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1. 发明授权

US07071000B2 Method for sampling reaction products 失效
公开(公告)号：US07071000B2
公开(公告)日：2006-07-04
申请号：US10334099
申请日：2002-12-30
申请人： Youqi Wang , Peijun Cong , Tony N. Wheeler , Lynn Thomas Van Erden , H. Sam Bergh
发明人： Youqi Wang , Peijun Cong , Tony N. Wheeler , Lynn Thomas Van Erden , H. Sam Bergh
IPC分类号： G01N31/10 , G01N1/22 , G01N35/10 , H01J49/00
CPC分类号： G01N35/109 , G01N1/14 , G01N2035/00277 , Y10T436/11 , Y10T436/24 , Y10T436/2575 , Y10T436/25875
摘要： A method for sampling reaction products includes delivering a reactant through a sampling probe to contact a substance deposited on a substrate and reacting the reactant to form a reaction product. At least a portion of the reaction product is withdrawn through the sampling probe and analyzed. The sampling probe is contacted with the substrate during at least a portion of the delivering, reacting and withdrawing steps.

2. 发明授权

US06864091B1 Sampling probe 失效
标题翻译：采样探头
公开(公告)号：US06864091B1
公开(公告)日：2005-03-08
申请号：US09652489
申请日：2000-08-31
申请人： Youqi Wang , Peijun Cong , Tony N. Wheeler , Lynn Thomas Van Erden , H. Sam Bergh
发明人： Youqi Wang , Peijun Cong , Tony N. Wheeler , Lynn Thomas Van Erden , H. Sam Bergh
IPC分类号： G01N1/00 , G01N35/00 , G01N35/10 , G01N31/10 , G01N1/22 , H01J49/00
CPC分类号： G01N35/109 , G01N1/14 , G01N2035/00277 , Y10T436/11 , Y10T436/24 , Y10T436/2575 , Y10T436/25875
摘要： A sampling probe for delivering a reactant to a substance deposited on a substrate to form a reaction product and for transporting the reaction product to a product analyzer for analysis. The probe includes a tip positionable over the substance on the substrate. The probe has a recess in the tip sized and shaped for receiving at least a portion of the reaction product. The probe has a product sampling passage extending from the recess adapted for connection to the product analyzer for transporting the portion of the reaction product to the product analyzer. Further, a reactant delivery passage extends to an outlet at the recess for delivering reactant to the substance on the substrate to form the reaction product.
摘要翻译：用于将反应物递送到沉积在基底上的物质以形成反应产物并用于将反应产物输送到产物分析器进行分析的取样探针。探针包括位于衬底上的物质上的尖端。探针具有尖端中的凹部，其尺寸和形状用于容纳至少一部分反应产物。探针具有从适于连接到产品分析器的凹部延伸的产品取样通道，用于将反应产物的一部分输送到产品分析器。此外，反应物输送通道延伸到凹部处的出口，用于将反应物输送到基底上的物质以形成反应产物。

3. 发明授权

US07255474B2 Parallel infrared spectroscopy apparatus and method 失效
标题翻译：平行红外光谱仪和方法
公开(公告)号：US07255474B2
公开(公告)日：2007-08-14
申请号：US10900612
申请日：2004-07-28
申请人： Peijun Cong , Shenheng Guan , Stephen Cypes , Jason Wells , H. Sam Bergh
发明人： Peijun Cong , Shenheng Guan , Stephen Cypes , Jason Wells , H. Sam Bergh
IPC分类号： G01J3/10 , G01K11/00 , G01K13/02 , G01K25/00 , G01N31/00
CPC分类号： G01N21/253 , B01J2219/00286 , B01J2219/00306 , B01J2219/00704 , B01J2219/00745 , B01J2219/00747 , B01L3/5027 , C40B30/08 , C40B40/18 , G01N21/0303 , G01N21/05 , G01N21/3577 , G01N35/028 , G01N2021/0346 , G01N2035/00237
摘要： A library of material samples is provided in a condition suitable for imaging using infrared (IR) spectroscopy. The samples are provided to one or more detection cells, each of the cells including or containing a reflective surface. Preferably, for imaging, an energy source (e.g. a source of infrared radiation) provides energy to the detection cells to interact with the samples. Thereafter, images (e.g., spectra) related to the samples are created based upon the interaction.
摘要翻译：以适于使用红外（IR）光谱法进行成像的条件提供材料样品库。将样品提供给一个或多个检测细胞，每个细胞包括或包含反射表面。优选地，对于成像，能量源（例如，红外辐射源）向检测单元提供能量以与样品相互作用。此后，基于相互作用创建与样本相关的图像（例如，光谱）。

