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1. 发明授权

US08048912B2 Benzopyran derivatives having inhibitory activities against liver fibrosis and cirrhosis and their pharmaceutical uses 有权
标题翻译：具有对肝纤维化和肝硬化的抑制活性的苯并吡喃衍生物及其药物用途
公开(公告)号：US08048912B2
公开(公告)日：2011-11-01
申请号：US11794564
申请日：2005-06-15
申请人： Young-Dae Gong , Jin-Soo Seo , Moon-Kook Jeon , Wie-Jong Kwak , Yong-Baik Cho , Nam Kyu Lee , Eun Ju Lee , Jung Bum Lee , Jun Won Lee , Sukho Lee , Mi-Sook Dong , Jeong-Ran Kim
发明人： Young-Dae Gong , Jin-Soo Seo , Moon-Kook Jeon , Wie-Jong Kwak , Yong-Baik Cho , Nam Kyu Lee , Eun Ju Lee , Jung Bum Lee , Jun Won Lee , Sukho Lee , Mi-Sook Dong , Jeong-Ran Kim
IPC分类号： A61K31/352 , C07D311/60 , C07D311/70
CPC分类号： C07D311/70
摘要： The present invention relates to a novel benzopyran derivative having goodantagonistic activity on TGF-β receptor which can be effectively used as a prophylactic and therapeutic agent for liver disease as well as several fibroplasiadiseases such as hepatic fibrosis, liver cirrhosis, pulmonary fibrosis, dermatosclerosis, glomerular fibrosis and the like; and a pharmaceutical use thereof.
摘要翻译：本发明涉及一种对TGF-βb具有优异活性的新型苯并吡喃衍生物。受体，其可以有效地用作肝脏疾病的预防和治疗剂以及若干纤维平滑酶如肝纤维化，肝硬化，肺纤维化，皮肤硬化，肾小球纤维化等; 及其药物用途。

2. 发明申请

US20090118302A1 Novel Benzopyran Derivatives Having Inhibitory Activities Against Liver Fibrosis and Cirrhosis and Their Pharmaceutical Uses 有权
标题翻译：具有抑制肝纤维化和肝硬化及其药物用途的新型苯并吡喃衍生物
公开(公告)号：US20090118302A1
公开(公告)日：2009-05-07
申请号：US11794564
申请日：2005-06-15
申请人： Young-Dae Gong , Jin-Soo Seo , Moon-Kook Jeon , Wei-Jong Kwak , Yong-Baik Cho , Nam Kyu Lee , Eun Ju Lee , Jung Bum Lee , Jun Won Lee , Sukho Lee , Mi-Sook Dong , Jeong-Ran Kim
发明人： Young-Dae Gong , Jin-Soo Seo , Moon-Kook Jeon , Wei-Jong Kwak , Yong-Baik Cho , Nam Kyu Lee , Eun Ju Lee , Jung Bum Lee , Jun Won Lee , Sukho Lee , Mi-Sook Dong , Jeong-Ran Kim
IPC分类号： A61K31/496 , C07D311/58 , A61K31/352 , A61P1/16 , A61P17/00 , A61P9/00 , A61P11/00 , A61K31/453 , C07D405/12
CPC分类号： C07D311/70
摘要： The present invention relates to a novel benzopyran derivative having goodantagonistic activity on TGF-β receptor which can be effectively used as a prophylactic and therapeutic agent for liver disease as well as several fibroplasiadiseases such as hepatic fibrosis, liver cirrhosis, pulmonary fibrosis, dermatosclerosis, glomerular fibrosis and the like; and a pharmaceutical use thereof.
摘要翻译：本发明涉及一种对TGF-β受体具有良好的拮抗作用的新型苯并吡喃衍生物，可有效地用作肝脏疾病的预防和治疗剂，以及若干纤维样天然酶，如肝纤维化，肝硬化，肺纤维化，皮肤硬化，肾小球纤维化等; 及其药物用途。

