的表面增强的拉曼散射光。然后可以从光谱仪获得波长特征。签名可以提供关于分子的信息。

2. 发明申请

US20080074662A1 SERS ANALYZER 失效
标题翻译： SERS分析仪
公开(公告)号：US20080074662A1
公开(公告)日：2008-03-27
申请号：US11533984
申请日：2006-09-21
申请人： Yuandong Gu , James A. Cox , Barrett E. Cole
发明人： Yuandong Gu , James A. Cox , Barrett E. Cole
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658
摘要： A surface enhanced Raman scatter (SERS) analyte analyzer. The analyzer has floating surfaces for enhancement of the Raman scattered light from sample molecules. An injector may provide a spray of charged nanoparticles suspended in droplets of an evaporable solution into a chamber. When the solution quickly evaporates, droplets of nanoparticles are left without a supporting solution. These droplets or cloud of charged nanoparticles may then explode into a dispersion or aerosol. The charged nanoparticles may attract molecules of a sample for attachment to their surfaces. A laser light may impinge the attached molecules which may result in surface enhanced Raman scattered light received by a detector or a light spectrometer. Wavelength signatures may then be obtained from the spectrometer. The signatures may provide information about the molecules.
摘要翻译：表面增强拉曼散射（SERS）分析仪。分析仪具有用于增强样品分子的拉曼散射光的浮动表面。注射器可以将悬浮在可蒸发溶液的液滴中的带电荷的纳米颗粒的喷雾提供到室中。当溶液快速蒸发时，留下纳米颗粒液滴而没有支撑溶液。这些液滴或带电的纳米颗粒云可能会爆炸成分散体或气溶胶。带电的纳米颗粒可以吸引样品的分子以附着到它们的表面。激光可以撞击附着的分子，这可能导致由检测器或光谱仪接收的表面增强的拉曼散射光。然后可以从光谱仪获得波长特征。签名可以提供关于分子的信息。

3. 发明授权

US07531363B2 Particle detection using fluorescence 失效
标题翻译：使用荧光的粒子检测
公开(公告)号：US07531363B2
公开(公告)日：2009-05-12
申请号：US10748398
申请日：2003-12-30
申请人： Barrett E. Cole , Yuandong Gu
发明人： Barrett E. Cole , Yuandong Gu
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , G01N15/0612 , G01N21/0332 , G01N21/6456 , G01N2021/6482
摘要： Detection systems and methods for capturing and analyzing particles within a particle sample are provided. The detection system may include, for example, a particle concentrator that can be used to collect and concentrate particles on a sample collection surface, an energy source for providing energy to induce fluorescence in the particles, and a detector for detecting at least some fluorescence induced in the particles by the energy source. The detection system may include a heater and/or cooler for controlling the temperature of the particle sample during testing.
摘要翻译：提供了用于捕获和分析颗粒样品中的颗粒的检测系统和方法。检测系统可以包括例如可用于收集和浓缩样品收集表面上的颗粒的颗粒聚集器，用于提供能量以在颗粒中诱导荧光的能量源，以及用于检测至少一些荧光诱导的检测器在颗粒中由能量来源。检测系统可以包括用于在测试期间控制颗粒样品的温度的加热器和/或冷却器。

4. 发明授权

US07612885B2 Spectroscopy method and apparatus for detecting low concentration gases 有权
标题翻译：用于检测低浓度气体的光谱法和设备
公开(公告)号：US07612885B2
公开(公告)日：2009-11-03
申请号：US11615617
申请日：2006-12-22
申请人： Barrett E. Cole , James Allen Cox , Yuandong Gu , Rodney H. Thorland
发明人： Barrett E. Cole , James Allen Cox , Yuandong Gu , Rodney H. Thorland
IPC分类号： G01N21/00
CPC分类号： G01J3/02 , G01J3/021 , G01J3/027 , G01J3/0286 , G01J3/42 , G01N21/15 , G01N21/39 , G01N2021/151 , G01N2021/391
摘要： The invention is a method and apparatus capable of detecting constituents of a gas at extremely low concentrations comprising providing a medium that is absorbent of at least a first particular gas under a first environmental condition and desorbent of the particular gas under a second environmental condition, exposing the medium to a sample gas for a first period of time under the first environmental condition, during a second period of time after the first period of time, exposing the medium to the second environmental condition to cause the medium to desorb gas into an optical cavity of a cavity ring down spectrometer and introducing electromagnetic radiation into the cavity, during a third period of time after the second period of time, ceasing introduction of the electromagnetic radiation into the cavity and detecting the decay of the electromagnetic radiation in the cavity, and analyzing the decay of the light in the cavity to obtain a spectral analysis of the sample gas.
摘要翻译：本发明是能够以非常低的浓度检测气体的成分的方法和装置，其包括在第一环境条件下提供至少第一特定气体的吸收剂的介质和在第二环境条件下特定气体的解吸附剂在第一环境条件下在第一时间段内的样品气体的介质，在第一时间段之后的第二时间段内，将介质暴露于第二环境条件，以使介质将气体解吸到光腔中的腔环下光谱仪，并在第二时间段内的第三个时间段内将电磁辐射引入空腔，停止将电磁辐射引入空腔中，并检测腔内电磁辐射的衰减，并分析在空腔中的光的衰减以获得样品气体的光谱分析。