4. 发明授权

US06799629B1 Cooling apparatus for a multiplexed capillary electrophoresis system 失效
标题翻译：多重毛细管电泳系统的冷却装置
公开(公告)号：US06799629B1
公开(公告)日：2004-10-05
申请号：US09852159
申请日：2001-05-09
申请人： Peijun Cong , Robert D. Doolen , Tony N. Wheeler
发明人： Peijun Cong , Robert D. Doolen , Tony N. Wheeler
IPC分类号： F28F500
CPC分类号： G01N27/44782 , G01N27/44708 , G01N27/44721
摘要： Apparatus for cooling a bundle of capillary tubes to prevent overheating of the tubes during a parallel capillary electrophoresis procedure. The apparatus includes a jacket of thermally conductive solid material comprising mating jacket members movable between an open position in which the jacket members are separated to allow placement of the bundle in the jacket and a closed position in which the jacket members are mated together and the bundle is disposed inside the jacket in thermally conductive relation with the jacket. Window openings in the mating jacket members define a window to permit the passage of light through the window and the capillary tubes of the bundle at the location of the window.
摘要翻译：用于冷却一束毛细管以在平行毛细管电泳过程中防止管过热的装置。该装置包括导热固体材料夹套，其包括配合护套构件，其可在打开位置之间移动，在打开位置中，夹套构件被分离，以允许将束放置在护套中，并且封闭位置，夹套构件配合在一起，与护套以导热关系设置在护套内。配合护套构件中的窗口开口限定窗口，以允许光通过窗口的位置处的窗口和毛细管的通道。

5. 发明授权

US06572750B1 Hydrodynamic injector 失效
标题翻译：流体动力注射器
公开(公告)号：US06572750B1
公开(公告)日：2003-06-03
申请号：US09620987
申请日：2000-07-21
申请人： Peijun Cong , Robert D. Doolen , Tony N. Wheeler
发明人： Peijun Cong , Robert D. Doolen , Tony N. Wheeler
IPC分类号： G01N27447
CPC分类号： G01N27/44743
摘要： A hydrodynamic injector for substantially concurrently loading fluid samples to be analyzed into multiple capillary tubes of a capillary electrophoresis system. The injector includes an enclosure defining a pressure chamber for holding multiple receptacles, each containing a fluid sample, and apertures in the enclosure for passing capillary tubes into a position inside the pressure chamber and in fluid communication with the samples in respective receptacles. Electrodes on the enclosure extend into the pressure chamber for reception in the receptacles. The pressure chamber is pressurized with gas to substantially concurrently force the fluid samples from respective receptacles into the capillary tubes in preparation for a capillary electrophoresis operation.
摘要翻译：一种流体动力注射器，用于将要分析的流体样品基本上同时加载到毛细管电泳系统的多个毛细管中。注射器包括限定用于容纳多个容器的压力室的外壳，每个容器包含流体样品，以及在外壳中的孔，用于将毛细管通入压力室内的位置并与相应容器中的样品流体连通。外壳上的电极延伸到压力室中以在接收器中接收。用气体对压力室进行加压以基本上同时迫使来自相应容器的流体样品进入毛细管，以准备毛细管电泳操作。

6. 发明申请

US20080191147A1 High Throughput Detecting System and Method Thereof 失效
标题翻译：高通量检测系统及其方法
公开(公告)号：US20080191147A1
公开(公告)日：2008-08-14
申请号：US11914222
申请日：2006-05-11
申请人： Peijun Cong , Zhuo Wang , Youqi Wang
发明人： Peijun Cong , Zhuo Wang , Youqi Wang
IPC分类号： G01N21/00 , B01J19/00
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/0838 , B01L2300/1805 , B01L2300/1883 , B01L2400/0433 , B01L2400/0457 , B01L2400/0487 , B01L2400/049 , G01N33/442
摘要： The present invention discloses a high throughput screening method and system, which can be used to screen a plurality of fluid samples to ascertain their corresponding information. For example, a polymer solution sample is screened to ascertain information about its micro structure character such as including its crystallinity property. The high throughput screen system comprises a plurality of sampling passages and one or more screening devices for screening multiple samples simultaneously or almost simultaneously to get their corresponding information so as to meet research requirement of the relevant field.
摘要翻译：本发明公开了一种高通量筛选方法和系统，其可用于筛选多个流体样品以确定其相应的信息。例如，筛选聚合物溶液样品以确定关于其微结构特征的信息，例如包括其结晶性质。高通量屏幕系统包括多个采样通道和一个或多个筛选装置，用于同时或几乎同时筛选多个样品以获得相应的信息，以满足相关领域的研究要求。