3. 发明申请

US20080207614A1 QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY 审中-公开
标题翻译：用于治疗和预防糖尿病和肥胖的喹诺酮衍生物
公开(公告)号：US20080207614A1
公开(公告)日：2008-08-28
申请号：US11772098
申请日：2007-06-29
申请人： Nam Kyu Lee , Jun Won Lee , Sukho Lee , Guang-Jin Im , Hye Young Han , Tae Kon Kim , Yong Hyuk Kim , Wie-Jong Kwak , Sang Woong Kim , Joohun Ha , Eon Kyum Kim , Jung Kyu Lee , Choong Yeul Yoo , Dae Yeon Lee
发明人： Nam Kyu Lee , Jun Won Lee , Sukho Lee , Guang-Jin Im , Hye Young Han , Tae Kon Kim , Yong Hyuk Kim , Wie-Jong Kwak , Sang Woong Kim , Joohun Ha , Eon Kyum Kim , Jung Kyu Lee , Choong Yeul Yoo , Dae Yeon Lee
IPC分类号： A61K31/517 , A61P3/10 , C07D239/72 , C07D413/02 , C07D401/02 , C07D239/86 , A61P3/04
CPC分类号： C07D239/91 , C07D239/93 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to novel quinazoline derivatives effective in lowering blood glucose level and body weight, and a medicine for treatment and/or prevention of diabetes and/or obesity, which comprises the compound as an active ingredient.
摘要翻译：本发明涉及有效降低血糖水平和体重的新型喹唑啉衍生物，以及用于治疗和/或预防糖尿病和/或肥胖症的药物，其包含该化合物作为活性成分。

4. 发明授权

US07601736B2 Pyridine derivatives, a process for their preparation and a pharmaceutical composition containing the same 有权
标题翻译：吡啶衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US07601736B2
公开(公告)日：2009-10-13
申请号：US10585029
申请日：2004-12-30
申请人： Hyung Ook Kim , Nam Kyu Lee , Joo Hyon Kim , Hae In Rhee , Yong-Baik Cho , Je Ho Ryu , Nam Ho Kim , Keun Ho Ryu , Jung Bum Yi , Jae Yoon Jung
发明人： Hyung Ook Kim , Nam Kyu Lee , Joo Hyon Kim , Hae In Rhee , Yong-Baik Cho , Je Ho Ryu , Nam Ho Kim , Keun Ho Ryu , Jung Bum Yi , Jae Yoon Jung
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02
CPC分类号： C07D471/04 , C07D491/052
摘要： The invention relates to novel pyridine derivatives having an inhibitory effect on production of cytokines, which are involved in inflammatory responses, thus suggesting its usefulness as therapeutic agents for treating diseases related to inflammation, immune, chronic inflammation as well as an agent having an anti-inflammatory and analgesic effect. Further, this invention relates to a method of manufacturing the same and a pharmaceutical composition containing the same.
摘要翻译：本发明涉及具有抑制细胞因子产生抑制作用的新型吡啶衍生物，其涉及炎性反应，因此表明其用作治疗与炎症，免疫，慢性炎症有关的疾病的治疗剂以及具有抗炎作用的药物，炎症和镇痛作用。此外，本发明涉及其制造方法和含有该组合物的药物组合物。

5. 发明授权

US08144111B2 Light emitting diode driving circuit having voltage detection 有权
标题翻译：具有电压检测的发光二极管驱动电路
公开(公告)号：US08144111B2
公开(公告)日：2012-03-27
申请号：US12251176
申请日：2008-10-14
申请人： Jin Hwan Kim , Nam Kyu Lee , Doo Ho Yoo , Young Jong Yoo
发明人： Jin Hwan Kim , Nam Kyu Lee , Doo Ho Yoo , Young Jong Yoo
IPC分类号： G09G3/36
CPC分类号： H05B33/0815 , G09G3/342 , G09G2320/064 , G09G2330/04 , H05B33/0827 , Y02B20/347
摘要： There is provided a driving circuit of a light emitting device. The driving circuit of a light emitting may include: a DC/DC converter converting an input DC voltage into an output DC voltage; a light emitting device block including a plurality of LED groups connected to an output terminal of the DC/DC converter; a current source circuit unit including a plurality of current sources; a voltage detection unit detecting the output DC voltage of the DC/DC converter; a minimum voltage detection unit detecting a minimum voltage among a plurality of voltages between the plurality of LED groups and the plurality of current sources, respectively; and a single comparator including a first non-inverting input terminal receiving the voltage detected by the voltage detection unit, a second non-inverting input terminal receiving the minimum voltage detected by the minimum voltage detection unit, and an inverting input terminal receiving a predetermined reference voltage.
摘要翻译：提供了一种发光装置的驱动电路。发光的驱动电路可以包括：将输入DC电压转换为输出DC电压的DC / DC转换器; 发光器件块，包括连接到DC / DC转换器的输出端子的多个LED组; 包括多个电流源的电流源电路单元; 电压检测单元，检测DC / DC转换器的输出直流电压; 最小电压检测单元，分别检测所述多个LED组和所述多个电流源之间的多个电压中的最小电压; 以及单个比较器，包括接收由电压检测单元检测到的电压的第一非反相输入端子，接收由最小电压检测单元检测到的最小电压的第二非反相输入端子和接收预定参考值的反相输入端子电压。