5. 发明申请

US20080151248A1 Spectroscopy Method and Apparatus for Detecting Low Concentration Gases 有权
标题翻译：用于检测低浓度气体的光谱法和装置
公开(公告)号：US20080151248A1
公开(公告)日：2008-06-26
申请号：US11615617
申请日：2006-12-22
申请人： Barrett E. Cole , James Allen Cox , Yuandong Gu , Rodney H. Thorland
发明人： Barrett E. Cole , James Allen Cox , Yuandong Gu , Rodney H. Thorland
IPC分类号： G01N21/00
CPC分类号： G01J3/02 , G01J3/021 , G01J3/027 , G01J3/0286 , G01J3/42 , G01N21/15 , G01N21/39 , G01N2021/151 , G01N2021/391
摘要： The invention is a method and apparatus capable of detecting constituents of a gas at extremely low concentrations comprising providing a medium that is absorbent of at least a first particular gas under a first environmental condition and desorbent of the particular gas under a second environmental condition, exposing the medium to a sample gas for a first period of time under the first environmental condition, during a second period of time after the first period of time, exposing the medium to the second environmental condition to cause the medium to desorb gas into an optical cavity of a cavity ring down spectrometer and introducing electromagnetic radiation into the cavity, during a third period of time after the second period of time, ceasing introduction of the electromagnetic radiation into the cavity and detecting the decay of the electromagnetic radiation in the cavity, and analyzing the decay of the light in the cavity to obtain a spectral analysis of the sample gas.
摘要翻译：本发明是能够以非常低的浓度检测气体的成分的方法和装置，其包括在第一环境条件下提供至少第一特定气体的吸收剂的介质和在第二环境条件下特定气体的解吸附剂在第一环境条件下在第一时间段内的样品气体的介质，在第一时间段之后的第二时间段内，将介质暴露于第二环境条件，以使介质将气体解吸到光腔中的腔环下光谱仪，并在第二时间段内的第三个时间段内将电磁辐射引入空腔，停止将电磁辐射引入空腔中，并检测腔内电磁辐射的衰减，并分析在空腔中的光的衰减以获得样品气体的光谱分析。

6. 发明授权

US07369242B2 Cavity ring-down spectrometer for semiconductor processing 有权
标题翻译：用于半导体加工的腔下降光谱仪
公开(公告)号：US07369242B2
公开(公告)日：2008-05-06
申请号：US11384017
申请日：2006-03-17
申请人： Barrett E. Cole , Yuandong Gu
发明人： Barrett E. Cole , Yuandong Gu
IPC分类号： G01N21/00
CPC分类号： G01N21/39 , G01J3/42
摘要： An apparatus is provided for measuring a gas within a semiconductor thin film process. The apparatus includes an optical resonator disposed within an environment of the thin-film process, a tunable laser that excites the optical resonator at a characteristic frequency of the gas and a detector that detects an energy within the resonator.
摘要翻译：提供了一种用于测量半导体薄膜工艺中的气体的装置。该装置包括设置在薄膜处理环境中的光学谐振器，可激励激光器以特定频率的气体激发光学谐振器，以及检测谐振器内的能量的检测器。

