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    • 7. 发明授权
    • N, N-dimethyl imidodicarbonimidic diamide acetate, method for producing the same and pharmaceutical compositions comprising the same
    • N,N-二甲基亚氨基二甲酰亚胺二酰胺乙酸盐,其制备方法和包含其的药物组合物
    • US08058312B2
    • 2011-11-15
    • US12524695
    • 2008-01-29
    • Sung Wuk KimSung Soo JunYoung Gwan JoJa Seong KooYoung Woong Kim
    • Sung Wuk KimSung Soo JunYoung Gwan JoJa Seong KooYoung Woong Kim
    • A01N37/52A61K31/155C07C277/00C07C279/00
    • A61K31/155C07C279/26
    • The present invention relates to N,N-dimethyl imidodicarbonimidic diamide acetate, a method of preparing the same and a pharmaceutical composition comprising the same, and more particularly, to N,N-dimethyl imidodicarbonimidic diamide acetate which is a crystalline acid addition salt prepared by reacting N,N-dimethyl imidodicarbonimidic diamide with acetic acid, and which is very effective as a therapeutic agent for treating metabolic syndromes that glycosuria and diabetes mellitus, obesity, hyperlipidemia, fatty liver, coronary heart disease, osteoporosis, polycystic ovarian syndrome, a cancer depleted of gene P53, etc. are complexly occurred; treating diabetes mellitus and preventing its complication; and treating a cancer and preventing myalgia, muscle cell cytotoxicity and rhabdomyolysis, etc. since the acid addition salt is excellent in physicochemical properties such as solubility, stability, non-hygroscopicity, anti-adhering property, etc., and low toxicity, a method of preparing the same and a pharmaceutical composition comprising the same.
    • 本发明涉及N,N-二甲基亚氨基二甲酰亚胺二酰胺乙酸盐,其制备方法和包含其的药物组合物,更具体地涉及作为结晶酸加成盐的N,N-二甲基亚氨基二甲酰亚胺二酰胺乙酸盐,其是由 使N,N-二甲基亚氨基二亚甲基二酰胺与乙酸反应,作为治疗代谢综合征的糖尿病,糖尿病,肥胖症,高脂血症,脂肪肝,冠心病,骨质疏松症,多囊卵巢综合症,癌症, 贫血基因P53等复杂发生; 治疗糖尿病并预防其并发症; 并且由于酸加成盐在溶解性,稳定性,非吸湿性,抗附着性等等的物理化学性质和低毒性方面都是优异的,因此治疗癌症并防止肌肉痛,肌肉细胞毒性和横纹肌溶解等。 的制备方法和包含其的药物组合物。
    • 8. 发明申请
    • N, N -DIMETHYL IMIDODICARBONIMIDIC DIAMIDE ACETATE, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
    • N,N-二甲基咪唑二羧酸二乙酸酯,其制备方法和包含其的药物组合物
    • US20100087544A1
    • 2010-04-08
    • US12524695
    • 2008-01-29
    • Sung Wuk KimSung Soo JunYoung Gwan JoJa Seong KooYoung Woong Kim
    • Sung Wuk KimSung Soo JunYoung Gwan JoJa Seong KooYoung Woong Kim
    • A61K31/155C07C279/00A61P3/04A61P3/10A61P9/00A61P35/00A61P19/10
    • A61K31/155C07C279/26
    • The present invention relates to N,N-dimethyl imidodicarbonimidic diamide acetate, a method of preparing the same and a pharmaceutical composition comprising the same, and more particularly, to N,N-dimethyl imidodicarbonimidic diamide acetate which is a crystalline acid addition salt prepared by reacting N,N-dimethyl imidodicarbonimidic diamide with acetic acid, and which is very effective as a therapeutic agent for treating metabolic syndromes that glycosuria and diabetes mellitus, obesity, hyperlipidemia, fatty liver, coronary heart disease, osteoporosis, polycystic ovarian syndrome, a cancer depleted of gene P53, etc. are complexly occurred; treating diabetes mellitus and preventing its complication; and treating a cancer and preventing myalgia, muscle cell cytotoxicity and rhabdomyolysis, etc. since the acid addition salt is excellent in physicochemical properties such as solubility, stability, non-hygroscopicity, anti-adhering property, etc., and low toxicity, a method of preparing the same and a pharmaceutical composition comprising the same.
    • 本发明涉及N,N-二甲基亚氨基二甲酰亚胺二酰胺乙酸盐,其制备方法和包含其的药物组合物,更具体地涉及作为结晶酸加成盐的N,N-二甲基亚氨基二甲酰亚胺二酰胺乙酸盐,其是由 使N,N-二甲基亚氨基二亚甲基二酰胺与乙酸反应,作为治疗代谢综合征的糖尿病,糖尿病,肥胖症,高脂血症,脂肪肝,冠心病,骨质疏松症,多囊卵巢综合征,癌症, 贫血基因P53等复杂发生; 治疗糖尿病并预防其并发症; 并且由于酸加成盐在溶解性,稳定性,非吸湿性,抗附着性等等的物理化学性质和低毒性方面都是优异的,因此治疗癌症并防止肌肉痛,肌肉细胞毒性和横纹肌溶解等。 的制备方法和包含其的药物组合物。