6. 发明授权

US07772400B2 Optical resolution method of amlodipine 失效
标题翻译：氨氯地平的光学拆分方法
公开(公告)号：US07772400B2
公开(公告)日：2010-08-10
申请号：US11792281
申请日：2005-12-02
申请人： Jae-Sun Kim , Jin Young Choi , Nam Ho Kim , Nam Kyu Lee
发明人： Jae-Sun Kim , Jin Young Choi , Nam Ho Kim , Nam Kyu Lee
IPC分类号： C07D213/803
CPC分类号： C07D211/90
摘要： The present invention relates to a method for optical resolution of amlodipines by using isopropanol solvent and optically active O,O′-dibenzoyl tartaric acid as chiral reagent. More particularly, the present invention relates to a method comprising (a) obtaining (R)- or (S)-amlodipine dibenzoyl tartrate salt or solvate thereof by reacting (R,S)-amlodipines with optically active O,O′-dibenzoyl tartaric acid in isopropanol solvent, and (b) treating the (R)- or (S)-amlodipine salt with a base, thus obtaining optically active amlodipine.
摘要翻译：本发明涉及通过使用异丙醇溶剂和光学活性的O，O-二苯甲酰基酒石酸作为手性试剂来旋光拆分氨氯地平的方法。更具体地说，本发明涉及一种方法，其包括（a）通过使（R，S） - 氨氯地平与光学活性的O，O-二苯甲酰基酒石酸盐反应获得（R） - 或（S） - 氨氯地平二苯甲酰酒石酸盐或其溶剂合物异丙醇溶剂中的酸，和（b）用碱处理（R） - 或（S） - 氨氯地平盐，从而得到光学活性的氨氯地平。

7. 发明申请

US20080306277A1 Process for Preparation of Chiral Amlodipine Gentisate 审中-公开
标题翻译：手性氨氯地平龙胆酸的制备方法
公开(公告)号：US20080306277A1
公开(公告)日：2008-12-11
申请号：US12090264
申请日：2006-10-17
申请人： Jae-Sun Kim , Nam Ho Kim , Nam Kyu Lee
发明人： Jae-Sun Kim , Nam Ho Kim , Nam Kyu Lee
IPC分类号： C07D211/90
CPC分类号： C07D211/90
摘要： The present invention relates to a process for the preparation of optically pure amlodipine gentisate, more particularly to a continuous process for the preparation of optically pure amlodipine gentisate with good yield and high optical purity. The processes can be preformed by first reacting racemic (R,S)-amlodipine and optically pure O,O′-dibenzoyltartaric acid in the presence of a solvent including isopropanol to prepare (R)- or (S)-amlodipine dibenzoyltartarate diastereomer or a solvate thereof, treating the prepared amlodipine diastereomeric salt or a solvate thereof with a base and then finally adding gentisic acid.
摘要翻译：本发明涉及一种制备光学纯氨氯地平龙胆酸盐的方法，更具体地说，涉及一种以高产率和高光学纯度制备光学纯氨氯地平龙胆酸盐的连续方法。该方法可以通过在包含异丙醇的溶剂的存在下首先使外消旋（R，S） - 氨氯地平和光学纯的O，O-二苯甲酰基酒石酸反应来制备（R） - 或（S） - 氨氯地平二苯甲酰三酸盐非对映异构体或溶剂合物，用碱处理制备的氨氯地平非对映体盐或其溶剂合物，然后最后加入龙胆酸。