7. 发明申请

US20080159064A1 Apparatus For Processing Materials And Its Application 审中-公开
标题翻译：加工材料及其应用装置
公开(公告)号：US20080159064A1
公开(公告)日：2008-07-03
申请号：US11793193
申请日：2005-12-13
申请人： Youqi Wang , Peijun Cong , Guilin Wang , Wenhui Wang , Lichen Diao , Youshu Kang , Yubin Zhong , Bohejin Tang , Fuxin Huang
发明人： Youqi Wang , Peijun Cong , Guilin Wang , Wenhui Wang , Lichen Diao , Youshu Kang , Yubin Zhong , Bohejin Tang , Fuxin Huang
IPC分类号： B01F15/02 , B01F15/06
CPC分类号： B01F7/008 , B01F3/0807 , B01F7/00816 , B29B7/407
摘要： The present invention discloses an apparatus for processing materials, which is used to process the materials introduced thereinto, comprising a working part and a driving part, wherein the working part comprises, in cylindrical form, a first element and a second element arranged within the first element, and a containing chamber for storing materials to be processed being formed by the gap between the first element and the second element, and the second element is driven by the driving part to rotate relatively to the first element, and on the surface of the second element toward the containing chamber, provided is a disturbing part capable of producing axial forces in a direction parallel to the axis of the first element. Thanks to the disturbing part of the second element, the apparatus of the present invention can process materials thoroughly, control retention time of materials within the containing chamber, prevent materials from entering into the mixing blind area and thus make all materials processed thoroughly.
摘要翻译：本发明公开了一种用于处理材料的装置，其用于处理引入其中的材料，包括工作部分和驱动部分，其中工作部件包括圆柱形形式的第一元件和布置在第一元件和用于存储待处理材料的容纳室由第一元件和第二元件之间的间隙形成，并且第二元件由驱动部分驱动以相对于第一元件旋转，并且在第二元件的表面上第二元件朝向容纳室设置有能够在平行于第一元件的轴线的方向上产生轴向力的扰动部。由于第二元件的干扰部分，本发明的装置可以充分地处理材料，控制容纳室内材料的保留时间，防止材料进入混合遮光区域，从而使所有材料被彻底处理。

8. 发明授权

US07728309B2 High throughput screen method and system 失效
标题翻译：高吞吐量的屏幕方法和系统
公开(公告)号：US07728309B2
公开(公告)日：2010-06-01
申请号：US11914222
申请日：2006-05-11
申请人： Peijun Cong , Zhuo Wang , Youqi Wang
发明人： Peijun Cong , Zhuo Wang , Youqi Wang
IPC分类号： B01D39/00 , B01D59/38 , B07B1/46 , B65B3/04
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/0838 , B01L2300/1805 , B01L2300/1883 , B01L2400/0433 , B01L2400/0457 , B01L2400/0487 , B01L2400/049 , G01N33/442
摘要： The present invention discloses a high throughput screening method and system, which can be used to screen a plurality of fluid samples to ascertain their corresponding information. For example, a polymer solution sample is screened to ascertain information about its micro structure character such as including its crystallinity property. The high throughput screen system comprises a plurality of sampling passages and one or more screening devices for screening multiple samples simultaneously or almost simultaneously to get their corresponding information so as to meet research requirement of the relevant field.
摘要翻译：本发明公开了一种高通量筛选方法和系统，其可用于筛选多个流体样品以确定其相应的信息。例如，筛选聚合物溶液样品以确定关于其微结构特征的信息，例如包括其结晶性质。高通量屏幕系统包括多个采样通道和一个或多个筛选装置，用于同时或几乎同时筛选多个样品以获得相应的信息，以满足相关领域的研究要求。