7. 发明授权

US07955483B2 Carbon nanotube-based glucose sensor 有权
标题翻译：基于碳纳米管的葡萄糖传感器
公开(公告)号：US07955483B2
公开(公告)日：2011-06-07
申请号：US11144292
申请日：2005-06-03
申请人： Yuandong Gu , Barrett E. Cole
发明人： Yuandong Gu , Barrett E. Cole
IPC分类号： C12Q1/26 , C12Q1/54
CPC分类号： G01N33/551 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B32/168 , C01B2202/02 , G01N33/66 , G01N2610/00
摘要： The present invention provides a sensor, such as a biosensor, comprising at least one self-assembled monolayer (SAM) comprising analyte-sensitive groups, such as glucose-sensitive groups, attached to the surface of the outer wall of a carbon nanotube (CNT), such as a single-walled carbon nanotube (SWNT), by terminal groups, which bind to a thin layer of a metal or metal oxide, which has been deposited on the surface of the outer wall of the nanotube.
摘要翻译：本发明提供了一种传感器，例如生物传感器，其包括至少一个自组装单层（SAM），其包含分析物敏感基团，例如葡萄糖敏感基团，其连接到碳纳米管（CNT）的外壁表面），例如单壁碳纳米管（SWNT），其结合到已经沉积在纳米管的外壁表面上的金属或金属氧化物的薄层上。

8. 发明申请

US20090056418A1 Method and System for Groundwater Contaminant Monitoring 审中-公开
标题翻译：地下水污染物监测方法与系统
公开(公告)号：US20090056418A1
公开(公告)日：2009-03-05
申请号：US11847932
申请日：2007-08-30
申请人： Barrett E. Cole , Yuandong Gu
发明人： Barrett E. Cole , Yuandong Gu
IPC分类号： G01N21/00 , G01N1/00
CPC分类号： G01N1/10 , E02D1/06 , G01N1/4022
摘要： A method and system for groundwater contaminant monitoring is described. Groundwater is pumped to a stage above the groundwater table where at least a portion of the groundwater is vaporized. The vapor is sampled using cavity ring down spectrometer and the measured vapor concentration of a contaminant is converted to a liquid contaminant concentration.
摘要翻译：描述了地下水污染物监测的方法和系统。地下水被泵送到地下水位上方的阶段，至少部分地下水被蒸发。使用空腔环形光谱仪对蒸汽进行采样，并将所测量的污染物的蒸汽浓度转化为液体污染物浓度。

9. 发明授权

US07628907B2 Gas sensor 有权
标题翻译：气体传感器
公开(公告)号：US07628907B2
公开(公告)日：2009-12-08
申请号：US11162060
申请日：2005-08-26
申请人： Yuandong Gu , Barrett E. Cole , Robert E. Higashi
发明人： Yuandong Gu , Barrett E. Cole , Robert E. Higashi
IPC分类号： G01N27/14 , G01N25/02
CPC分类号： G01N25/4846 , G01N33/004 , Y02A50/244
摘要： A gas sensor is provided for detecting one or more gases in a gas sample. The gas sensor includes a substrate, a solid electrolyte layer including lanthanum oxide for sensing carbon dioxide, a heating element thermally coupled to the solid electrolyte layer, and a controller coupled to the heating element and the solid electrolyte layer. The controller heats the heating element so that the solid electrolyte layer reaches an operating. Methods of sensing carbon dioxide and humidity are also disclosed.
摘要翻译：气体传感器用于检测气体样品中的一种或多种气体。气体传感器包括基板，包括用于感测二氧化碳的氧化镧的固体电解质层，与固体电解质层热耦合的加热元件，以及耦合到加热元件和固体电解质层的控制器。控制器加热加热元件使得固体电解质层达到操作。还公开了检测二氧化碳和湿度的方法。

10. 发明申请

US20110199611A1 Detector for cavity ring-down spectroscopy 有权
标题翻译：腔体衰减光谱检测器
公开(公告)号：US20110199611A1
公开(公告)日：2011-08-18
申请号：US12658918
申请日：2010-02-16
申请人： Barrett E. Cole , James A. Cox , Teresa M. Marta , Rodney H. Thorland
发明人： Barrett E. Cole , James A. Cox , Teresa M. Marta , Rodney H. Thorland
IPC分类号： G01N21/31
CPC分类号： G01J3/42
摘要： A cavity ring-down spectroscope includes a ring-down cavity. A trigger detector is optically coupled within the ring-down cavity to generate a signal to indicate a desired radiation level in the ring-down cavity. A controller is coupled to the trigger detector to control light provided to the ring-down cavity. A ring-down time may then be measured.
摘要翻译：空腔衰减分光镜包括一个下降腔。触发检测器在环形腔内被光学耦合以产生一个信号，以指示在下降腔中的期望的辐射水平。控制器耦合到触发检测器以控制提供给环形腔的光。然后可以测量停机时间。

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