8. 发明授权

US06981644B2 Apparatus and method for recognizing code 有权
标题翻译：用于识别代码的装置和方法
公开(公告)号：US06981644B2
公开(公告)日：2006-01-03
申请号：US10492305
申请日：2002-05-13
申请人： Cheol Ho Cheong , Nam Kyu Lee , Tack Don Han
发明人： Cheol Ho Cheong , Nam Kyu Lee , Tack Don Han
IPC分类号： G06K7/10
CPC分类号： G06T1/0021
摘要： An apparatus and method for recognizing a code from a code image that is expressed physically or electronically and extracting data represented in the code image is provided. The method includes the steps of receiving a raw image in which a code image is contained, detecting a background image included in the raw image, extracting a code image region in which a background image is excluded, recognizing the shape and type of the code image and the color or shade represented in each of cells, converting the color or shade recognized from each of the cells into a corresponding character, number, or symbol and generating code data. The code image in which predetermined data are represented as colors or shades are received, and original colors or shades can be precisely discriminated regardless of an environment in which the code image is recognized.
摘要翻译：提供一种用于从物理或电子表示的代码图像中识别代码并提取代码图像中表示的数据的装置和方法。该方法包括以下步骤：接收包含代码图像的原始图像，检测原始图像中包括的背景图像，提取其中排除背景图像的代码图像区域，识别代码图像的形状和类型以及在每个单元格中表示的颜色或阴影，将从每个单元识别的颜色或阴影转换为相应的字符，数字或符号并生成代码数据。接收预定数据被表示为颜色或阴影的代码图像，并且无论识别代码图像的环境如何，都可以精确地识别原始颜色或阴影。

9. 发明授权

US06693609B2 Method of generating optimal pattern of light emission and method of measuring contour noise and method of selecting gray scale for plasma display panel 失效
标题翻译：产生最佳发光模式的方法和轮廓噪声测量方法等离子显示面板灰度选择方法
公开(公告)号：US06693609B2
公开(公告)日：2004-02-17
申请号：US10001926
申请日：2001-12-05
申请人： Nam Kyu Lee , Bon Cheol Koo , Ki Sang Hong , Jae Woo Kim , Yong Duek Kim , Seong Ho Kang
发明人： Nam Kyu Lee , Bon Cheol Koo , Ki Sang Hong , Jae Woo Kim , Yong Duek Kim , Seong Ho Kang
IPC分类号： G09G328
CPC分类号： G09G3/2059 , G09G3/2029 , G09G3/288 , G09G2320/0261 , G09G2320/0266
摘要： An optimal light-emission pattern generation method for a plasma display panel according to an embodiment of the present invention includes steps of determining a plurality of light-emission patterns with respect to an arbitrary gray level; calculating a contour noise degree between a contour noise free gray level being set in advance and the light-emission patterns given to each gray level in plurality; and selecting a light-emission pattern whose contour noise degree is minimal as a light-emission pattern with respect to an arbitrary gray level.
摘要翻译：根据本发明的实施例的用于等离子体显示面板的最佳发光图案生成方法包括以下步骤：相对于任意灰度级确定多个发光图案; 计算预先设定的轮廓无噪声灰度级与给出多个灰度级的发光图案之间的轮廓噪声度; 并且选择其轮廓噪声程度最小的发光图案作为相对于任意灰度级的发光图案。

10. 发明申请

US20100099773A1 INCLUSION COMPLEX OF SIBUTRAMINE AND BETA-CYCLODEXTRIN 审中-公开
标题翻译：包含SIBUTRAMINE和BETA-CYCLODEXTRIN的复合物
公开(公告)号：US20100099773A1
公开(公告)日：2010-04-22
申请号：US12444080
申请日：2007-11-22
申请人： Jae-Sun Kim , Nam Ho Kim , Jin Young Lee , Nam Kyu Lee , Joon Gyo Oh , Yong Youn Hwang , Dong-Chul Shin , Yoon-Jung Lee , Key An Um , Sun Ho Kim , Jin-Heung Sung
发明人： Jae-Sun Kim , Nam Ho Kim , Jin Young Lee , Nam Kyu Lee , Joon Gyo Oh , Yong Youn Hwang , Dong-Chul Shin , Yoon-Jung Lee , Key An Um , Sun Ho Kim , Jin-Heung Sung
IPC分类号： A61K31/135 , A61P25/00
CPC分类号： A61K31/135 , A61K47/6951 , B82Y5/00 , C08B37/0015
摘要： The present invention relates to a sibutramine-containing inclusion complex having superior storage stability, and particularly to a pharmaceutically stable inclusion complex suitable for the drug formulation, which prepared by reacting a sibutramine (N,N-dimethyl-1-[1-(4-chlorophenyl)-cyclobutyl]-3-methylbutylamine) of Formula 1 and beta-cyclodextrin in a predetermined ratio, its preparation method and a pharmaceutical composition comprising the same.
摘要翻译：本发明涉及具有优异储存稳定性的西布曲明含量复合物，特别涉及适用于药物制剂的药学上稳定的包合络合物，其通过使西布曲明（N，N-二甲基-1- [1-（4 - 氯苯基） - 环丁基] -3-甲基丁胺）和β-环糊精，其制备方法和包含其的药物组合物。

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