9. 发明申请

US20100080733A1 NEEDLE ASSEMBLY FOR ASPIRATING AND DISPENSING FROM SEALED CONTAINERS 审中-公开
标题翻译：用于吸收和分配密封容器的针头组件
公开(公告)号：US20100080733A1
公开(公告)日：2010-04-01
申请号：US12489159
申请日：2009-06-22
申请人： Eric D. Carlson , Peijun Cong , William H. Chandler, JR. , Peter J. Desrosiers , J. Christopher Freitag , John F. Varni
发明人： Eric D. Carlson , Peijun Cong , William H. Chandler, JR. , Peter J. Desrosiers , J. Christopher Freitag , John F. Varni
IPC分类号： G01N1/02 , B01L3/02
CPC分类号： B01L3/50255 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00315 , B01J2219/00335 , B01J2219/00364 , B01J2219/00373 , B01J2219/00423 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/00725 , B01J2219/00756 , B01L3/06 , B01L7/00 , B01L2300/0829 , B01L2300/185 , C40B40/04 , C40B40/10 , C40B60/10 , C40B60/14 , G01N5/045 , G01N21/23 , G01N21/65 , G01N25/04 , G01N33/15 , G01N33/54366 , G01N35/028 , G01N2013/006 , G01N2021/651 , G01N2500/00 , G16C20/20 , G16C20/90 , Y10T117/10
摘要： A needle assembly has at least one guide member supported by a first body for sliding movement between an extended position and a retracted position. A second body is attached to the guide member. A biasing member biases the guide member to the extended position. A liquid handling needle is coupled to the first body so sliding movement of the guide member toward the retracted position retracts the second body relative to the liquid handling needle. The second body is adapted to contact a sealed receptacle. The biasing member urges the guide member toward said extended position during insertion and during said removal of the needle from the receptacle whereby the second body remains in contact with the sealed receptacle as the guide member moves from its extended position to its retracted position during said insertion and from its retracted position to its extended position during said removal.
摘要翻译：针组件具有由第一主体支撑的至少一个引导构件，用于在延伸位置和缩回位置之间滑动。第二主体附接到引导构件。偏置构件将引导构件偏压到延伸位置。液体处理针联接到第一主体，使得引导构件朝向缩回位置的滑动运动使第二主体相对于液体处理针退回。第二主体适于接触密封的容器。偏置构件在插入期间以及在从插座中取出针时将引导构件推向所述延伸位置，由此当引导构件在插入期间从其延伸位置移动到其缩回位置时，第二主体与密封容器保持接触并且在所述移除期间从其缩回位置到其延伸位置。

10. 发明申请

US20050211622A1 Apparatuses and methods for creating and testing pre-formulations and systems for same 有权
公开(公告)号：US20050211622A1
公开(公告)日：2005-09-29
申请号：US11131277
申请日：2005-05-16
申请人： Eric Carlson , Peijun Cong , William Chandler , Peter Desrosiers , J. Freitag , John Varni
发明人： Eric Carlson , Peijun Cong , William Chandler , Peter Desrosiers , J. Freitag , John Varni
IPC分类号： G01N21/64 , B01J19/00 , B01L3/00 , B01L3/06 , B01L7/00 , C07B61/00 , C07D209/20 , C07D293/00 , C40B40/10 , C40B60/08 , C40B60/14 , G01N5/04 , G01N13/00 , G01N21/23 , G01N21/27 , G01N21/33 , G01N21/35 , G01N21/47 , G01N21/65 , G01N21/78 , G01N24/08 , G01N25/04 , G01N30/88 , G01N33/15 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/543 , G01N35/02 , G01N37/00 , B01D29/88
CPC分类号： B01L3/50255 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00315 , B01J2219/00335 , B01J2219/00364 , B01J2219/00373 , B01J2219/00423 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/00725 , B01J2219/00756 , B01L3/06 , B01L7/00 , B01L2300/0829 , B01L2300/185 , C40B40/04 , C40B40/10 , C40B60/10 , C40B60/14 , G01N5/045 , G01N21/23 , G01N21/65 , G01N25/04 , G01N33/15 , G01N33/54366 , G01N35/028 , G01N2013/006 , G01N2021/651 , G01N2500/00 , G06F19/703 , G06F19/709 , Y10T117/10
摘要： The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.

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